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Ultrasmall copper-based clusterzymes ameliorate Achilles tendinopathy by inhibiting acute oxidative stress

Nano Research 2024年第6期17卷 5374-5389页

作者： Xuzhuo Chen Yi Du Yazi Huang Xianhao Zhou xinru xie Chang Li Chen Zhao Fengrong Dai Xijiao Yu Shanyong Zhang Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai 200011China Department of Endodontics Central LaboratoryJinan Stomatological HospitalJinan Key Laboratory of Oral Tissue RegenerationShandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue RegenerationJinan 250001China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Department of Chemistry College of Chemistry and EnvironmentGuangdong Ocean UniversityZhanjiang 524088China Department of Orthopedics Shanghai Key Laboratory of Orthopedic ImplantShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Tendinopathy is a prevalent musculoskeletal disorder,accounting for over 30%of musculoskeletal ***,current therapeutic strategies for tendinopathy are limited and often yield unsatisfactory clinical ***,there is a critical need to explore novel therapeutic approaches with minimal side effects for tendinopathy and its early *** this study,we successfully designed and synthesized a copper(I)-based nanocluster,named Cu_(11),which possesses remarkable enzyme-like and ROS-scavenging *** unique combination of properties qualifies Cu_(11)as an attractive anti-inflammatory and anti-ROS *** Cu_(11)clusterzymes specifically target mitochondria,effectively scavenging excessive reactive oxygen species(ROS)and reducing oxidative ***,Cu_(11)clusterzymes inhibit the activation of key signaling pathways involved in inflammation,namely tumor necrosis factor(TNF),mitogen-activated protein kinase(MAPK),and nuclear factor(NF)-κB,leading to a decrease in the release of proinflammatory ***,our in vivo experiments using a collagenase-induced acute Achilles tendinopathy model demonstrated that Cu_(11)clusterzymes effectively alleviate inflammation and oxidative stress,without causing systemic *** study highlights the potential of copper-based clusterzymes as therapeutic agents for the treatment of Achilles tendinopathy and other inflammatory *** unique enzyme-like and ROS-scavenging activities of Cu_(11)make it a promising candidate for further development and clinical translation.

关键词： nanoclusters clusterzymes oxidative stress tendinopathy reactive oxygen species(ROS)

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社会工作视角下抑郁症病人服药依从性研究进展

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护理研究 2024年第19期38卷 3518-3522页

作者：谢欣如刘春山西医科大学山西030001

通过对抑郁症病人服药依从性进行综述,分析其影响因素包括:病人自身负性评价、疾病认知偏差、自我管理能力不足;家庭支持系统缺失;医疗场域内医患信任缺失及社会资源总量不足,资源配置不平衡与公众偏见。提出医务社会工作介入的实践路... 详细信息

通过对抑郁症病人服药依从性进行综述,分析其影响因素包括:病人自身负性评价、疾病认知偏差、自我管理能力不足;家庭支持系统缺失;医疗场域内医患信任缺失及社会资源总量不足,资源配置不平衡与公众偏见。提出医务社会工作介入的实践路径包括:帮助病人重塑认知、降低病耻感、提高自我管理能力,构建病人家庭支持网络;融入医疗场域,发挥社会医护角色的作用;链接社会资源,倡导基层医疗资源配置的优化及提升社会大众的疾病包容度。

关键词：社会工作抑郁症服药依从性问题剖析实践路径综述

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工业物联网中基于信息熵的联邦增量学习算法与优化

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电子与信息学报 2024年第8期46卷 3146-3154页

作者：杨睿哲谢欣儒滕颖蕾李萌孙艳华张大君北京工业大学信息学部北京100124 北京工业大学先进信息网络北京实验室北京100124 北京邮电大学电子工程学院北京100083 卡尔顿大学渥太华K1S 5B6

面对工业生产过程中大规模、多样且随时间增长的数据和机器学习任务,该文提出一种基于信息熵的联邦增量学习(FIL)与优化方法。基于联邦框架,各本地计算节点可利用本地数据进行模型训练,并计算信息平均熵上传至服务器,以此辅助识别类增任... 详细信息

