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Global threshold dynamics of SIQS epidemic model in time fluctuating environment

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International Journal of Biomathematics 2017年第4期10卷 371-392页

作者： Shang li Meng Fan xinmiao Rong School of Mathematics and StatisticsNortheast Normal University 5268 Renmin Street Changchun Jilin 130024 P. R. China

The paper characterizes the global threshold dynamics of an epidemic model of SIQS type in environments with fluctuations, where the quarantine class is explicitly involved. Criteria are established for the permanence and extinction of the infective in environ- ments with time oscillations. In particular, we further consider an environment which varies periodically in time. The global threshold dynamic scenarios i.e. the existence and global asymptotic stability of the disease-free periodic solution, the existence of the endemic periodic solution and the permanence of the infective are completely character- ized by the basic reproduction number defined by the spectral radius of an associated linear integral operator.

关键词： SIQS model non-autonomous periodic global threshold dynamics.

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人造肉技术的研究现状及展望

食品工业科技 2024年第17期45卷 416-425页

作者：张智霞马鑫淼许慧车丽娜李玉王稳航王楠天津科技大学生物工程学院天津300457 天津科技大学食品科学与工程学院天津300457

全球人口持续增长使得人们对肉制品的需求持续上升,然而,传统的肉类生产方式既无法满足人们的需求,也带来了环境压力和动物福利等一系列问题,而人造肉技术的发展有望解决这些问题。目前人造肉可以分为植物基肉、菌类蛋白肉类似物和细胞... 详细信息

全球人口持续增长使得人们对肉制品的需求持续上升,然而,传统的肉类生产方式既无法满足人们的需求,也带来了环境压力和动物福利等一系列问题,而人造肉技术的发展有望解决这些问题。目前人造肉可以分为植物基肉、菌类蛋白肉类似物和细胞培养肉三大类。本文主要介绍了三种人造肉的生产过程,综述了它们各自的优势及市场前景,并分析人造肉目前面临的主要困难与技术挑战,对其相应的发展建议及解决策略进行探讨,以期为人造肉的研究及其产业化提供参考。

关键词：人造肉植物蛋白肉菌类蛋白肉细胞培养肉

Emotional dialog generation via multiple classifiers based on a generative adversarial network

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Virtual Reality & Intelligent Hardware 2021年第1期3卷 18-32页

作者： Wei CHEN xinmiao CHEN Xiao SUN School of Computer and Information Hefei University of TechnologyHefei 230601China

Background Human-machine dialog generation is an essential topic of research in the field of natural language *** high-quality,diverse,fluent,and emotional conversation is a challenging *** on continuing advancements in artificial intelligence and deep learning,new methods have come to the forefront in recent *** particular,the end-to-end neural network model provides an extensible conversation generation framework that has the potential to enable machines to understand semantics and automatically generate ***,neural network models come with their own set of questions and *** basic conversational model framework tends to produce universal,meaningless,and relatively"safe"*** Based on generative adversarial networks(GANs),a new emotional dialog generation framework called EMC-GAN is proposed in this study to address the task of emotional dialog *** proposed model comprises a generative and three discriminative *** generator is based on the basic sequence-to-sequence(Seq2Seq)dialog generation model,and the aggregate discriminative model for the overall framework consists of a basic discriminative model,an emotion discriminative model,and a fluency discriminative *** basic discriminative model distinguishes generated fake sentences from real sentences in the training *** emotion discriminative model evaluates whether the emotion conveyed via the generated dialog agrees with a pre-specified emotion,and directs the generative model to generate dialogs that correspond to the category of the pre-specified ***,the fluency discriminative model assigns a score to the fluency of the generated dialog and guides the generator to produce more fluent *** Based on the experimental results,this study confirms the superiority of the proposed model over similar existing models with respect to emotional accuracy,fluency,and *** The proposed EMC-

关键词： Emotional dialog generation Sequence-to-sequence model Emotion classification Generative adversarial networks Multiple classifiers

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Contents

故宫博物院院刊 2005年第6期 154-161页

作者： Zheng xinmiao

氯己定对粪肠球菌耐药性和致病性的影响及其机制

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吉林大学学报（医学版） 2024年第3期50卷 676-681页

