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Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo

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Journal of Environmental Sciences 2021年第3期33卷 236-247页

作者： Qidong Ren xinni xie Yue Tang Qing Hu Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-Toxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The biosafety of methyl tertiary-butyl ether(MTBE),mainly used as a gasoline additive,has long been a contentious topic.In addition to its routine toxicities,MTBE has been demonstrated to disrupt glucose and lipid metabolism and contribute to the development of type2 diabetes as well as obesity.As one of the morbidities related to dyslipidemia,atherosclerosis is worthy of being investigated under MTBE exposure.Since foam cells derived from macrophages play pivotal roles during atherosclerosis development,we studied the effects of MTBE on macrophages in vitro and assessed the effect of MTBE on atherosclerosis plaque formation with the ApoE^(-/-)mouse model in uiuo for the first time.Our results demonstrated that exposure to MTBE at environmentally relevant concentrations decreased the expression of ABCA1 and ABCG1,which are responsible for macrophage cholesterol efflux,at both mRNA and protein levels in THP-1 macrophages.Consequently,treatment with MTBE inhibited the transport of cholesterol from macrophages to High-density lipoprotein.ApoE^(-/-)mice exposed to MTBE at environmentally relevant concentrations(100,1000μg/kg)displayed significant increases in lesion area in the aorta and aortic root compared to vehicletreated ones.Further analysis indicated that MTBE exposure enhanced the macrophagespecific marker Mac-2 contents within plaques in the aortic root,implying that MTBE could promote macrophage-derived foam cell formation and thus accelerate atherosclerosis plaque formation.We for the first time demonstrated the pro-atherogenic effect of MTBE via eliciting disruption of macrophage cholesterol efflux and accelerating foam cell formation and atherosclerosis plaque development.

关键词： Methyl tertiary–butyl ether(MTBE) macrophage cholesterol efflux ApoE^(-/-)mouse Atherosclerosis

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Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo

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Journal of Environmental Sciences 2019年第11期31卷 208-219页

作者： Yue Tang Qidong Ren Qing Wen Caixia Yu xinni xie Qing Hu Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China School of Chemical Sciences University of Chinese Academy of Sciences Beijing 100049 China School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen 518055 China

Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota.

关键词： MTBE Adipogenesis Glucose metabolism Metabolic disorder Gut microbiota

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New synthetic compound DBZ attenuates atherosclerosis in ApoE-/-mice fed a western type diet.

New synthetic compound DBZ attenuates atherosclerosis in Apo...

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脂质组学与脂蛋白的新功能——第十二届全国脂质与脂蛋白学...

作者： Jing Wang xinni xie Pengfei Xu Rong Fan Yonggong Zhai Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry College of Life SciencesBeijing Normal University

Objective:We have previously shown that new synthetic compound Danshensu Bingpian Zhi(DBZ)could block LPS-induced monocyte activation and foam cell formation,which is the hallmark of atherosclerosis development.We hypothesize whether DBZ exerts several potentially important antiatherosclerotic effects.Methods:To determine DBZ’s clinical role,we performed in vivo prevention(5-week old)and treatment(10

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DBZ exert anti-atherosclerotic role via regulating macrophage inflammation and cholesterol efflux

DBZ exert anti-atherosclerotic role via regulating macrophag...

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第11届全国脂质与脂蛋白学术会议

作者： xinni xie 王静 Jun Zhang Jiao Li Shixiang Wang Xiaohui Zheng Yonggong Zhai Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry and College of Life Sciences Beijing Normal University 北京师范大学生命科学学院 Beijing Key Laboratory of Gene Resource and Molecular Development College of Life SciencesBeijing Normal University Key Laboratory of Resource Biology and Biotechnology in Western China and College of Life Sciences Northwest University Key Laboratory of Gene Resource and Molecular Development College of Life SciencesBeijing Normal University

Objective To observe the anti inflammation and anti atherosclerosis effects of DBZ and discuss the possible mechanisms. Methods We take in vitro cell model to examine the effects of DBZ on monocyte/macrophage activation and foam cell formation,Agonists of PPARs and LXRs have been reported to inhibit atherosclerotic lesions formation in atherosclerotic mouse models.We construct a screening system based on nuclear

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纳米铝粉对氧化铝陶瓷晶粒形态的影响

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稀有金属材料与工程 2009年第A2期38卷 172-174页

