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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1456-1461页

作者： Anran Zhang xinquan Zhou Ranran gu Zhiguo Xia State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied TechniquesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China

Mn^(2+)doping has been adopted as an efficient approach to regulating the luminescence properties of halide perovskite nano-crystals(NCs).However,it is still difficult to understand the interplay of Mn^(2+)luminescence and the matrix self-trapped exciton(STE)emission therein.In this study,Mn^(2+)-doped CsCdCl_(3) NCs are prepared by hot injection,in which CsCdCl_(3) is selected because of its unique crystal structure suitable for STE emission.The blue emission at 441 nm of undoped CsCdCl_(3) NCs originates from the defect states in the NCs.Mn^(2+)doping promotes lattice distortion of CsCdCl_(3) and generates bright orange-red light emission at 656 nm.The en-ergy transfer from the STEs of CsCdCl_(3) to the excited levels of the Mn^(2+)ion is confirmed to be a significant factor in achieving efficient luminescence in CsCdCl_(3):Mn^(2+)NCs.This work highlights the crucial role of energy transfer from STEs to Mn^(2+)dopants in Mn^(2+)-doped halide NCs and lays the groundwork for modifying the luminescence of other metal halide perovskite NCs.

关键词： perovskite nanocrystals self-trapped excitons luminescence energy transfer

Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma A meta-analysis

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Neural Regeneration Research 2013年第26期8卷 2468-2477页

作者： xinquan gu Hongyan Sun Liping Chang Ran Sun Hongfeng Yang Xuewen Zhang Xianling Cong Department of Urinary Surgery China-Japan Union Hospital of Jilin University Tissue Bank China-Japan Union Hospital of Jilin University Department of Cardiopathy the Affiliated Hospital of Changchun University of Chinese Medicine Department of Dermatology China-Japan Union Hospital of Jilin University

OBJECTIVE： To evaluate the association of X-ray cross-complementing group 1 （XRCC1） Arg399GIn, Arg194Trp and Arg280His polymorphisms with the risk of glioma. DATA SOURCES： A systematic literature search of papers published from January 2000 to August 2012 in PubMed, Embase, China National Knowledge Infrastructure database, and Wanfang da- tabase was performed. The key words used were ＂glioma＂, ＂polymorphism＂, and ＂XRCC1 or X-ray repair cross-complementing group 1＂. References cited in the retrieved articles were screened manually to identify additional eligible studies. STUDY SELECTION： Studies were identified according to the following inclusion criteria： case-control design was based on unrelated individuals; and genotype frequency was available to estimate an odds ratio （OR） and 95% confidence interval （CI）. Meta-analysis was performed for the selected studies after strict screening. Dominant and recessive genetic models were used and the relationship between homozygous mutant genotype frequencies and mutant gene frequency and glioma incidence was investigated. We chose the fixed or random effect model according to the heterogeneity to calculate OR and 95%CI, and sensitivity analyses were conducted. Publication bias was examined using the inverted funnel plot and the Egger＇s test using Stata 12.0 software. MAIN OUTCOME MEASURES： Association of XRCC1 Arg399GIn, Arg194Trp, and Arg280His polymorphisms with the risk of glioma, and subgroup analyses were performed according to differ- ent ethnicities of the subjects.RESULTS： Twelve articles were included in the meta-analysis. Eleven of the articles were concerned with the Arg399GIn polymorphism and glioma onset risk. Significantly increased glioma risks were found only in the dominant model （Gin/Gin ＋ GIn/Arg versus Arg/Arg： OR = 1.26, 95%CI= 1.03-1.54, P = 0.02）. In the subgroup analysis by ethnicity, significantly increased risk was found in Asian subjects in the recessive （OR = 1.46, 95%CI= 1.04-2.45, P = 0.03） and dominant models （OR = 1.40, 95%CI= 1.10-1.78, P

关键词： neural regeneration meta-analysis glioma X-ray cross-complementing group 1 gene polymorphism meta-analysis susceptibility onset risk gene mutation grants-supported paper neuroregeneration

Biotinylated dextran amine is an ideal anterograde tracer for the corticospinal tract in a goat model of ischemic corticospinal tract injury

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Neural Regeneration Research 2011年第25期6卷 1960-1964页

作者： Xiaoyu Yang Yufei Gao Zhigang Qin Xia Cao xinquan gu China-Japan Union Hospital Jifin University Changchun 130033 Jilin Province China School of Pharmaceutical Sciences Jilin University Changchun 130021 Jifin Province China