作者：徐智博姜鑫淼甄雨琦白玛曲珍孙梦瑶孟秀萍吉林大学口腔医院牙体牙髓科吉林长春130021 吉林省牙发育及颌骨重塑与再生重点实验室吉林长春130021

目的:探讨长期使用氯己定对粪肠球菌(***)耐药性的影响,并阐明其作用机制。方法:将***标准菌株反复暴露于氯己定中传代10代,记录每一次传代时的最低抑菌浓度(MIC)值。收集第10代且MIC值增加的细菌,即为***氯己定耐药菌株(***-Cs)。绘制... 详细信息

目的:探讨长期使用氯己定对粪肠球菌(***)耐药性的影响,并阐明其作用机制。方法:将***标准菌株反复暴露于氯己定中传代10代,记录每一次传代时的最低抑菌浓度(MIC)值。收集第10代且MIC值增加的细菌,即为***氯己定耐药菌株(***-Cs)。绘制2种菌株生长曲线,透射电子显微镜观察2种菌株形态表现,结晶紫染色法检测2种菌株细菌生物膜形成量,微生物黏着碳氢化合物(MATH)法检测2种菌株细菌疏水率,实时荧光定量PCR(RT-qPCR)法检测2种菌株细菌生物膜中S-核糖基高半胱氨酸裂解酶(luxS)mRNA表达水平。结果:随着传代次数(第0~10代)的增加,***的MIC值逐渐升高。***和***-Cs的生长曲线无明显差异。透射电镜,***和***-Cs均呈椭圆形或双球型,细胞壁结构完整,边缘光滑,细胞质分布均匀,2种细菌形态大小和细胞壁厚度及完整性方面无明显差异。结晶紫染色法,与***比较,***-Cs生物膜形成量明显增加(PluxS mRNA表达水平明显升高(PluxS基因高表达和更强的细菌生物膜形成能力可能是***对氯己定产生耐药性的潜在机制。

关键词：粪肠球菌氯己定耐药性粪肠球菌氯己定耐药菌株群体感应系统

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Update on Mayer—Rokitansky—Küster—Hauser syndrome

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Frontiers of Medicine 2022年第6期16卷 859-872页

作者： Na Chen Shuang Song xinmiao Bao lan Zhu National Clinical Research Center for Obstetric and Gynecologic Diseases Department of Obstetrics and GynecologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing100730China Peking Union Medical College M.D.ProgramBeijing100730China

This review presents an update of Mayer—Rokitansky—Küster—Hauser(MRKH)syndrome on its etiologic,clinical,diagnostic,psychological,therapeutic,and reproductive *** etiology of MRKH syndrome remains unclear due to its intrinsic *** and genetic causes that may interact during the embryonic development have been proposed with no definitive etiopathogenesis *** proportion of concomitant extragenital malformations varies in different studies,and the discrepancies may be explained by ethnic *** addition to physical examination and pelvic ultrasound,the performance of pelvic magnetic resonance imaging is crucial in detecting the presence of rudimentary uterine *** syndrome has long-lasting psychological effects on patients,resulting in low esteem,poor coping strategies,depression,and anxiety *** psychological counseling and peer support to diagnosed patients is *** and timely psychological intervention could significantly improve a patient’s *** nonsurgical and surgical methods have been suggested for treatment of MRKH *** to the high success rate and minimal risk of complications,vaginal dilation has been proven to be the first-line *** is the second-line option for patients experiencing dilation *** transplantation and gestational surrogacy are options for women with MRKH syndrome to achieve biological motherhood.

关键词： MRKH(Mayer-Rokitansky-Küster-Hauser)syndrome etiology clinical characteristic diagnosis treatment psychological effect

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四个甜樱桃品种的开花生物学特性研究

北方园艺 2024年第3期 25-32页

作者：李新苗刘志应祝洋王梦圆张娟塔里木大学园艺与林学学院新疆阿拉尔843300 塔里木大学南疆设施农业兵团重点实验室新疆阿拉尔843300 塔里木大学南疆特色果树高效优质栽培与深加工技术国家地方联合工程实验室新疆阿拉尔843300

以八年生甜樱桃品种‘布鲁克斯’‘美早’‘早大果’‘晚红珠’为试材,对其开花物候期、花器官特征、花粉特性、柱头可授性等指标进行测定,系统了解甜樱桃在阿拉尔地区开花生物学特征,以期为阿拉尔地区甜樱桃的高效栽培提供参考依据。... 详细信息

