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Chinese Medical Journal 2023年第7期136卷 863-865页

作者： Jiani Wang Yuwei Liu Renzhi Zhang Zhenyu Liu Zongbi Yi Xiuwen Guan xinming zhao Jingying Jiang Jie Tian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular ImagingInstitute of AutomationChinese Academy of SciencesBeijing 100190China School of Engineering Medicine Beihang UniversityBeijing 100191China Department of Diagnostic Radiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100080China

To the Editor:Oncology precision medicine aims to identify patientsmostlikely torespondeffectivelytotherapies.Efforts to establish a survival prediction model using a single platform have not yet met the precision med... 详细信息

关键词： breast HER2 prospective

Histogram analysis of apparent diffusion coefficient predicts response to radiofrequency ablation in hepatocellular carcinoma

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Chinese Journal of Cancer Research 2019年第2期31卷 366-374页

作者： Xiaohong Ma Han Ouyang Shuang Wang Meng Wang Chunwu Zhou xinming zhao Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Department of Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College

Objective: The aim of this study was to predict tumor progression in patients with hepatocellular carcinoma(HCC) treated with radiofrequency ablation(RFA) using histogram analysis of apparent diffusion coefficients(ADC).Methods: Breath-hold diffusion weighted imaging(DWI) was performed in 64 patients(33 progressive and 31 stable) with biopsy-proven HCC prior to RFA. All patients had pre-treatment magnetic resonance imaging(MRI)and follow-up computed tomography(CT) or MRI. The ADC values(ADC_(10), ADC_(30_, ADC_(median) and ADC_(max))were obtained from the histogram's 10 th, 30 th, 50 th and 100 th percentiles. The ratios of ADC_(10), ADC_(30_,ADCmedian and ADCmax to the mean non-lesion area-ADC(RADC_(10), RADC_(30_, RADC_(median), and RADC_(max)) were calculated. The two patient groups were compared. Key predictive factors for survival were determined using the univariate and multivariate analysis of the Cox model. The Kaplan-Meier survival analysis was performed, and pairs of survival curves based on the key factors were compared using the log-rank test.Results: The ADC_(30_, ADCmedian, ADCmax, RADC_(30_, RADC_(median), and RADC_(max) were significantly larger in the progressive group than in the stable group(P<0.05). The median progression-free survival(PFS) was 22.9 months for all patients. The mean PFS for the stable and progressive groups were 47.7±1.3 and 9.8±1.3 months,respectively. Univariate analysis indicated that RADC_(10), RADC_(30_, and RADC_(median) were significantly correlated with the PFS [hazard ratio(HR)=31.02, 43.84, and 44.29, respectively, P<0.05 for all]. Multivariate analysis showed that RADCmedian was the only independent predictor of tumor progression(P=0.04). And the cutoff value of RADC_(median) was 0.71.Conclusions: Pre-RFA ADC histogram analysis might serve as a useful biomarker for predicting tumor progression and survival in patients with HCC treated with RFA.

关键词： Diffusion-weighted imaging apparent diffusion coefficient histogram analysis hepatocellular carcinoma radiofrequency ablation survival time

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微点蚀损伤的研究进展与展望

摩擦学学报（中英文） 2024年第5期44卷 715-728页

作者：赵景鑫姜程李维民刘海超栗心明青岛理工大学机械与汽车工程学院山东青岛266520 中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 淄博高端合成润滑材料创新中心山东淄博255000

微点蚀是高应力滑滚接触副在润滑油膜不能充分建立的条件下由于表面粗糙度的塑性变形引发的1种表面起源型疲劳损伤现象,常见于硬齿面齿轮、滚动轴承等关键机械零部件中,严重影响运动部件传动精度、服役寿命及可靠性.本文中重点调研了微... 详细信息

微点蚀是高应力滑滚接触副在润滑油膜不能充分建立的条件下由于表面粗糙度的塑性变形引发的1种表面起源型疲劳损伤现象,常见于硬齿面齿轮、滚动轴承等关键机械零部件中,严重影响运动部件传动精度、服役寿命及可靠性.本文中重点调研了微点蚀研究与润滑材料评价所用的试验方法、微点蚀的成因及其关键影响因素,总结了微点蚀形成所涉及的表面/次表面微裂纹萌生及可能的演化过程.从摩擦学角度给出了工程实践中抑制微点蚀的可行性措施,并对未来关于微点蚀的重点研究问题进行了展望.本文中对润滑界面微点蚀失效分析、表面合理润滑设计和润滑油品抗微点蚀的添加剂关键组分筛选与评定有一定指导意义.

