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Food Science and Human Wellness 2024年第3期13卷 1168-1185页

作者： Wenhui Li Yu Xi Junru Wang Yinxiao Zhang He Li xinqi liu Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Soybean Processing Industry Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China

Globally,the prevalence of anxiety and depression has reached epidemic proportions.Food-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with traditional pharmaceuticals while delivering superior anxiolytic and antidepressant effects.This review summarizes current research on food-derived anxiolytic and antidepressant protein hydrolysates and peptides,and subsequently analyses their physicochemical characteristics and elaborates on their mechanisms.The aim of this work is to contribute to the in-depth study and provide a theoretical foundation for the development of related products to better serve patients with anxiety and depression.

关键词： Anxiolytic Antidepressant Peptides Protein hydrolysates Neurotransmitter

Antioxidant and ACE inhibitory activities of peptides prepared from adzuki bean by semi-solid enzymatic hydrolysis

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Food Bioscience 2022年第3期47卷 253-261页

作者： Mengdi Cao Wenhui Li He Li Jian Zhang Yu liu xinqi liu National Soybean Processing Industry Technology Innovation Center School of Food and HealthBeijing Technology and Business UniversityBeijing100048China Beijing Institute of Collaborative Innovation Beijing100094China Chinese Academy of Inspection and Quarantine Beijing100123China

In this study,adzuki bean peptides were prepared by semi-solid enzymatic hydrolysis(SEH)and their antioxidant and Angiotensin-I-converting enzyme(ACE)inhibitory activities and internal absorption were studied.By modifying different enzymatic hydrolysis times and enzyme additions,the optimal enzymatic hydrolysis condition for SEH could be obtained as adzuki bean powder:water=4:1(w/w),alcalase:neutrase=2:1(w/w),enzyme addition 3.75%(w/w),4 h enzymatic hydrolysis at 50℃ and pH=8.Within these hydrolysis conditions,the content of adzuki bean peptides was 11.37%,the OH−scavenging rate of 1 mg/mL peptides was 72.75%,the total antioxidant capacity was 0.88±0.02 mmol/L FeSO4,the ACE inhibition rate was 77.49%.In vivo absorption test proved that the peptides prepared by SEH were absorbed faster and exhibited higher antioxidant activity compared with liquid enzymatic hydrolysis.In conclusion,the process of SEH can improve not only the efficiency of hydrolysis,but also the antioxidant and ACE inhibitory activity as well as the internal absorption of adzuki bean peptides.

关键词： Adzuki bean peptides Semi-solid enzymolysis Antioxidant ACE inhibition Absorption

Transcriptome analysis revealing the mechanism of soybean protein isolates and soybean peptides on Lacticaseibacillus rhamnosus Lra05

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Food Bioscience 2022年第3期47卷 736-744页

作者： Yinxiao Zhang Shuya Zhu Chi Zhang Mohamed Mohamed Soliman He Li xinqi liu Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Soybean Processing Industry Technology Innovation CenterBeijing Technology and Business UniversityBeijing100048China Clinical Laboratory Sciences Department Turabah University CollegeTaif University21995Saudi Arabia

To further investigate the promoting effect of soybean protein and peptides on Lacticaseibacillus rhamnosus Lra05(L.rhamnosus Lra05),the overall changes of gene expression of it was investigated through transcriptome analysis treated with dPEP and dSPI The results showed that there were 890,113,and 1073 differentially expressed genes(DEGs)in dPEP/MRS,dSPI/MRS and dPEP/dSPI comparison,respectively.Besides,we found dPEP could promote the expression of acc and fab family genes related to fatty acid biosynthesis,but dSPI played the opposite role.Moreover,dPEP stimulated genes clustered in pur family and ribosome protein,responsible for purine and protein synthesis.Interestingly,dPEP suppressed genes regulating peptides and amino acids transportation and dSPI specially inhibited the pyr family genes involved in pyrimidine metabolism.These data revealed the knowledge about the metabolic pathways affected by dPEP and dSPI and provide a preliminary understanding of the relationship between soybean proteins and peptides and L.rhamnosus Lra05.

关键词： Lacticaseibacillus rhamnosus Soybean protein isolates Soybean peptides Transcriptome analysis

LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection

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Cellular & Molecular Immunology 2023年第5期20卷 475-488页

作者： Yunhuan Gao Yazheng Yang Jianmei Wei Jianmei Yue Ya Wang Qianjing Zhang Mengli Jin Rong Wang Xiaorong Yang Junqi Zhang xinqi liu Lin liu Yuan Zhang Rongcun Yang Department of Immunology Nankai University School of Medicine and Translational Medicine InstituteAffiliated Tianjin Union Medical Center of Nankai UniversityNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China College of Life Science Nankai UniversityTianjin 300121China China National Center for Bioinformation&Bejing Institute of Genomics Chinese Academy of SciencesBejingChina.