面对工业生产过程中大规模、多样且随时间增长的数据和机器学习任务,该文提出一种基于信息熵的联邦增量学习(FIL)与优化方法。基于联邦框架,各本地计算节点可利用本地数据进行模型训练,并计算信息平均熵上传至服务器,以此辅助识别类增任务;全局服务器则根据本地反馈的平均熵选择参与当前轮次训练的本地节点,并判决任务是否产生增量后,进行全局模型下发与聚合更新。所提方法结合平均熵和阈值进行不同情况下的节点选择,实现低平均熵下的模型稳定学习和高平均熵下的模型增量式扩展。在此基础上,采用凸优化,在资源有限的情况下自适应地调整聚合频率和资源分配,最终实现模型的有效收敛。仿真结果表明,在不同的情景下,该文所提方法都可以加速模型收敛并提升训练精度。

关键词：工业物联网联邦增量学习信息平均熵

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Adaptive coupled-sliding-variable-based finite-time control of composite formation for multi-robot systems

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Science China(Information Sciences) 2024年第10期67卷 244-260页

作者： xinru MA Hengyu LI Jun LIU Yueying WANG Shaorong xie Jun LUO School of Mechatronic Engineering and Automation Shanghai University School of Mathematics and Computer Application Technology Jining University School of Computer Science Shanghai University College of Mechanical and Vehicle Engineering Chongqing University

This paper focuses on the finite-time control(FTC) of the composite formation consensus(CFC)problems for multi-robot systems(MRSs). The CFC problems are firstly proposed for MRSs under the complex network topology of cooperative or cooperative-competitive networks. Regarding the problems of FTC and CFC on multiple Lagrange systems(MLSs), coupled sliding variables are introduced to deal with the robustness and consistent convergence. Then, the adaptive finite-time protocols are given based on the displacement approaches. With the premised FTC, tender-tracking methods are further developed for the problems of tracking information disparity. Stability analyses of those MLSs mentioned above are clarified with Lyapunov candidates considering the coupled sliding vectors, which provide new verification for tender-tracking systems. Under the given coupled-sliding-variable-based finite-time protocols, MLSs distributively adjust the local formation error to achieve global CFC and perform uniform convergence in time-varying tracking. Finally, simulation experiments are conducted while providing practical solutions for the theoretical results.

关键词： composite formation time-vary tracking information disparity tender-tracking finite-time control nonlinear robots complex networks symmetry consensus

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海南医学院学报 2024年第11期30卷 817-823页

作者：古丽沙提·海米提朱玥洁谢忻汝郭文宏丁剑冰鲁晓擘张峰波新疆医科大学第一附属医院检验科新疆乌鲁木齐830011 新疆医科大学第一附属医院感染病·肝病中心新疆乌鲁木齐830011 新疆医科大学第一附属医院生殖助孕科新疆乌鲁木齐830011 新疆医科大学省部共建中亚高发病成因与防治国家重点实验室新疆乌鲁木齐830003

目的:探讨乙型肝炎病毒(hepatitis B virus,HBV)相关慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)患者病程中可溶性程序性死亡蛋白1(soluble Programmed cell death protein1,sPD-1)、可溶性程序性死亡蛋白配体-1(soluble Programmed cell death ligand1,sPD-L1)、T淋巴细胞、白细胞介素-10(interleukin-10,IL-10)和转化生长因子-β(transforming growth factor-β,TGF-β)的表达水平及各指标间的相关性。方法:收集71例确诊为HBV-ACLF患者的资料及外周血标本,根据研究对象28 d的随访结果,分为存活组40例和死亡组31例。采用流式细胞术检测研究对象外周血CD4+T及CD8+T细胞的比例。采用流式液相多重蛋白定量(cytometric bead array,CBA)技术检测sPD-1和sPD-L1的表达。采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)检测TGF-β和IL-10的表达。Pearson法分析HBVACLF患者血清中sPD-1/sPD-L1与患者MELD评分、T细胞及细胞因子水平的相关性。结果:死亡组外周血及血清中CD4+T细胞百分比、sPD-1、sPD-L1、IL-10和TGF-β高于存活组,而CD8+T细胞百分比低于存活组(P均<0.05)。经相关性分析显示,sPD-1水平与IL-10、TGF-β和CD4+T细胞百分比呈正相关,与CD8+T细胞百分比呈负相关。sPD-L1水平与终末期肝病模型(model for end-stage liver disease,MELD)评分、IL-10、TGF-β和CD4+T呈正相关,与CD8+T细胞比例呈负相关(P均<0.05)。结论:sPD-1/sPDL1可能参与了HBV-ACLF发生、发展过程中的免疫应答,通过综合考虑患者sPD-1和sPD-L1水平可以为HBV-ACLF患者开展及时有效的治疗提供一定的参考。