关键词：微点蚀滑滚接触失效分析润滑材料润滑

冷却速率对7050铝合金淬火析出行为的影响

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中国有色金属学报 2024年第3期34卷 739-750页

作者：李承波赵偲肖博朱戴博张新明湘潭大学机械工程与力学学院湘潭411105 中南大学材料科学与工程学院长沙410083 广东兴发铝业有限公司佛山5281371

基于末端淬火的高通量实验,结合扫描电子显微镜(SEM)、电子背散射衍射(EBSD)、透射电子显微镜(TEM)、高分辨率透射电子显微镜(HRTEM)和扫描透射电子显微镜(STEM)研究了7050铝合金的淬火析出行为。结果表明:随着冷却速率的降低,电导率增... 详细信息

基于末端淬火的高通量实验,结合扫描电子显微镜(SEM)、电子背散射衍射(EBSD)、透射电子显微镜(TEM)、高分辨率透射电子显微镜(HRTEM)和扫描透射电子显微镜(STEM)研究了7050铝合金的淬火析出行为。结果表明:随着冷却速率的降低,电导率增加,淬火析出相的种类和形核位置均增加。有利形核析出的位置顺序为大角度晶界、小角度晶界(亚晶界)、再结晶晶内(Al_(3)Zr粒子)、位错和亚晶内(Al_(3)Zr粒子)。淬火析出相的析出顺序为η相、S相、T相和Y相。随冷却速率的降低,η相依次在大角度晶界、小角度晶界、再结晶晶内(Al_(3)Zr粒子)和部分亚晶内析出;当冷却速率低于630℃/min时,S相在亚晶(界)析出,T相在再结晶晶内(Al_(3)Zr粒子)和高位错密度的亚晶(界)处析出;当冷却速率低于164℃/min时,Y相在亚晶的位错处析出,η相和T相也在亚晶内析出。

关键词： 7050铝合金末端淬火显微组织非均匀析出

自然资源陆地卫星激光测高标准产品高程精度评价

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遥感学报 2024年第3期28卷 704-716页

作者：陈继溢唐新明李国元刘诏周晓青自然资源部国土卫星遥感应用中心北京100048 江苏省地理信息资源开发与利用协同创新中心南京210023

卫星激光测高技术能够获取高精度地表高程分布信息,在对地观测领域具有独特的优势。中国近年来陆续发射的高分七号卫星和资源三号03星均搭载了激光测高系统,用于全球高程控制点获取。随着高分七号卫星、资源三号03星稳定在轨运行,并持... 详细信息

卫星激光测高技术能够获取高精度地表高程分布信息,在对地观测领域具有独特的优势。中国近年来陆续发射的高分七号卫星和资源三号03星均搭载了激光测高系统,用于全球高程控制点获取。随着高分七号卫星、资源三号03星稳定在轨运行,并持续获取激光测高数据,中国首次在激光测高领域形成相关数据产品,即自然资源卫星激光测高标准产品(SLA03)。本文以平原、有森林覆盖的山地两个不同类型区域的高精度机载点云数据为参考,对中国自然资源卫星激光测高标准产品的高程精度进行综合评价。结果显示:在使用合适的阈值剔除人工建筑、树木冠层的激光点后,高分七号卫星SLA03数据在平原地区高程精度RMSE达到0.653 m,LE90为1.055 m,其中60%以上精度优于0.3 m,而在有森林覆盖的山地下降至1.210 m (RMSE)和2.002 m(LE90);资源三号03星SLA03数据在平原地区达到1.312 m (RMSE)和2.389 m (LE90),其中50%以上精度优于0.5 m,有森林覆盖的山地则为1.661 m (RMSE)和2.999 m (LE90)。另外,高分七号卫星SLA03数据受季节因素影响较为明显,主要由植被生长引起。相关结论能够指导自然资源卫星激光测高标准产品的深入应用,并为后续卫星激光测高载荷设计与参数论证提供支撑。

关键词：遥感卫星激光测高高分七号卫星资源三号03星高程精度激光测高标准产品

Wheat straw return can lead to biogenic toluene emissions

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Journal of Environmental Sciences 2023年第2期124卷 281-290页