Existing visualized tracer studies of the corticospinal tract have been focused on rodents, which have markedly different spinal cord structures compared with humans. In this study, the segmental artery feeding the spinal cord was embolized with digital subtraction angiography to establish a goat model of ischemic spinal cord injury. Biotinylated dextran amine was injected into the motor function areas of the cortex in goats with ischemic spinal cord injury. The corticospinal tract originates from the cerebral cortex motor function area, and travels towards the lateral funiculus at the contralateral spinal dorsal horn after decussation at the pyramid. The number of corticospinal tract positive fibers was found to be gradually reduced. These findings indicate that digital subtraction angiography can be applied to a goat model of ischemic spinal cord injury. Biotinylated dextran amine visualizes the course of the goat corticospinal tract in the spinal cord, which is similar to the human spinal cord. Biotinylated dextran amine is an ideal tracer for the corticospinal tract.

关键词： corticospinal tract biotinylated dextran amine ischemic spinal cord injury digital subtraction angiography tracer neuroanatomy neural regeneration

Hippocampal mitochondrial cytochrome C oxidase activity and gene expression in a rat model of chronic cerebral ischemia

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Neural Regeneration Research 2011年第32期6卷 2527-2531页

作者： Qing Zhao Yingli Zhang Mingming Zhao Yu Wang Ming Ma xinquan gu Xia Cao China-Japan Union Hospital Jilin University Changchun 130033 Jilin Province China School of Pharmaceutical Sciences Jilin University Changchun 130021 Jilin Province China

The present study established a rat model of chronic cerebral ischemia using bilateral common carotid artery permanent ligation to analyze cytochrome C oxidase activity and mRNA expression in hippocampal mitochondria. Results showed significantly decreased cytochrome C oxidase activity and cytochrome C oxidase II mRNA expression with prolonged ischemia time. Further analysis revealed five mitochondrial cytochrome C oxidase II gene mutations, two newly generated mutations, and four absent mutational sites at 1 month after cerebral ischemia, as well as three mitochondrial cytochrome C oxidase III gene mutations, including two newly generating mutations, and one disappeared mutational site at 1 month after cerebral ischemia. Results demonstrated that decreased cytochrome C oxidase gene expression and mutations, as well as decreased cytochrome C oxidase activity, resulting in energy dysmetabolism, which has been shown to be involved in the DatholoQical Process of ischemic brain iniurv.

关键词： cerebral ischemia cytochrome C oxidase gene mutation hippocampus mitochondrion neural regeneration

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数字化上颌骨缺损赝复体修复新进展

中国口腔医学继续教育杂志 2024年第1期27卷 13-18页

作者：顾晓宇蒋欣泉上海交通大学医学院附属第九人民医院口腔修复工艺科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海交通大学医学院附属第九人民医院口腔修复科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所

上颌骨缺损是口腔颌面部缺损最常见的类型,但传统取模制作赝复体的方式操作复杂、修复效果欠佳。数字化技术为上颌骨缺损的赝复体修复提供了新的途径。不同学者的研究提出不同的数字化实现方式,都大大改善了赝复体的制作过程和临床效果... 详细信息

上颌骨缺损是口腔颌面部缺损最常见的类型,但传统取模制作赝复体的方式操作复杂、修复效果欠佳。数字化技术为上颌骨缺损的赝复体修复提供了新的途径。不同学者的研究提出不同的数字化实现方式,都大大改善了赝复体的制作过程和临床效果,成为上颌骨缺损赝复体修复的重要发展方向之一。本文利用万方数据平台及PubMed数据库进行检索,从上颌骨缺损的数字模型获取方式、赝复体三维设计、赝复体数字化加工、数字化种植辅助修复上颌骨缺损等方面对数字化上颌骨缺损赝复体修复技术进行分析,其中包括各种新技术和新设计理念的联合应用,以及新材料制作赝复体的临床尝试。以多学科融合方式,以外形和功能重建的综合性修复为理念,为上颌骨缺损数字化修复指明新的发展方向。

关键词：上颌骨缺损赝复体阻塞器口内扫描三维打印

Long-term anodal block stimulation at sacral anterior roots promoted recovery of neurogenic bladder function in a rabbit model of complete spinal cord injury

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Neural Regeneration Research 2012年第5期7卷 352-358页