The activation of NLRC4 is a major host response against intracellular bacteria infection.However,NLRC4 activation after a host senses diverse stimuli is difficult to understand.Here,we found that the IncRNA LNCGM1082 plays a critical role in the activation of NLRC4.LNCGM1082 in macrophages affects the maturation of interleukin(IL)-1βand pyroptotic cell death only after exposure to an NLRC4 ligand.Similar to NLRC4-/-mice,LNCGM1082-/-mice were highly sensitive to Salmonella Typhimurium(S.T)infection.LNCGM1082 deficiency in mouse or human macrophages inhibited IL-1βmaturation and pyroptosis.Mechanistically,LNCGM1082 induced the binding of PKCS with NLRC4 in both mice and humans.In contrast,NLRC4 did not bind PKCo in LNCGM1082-/-macrophages.The activity of the IncRNA LNCGM1082 induced by S.T may be mediated through TLR5 in the macrophages of both mice and humans.In summary,our data indicate that TLR5-mediated LNCGM1082 activity can promote the binding of PKC with NLRC4 to activate NLRC4 and induce resistance to bacterial infection.

关键词： Macrophages Inflammasome IncRNA Cell pyroptosis NLRC4 PKCδ

基于背景感知相关滤波跟踪器的目标快速跟踪方法

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兵工学报 2024年第2期45卷 497-503页

作者：马潇李新祺刘镇源邸超中国兵器工业导航与控制技术研究所北京100089

图像跟踪算法是弹载图像末制导及光电侦查装备的关键技术,其高效低延时的实时实现可以极大提高光电载荷跟踪的稳定性和精确性。为解决弹载环境受体积、功耗等因素约束下图像末制导跟踪算法的高效性,基于背景感知的相关跟踪算法,提出一... 详细信息

图像跟踪算法是弹载图像末制导及光电侦查装备的关键技术,其高效低延时的实时实现可以极大提高光电载荷跟踪的稳定性和精确性。为解决弹载环境受体积、功耗等因素约束下图像末制导跟踪算法的高效性,基于背景感知的相关跟踪算法,提出一种基于数据驱动的多任务分配策略,并针对相关滤波计算是影响算法实时性的关键路径,提出Cache优化的快速傅里叶变换高效实现方法。通过将跟踪算法映射到多核DSP处理器平台上并行实现,相对原处理方法多核处理实时性能整体提升约56.3%。经无人机挂载试验验证表明,该优化方法可以满足空间约束条件下目标跟踪实时性需求,为智能化弹药的工程化应用提供了有力的技术支撑。

关键词：目标跟踪算法背景感知相关滤波器任务分配快速傅里叶变换

基于自适应校正技术的拼接型像素阵列一致性驱动方法研究

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西北工业大学学报 2024年第2期42卷 353-361页

作者：郭仲杰程新齐许睿明刘绥阳西安理工大学自动化与信息工程学院陕西西安710048

随着拼接工艺在超大阵列CMOS图像传感器中的应用,传统的时钟树同步设计方法已不再适用于像素阵列的双侧驱动电路中,同一行像素阵列的双侧驱动面临直流穿通和坏行的严重问题。基于片上自适应校正思想提出了一种可应用于拼接型像素阵列的... 详细信息

随着拼接工艺在超大阵列CMOS图像传感器中的应用,传统的时钟树同步设计方法已不再适用于像素阵列的双侧驱动电路中,同一行像素阵列的双侧驱动面临直流穿通和坏行的严重问题。基于片上自适应校正思想提出了一种可应用于拼接型像素阵列的一致性驱动方法。该方法根据芯片工作环境的变化进行自适应实时校正,具有结构简单和可靠性高等特点。基于55 nm工艺,采用所提方法在一款12288×12288的150M像素规模、芯片面积高达77 mm×84 mm的超大阵列CMOS图像传感器中进行了实际应用和全面验证。实验结果表明:在500 MHz的主时钟、125 kHz的行时钟下,双侧行驱动的非一致性由17.5 ns减小至2 ns(一个时钟周期)以内,一致性提高了9倍以上,确保了亿级像素规模的超大面阵图像传感器的帧频达到10帧以上。

关键词： CMOS图像传感器超大阵列行驱动一致性

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积极财政政策的回顾与展望

财政研究 2024年第1期 16-28页

作者：吕炜刘欣琦东北财经大学经济学院东北财经大学杂志社

从1998年应对亚洲金融危机,到2008年应对全球金融危机,再到2020年及以后应对新冠疫情冲击与推动经济复苏,积极财政政策发挥着推动经济企稳向好的关键作用,但同样也因其可持续性和有效性以及可能带来的经济变化而引起广泛争论。为此,回... 详细信息