作者： Ting Wu Xiaoyu zhao Mengdi Liu Juan zhao xinming Wang School of Ecology and Environment Anhui Normal UniversityWuhu 241000China Center of Cooperative Innovation for Recovery and Reconstruction of Degraded Ecosystem in Wanjiang City Belt Wuhu 241000China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

As a common practice in agricultural system,straw return has been reported to release a large number of trace gases and attractedmuch attention.However,the role of straw return in toluene emission remains poorly understood.In this study we measured the emissions of toluene as well as other 50 volatile organic compounds(VOCs)from wheat straw return for 66 days under flooded and non-flooded conditions,respectively.The results showed that substantial toluene was released from the returned wheat straw particularly under flooded condition,and primarily derived from the secondary product.Toluene emissions from the returned wheat straw were 36.8 and 8.45 mg C/kg,sharing 28.0%and 8.6%of total VOCs released,and over 90% of toluene emissions occurred between days 24-56 and 0-17 under flooded and non-flooded conditions,respectively.The emission rates of toluene were relatively high but decreased sharply at the beginning 2 days,and then was steady until 24 days under the two moisture conditions.After the initial decrease these rose again to form one“peak emission window”between days 24-56 under flooded condition,while these were still very low and steady until the end under non-flooded condition.The toluene emission rates significantly positively correlated with microbial biomass C under flooded condition,but negatively associated with bacteria and fungus number,microbial biomass C,and CO_(2) flux under non-flooded condition,suggesting that microorganism might play an important role in toluene emissions from wheat straw return.A rough estimate indicated that straw return might be important for biogenic toluene.

关键词： Toluene Boigenic volatile organic compounds(BVOCs) Emission profile Straw return

Simultaneous enhancement in mechanical and corrosion properties of Al-Mg-Si alloys using machine learning

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Journal of Materials Science & Technology 2023年第36期167卷 1-13页

作者： xinming Feng Zhilei Wang Lei Jiang Fan zhao Zhihao Zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Al-Mg-Si alloys with high strength and good corrosion resistance are regarded as desirable materials for all-aluminum vehicles.However,the traditional trial-and-error experimental methods are insufficient to address the trade-offbetween strength and corrosion resistance.In this work,a non-dominated sorting genetic machine-learning algorithm(NSGA-II)was employed to optimize the chemical composition,so as to simultaneously improve the strength and corrosion resistance.Three high-performance Al-Mg-Si alloys with low Mg,Si,and Cu contents were successfully developed,where the yield strength(YS),ultimate tensile strength(UTS),and the elongation(δ)reached 375-380 MPa,410-416 MPa,and 13.7%-15.2%,re-spectively.Compared with higher-Cu-content 6013 alloy,the YS and UTS of the present alloys increase by about 60 MPa,and the intergranular corrosion resistance is also significantly improved.Microstruc-ture characterization demonstrated thatβ’’and QP phases introduced a significant synergistic precipita-tion strengthening effect;the dispersoids formed by trace Mn,Cr,Fe,Zr,and Ti contributed dispersion strengthening effect;and the good pitting corrosion resistance is attributed to lower Mg and Si contents.

关键词： Aluminum alloy Machine learning High strength Corrosion resistance

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韶关市典型香芋产区土壤养分状况及肥力评价

华南农业大学学报 2024年第3期45卷 344-353页

作者：崔罗肖刘娅赵兰凤张新明许一武谢健任宗玲华南农业大学资源环境学院广东广州510642 广东天禾农资股份有限公司广东广州510080 广西壮族自治区南宁市宾阳县黎塘镇农业综合服务中心广西南宁530409

【目的】了解广东省韶关市典型香芋产区的土壤肥力情况,以期为香芋产区土壤养分资源管理提供参考依据。【方法】分别于韶关市的3个香芋种植区(桂头镇老均村,廊田镇官坡滩村、农庄村)采集0~30 cm香芋根际土壤样品,测定土壤理化性质,通过... 详细信息

