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Stem cell transplantation for treatment of cerebral ischemia in rats Effects of human umbilical cord blood stem cells and human neural stem cells

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Neural Regeneration Research 2010年第7期5卷 485-490页

作者： Fenghua Pan xinsheng ding Haixia ding Weimin Zhang Xiaoxuan Deng Juan Yao Department of Neurology Second Affiliated Hospital Nanjing Medical University Nanjing 210011 Jiangsu Province China Department of Neurology First Affiliated Hospital Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Pathology First Affiliated Hospital Nanjing Medical University Nanjing 210029 Jiangsu Province China

BACKGROUND： Exogenous neural stem cell transplantation promotes neural regeneration. However, various types of stem cells transplantation outcomes remain controversial. OBJECTIVE： To explore distribution, proliferation and differentiation of human neural stem cells （hNSCs） and human umbilical cord blood stem cells （hUCBSCs） following transplantation in ischemic brain tissue of rats, and to compare therapeutic outcomes between hNSCs and hUCBSCs. DESIGN, TIME AND SETTING： Randomized controlled animal studies were performed at the Experimental Animal Center of Nanjing Medical University and Central Laboratory of Second Affiliated Hospital of Nanjing Medical University of China from September 2008 to April 2009. MATERIALS： hNSCs were harvested from brain tissue of 10 13 week old fetuses following spontaneous abortion, and hUCBSCs were collected from umbilical cord blood of full-term newborns at the Second Affiliated Hospital of Nanjing Medical University of China. hNSCs and hUCBSCs were labeled by 5-bromodeoxyuridine （BrdU） prior to transplantation. METHODS： Rat models of cerebral ischemia were established by the suture method. A total of 60 healthy male Sprague Dawley rats aged 7-9 weeks were randomly assigned to hNSC transplantation, hUCBSC transplantation and control groups. The rat models in the hNSC transplantation, hUCBSC transplantation and control groups were infused with hNSC suspension, hUCBSC suspension and saline via the caudal vein, respectively. MAIN OUTCOME MEASURES： The distribution, proliferation and differentiation of hNSCs and hUCBSCs in ischemic brain tissue were observed using immunohistochemical methods. Neurological function in rats was assessed using the neurological severity score. RESULTS： The number of BrdU-positive cells was significantly greater in the hNSC transplantation group compared with hUCBSC transplantation group at 14 days following transplantation （P 〈 0.05） The number of BrdU-positive cells reached a peak at 28 days following tran

关键词： human neural stem cells human umbilical cord blood stem cells transplantation cerebral ischemia neural regeneration

Association of ALOX5AP and PDE4D with the risk of lacunar infarct in people from Jiangsu Province,China

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Neural Regeneration Research 2011年第12期6卷 935-940页

作者： Hong Cheng Qingwen Jin Lixin Li xinsheng ding Xinjian Song Yanying Zeng Department of Neurology First Affiliated Hospital of Nangjing Medical University Nanjing 210029 Jiangsu Province China Department of Neurosurgery First Affiliated Hospital of Nangjing Medical University Nanjing 210029 Jiangsu Province China Department of Senile Neurology First Affiliated Hospital of Nangjing Medical University Nanjing 210029 Jiangsu Province China

The genes for 5-1ipoxygenase activating protein （ALOX5AP） and phosphodiesterase 4D （PDE4D） have been demonstrated as susceptibility genes for lacunar in the Icelandic and Pakistani populations, but little is known about the role of these genes in Chinese populations. The present study utilized polymerase chain reaction and ligase detection reaction to detect single nucleotide polymorphisms （SNPs） in 280 consecutive stroke patients and 258 unrelated population-based controls from Nanjing, Jiangsu Province, China. The allele frequency, genotypes, and haplotypes of the two SNPs （rs456009 and rs966221） in PDE4D were similar between the two groups. However, A allele frequency of rs4073259 （A/G） and rs4769055 （A/C） in the ALOX5AP gene exhibited differences in two groups, and especially the haplotype of the SNP was significantly different between the two groups. Results suggested that the ALOX5AP gene might be involved in lacunar infarct, while PDE4D gene was not a risk factor for lacunar infarct in individuals from Jiangsu Province, China.

关键词： lacunar infarct 5-1ipoxygenase activating protein phosphodiesterase 4D single nucleotide polymorphism polymerase chain reaction ligase detection reaction gene polymorphism

Enantioselective Rh-Catalyzed Hydrogenation of N-Acyl Dehydroamino Esters and Enamides with Monodentate Phosphoramidite Ligands

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Wuhan University Journal of Natural Sciences 2009年第4期14卷 369-372页

作者： LI xinsheng,ding Qianchang,LI Liangchao, XU Dongcheng College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua 321004,Zhejiang,China College of Chemistry and Life Sciences Zhejiang Normal University Jinhua China

Chiral monodentate phosphoramidite ligands were conveniently prepared from 1,1＇-bi-2-naphthol （BINOL） and （S）-pyrrolidine in good yields, which were effective chiral ligands in the enantioselective rhodium-catalyzed hydrogenation of dehydroamino esters and enamides at low hydrogenation pressure. High conversion rate （up to 99% for dehydroamino esters and enamides） and good enantioselectivity （up to 96.3% ee for dehy- droamino esters and 91.7% ee for enamides） were obtained.