作者： Xiaoran Wang Qi Gao Xiaoyu Yang Weihua Wang xinquan gu guifeng Liu Peng Yan Ge Gao Xin Yu Yongjie Wang Jihu Lian Chaoling Shi Yao Wang Li Fan Department of Urology China-Japan Union Hospital of Jilin University Chan.clchun 130033 Jilin Province China Department of Orthopedics China-Japan Union Hospital of Jilin University Chan.qchun 130033 Jilin Province China Department of Radiology China-Japan Union Hospital of Jilin University Changchun 130033 Jilin Province China Department of Pathology China-Japan Union Hospital of Jilin University Changchun 130033 Jilin Province China Department of Critical Care Medicine People＇s Hospital of Jilin Province Changchun 130021 Jilin Province China Department of Urology Jilin Provincial Hospital changchun 130021 Jilin Province China Department of Urology the Fourth Hospital of Jilin University Changchun 13001 I Jilin Province China

A complete spinal cord injury model was established in experimental rabbits using the spinal cord clip compression method. Urodynamic examination was performed 2 weeks later to determine neurogenic bladder status. The rabbits were treated with anodal block stimulation at sacral anterior roots for 4 weeks. Electrical stimulation of sacral anterior roots improved urodynamic parameters of neurogenic bladder in rabbit models of complete spinal cord injury, effectively promoted urinary function, and relieved urinary retention. Immunohistochemistry results showed that a balance was achieved among expression of muscarinic receptor subunits M2, M3, ATP-gated ion channel P2X3 receptors, and 132-adrenergic receptor, and nerve growth factor expression decreased. These results suggested that long-term sacral anterior root stimulation of anodal block could＇be used to treat neurogenic bladder in a rabbit model of complete spinal cord injury.

关键词： anode block electrical stimulation immunohistochemistry neurogenic bladder urodynamics spinal cord injury

保留膀胱颈对机器人辅助腹腔镜前列腺根治性切除术后早期尿控恢复的研究

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长春中医药大学学报 2024年第1期40卷 83-86页

作者：姜勇男王凯晨刘斌李杨谷欣权吉林大学中日联医院泌尿外科一病区长春130000

目的探讨膀胱颈保留技术应用于机器人辅助腹腔镜根治性前列腺切除术(robot-assisted laparoscopic radical prostatectomy,RALP)中对患者术后早期尿控恢复的有效性。方法回顾性分析2020年5月-2022年8月于吉林大学白求恩第三医院行机器... 详细信息

目的探讨膀胱颈保留技术应用于机器人辅助腹腔镜根治性前列腺切除术(robot-assisted laparoscopic radical prostatectomy,RALP)中对患者术后早期尿控恢复的有效性。方法回顾性分析2020年5月-2022年8月于吉林大学白求恩第三医院行机器人辅助根治性前列腺切除术53例,其中保留膀胱颈患者31例为研究组,未保留膀胱颈患者22例为对照组。收集患者年龄、前列腺体积、术前PSA、手术时长、出血量、切缘阳性率、引流管拔除时间、导尿管留置时间、术后病理分期、Gleason评分、术后并发症、术后尿垫使用量等资料,并进行统计学分析。结果经过非参数秩和检验,研究组与对照组术后即刻、术后1月、术后2月、术后3月尿垫使用量差异有统计学意义(P <0.05);术后6月尿垫使用量差异无统计学意义(P=0.090)。结论在不影响肿瘤切缘及手术疗效的前提下,机器人辅助前列腺根治性切除术中保留膀胱颈可提升术后即刻尿控率及早期尿控率,优化患者生存质量。

关键词：前列腺癌根治性前列腺切除术保留膀胱颈早期尿控

Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

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Bone Research 2022年第4期10卷 816-825页

作者： Qianju Wu Longwei Hu Ran Yan Junfeng Shi Hao gu Yuwei Deng Ruixue Jiang Jin Wen xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina Stomatological Hospital of Xiamen Medical College XiamenFujian 361008China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina

The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis.

