检索结果-南通市图书馆

红藤方从Hippo/YAP通路抑制子宫腺肌症纤维化的机制研究

在线全文

学校读者我要写书评

暂无评论

国际中医中药杂志 2024年第7期46卷 867-873页

作者：曾薇薇陈欣敏陆黎娟黄圣惠曹阳张婷婷上海中医药大学附属曙光医院妇产科上海201203 南京中医药大学附属苏州市中医医院妇科苏州215007 上海中医药大学附属岳阳中西医结合医院妇科上海200083

目的通过观察红藤方对子宫腺肌症(ADS)小鼠子宫组织上皮细胞间充质转化(EMT)、成纤维细胞向肌成纤维细胞转化(FMT)及Hippo通路中关键蛋白的影响, 探讨红藤方抑制ADS纤维化的作用机制。方法将小鼠按随机数字表法分为空白组、模型组、红... 详细信息

目的通过观察红藤方对子宫腺肌症(ADS)小鼠子宫组织上皮细胞间充质转化(EMT)、成纤维细胞向肌成纤维细胞转化(FMT)及Hippo通路中关键蛋白的影响, 探讨红藤方抑制ADS纤维化的作用机制。方法将小鼠按随机数字表法分为空白组、模型组、红藤方组、维替泊芬组, 每组8只。小鼠出生当日为第0天, 从第1天开始, 模型组、红藤方组、维替泊芬组小鼠灌胃1 mg/kg他莫昔芬溶剂, 连续给药 5 d。造模后第42天, 经HE染色验证造模成功。第43天开始, 红藤方组小鼠每日灌胃红藤方水煎液16.5 g/kg, 每3日腹腔注射0.9%NaCl溶液(100 μl/10 g);维替泊芬组小鼠每3日腹腔注射维替泊芬溶液100 mg/kg, 同时每日灌胃蒸馏水100 μl/10 g;空白组及模型组小鼠每日灌胃等体积蒸馏水及每3日腹腔注射等体积0.9%NaCl溶液, 共给药60 d。采用Masson染色法评估各组小鼠子宫组织纤维化程度;采用免疫组化染色及Western blot法检测各组小鼠子宫组织中E-钙黏附蛋白(E-cadherin)、波形蛋白(Vimentin)、α-平滑肌肌动蛋白(α-SMA)、Yes相关蛋白(YAP)、锌指转录因子(Snail)表达情况。结果与模型组比较, 红藤方组Masson染色蓝染面积与总染色面积比值降低(P<0.05);免疫组化和Western blot检测显示, 与模型组比较, 红藤方组小鼠子宫组织E-cadherin表达升高(P<0.05), Vimentin、α-SMA、YAP表达降低(P<0.01或P<0.05)。结论红藤方可抑制ADS发生EMT、FMT, 从而抑制纤维化, 其作用机制与调控Hipoo/YAP通路相关。

关键词：纤维化子宫腺肌症红藤方 Hippo信号通路 YAP-信号蛋白小鼠

Numerical Analysis on Soil and Rock Formation of Ancient Gravel Strata Around Nanjing

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2001年第3期11卷 263-269页

作者： XIA JIA and chen xinmin Dept. of Civil Engineering, Nanjing Architectural and Civil Engineering institute, Nanjing 210009 (China) 南京航空航天大学江苏南京 210009

Research samples were taken from an ancient gravel stratum which is not only a representative soil layer along the middle-lower reaches of the Yangtze River in East China, but also one of the primary Neozoic strata in Naming district. Located mostly on the second and third terraces, the ancient gravel strata formed the geomorphic landscapes of terrace and step. They were complex in constitution, varied widely in stability, of multiple sources, locally derived, and associated with braided streams in the deposition environment. A CIPW (Cross, Iddings, Pirsson and Washington) method modified by the author was used to analyze the soil-rock-forming materials of finer grains (less than 2 mm in size) of the ancient gravel stratum. Results of the analysis showed that the sandy grains were composed of apatite, ilmenite, potassium feldspar, plagioclase, enstatite and free quartz, the clay mainly of kaolinite, and the cement of a combination of silicon, aluminum and iron at a ratio of 46:44:10. In the soil-rock-forming processes, including compactional solidification, water-stable illuviation-cementation t homogeneous overgrowth and so on, the loose soil-rock-forming components gradually changed into consolidated soil and further to the early stage of lithification. Meanwhile, from the analysis, we found that the ancient gravel stratum had been protected by the overlying Xiashu loess or basalt and the overloading resulted in overconsolidated strata. The modified CIPW method was applicable and effective for semi-quantitative analysis.