关键词： phosphoramidite chirality hydrogenation dehy- droamino ester enamide

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幼儿教师同侪互助观课的理念与运作

学前教育研究 2007年第7期 103-105页

作者：丁新胜南阳师范学院教科院南阳473061

教师同侪互助观课是一种促进幼儿教师教育、提高幼儿教育教学质量的园本培训新模式。教师同侪互助观课有其特定内涵、表现形式、特征及其实施策略。教师同侪互助观课能为我国正在开展的园本培训和园本教研活动提供指导。

关键词：幼儿教师专业化园本培训同侪互助观课

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双江口水电站白湾隧道施工

水力发电 2008年第9期34卷 22-23,26页

作者：曾云丁新胜葛洲坝集团基础工程有限公司湖北宜昌443002

双江口水电站为大渡河干流梯级水电开发的上游控制性工程。拦河大坝为堆石坝。在前期厂内交通工程工期要求紧,且隧洞埋深大、地应力高、岩爆情况突出的条件下,白湾隧洞施工中,施工单位进行持续爆破试验,及时调整爆破参数,不断优化爆破设... 详细信息

双江口水电站为大渡河干流梯级水电开发的上游控制性工程。拦河大坝为堆石坝。在前期厂内交通工程工期要求紧,且隧洞埋深大、地应力高、岩爆情况突出的条件下,白湾隧洞施工中,施工单位进行持续爆破试验,及时调整爆破参数,不断优化爆破设计;采取在围岩表层高压喷洒流水降温,并加大通风,钻设大孔径应力释放孔,超前应力释放爆破,水胀式锚杆,喷射钢纤维混凝土等措施控制岩爆;取得了较好的效果。为以后同类工程施工提供一定的经验和借鉴。

关键词：高地应力岩爆开挖爆破参数双江口水电站

Design of a high sensitivity and wide range angular rate sensor based on exceptional surface

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Chinese Physics B 2024年第8期33卷 277-286页

作者：丁鑫圣刘文耀王师贤陶煜周彦汝白禹刘来邢恩博唐军刘俊 State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement North University of ChinaTaiyuan 030051China

It is found that when the parity–time symmetry phenomenon is introduced into the resonant optical gyro system and it works near the exceptional point,the sensitivity can in theory be significantly amplified at low angular ***,in fact,the exceptional point is easily disturbed by external environmental variables,which means that it depends on harsh experimental environment and strong control ability,so it is difficult to move towards practical ***,we propose a new angular rate sensor structure based on exceptional surface,which has the advantages of high sensitivity and high *** system consists of two fiber-optic ring resonators and two optical loop mirrors,and one of the resonators contains a variable ratio coupler and a variable optical *** theoretically analyze the system response,and the effects of phase and coupling ratio on the system ***,compared with the conventional resonant gyro,the sensitivity of this exceptional surface angular rate sensor can be improved by about 300 times at low *** addition,by changing the loss coefficient in the ring resonator,we can achieve a wide range of 600 rad/*** scheme provides a new approach for the development of ultra-high sensitivity and wide range angular rate sensors in the future.

关键词： exceptional surface exceptional points ring resonator angular rate sensing rotational direction recognition wide operating range

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桥梁BIM技术应用现状分析与思考

城市建筑 2020年第15期17卷 167-168页

作者：丁新胜中铁七局集团郑州工程有限公司河南郑州450000

BIM技术是一种全新的信息管理系统,接下来将通过对它的内涵、本质及其优势进行介绍,阐述该技术在桥梁工程的理论应用和应用现状,讨论该技术在桥梁工程研究中存在的问题和该项技术的发展前景。

关键词：桥梁 BIM技术应用现状

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教师心理健康影响因素探微

中国健康心理学杂志 2005年第5期13卷 359-361页

作者：丁新胜中国河南南阳师范学院教育系 473061

目的从微观层面探讨归因、自我效能感、教育观念、人格因素对教师心理健康的影响。方法使用《教师心理健康问卷》和《PSQ人格问卷》进行问卷调查。结果能力和努力归因对教师心理健康有正向的预测作用;任务难度和运气归因对教师心理健康... 详细信息

目的从微观层面探讨归因、自我效能感、教育观念、人格因素对教师心理健康的影响。方法使用《教师心理健康问卷》和《PSQ人格问卷》进行问卷调查。结果能力和努力归因对教师心理健康有正向的预测作用;任务难度和运气归因对教师心理健康有负向的预测作用。工作效能和创造效能对教师心理健康都有正向的预测作用。成功教育、挫折教育和主动探索的教育观念对教师的心理健康都是正向的预测作用。神经质分数低的教师出现心理问题的几率不大;趋向于外向、开放、随和以及尽职尽责的教师,心理健康水平较高。结论归因、自我效能感、教育观念、人格因素对教师心理健康都有程度不同的影响。

关键词：教师心理健康归因自我效能教育观念人格心理健康问卷健康影响因素自我效能感预测作用

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气化炉内夹套开裂原因分析及改造

大氮肥 2019年第1期42卷 62-65页

作者：丁新生天脊煤化工集团股份有限公司山西长治047507

为解决气化炉内夹套频繁开裂问题,通过对气化炉现场温度、流量试验及开裂部位材料取样试验,对气化炉有限元温度场、应力场进行计算分析,并对气化炉内水动力进行计算分析,针对气化炉内夹套开裂的原因,采取相应措施,效果良好。

关键词：气化炉内夹套应力场水动力