【目的】了解广东省韶关市典型香芋产区的土壤肥力情况,以期为香芋产区土壤养分资源管理提供参考依据。【方法】分别于韶关市的3个香芋种植区(桂头镇老均村,廊田镇官坡滩村、农庄村)采集0~30 cm香芋根际土壤样品,测定土壤理化性质,通过主成分分析和相关性分析,筛选出最能代表当地土壤肥力的指标进入最小数据集,通过隶属度函数对所有的指标进行归一化处理,计算土壤质量指数并评价土壤肥力。【结果】3个香芋产区土壤均呈酸性;容重为1.17 g·cm^(−3),质地适宜;阳离子交换量(Cation exchange capacity,CEC)为9.17 cmol·kg^(−1),处于较低水平;速效P(54.20 mg·kg^(−1))、有效Cu(2.07 mg·kg^(−1))、有效Fe(186.33 mg·kg^(−1))、有效Zn(1.87 mg·kg^(−1))丰富,有效Mn(4.21 mg·kg^(−1))、有效B(0.12 mg·kg^(−1))、有效Mo(0.10 mg·kg^(−1))缺乏或极缺乏,其他养分含量处于中等及以上水平。3个香芋产区土壤粒级占比、碱解N、交换性Ca及交换性Mg含量差异显著,其他指标差异均不显著。从20个指标中筛选出7个指标构成土壤质量评价的最小数据集,分别为碱解N、砂粒、黏粒、交换性Ca、有效B和有效Fe含量以及CEC。评价结果表明,3个香芋产区的土壤肥力均处于中等水平,其中,碱解N和交换性Ca含量为肥力水平的主要限制因子。【结论】韶关市典型香芋产区的土壤肥力水平整体处于中等水平,土壤保肥能力较差,有效Mn、B、Mo等微量元素缺乏。因此,在香芋种植时,要注重有机肥以及微量元素肥料的施用,平衡施肥,改善土壤理化性质,提高土壤保肥能力。

关键词：香芋产区养分水平最小数据集土壤肥力评价

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Heterostructure design of MOFs derived Co_(9)S_(8)/FeCoS_(2)/C composite with efficient microwave absorption and waterproof functions

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Journal of Materials Science & Technology 2022年第34期129卷 15-26页

作者： Runrun Cheng Yan Wang Xiaochuang Di zhao Lu Ping Wang xinming Wu School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an 710021China

At present, the problem of electromagnetic wave(EMW) pollution is critical, and the design of highperformance absorbers is of great significance. Based on the synergy between dielectric and magnetic losses, and between multicomponents in heterostructures, the development of light-weight absorbers with a strong absorption capability and multiple scattering is a promising strategy to achieve highperformance absorbers. In this work, CoFe-MOF precursors with a bouquet-like structure were prepared via the hydrothermal method, and Co_(7)Fe_(3)/C and Co_(9)S_(8)/FeCoS_(2)/C composites were obtained through a carbonization and sulfuration treatment during the high-temperature pyrolysis process, respectively. The experimental and theoretical results show that the Co_(9)S_(8)/FeCoS_(2)/C composite has a better EMW absorption performance, and its optimal reflection loss(RL) value is-53.9 d B at a low filler loading of 20 wt.%,which is due to the S doping that enhances the interface polarization relaxation process and improves the impedance matching characteristics. Moreover, the Co_(9)S_(8)/FeCoS_(2)/C composite can be as candidates of high-efficiency absorbers in extreme application environments.

关键词： Electromagnetic absorption Metal-organic frameworks(MOFs) Bouquet-like CoFe-MOF Sulfur doping

A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers

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Chinese Journal of Cancer Research 2021年第3期33卷 352-363页

作者： Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui zhao Xiang Liu Chunyun Dai Chunsun Fan Can zhao Deyin Guo Hong zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu xinming zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu State Key Lab of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Ultrasonography National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Qidong Liver Cancer Institute&Qidong People’s Hospital Qidong 226200China Lingbi Center for Disease Control and Prevention Suzhou 234200China Mengcheng Center for Disease Control and Prevention Bozhou 233500China Sheyang Center for Disease Control and Prevention Yancheng 224300China Shenqiu County Center for Disease Control and Prevention Zhoukou 411624China Dancheng Center for Disease Control and Prevention Zhoukou 477150China Channing Division of Network Medicine Department of MedicineBrigham and Womens Hospital and Harvard Medical SchoolBostonMA 02115USA Department of Nutrition T

Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.

关键词： Hepatocellular carcinoma asymptotic HBs Ag carriers risk prediction model screening laboratory tests