关键词： ancient gravel stratum numerical analysis soil-rock-forming processes

KINETICS OF OXYGEN EVOLUTION REACTION ON PbO_2-Ti/MnO_2 ELECTRODE AND ELEC TRO CATALYSIS

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1992年第10期5卷 280-286页

作者： chen Zhenfang JIANC Hanying SHU Yude chen xinmin Central South University of Technology,Changsha,China

The kinetics of oxygen evolution reaction(OER)on PbO_2-Ti/MnO_2 electrode has been studied using galvanistatic *** terms of kinetic parameters,the reaction path of OER is *** electrocataIytic activity of lead dioxide and manganese dioxide has been discussed according to the theory of molecular orbit and quantum chemistry *** is concluded that the electrocatalytic activity of manganese dioxide is higher than that of lead dioxid,which is in agreement with the experimental result.

关键词： manganese dioxide lead dioxide oxygen evolution reaction electrocatalysis

Research and Development of 250keV Electrocurtain

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 1995年 197-198页

作者： Li xinmin and chen Pengfei

Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　２５０ｋｅＶ　ＥｌｅｃｔｒｏｃｕｒｔａｉｎＲｅｓｅａｒｃｈａｎｄＤｅｖｅｌｏｐｍｅｎｔｏｆ２５０ｋｅＶＥｌｅｃｔｒｏｃｕｒｔａｉｎ￥ＬｉＸｉｎｍｉｎａｎｄＣｈｅ...

Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　２５０ｋｅＶ　ＥｌｅｃｔｒｏｃｕｒｔａｉｎＲｅｓｅａｒｃｈａｎｄＤｅｖｅｌｏｐｍｅｎｔｏｆ２５０ｋｅＶＥｌｅｃｔｒｏｃｕｒｔａｉｎ￥ＬｉＸｉｎｍｉｎａｎｄＣｈｅｎＰｅｎｇｆｅｉＥｌｅｃｔｒｏｃｕ...

关键词：

成都地区913例0~18岁儿童地中海贫血的筛查及基因分析

在线全文

学校读者我要写书评

暂无评论

四川医学 2024年第5期45卷 512-516页

作者：龙芳张云陈新敏谢成彬刘宗能秦胜芳伍媚李婷四川省妇幼保健院·成都医学院附属妇女儿童医院检验科医学遗传与产前诊断科四川成都610000 济南市章丘区人民医院检验科山东济南250200 成都儿童专科医院检验科四川成都610015 北京陆道培医院检验科北京100176

目的分析成都地区0~18岁儿童地中海贫血的发病率、基因突变类型构成比,评估血红蛋白电泳联合红细胞相关参数在地中海贫血中的筛查价值。方法回顾性分析成都地区913例地中海贫血初筛阳性病例的血液学特征、血红蛋白电泳检测数据及地中海... 详细信息

目的分析成都地区0~18岁儿童地中海贫血的发病率、基因突变类型构成比,评估血红蛋白电泳联合红细胞相关参数在地中海贫血中的筛查价值。方法回顾性分析成都地区913例地中海贫血初筛阳性病例的血液学特征、血红蛋白电泳检测数据及地中海贫血基因检测数据。结果913例地贫初筛阳性的患儿,有523例基因诊断阳性(检出率57.28%),以α地贫为主,α地贫323例,β地贫195例,α复合β地贫5例。α地贫共检出6种基因型,其中以-α^(3.7)/αα、--^(SEA)/αα、-α^(4.2)/αα为主。β地贫患儿共检出11种基因突变类型,以CD17(A→T)/β、IVS-II-654(C→T)/β和CD41-42(-TCTT)/β为主,6个月~18岁地中海贫血患儿以β地贫为主(构成比54.39%)。用血红蛋白电泳联合红细胞相关参数筛查地中海贫血患儿时,在0~28 d组,MCH的敏感度(86.84%)和MCV的特异度(83.98%)最高,在29 d~6个月组,MCV的敏感度(76.67%)和MCH的特异度(77.78%)最高,在6个月~18岁组,MCHC的敏感度(65.70%)和MCV(68.89%)的特异度最高,所有组里三项平行联和的敏感度和三项系列联合的特异度都比单项要高。结论成都地区儿童地中海贫血基因突变发生率较高,血红蛋白电泳和红细胞相关参数能较好的筛查地中海贫血,降低漏诊率。