关键词：慢加急性肝衰竭 T细胞可溶性程序性死亡蛋白-1 可溶性程序性死亡蛋白配体-1

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布鲁菌病患者CD4^(+)T细胞Tim-3及其相关细胞因子的表达及临床意义

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中国热带医学 2024年第4期24卷 433-437页

作者：郭文宏谢忻汝古丽沙提·海米提麦尔哈巴·艾斯卡尔殷郑伟丁剑冰张峰波新疆医科大学第一附属医院检验科新疆乌鲁木齐830054 新疆医科大学基础医学院新疆乌鲁木齐830011 省部共建中亚高发病成因与防治国家重点实验室新疆医科大学第一附属医院新疆乌鲁木齐830011

目的探讨布鲁菌病(brucellosis melitensis,Bm,简称布病)患者T细胞表面T细胞免疫球蛋白和黏蛋白结构域蛋白3(T cell immunoglobulin and mucin domain-containing protein 3,Tim-3)以及血清中白细胞介素-10(interleukin-10,IL-10)和转化生长因子-β(transforming growth factor beta,TGF-β)的表达情况,分析这些指标在急慢性期患者中的表达差异,为急慢性期布病鉴别诊断提供新方案。方法选取2023年4—9月在新疆医科大学第一附属医院确诊为布鲁菌病患者56例,其中31例为急性期患者,25例为慢性期患者。同期35例健康体检者为健康对照。运用流式细胞术检测并比较各组CD4+T细胞表面Tim-3水平,运用流式液相多重蛋白定量实验(cytometric bead array,CBA)和酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)检测并比较各组血清中IL-10和TGF-β的水平,并分析这些因素与布病患者分期的关系。结果对照组、急性组和慢性组的Tim-3^(+)CD3^(+)CD4^(+)T细胞占比分别为(2.56±1.25)%、(5.14±1.98)%和(13.66±2.66)%,患者组的Tim-3水平较健康对照组高,且慢性组更高,差异有统计学意义(P<0.05)。患者组的IL-10和TGF-β水平较健康对照组高,且慢性组IL-10、TGF-β水平均明显高于急性组,差异有统计学意义(P<0.05)。Tim-3、IL-10和TGF-β评分预测布病患者慢性期的受试者工作特征(receiver operating characteristic,ROC)曲线下面积分别为0.876、0.865、0.663。结论Tim-3以及血清IL-10和TGF-β在布病患者中表达存在一定的差异性,Tim-3、IL-10和TGF-β高表达提示患者有可能转变为布病慢性期,且Tim-3的诊断效果最好。因此,Tim-3作为诊断指标可能为布病的治疗与鉴别诊断提供新的思路和策略。

关键词：布鲁菌病 T细胞免疫球蛋白和黏蛋白结构域蛋白3 细胞因子鉴别诊断

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Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer

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Chinese Chemical Letters 2024年第8期35卷 443-448页

作者： Yiran Tao Chunlei Dai Zhaoxiang xie xinru You Kaiwen Li Jun Wu Hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Guangdong Provincial Clinical Research Center for Urological Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Traditional therapies such as surgery and endocrine therapy no longer meet the clinical needs in prostate cancer treatment,and more effective treatments are urgently *** studies have reported that targeted inhibition of the transcription factor cyclin dependent kinase 7(CDK7)could effectively suppress prostate cancer ***,the toxicity of CDK7 inhibitors such as THZ1 is the main limitation of the clinical *** this work,we synthesized Cys8E(C8E)nanoparticles(NPs)loaded with THZ1(C8E@THZ1),a novel GSH-targeting and stimuli-responsive nano-delivery platform,and investigated its anti-tumor potential and biosafety *** vitro,C8E@THZ1 potently inhibited the proliferation and promoted the apoptosis of prostate cancer *** tumor-bearing mice,C8E@THZ1 inhibited tumors by up to 85%,while the damage of THZ1 to liver function was effectively *** results confirmed that inhibition of CDK7 can effectively block the progression of prostate cancer,and that Cys8E NPs is a highly prospective delivery platform to promote the clinical application of CDK7 inhibitors.