关键词： osteoporosis treatment regeneration

STABILITY OF ALPINE MEADOW ECOSYSTEM ON THE QINGHAI-TIBETAN PLATEAU

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Chinese Science Bulletin 2006年第3期51卷 320-327页

作者： ZHOU Huakun ZHOU Li ZHAO xinquan LIU Wei LI Yingnian gu Song ZHOU Xinmin Northwest Plateau Institute of Biology Chinese Academy of Sciences Xining 810001 China Graduate University of Chinese Academy of Sciences Beijing 100049China

The meadow ecosystem on the Qing- hai-Tibetan Plateau is considered to be sensitive to climate change. An understanding of the alpine meadow ecosystem is therefore important for pre- dicting the response of ecosystems to climate change. In this study, we use the coefficients of variation (Cv) and stability (E) obtained from the Haibei Alpine Meadow Ecosystem Research Station to characterize the ecosystem stability. The results suggest that the net primary production of the alpine meadow eco- system was more stable (Cv = 13.18%) than annual precipitation (Cv = 16.55%) and annual mean air temperature (Cv = 28.82%). The net primary produc- tion was insensitive to either the precipitation (E = 0.0782) or air temperature (E = 0.1113). In summary, the alpine meadow ecosystem on the Qinghai- Tibetan Plateau is much stable. Comparison of alpine meadow ecosystem stability with other five natural grassland ecosystems in Israel and southern African indicates that the alpine meadow ecosystem on the Qinghai-Tibetan Plateau is the most stable ecosys- tem. The alpine meadow ecosystem with relatively simple structure has high stability, which indicates that community stability is not only correlated with biodiversity and community complicity but also with environmental stability. An average oscillation cycles of 3―4 years existed in annual precipitation, annual mean air temperature, net primary production and the population size of consumers at the Haibei natural ecosystem. The high stability of the alpine meadow ecosystem may be resulting also from the adaptation of the ecosystem to the alpine environment.

关键词：高山草甸生态系统生态稳定性变异系数生态多样性青藏高原

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人工种植牙邻接触丧失应对策略的专家共识

口腔疾病防治 2024年第7期32卷 485-493页

作者：宋光保蒋欣泉万乾炳黄翠李彦顾新华吴哲汪振华李鸿波邵龙泉刘洪臣南方医科大学口腔医院特诊中心广东广州510280 上海交通大学医学院附属第九人民医院上海200011 四川大学华西口腔医院修复科四川成都610041 武汉大学口腔医院修复科湖北武汉430079 中山大学附属光华口腔医院修复科广东广州510260 浙江大学医学院附属口腔医院修复科浙江杭州310016 广州医科大学附属口腔医院修复科广东广州510145 乌鲁木齐口腔医院新疆维吾尔自治区乌鲁木齐830002 中国人民解放军总医院第一医学中心口腔科北京100853

人工种植牙邻接触丧失(proximal contact loss,PCL)所引发的问题是近年研究热点,学者们一致致力于其原因和相关因素分析,旨在寻求解决与PCL相关问题的方案。前驱力作用、颌骨及牙槽窝等终身改建以及种植牙的骨整合特性是PCL的主要原因... 详细信息

人工种植牙邻接触丧失(proximal contact loss,PCL)所引发的问题是近年研究热点,学者们一致致力于其原因和相关因素分析,旨在寻求解决与PCL相关问题的方案。前驱力作用、颌骨及牙槽窝等终身改建以及种植牙的骨整合特性是PCL的主要原因。一方面,下颌的闭口运动通过后牙牙尖产生了将牙齿往近中移位的前驱力,使上下颌后牙、下颌前牙近中漂移,同时,可使上下颌前牙唇向移位;另一方面,颌骨、牙槽窝、牙根的改建以及咀嚼肌的前向水平分力、下颌向前向上的动力分量以及牙尖斜面产生的向前分力使天然牙向近中漂移;此外,天然牙终身具备水平、垂直向移位以及旋转的能力,以适应口颌系统的改建和维持口腔的功能,而种植牙骨整合缺乏天然的牙周膜,缺乏近中漂移生理基础,垂直向平均动度微小,种植牙骨整合沉默性不具备天然牙整体漂移特点,增加了PCL发生的可能性。PCL高发生率与戴牙时间和近中位置有明显相关性,但也受咬合力大小、对颌牙状况、邻牙情况、修复方式、牙位、上下颌骨、年龄、性别等因素影响。PCL与食物嵌塞呈显著相关性,但并不一一对应,不满足充分必要条件。PCL也与种植体周病变以及龋齿等有关。PCL的预防包括知情同意、定期检查、固位方式选择、接触点增强、配戴保持器以及应用多用途数字化牙冠。PCL的处理包括邻接触点增补、正畸牵引以及咬合调整。现有方法可以短期解决食物嵌塞情况,综合干预以寻求稳定的远期效果。对称、平衡的考量将拓展处理有关PCL引发的问题。

关键词：牙种植种植修复体邻接触邻接触丧失近中漂移食物嵌塞邻接天然牙种植并发症