作者：张新霓谢志鹏徐利华清华大学新型陶瓷与精细工艺国家重点实验室北京100084 青岛大学山东青岛266071 北京科技大学北京100083

通过改变氧化铝粉体中纳米铝粉含量,研究了纳米铝粉对烧结氧化铝晶粒形态的影响。当铝粉质量分数为0.01%和0.1%时,氧化铝的晶粒分布具有双峰结构,部分晶粒为长柱状和板状晶粒,而当铝粉质量分数为0.5%时,整个氧化铝晶粒都呈现均匀、等轴... 详细信息

通过改变氧化铝粉体中纳米铝粉含量,研究了纳米铝粉对烧结氧化铝晶粒形态的影响。当铝粉质量分数为0.01%和0.1%时,氧化铝的晶粒分布具有双峰结构,部分晶粒为长柱状和板状晶粒,而当铝粉质量分数为0.5%时,整个氧化铝晶粒都呈现均匀、等轴结构,其与氧化镁的作用相类似。

关键词：氧化铝长柱状晶粒纳米铝粉生长机制

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先秦至隋唐时期“痈”和“疽”的演变

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中医药文化 2020年第5期15卷 89-94页

作者：谢欣妮纪军上海中医药大学岳阳临床医学院 200437 上海市针灸经络研究所 200030

"痈"和"疽"是中医外科学中两个重要的概念,《灵枢·痈疽》所载二者的区别被历代医家奉为圭皋,但后世医家在实际运用中却常混淆不清。通过对先秦至隋唐时期相关医学文献进行整理与分析,梳理"痈""疽"二者概念演变的大致脉络,发现此二者的... 详细信息

"痈"和"疽"是中医外科学中两个重要的概念,《灵枢·痈疽》所载二者的区别被历代医家奉为圭皋,但后世医家在实际运用中却常混淆不清。通过对先秦至隋唐时期相关医学文献进行整理与分析,梳理"痈""疽"二者概念演变的大致脉络,发现此二者的区别除《灵枢·痈疽》所述内容外,还在于二者词性和字义不同,即"疽"仅用于疾病的名称使用上,均为名词;而"痈"字通过假借的方式使其字义逐渐丰富,除表示病名外,还用于特指某具体病灶、表肿胀、表壅滞和浮肿之意,既可为名词,亦可为形容词。二者在古籍中有着看似混乱,实则规律的运用。

关键词：中医病名痈疽痈疽《黄帝内经》《灵枢》

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探讨髓系细胞触发受体-1在慢性阻塞性肺疾病急性加重期中的临床应用

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国际呼吸杂志 2014年第11期34卷 805-809页

作者：王欣妮叶枫谢佳星陈荣昌广州医科大学附属第一医院呼吸疾病国家重点实验室(广州医科大学)广州呼吸疾病研究所 510120

目的探讨髓系细胞触发受体-1（triggeringreceptorexpressedonmyeloidcell-1，TREM-1）在慢性阻塞性肺疾病急性加重期（acuteexacerbationofchronicobstructivepulmonarydisease，AECOPD）的临床应用。方法随机抽取在我院门诊或住院部诊治的COPD稳定期患者共40例（n=40），按GOLD（肺功能）分级：轻度5例，中度16例，重度13例，极重度6例。全部患者均于稳定期、急性加重期测定TREM1、降钙素原（PCT），急性加重期行痰细菌培养及痰病毒PCR检查。结果AECOPD患者TREM-1水平均较稳定期升高，PCT阳性，差异具有统计学意义（P〈0．05）。痰细菌培养结果阳性患者TREM-1水平、PCT阳性率较阴性患者均升高，差异具有统计学意义（P〈0．05）。痰病毒PCR结果阳性AECOPD患者血清TREM-1水平、PCT阳性率差异无统计学意义。结论TREM-1在AECOPD中是-个敏感的炎症标志物，可作为早期诊断AECOPD的客观指标。在细菌感染相关的AECOPD患者中TREM-1水平升高，但病毒感染相关者无变化，联合PCT可用于判断细菌感染相关的AECOPD，有利于指导临床抗生素的用药。

关键词：慢性阻塞性肺疾病急性加重髓系细胞触发受体1 降钙素原

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