关键词： Prostate cancer Nanoparticles CDK7 THZ1 THZ1@Cys8E NPs

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Mechanism of Spine Motion About Contact Time in Quadruped Running

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Chinese Journal of Mechanical Engineering 2019年第2期32卷 53-60页

作者： Qi Liu Yannian Bao Wei Yu Jianming Zhang Chao Li xinru xie Institute of Chemical Materials China Academy of Engineering Physics College of Automation Harbin Engineering University

The current research of quadruped robot focuses on the quadruped robot with spine motion. Contact time is a very important part of system performance. However, the mechanism of spine motion about contact time has not been clearly elucidated. In this paper, the e ect of spine motion on contact time is studied deeply from dynamic ***, a simplified model of the quadruped robot with spine joint is set up, its dynamic equations are derivated, and a method that can generate passive periodic locomotion is proposed. Secondly, according to the vertical spring oscillator model, the two-dimension planar locomotion of the simplified model is regarded as a special vibration in the vertical direction, and the approximate formula of calculating contact time is obtained. Finally, the approximate formula of calculating contact time is verified by the simulation results of passive periodic locomotion, and the e ect of spine motion on contact time is deeply discussed based on the approximate formula of calculating contact time. The discussion proves that spine motion indeed has little e ect on contact time, but spine motion can slightly reduce body pith movement and regulate the leg sti ness in leg contact phase. This research proposes an e ective research method which can be used to study the motion mechanism of the quadruped robot with spine motion,and the mechanism of spine motion about contact time is clearly elucidated which is helpful to set the parameters of mechanical structure and study control algorithm about the quadruped robot with spine motion.

关键词： Quadruped robot Spine motion Passive locomotion Contact time Leg sti ness

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Adaptive Impedance Control Method for Industrial Manipulator Writing Based on Kalman Filter

Adaptive Impedance Control Method for Industrial Manipulator...

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第37届中国控制会议

作者： Qidan Zhu xinru xie Chao Li Guihua Xia College of Automation Harbin Engineering University

This paper presents an adaptive impedance control method based on Kalman filter to write Chinese characters for industrial manipulator. Kalman filter is used to estimate the actual contact force. For safety, the contact force is controlled to maintain constant using the adaptive impedance control method. There is no need for the knowledge of the environment. A robot Chinese characters writing system is designed to write characters on a stiff board. The writing experiment results verified the performance of the proposed method, and the trajectory and force can be tracked simultaneously.

关键词： characters writing adaptive impedance control Kalman filter industrial manipulator

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基于光轴约束的机械臂运动学标定方法

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哈尔滨工程大学学报 2019年第3期40卷 433-439页

作者：朱齐丹谢心如夏桂华李超刘琦哈尔滨工程大学自动化学院黑龙江哈尔滨150001 中国工程物理研究院化工材料研究所四川绵阳621000

为了提高机械臂的绝对定位精度,本文提出一种基于光轴虚拟约束的运动学参数标定方法。建立基于虚拟直线约束的运动学误差模型;本文在相机光轴的约束下,使用基于图像的视觉控制方法,使机械臂末端标定板的固定特征点依次到达光轴的多个位... 详细信息

为了提高机械臂的绝对定位精度,本文提出一种基于光轴虚拟约束的运动学参数标定方法。建立基于虚拟直线约束的运动学误差模型;本文在相机光轴的约束下,使用基于图像的视觉控制方法,使机械臂末端标定板的固定特征点依次到达光轴的多个位置;根据运动学模型计算特征点的对齐位置差,并使用迭代最小二乘法求解运动学参数误差。设计了Reinovo六自由度工业机械臂的运动学参数标定实验,对于随机产生的测试点,标定前的平均对齐误差为1. 50 mm,标定后降至0. 72 mm,机械臂末端的定位精度提高了52%,实验结果验证了该方法的有效性。

关键词：机械臂虚拟约束光轴参数标定视觉控制定位精度迭代最小二乘

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