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International Journal of Mental Health Promotion 2024年第2期26卷 105-116页

作者： xinqiao Liu Linxin Zhang Xinran Zhang School of Education Tianjin UniversityTianjin300350China

Under the effects of COVID-19 and a number of ongoing lockdown tactics,anxiety symptoms and poor sleep quality have become common mental health issues among college freshmen and are intimately related to their emotional adaptation.To explore this connection,this study gathered data from a sample of 256 freshmen enrolled in an elite university in China in September 2022.The association between sleep quality,anxiety symptoms,and emotional adaptation was clarified using correlation analysis.Additionally,the mediating function of anxiety symptoms between sleep quality and emotional adaptation was investigated using a structural equation model.The results reveal that:(1)Chinese elite university freshmen who were subjected to prolonged lockdown had poor sleep quality and mild anxiety symptoms;(2)a significant positive correlation between poor sleep quality and anxiety symptoms was identified;(3)anxiety symptoms were found to have a significant negative impact on emotional adaptation;(4)poor sleep quality had a negative impact on emotional adaptation through anxiety symptoms.This research makes a valuable contribution by offering insights into the intricate relationship between sleep quality and emotional adaptation among freshmen in elite Chinese universities during prolonged lockdown conditions,and it is beneficial for schools and educators to further improve school schedules and psychological health initiatives.

关键词： COVID-19 pandemic sleep quality emotional adaptation anxiety symptoms lockdown freshmen

Fast Cycle Structure Detection for Power Grids Based on Graph Computing

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CSEE Journal of Power and Energy Systems 2023年第6期9卷 2204-2213页

作者： xinqiao wang Kewen Liu Weijiang Lu Ting Zhao Baohua Zhao Xiaoming Liu the Computing&Application Technology Research Division Global Energy Interconnection Research InstituteBeijing 102209China

The cycle structure in a power grid may lower the stability of the network;thus,it is of great significance to accu-rately and timely detect cycles in power grid networks.However,detecting possible cycles in a large-scale network can be highly time consuming and computationally intensive.In addition,since the power grid's topology changes over time,cycles can appear and disappear,and it can be difficult to monitor them in real time.In traditional computing systems,cycle detection requires considerable computational resources,making real-time cycle detection in large-scale power grids an impossible task.Graph computing has shown excellent performance in many areas and has solved many practical graph-related problems,such as power flow calculation and state estimation.In this article,a cycle detection method,the Paton method,is implemented and optimized on a graph computing platform.Two cases are used to test its performance in an actual power grid topology scenario.The results show that the graph computing-based Paton method reduces the time consumption by at least 60%compared to that of other methods.

关键词： Cycle detection graph computing power grid distribution grid

基于改进CenterNet的轻量级无锚框SAR图像多尺度舰船检测算法

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哈尔滨工程大学学报 2024年第3期45卷 504-516页

作者：谢洪途姜新桥王国倩谢恺中山大学(深圳)电子与通信工程学院广东深圳518107 广州医科大学第五附属医院广东广州510700

针对复杂场景下多尺度舰船检测精度较差、效率较低、泛化性较弱等问题,本文构建了一个轻量级无锚框的合成孔径雷达图像舰船检测框架。为满足合成孔径雷达图像舰船实时检测的需求,提出了基于改进CenterNet的轻量级无锚框合成孔径雷达图... 详细信息

针对复杂场景下多尺度舰船检测精度较差、效率较低、泛化性较弱等问题,本文构建了一个轻量级无锚框的合成孔径雷达图像舰船检测框架。为满足合成孔径雷达图像舰船实时检测的需求,提出了基于改进CenterNet的轻量级无锚框合成孔径雷达图像舰船检测方法,通过预测目标关键点的信息及检测框的相关属性,实现了合成孔径雷达图像舰船快速准确定位与检测。为解决合成孔径雷达图像样本稀缺的问题,采用了适用于合成孔径雷达舰船图像的数据增强方法以扩充训练样本,并引入了多尺度训练以增强模型泛化性能。实验结果表明:本文方法具有检测效率高、检测精度好、泛化性能强等优势,能实现复杂场景下多尺度舰船的实时高精度检测。

