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Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

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Green Synthesis and Catalysis 2020年第2期1卷 150-159页

作者： Bingmei Su Lian xu xinqi xu Lichao Wang Aipeng Li Juan Lin Lidan Ye Hongwei Yu College of Chemical Engineering Fuzhou UniversityFuzhou 350116China College of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China Institute of Bioengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China

As an important building block for the synthesis of angiotensin-converting enzyme inhibitors,ethyl(R)-2-hy-droxyl-4-phenylbutanoate[(R)-HPBE]has attracted increasing *** key to industrial biosynthesis of(R)-HPBE is a biocatalyst that efficiently reduces ethyl 2-oxo-4-phenylbutanoate(OPBE)with high *** paper proposed a strategy for identifying key residues involved in enantioselectivity control based on per-residue free energy decomposition and sequence conservatism *** this strategy,4 noncon-servative sites with high energy contribution to binding of OPBE were chosen as engineering targets,generating variant Mu27 with 99%conversion and 98%(R)ee value at substrate loading of up to 500 mmol/*** simu-lations suggested the higher stability and formation probability of Mu27-OPBEproR prereaction state as key rea-sons for the excellent R-enantioselectivity of Mu27 towards *** success in this study provides a viable approach for rational design of alcohol dehydrogenases with high enantioselectivity towards unnatural substrates.

关键词： Ethyl(R)-2-hydroxy-4-phenylbutanoate Rational design Enantioselectivity Short-chain dehydrogenase/reductase Per-residue free energy decomposition Sequence conservatism analysis

The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： Jiawen Li xinqi Huang Yumei An xueshi Chen Yiyang Chen Mingyuan xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life ***,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis *** is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of ***,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain *** manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral *** article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain ***,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

Tumor biomarkers for diagnosis,prognosis and targeted therapy

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2391-2476页

作者： Yue Zhou Lei Tao Jiahao Qiu Jing xu Xinyu Yang Yu Zhang Xinyu Tian xinqi Guan Xiaobo Cen Yinglan Zhao Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China School of Medicine Tibet UniversityLhasa 850000China National Chengdu Center for Safety Evaluation of Drugs State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Tumor biomarkers,the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression,have been demonstrated to possess critical and encouraging value in screening and early diagnosis,prognosis prediction,recurrence detection,and therapeutic efficacy monitoring of *** the past decades,continuous progress has been made in exploring and discovering novel,sensitive,specific,and accurate tumor biomarkers,which has significantly promoted personalized medicine and improved the outcomes of cancer patients,especially advances in molecular biology technologies developed for the detection of tumor ***,we summarize the discovery and development of tumor biomarkers,including the history of tumor biomarkers,the conventional and innovative technologies used for biomarker discovery and detection,the classification of tumor biomarkers based on tissue origins,and the application of tumor biomarkers in clinical cancer *** particular,we highlight the recent advancements in biomarker-based anticancer-targeted therapies which are emerging as breakthroughs and promising cancer therapeutic *** also discuss limitations and challenges that need to be addressed and provide insights and perspectives to turn challenges into opportunities in this ***,the discovery and application of multiple tumor biomarkers emphasized in this review may provide guidance on improved precision medicine,broaden horizons in future research directions,and expedite the clinical classification of cancer patients according to their molecular biomarkers rather than organs of origin.

关键词： diagnosis breakthrough biomarkers

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大型天文望远镜环境温度数据采集系统的设计

计算机工程 2006年第6期32卷 283-284,F0003页

作者：韩立昌徐欣圻中国科学院国家天文台南京天文光学技术研究所

环境参数监控系统是提高当代大天文望远镜成像质量和增加科学产出的重要组成部分。该文主要论述了望远镜环境温度数据采集系统的设计与实现,该系统的主要特点在于采用USB技术进行数据的快速传输与控制,以及低功耗设计。该文的研究成果... 详细信息

环境参数监控系统是提高当代大天文望远镜成像质量和增加科学产出的重要组成部分。该文主要论述了望远镜环境温度数据采集系统的设计与实现,该系统的主要特点在于采用USB技术进行数据的快速传输与控制,以及低功耗设计。该文的研究成果对于正在研制中的我国大科学工程项目大天区面积多目标光纤光谱天文望远镜LAMOST的环境监控系统的设计具有相当的参考价值。