以八年生甜樱桃品种‘布鲁克斯’‘美早’‘早大果’‘晚红珠’为试材,对其开花物候期、花器官特征、花粉特性、柱头可授性等指标进行测定,系统了解甜樱桃在阿拉尔地区开花生物学特征,以期为阿拉尔地区甜樱桃的高效栽培提供参考依据。结果表明:4个甜樱桃品种花期相近,‘布鲁克斯’的发育速率较快,‘早大果’和‘晚红珠’的花期较长。‘美早’的花冠直径、花瓣纵横径均为最大,‘布鲁克斯’和‘早大果’易出现多雌蕊现象。4个甜樱桃品种均为中等型花粉,其中‘布鲁克斯’的极轴长最大为49.07μm,赤道轴长‘美早’最大为24.53μm,花粉粒的外壁纹饰均呈条纹状。‘晚红珠’的柱头可授性最强,‘早大果’的单花花粉量最多,蔗糖浓度在10 g·l^(-1)时花粉萌发率最高,其中‘早大果’的花粉活力最高。不同品种甜樱桃的开花生物学特性存在差异,生产上建议选择物候期相近且花粉活力高的品种搭配种植来提高坐果率和产量。

关键词：甜樱桃生物学特性花粉特性花粉活力

不同施肥水平对玉树芫根农艺性状、产量及经济效益的影响

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中国瓜菜 2024年第6期37卷 159-166页

作者：吴延寻尕桑赵孟良王鑫淼任延靖青海大学农林科学院西宁810016 青藏高原种质资源研究与利用实验室西宁810016 青海大学农牧学院西宁810016 玉树藏族自治州农牧业综合服务中心青海玉树815000 三江源生态和高原农牧业国家重点实验室·青海大学西宁810016

为进一步提高芫根产量和种植芫根的经济效益,选取玉树藏族自治州地方品种玉树芫根为材料,以不施肥(CK)为对照,研究不同配比的N、P、K肥料对芫根根长、根粗、鲜质量的影响,采用隶属函数法综合评价其农艺性状,并对各个施肥处理获得的经济... 详细信息

为进一步提高芫根产量和种植芫根的经济效益,选取玉树藏族自治州地方品种玉树芫根为材料,以不施肥(CK)为对照,研究不同配比的N、P、K肥料对芫根根长、根粗、鲜质量的影响,采用隶属函数法综合评价其农艺性状,并对各个施肥处理获得的经济效益进行比较。结果表明,NP10处理下根长最长,为5.53 cm,N20处理下对玉树芫根根粗和根鲜质量促进效果最好,分别为9.43 cm和299.33 g。在NP10处理下,根形指数达到0.69,接近圆形,商品性较好。综合评价结果表明,N20(每667 m^(2)追施20 kg尿素)隶属函数值最高,达到0.84,产生的经济效益为1006.39元。综上所述,每667 m^(2)施用20 kg尿素提高了玉树芫根的产量及经济效益,研究结果为后续芫根高产种植提供了合理的施肥方案。

关键词：玉树芫根施肥水平农艺性状产量经济效益

Investigation of Peptoid Chiral Stationary Phases Terminated with N＇-Substituted PhenyI-l-proline/leucine Amide

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Chinese Journal of Chemistry 2012年第12期30卷 2791-2797页

作者： Wu Haibo Song Guangjun liang xinmiao Ke Yanxiong School of Pharmacy East China University of Science and Technology Shanghai 200237 China Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian Liaoning 116023 China

Eight peptoid chiral stationary phases （CSPs） terminated with N＇substituted phenyl-l-proline or l-leucine amide were prepared and evaluated under normal phase mode. With 59 racemic analytes, we compared the enantio- meric separations on CSPs terminated with p-methylphenyl, p-chlorophenyl and unsubstituted phenyl. For short peptoid selectors containing only one S-N-（1-phenylethyl） glycine （Nspe） unit, the terminal p-methyl substituent did not affect chiral recognition abilities significantly. In l-proline amide terminated CSPs, p-chloro substituent resulted in obviously inferior selectivity while in l-leucine amide terminated CSPs, it worked much better. longer peptoid selectors containing two more Nspe units generally performed much better than the shorter ones, due to the great contributions of peptoid chain to chiral recognition. Meanwhile, the effects of the terminal substituent on selectivity were found changed on these CSPs. For CSPs terminated with l-leucine amide, the terminal p-chloro substituent in longer selector no longer produced the best recognition ability; the CSP with unsubstituted phenyl instead performed best. Comparison of these peptoid CSPs varied in terminal substituents and chain length was conducted to gain a better understanding of the chiral recognition mechanism of this type CSP and promote the development of more useful CSPs.

关键词： chiral stationary phase peptoid enantiomeric separation proline amide leucine amide