关键词：合成孔径雷达图像复杂场景多尺度训练舰船检测改进CenterNet 轻量级无锚框数据增强

Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder

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Neural Regeneration Research 2024年第7期19卷 1618-1624页

作者： Luyi wang Man Xu Yan wang Feifei wang Jing Deng Xiaoya wang Yu Zhao Ailing Liao Feng Yang Shali wang Yingbo Li Institute of Neuroscience Department of PhysiologySchool of Basic Medical ScienceChongqing Medical UniversityChongqingChina Department of Pediatric Chongqing University Fuling HospitalChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Pathology Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina NHC Key Laboratory of Birth Defects and Reproductive Health Chongqing Population and Family Planning Science and Technology Research InstituteChongqingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina

Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate gene.Ctnnd2knockout mice,serving as an animal model of autis m,have been demonstrated to exhibit decreased density of dendritic spines.The role of melatonin,as a neuro hormone capable of effectively alleviating social interaction deficits and regulating the development of dendritic spines,in Ctnnd2 deletion-induced nerve injury remains unclea r.In the present study,we discove red that the deletion of exon 2 of the Ctnnd2 gene was linked to social interaction deficits,spine loss,impaired inhibitory neurons,and suppressed phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signal pathway in the prefrontal cortex.Our findings demonstrated that the long-term oral administration of melatonin for 28 days effectively alleviated the aforementioned abnormalities in Ctnnd2 gene-knockout mice.Furthermore,the administration of melatonin in the prefro ntal cortex was found to improve synaptic function and activate the PI3K/Akt signal pathway in this region.The pharmacological blockade of the PI3K/Akt signal pathway with a PI3K/Akt inhibitor,wo rtmannin,and melatonin receptor antagonists,luzindole and 4-phenyl-2-propionamidotetralin,prevented the melatonin-induced enhancement of GABAergic synaptic function.These findings suggest that melatonin treatment can ameliorate GABAe rgic synaptic function by activating the PI3K/Akt signal pathway,which may contribute to the improvement of dendritic spine abnormalities in autism spectrum disorders.

关键词： autism Ctnnd2 deletion GABAergic neurons melatonin PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins

Space advanced technology demonstration satellite

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Science China(Technological Sciences) 2024年第1期67卷 240-258页

作者： ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE Junwang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin wang YaMin SUN AnTai ZHANG KuoXiang SUN Ying wang YaoBin FAN ChengCheng XIONG ShaoLin LI xinqiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong wang ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong wang ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng wang XinYu DOU RunJiang WENG LuBin LUO Hao wang YaPing LIANG XianFeng FANG ZiRuo Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of China Beijing 100101China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China School of Earth and Space Sciences Peking UniversityBeijing 100871China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China Shenyang Institute of Automation Chinese Academy of SciencesShenyang 110016China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China Nanyang Technological University Singapore 569830Singapore Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100049China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China Institute of Automation Chinese Academy of SciencesBeijing 100190China School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310058China

The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance.

关键词： SATech-01 spacecraft design scientific instruments on-orbit performance

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基于物联网的无人机智能巡线路径规划方法

电网与清洁能源 2024年第3期40卷 78-83,91页

作者：刘岚吴新桥李彬王昊杨倩影南方电网数字电网研究院有限公司广东广州510000

为在输电线路环境不确定因素较多的情况下,确保智能巡线路径规划效果,提高障碍物勘测安全性及目标搜索准确率,提出基于物联网的无人机智能巡线路径规划方法。基于物联网平台特点,结合输电线路周围环境特征,利用视距测量方法测试安全距离... 详细信息

为在输电线路环境不确定因素较多的情况下,确保智能巡线路径规划效果,提高障碍物勘测安全性及目标搜索准确率,提出基于物联网的无人机智能巡线路径规划方法。基于物联网平台特点,结合输电线路周围环境特征,利用视距测量方法测试安全距离;采用加权距离公式,计算地面对飞行点间距离差,锁定地面差值与飞行距离差值间的加权关系,保证无人机稳定飞行;通过拉格朗日插值法计算输电线路周围节点,对噪声数据进行粗差剔除,补偿差值向量;采用强化学习算法中启发式回报函数,计算样本障碍物间路径,划分最优航线行驶路径,规划无人机智能巡线路径。实验结果表明:所提方法的无人机与障碍物之间的距离差值均未小于200 m,目标搜索个数可达33,数据剔除率高达98%,其智能巡线路径规划和数据粗差剔除效果较好,能够有效提高障碍物勘测安全性和目标搜索准确率。