关键词：儿童地中海贫血血红蛋白电泳

INTERFACIAL TENSION BETWEEN SLAG AND COPPER MATTE

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 1989年第12期2卷 386-391页

作者： LI Jing HUANG Kexiong chen xinmin Central South University of Technology,Changsha,China

The interfacial tension between FeO-CaO-SiO_2-MgO system slag and Cu-Fe-S system matte was determinated by the X-ray radiograph sessile drop *** effects of FeO/SiO_2 ratio in the slag,contents of CaO,FeO,ZnO and CaF_2 in the slag on interracial tension and the relation of inter facial tension with the grade of matte and temperature have been *** floatation coefficient and film coefficient of slag-matte system has been calculated and the mechanism of the transition of iron and oxygen from slag to matte has also been discussed.

关键词： interfacial tension matte slag sessile drop method

MASS TRANSFER AT GAS EVOLVING MERCURY ELECTRODE

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 1992年第2期2卷 42-46页

作者： Li Xinhai chen xinmin Central-South University of Technology Changsha 410083China

Mass transfer at hydrogen evolving mercury electrode has been studied by determining mass transfer coefficients of indicator ions as the function of current density of hydrogen evolution for various kinds of indica tor ions in sulphuric acid *** adhering to metal substrates of Ni,Cu or Ag is used as mercury electrode to overcome its trembling during the *** effect of difTerent indicator ions,electrode character istic,substrate material,diameter of electrode and temperature is *** is found that the transfer coefficient is proportional to the mass square root of current density of hydrogen evolution.

关键词： mercury electrode gas bubble mass transfer

KINETICS OF THERMAL DECOMPOSITION OF SYNTHETIC GIBBSITE

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 1993年第2期3卷 41-44页

作者： Zeng,Wenming Zhou,Hong chen,Qiyuan chen,xinmin Central-South University of Technology,Changsha 410083,China

The thermal decomposition of synthetic gibbsite has been investigated by means of DSC and X-raydiffraction *** mechanism of thermal decomposition and kinetic parameters were determined at tem-peratures ranging from ro... 详细信息

关键词： synthetic gibbsite decomposition kinetics DSC

Basic and clinical study of increased effect of partial anti-tumor agents by infusing sodium bicarbonate through target artery

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 13-17页

作者： Pingsheng Fan Shicun Wang Lin Xiu Jide Li Kehai Feng Feihu chen xinmin Lin Jiansheng Zhuang Department of Oncology Anhui Provincial Cancer Hospital Hefei 230031 China

Objective： To observe the influence of pH value on the proliferation of LAK cells and on the killing effect of rlL-2, IFN-α2b, TNF-α, LAK cells and doxorubicin on malignant tumor cells, and investigate the possibility of increasing the efficacy of rlL-2 or IFN-α2b and doxorubicin by infusing sodium bicarbonate （NaHCO3） through target arteries. Methods： Separating single nucleus cells from peripheral blood of healthy men, and observing the influence of pH on the activation of single nucleus cells by rlL-2. MTT assay was used to measure the killing effect of rlL-2, IFN-α2b and TNF-α on 7404 cells and the increased effect of doxorubicin on rlL-2 and IFN-α2b, the cytotoxity of LAK cells in different pH. Forty-two patients with advanced primary liver cancer were obtained by stratified random, NaHCO3, rIL-2/IFN-α2b and doxorubicin were infused through target arteries. The efficacy was estimated after two cycles. Results： The conditions of pH 7.3 and pH 7.6 in vitro helped the proliferation of LAK cells and the killing effect of rIL-2, IFN-α2b and LAK cells on 7404 cells. In the condition of pH 6.8 there was almost no killing effect for LAK cells. In the condition of pH 7.0, 7.2, 7.4 and 7.6, the killing rate of TNF-α to 7404 cells increased by degrees, and in pH 7.4 the killing effect was the optimum. After two cycles treatments in the 42 patients with advanced primary liver cancer, the response rate （CR＋PR） was 88% （37/42）. The median overall response and median overall survival were increased, and no complication associated with infusing sodium bicarbonate was observed. Conclusion： The killing effect of rIL-2, IFN-α2b, TNF-α and doxorubicin on malignant tumor cells was enhanced by increasing the pH value.

关键词： acid-base balance primary liver cancer sodium bicarbonate rIL-2 doxorubicin microenvironment tumor immunity