关键词： LAMOST 望远镜 USB 低功耗

An Integrated Optimization Method for CO_(2) Pre-Injection during Hydraulic Fracturing in Heavy Oil Reservoirs

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Fluid Dynamics & Materials Processing 2024年第9期20卷 1971-1991页

作者： Hong Dong Xiding Gao xinqi Zhang Qian Wang Haipeng xu Binrui Wang Chengguo Gao Kaiwen Luo Hengyi Jiang PetroChina Xinjiang Oilfield Company Karamay834000China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Department of Modern Mechanics University of Science and Technology of ChinaHefei230026China

CO_(2) pre-injection during hydraulic fracturing is an important method for the development of medium to deep heavy oil *** reduces the interfacial tension and viscosity of crude oil,enhances its flowability,maintains reservoir pressure,and increases reservoir drainage *** the Badaowan Formation as an example,in this study a detailed three-dimensional geomechanical model based on static data from well logging interpretations is elaborated,which can take into account both vertical and horizontal geological variations and mechanical characteristics.A comprehensive analysis of the impact of key construction parameters on Pre-CO_(2) based fracturing(such as cluster spacing and injection volume),is therefore ***,using optimized construction parameters,a non-structured grid for dynamic development prediction is introduced,and the capacity variations of different production scenarios are *** the basis of the simulation results,reasonable fracturing parameters are finally determined,including cluster spacing,fracturing fluid volume,proppant concentration,and well spacing.

关键词： Heavy oil reservoir pre-storage CO_(2)energy fracturing horizontal well fracturing parameters numerical simulation

Applications of Cerrena laccase in biodegradation

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Applications of Cerrena laccase in biodegradation

Degradation of tetracycline by immobilized laccase and the proposed transformation pathway

中国生物化学与分子生物学会2016年全国学术会议

作者： Jie Yang xinqi xu Yonghui Lin Juan Lin Xiuyun Ye Fujian Key Laboratory of Marine Enzyme Engineering Fuzhou University Technical Center Fujian Entry-Exit Inspection and Quarantine Bureau

Laccases comprise a class of multi-copper containing oxidases that are environmentally friendly and industrially *** have low substrate specificity and can oxidize a wide range of substrates such as phenolic lignin compounds,recalcitrant dyestuffs and other environment pollutants,accompanied by concomitant reduction of molecular oxygen to water.

关键词： Laccase Cerrena Biodegradation Immobilization

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Degradation of tetracycline by immobilized laccase and the p...

全国农业生物化学与分子生物学第十五届学术研讨会

作者： Jie Yang xinqi xu Yonghui Lin Xiuyun Ye Juan Lin Fujian Key Laboratory of Marine Enzyme Engineering Fuzhou University Technical Center Fujian Entry-Exit Inspection and Quarantine Bureau

Antibiotics are commonly used in human and veterinary medicine and have attracted increasing attention as emerging *** are copper-containing oxidases that can oxidize a wide range of phenolic and non-phenolic compounds and have application potentials in wastewater treatment and *** cross-linked enzyme aggregates(M-CLEAs)were prepared for

关键词： laccase tetracycline transformation products antimicrobial activity Methods

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某弹用涡轮喷气发动机动力特性分析

振动与冲击 2005年第5期24卷 104-106页

作者：徐学文袁书生徐新琦海军航空工程学院机械工程烟台264001

应用传递矩阵法计算了某弹用涡轮喷气发动机的临界转速和振动响应,分析了转子支承刚度对临界转速的影响,以及不同支承条件和不同油膜间隙下转子的稳态不平衡响应。研究表明,当转子系统的前支承刚度不高于1×107N/m,挤压油膜阻尼器的油... 详细信息

应用传递矩阵法计算了某弹用涡轮喷气发动机的临界转速和振动响应,分析了转子支承刚度对临界转速的影响,以及不同支承条件和不同油膜间隙下转子的稳态不平衡响应。研究表明,当转子系统的前支承刚度不高于1×107N/m,挤压油膜阻尼器的油膜间隙不小于7.0×10-5m时,发动机的动力特性能得到有效的改善。

关键词：传递矩阵法振动临界转速响应

Transient Temperature and Stress Analysis for Thermo-Viscoelastic SRM Grains

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Transient Temperature and Stress Analysis for Thermo-Viscoel...