关键词：物联网平台无人机智能巡线路径规划粗差剔除加权距离

橙皮苷通过抗炎和抗氧化对骨质疏松大鼠模型的影响

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世界科学技术-中医药现代化 2024年第1期26卷 190-201页

作者：义明东唐新桥张强南华大学附属湘潭市中心医院湘潭411100

目的研究不同浓度的橙皮苷通过减少炎性分子及氧化应激反应机制对去卵巢诱导骨质疏松症(Ovariectomy,OVX)大鼠模型的抗骨质疏松作用及与剂量之间的关系。方法将SD雌性大鼠随机分为OVX组和Sham组,分别进行OVX手术和假手术;将OVX组大鼠随... 详细信息

目的研究不同浓度的橙皮苷通过减少炎性分子及氧化应激反应机制对去卵巢诱导骨质疏松症(Ovariectomy,OVX)大鼠模型的抗骨质疏松作用及与剂量之间的关系。方法将SD雌性大鼠随机分为OVX组和Sham组,分别进行OVX手术和假手术;将OVX组大鼠随机分为5组,每组6只,随机选取6只Sham组大鼠作为正常对照,共6组。分别为Sham组(Sham大鼠+1%CMC混悬液)、对照组(OVX大鼠+1%CMC混悬液)、HP1组(OVX大鼠+5 mg·kg^(-1)HP)、HP2组(OVX大鼠+10 mg·kg^(-1)HP)、HP3组(OVX大鼠+20 mg·kg^(-1)HP)和AN组(OVX大鼠+2.5 mg·kg^(-1)AN)。在进行去卵巢手术或假手术4周后,每天早晨经口灌胃给药,持续10周。给药10周后,测定大鼠的体质量变化量。在处死大鼠前,取得大鼠的腹主动脉血清,放在-20℃标本柜中,测得大鼠的Ca^(2+)和P^(5+)的水平;测定了炎性因子TNF-α、IL-6和IL-1β的水平;也测得大鼠的骨周转换标志物质ALP、ACP、、β-CTx和OC水平。在处死大鼠后,取得大鼠的左股骨,同样放在-20℃标本柜中,经过处理后,测定大鼠左股骨的氧化应激因子TRARS的水平及抗氧化酶GSH、GST、GR、GPx及CAT的水平;测定了大鼠左股骨中段的骨密度、杨氏模量、最大载荷、能量吸收及最大应力;并且得到了大鼠SIRT1基因的表达水平。结果与对照组相比,经过10周不同浓度HP的处理可显著降低体质量增加量(P<0.001),显著降低了OVX大鼠的Ca^(2+)、P^(5+)水平(P<0.001);显著降低了骨周转换标志物ALP、ACP、β-CTx和OC的水平(P<0.001);显著增加了骨密度、杨氏模量、最大负荷、能量吸收、最大应力及刚度(P<0.001),显著降低了OVX诱导的大鼠的骨氧化应激酶硫代巴比妥酸反应物质水平并增加了抗氧化酶GSH、GST、GR、GPx及CAT的水平(P<0.001),显著降低了炎性分子TNF-α、IL-6和IL-1β的水平(P<0.001),显著降低了SIRT1基因的表达水平(P<0.001)相比较之下,高浓度HP组的上述参数指标与对照组相比呈现出更显著的差异(P<0.001)。结论表明橙皮苷对去卵巢诱导的骨质疏松症大鼠可通过降低促炎细胞因子及氧化应激反应发挥抗骨质疏松作用,且呈浓度依赖性。