从1998年应对亚洲金融危机,到2008年应对全球金融危机,再到2020年及以后应对新冠疫情冲击与推动经济复苏,积极财政政策发挥着推动经济企稳向好的关键作用,但同样也因其可持续性和有效性以及可能带来的经济变化而引起广泛争论。为此,回顾积极财政政策的整个历史脉络,有助于我们在观察历史的基础上理解当前积极财政政策正在展开的方式。从体制环境、政策工具和政策成本等角度努力求解积极财政政策的有效性,不难发现:其一,财政体制是适应和支撑积极财政政策有效运行的关键。财政承受力决定积极财政政策的信心和底气,而体制与政策的匹配有助于提升政策运行的效率。其二,中央采取不同的政策工具会促使地方政府做出不同反应,积极财政政策能否产生预期效果取决于中央和地方目标、行动的一致性。其三,政策成本的类型及其可被消化的程度决定着积极财政政策空间的大小。这就要求政策的最终目的不在于盲目救助,而是真正地将政府财政作为转化为与社会主体协力应对危机的行为,以发展活力消化政策成本。进一步将提升积极财政政策的有效性融入对国家宏观经济治理与全球经济危机应对的思考中,可以得出积极财政政策的未来方向在于处理好体制改革与政策选择、短期调节与中长期努力、国家能力与社会活力之间的关系,从而更加有力、有效、有序、有为地实施积极财政政策。

关键词：积极财政政策政策特征政策效果政策空间

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

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Genes & Diseases 2023年第4期10卷 1564-1581页

作者： Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun liu Wenchang Xu Lan Zhou Keling Wu xinqi liu Yuhua Lai Fuxiang Mao Weihua Li Chengguo Zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi liu Lin Lu Ling Zhao State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong 510060China Dongguan Guangming Ophthalmic Hospital Dongguan523000China Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Ophthalmology Huizhou Municipal Central HospitalHuizhouGuangdong 516000China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510000China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong 510530China Research Unit of Ocular Development and Regeneration Chinese Academy of Medical SciencesGuangzhouGuangdong 510060China

Glaucoma is the leading cause of irreversible blindness worldwide.In the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely unknown.We demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by microglia.As evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and death.These damages were effectively attenuated by PLSCR1 inhibition.In the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal neuroinflammation.Upregulation of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated microglia.Taken together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases.

关键词： Apoptosis Glaucoma Phagocytosis PLSCR1 Retinal ganglion cells

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2月龄小儿朗格汉斯组织细胞增生症一例

中华手外科杂志 2024年第3期40卷 220-221页

作者：佟昕琪刘燕刘飙吉林大学中日联谊医院手外科长春130033

患者男,2月龄,因右手肿物10余日来我院就诊.患儿母亲述10余日前无意中发现患儿右手背侧肿胀,就诊于当地医院,X线片示:右手第三掌骨骨密度低,部分骨质破坏.我院专科检查:右手背侧第三掌骨处略有隆起(图1),隆起处皮肤颜色正常,皮温正常,... 详细信息

患者男,2月龄,因右手肿物10余日来我院就诊.患儿母亲述10余日前无意中发现患儿右手背侧肿胀,就诊于当地医院,X线片示:右手第三掌骨骨密度低,部分骨质破坏.我院专科检查:右手背侧第三掌骨处略有隆起(图1),隆起处皮肤颜色正常,皮温正常,质较硬,无活动度,无波动,界限不清,触压痛不明显,中指屈伸活动基本正常,末梢血运良好.X线片示:右手第三掌骨膨胀性骨质破坏,皮质变薄、骨质连续性中断、病理性骨折(图2),未见明显骨膜反应.

关键词：骨膜反应病理性骨折屈伸活动触压痛膨胀性骨质破坏末梢血运皮温朗格汉斯组织细胞增生症

The Asparagine-Rich Protein NRP Facilitates the Degradation of the PP6-type Phosphatase FyPP3 to Promote ABA Response in Arabidopsis

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Molecular Plant 2018年第2期11卷 257-268页

作者： Tong Zhu Yanying Wu Xiaotong Yang Wenli Chen Qingqiu Gong xinqi liu State Key Laboratory of Medicinal Chemical Biology Department of Biochemistry and Molecular Biology College of Life Sciences Nankai UniversityTianjin 300071 China Tianjin Key Laboratory of Protein Science Department of Plant Biology and Ecology College of Life Sciences Nankai University Tianjin 300071 China

The phytohormone abscisic acid （ABA） plays critical roles in abiotic stress responses and plant develop- ment. In germinating seeds, the phytochrome-associated protein phosphatase, FyPP3, negatively regulates ABA signaling by dephosphorylating the transcription factor ABI5. However, whether and how FyPP3 is regulated at the posttranscriptional level remains unclear. Here, we report that an asparagine-rich protein, NRP, interacts with FyPP3 and tethers FyPP3 to SYP41/61-positive endosomes for subsequent degradation in the vacuole. Upon ABA treatment, the expression of NRP was induced and NRP-mediated FyPP3 turnover was accelerated. Consistently, ABA-induced FyPP3 turnover was abolished in an nrp null mutant. On the other hand, FyPP3 can dephosphorylate NRP in vitro, and overexpression of FyPP3 reduced the half-life of NRP in vivo. Genetic analyses showed that NRP has a positive role in ABA-mediated seed germination and gene expression, and that NRP is epistatic to FyPP3. Taken together, our results identify a new regulatory circuit in the ABA signaling network, which links the intracellular trafficking with ABA signaling.

关键词： protein interaction vacuolar degradation ABA response germination