关键词：橙皮苷去卵巢大鼠骨质疏松炎症氧化应激

不同时期Bobath球联合Kegel运动对二胎顺产分娩产妇盆底功能康复的影响

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新疆医学 2024年第3期54卷 297-300页

作者：李心巧商丘市立医院

目的研究产后不同时期给予Bobath球与Kegel运动训练对二胎顺产分娩产妇盆底功能恢复的影响。方法利用随机数字表法选取我科2020年2月-2022年2月期间132例二胎顺产分娩产妇产后盆底功能障碍患者作为研究对象，对照组66例产后4周后给予合... 详细信息

目的研究产后不同时期给予Bobath球与Kegel运动训练对二胎顺产分娩产妇盆底功能恢复的影响。方法利用随机数字表法选取我科2020年2月-2022年2月期间132例二胎顺产分娩产妇产后盆底功能障碍患者作为研究对象，对照组66例产后4周后给予合Bobath球和Kegel运动训练，研究组66例产后1周后进行Bobath球联合Kegel运动训练。干预前后对两组产妇盆底肌力、性功能、尿失禁以及子宫脱垂等的发生率进行比较。结果研究组在干预2周、4周后，盆底肌力评分升高幅度均高于对照组（P <0.05）；干预2周、4周后研究组性功能改善幅度均高于对照组（P <0.05）；研究组产妇在训练后，尿失禁和盆腔器官脱垂发生率低于对照组（P <0.05）。结论产妇在产后尽早开始盆底康复训练，能够有效促进产妇盆底肌力的恢复并提高性功能，同时能够降低尿失禁以及盆腔脏器脱垂等并发症的发生机率，提高产妇生活质量，安全可靠。

关键词：顺产盆底康复训练尿失禁盆腔器官脱垂

不同时机应用GT-4A导乐分娩镇痛仪护理对初产妇分娩的影响

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中国民康医学 2024年第5期36卷 187-189页

作者：李心巧商丘市立医院妇产科河南商丘476000

目的:观察不同时机应用GT-4A导乐分娩镇痛仪护理对初产妇分娩的影响。方法:选取2020年6月至2022年6月该院收治的125名初产妇进行前瞻性研究,按照随机数字表法将其分为研究组63例与对照组62例。对照组于产妇宫口开至2~3 cm时应用GT-4A导... 详细信息

目的:观察不同时机应用GT-4A导乐分娩镇痛仪护理对初产妇分娩的影响。方法:选取2020年6月至2022年6月该院收治的125名初产妇进行前瞻性研究,按照随机数字表法将其分为研究组63例与对照组62例。对照组于产妇宫口开至2~3 cm时应用GT-4A导乐分娩镇痛仪护理,研究组于产妇宫口开至1 cm时应用GT-4A导乐分娩镇痛仪护理。比较两组产程(第一产程、第二产程、第三产程以及总产程)时间、产妇不同时间(第一产程潜伏期末、第一产程活跃期末、第二产程末)疼痛视觉模拟评分法(VAS)评分、自然分娩率和母婴结局[产妇产后2 h出血量、新生儿出生5 min Apgar评分、脉搏血氧饱和度(SpO_(2))]。结果:研究组第一产程、第二产程、第三产程及总产程时间均短于对照组,差异有统计学意义(P<0.05);第一产程潜伏期末、第一产程活跃期末、第二产程末,研究组产妇VAS评分均低于对照组,差异有统计学意义(P<0.05);研究组自然分娩率为71.43%,高于对照组的53.23%,差异有统计学意义(P<0.05);研究组产后2 h出血量少于对照组,差异有统计学意义(P<0.05);研究组新生儿出生5 min Apgar评分、SpO_(2)水平均高于对照组,差异有统计学意义(P<0.05)。结论:初产妇宫口开至1 cm时应用GT-4A导乐分娩镇痛仪护理可缩短产程时间,提高自然分娩率,降低VAS评分,以及改善母婴结局,效果优于初产妇宫口开至2~3 cm时应用。

关键词：导乐分娩镇痛仪护理产程分娩结局初产妇 VAS评分自然分娩率

Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer

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中华医学杂志(英文版) 2024年第7期137卷 880-882页

作者： wang Huilan Cheng Xinyu Yang Fan Chen Lu Zhang Anmei Zhong Liangzhi Long Haixia Zhu Bo wang Zhongyu Institute of Cancer xinqiao Hospital Third Military Medical University Chongqing 400037 China