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Microenvironmental stiffness mediates cytoskeleton re-organization in chondrocytes through laminin-FAK mechanotransduction

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International Journal of Oral Science 2022年第2期14卷 182-191页

作者： Chenchen Zhou Mengmeng duan Daimo Guo Xinmei Du Demao Zhang Jing Xie State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina

Microenvironmental biophysical factors play a fundamental role in controlling cell behaviors including cell morphology,proliferation,adhesion and differentiation,and even determining the cell fate.Cells are able to actively sense the surrounding mechanical microenvironment and change their cellular morphology to adapt to it.Although cell morphological changes have been considered to be the first and most important step in the interaction between cells and their mechanical microenvironment,their regulatory network is not completely clear.In the current study,we generated silicon-based elastomer polydimethylsiloxane(PDMS)substrates with stiff(15:1,PDMS elastomer vs.curing agent)and soft(45:1)stiffnesses,which showed the Young’s moduli of~450 k Pa and 46 kPa,respectively,and elucidated a new path in cytoskeleton re-organization in chondrocytes in response to changed substrate stiffnesses by characterizing the axis shift from the secreted extracellular protein lamininβ1,focal adhesion complex protein FAK to microfilament bundling.We first showed the cellular cytoskeleton changes in chondrocytes by characterizing the cell spreading area and cellular synapses.We then found the changes of secreted extracellular linkage protein,lamininβ1,and focal adhesion complex protein,FAK,in chondrocytes in response to different substrate stiffnesses.These two proteins were shown to be directly interacted by Co-IP and colocalization.We next showed that impact of FAK on the cytoskeleton organization by showing the changes of microfilament bundles and found the potential intermediate regulators.Taking together,this modulation axis of lamininβ1-FAK-microfilament could enlarge our understanding about the interdependence among mechanosensing,mechanotransduction,and cytoskeleton re-organization.

关键词： laminin mec stiffness

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The role of TGF-beta3 in cartilage development and osteoarthritis

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Bone Research 2023年第1期11卷 108-123页

作者： Xinmei Du Linyi Cai Jing Xie Xuedong Zhou State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan University610041ChengduChina National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan University610041ChengduChina

Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment.

关键词： cartilage protective versatile

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Ultra-Stable and durable Piezoelectric Nanogenerator with All-Weather Service Capability Based on N Doped 4H-SiC Nanohole Arrays

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Nano-Micro Letters 2022年第2期14卷 151-160页

作者： Linlin Zhou Laipan Zhu Tao Yang xinmei Hou Zhengtao du Sheng Cao Hailong Wang Kuo-Chih Chou Zhong Lin Wang Beijing Advanced Innovation Center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083People’s Republic of China MOE Key Laboratory of New Processing Technology for Non‑Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non‑Ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004People’s Republic of China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Ultra-stable piezoelectric nanogenerator(PENG)driven by environmental actuation sources with all-weather service capability is highly desirable.Here,the PENG based on N doped 4H-SiC nanohole arrays(NHAs)is proposed to harvest ambient energy under low/high temperature and relative humidity(RH)conditions.Finite element method simulation of N doped 4H-SiC NHAs in compression mode is developed to evaluate the relationship between nanohole diameter and piezoelectric performance.The density of short circuit current of the assembled PENG reaches 313 nA cm^(-2),which is 1.57 times the output of PENG based on N doped 4H-SiC nanowire arrays.The enhancement can be attributed to the existence of nanohole sidewalls in NHAs.All-weather service capability of the PENG is verified after being treated at-80/80℃and 0%/100%RH for 50 days.The PENG is promising to be widely used in practice worldwide to harvest biomechanical energy and mechanical energy.

关键词： Piezoelectric nanogenerators N doped 4H-SiC nanohole arrays Environmental actuation sources All-weather service capability Enhanced short circuit current density

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Bifunctional hierarchical NiCoP@FeNi LDH nanosheet array electrocatalyst for industrial-scale high-current-density water splitting

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Journal of Materials Science & Technology 2023年第28期159卷 33-40页

作者： Liming Yang Tao Yang Enhui Wang Xiangtao Yu Kang Wang Zhentao du Sheng Cao Kuo-Chih Chou xinmei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China

Aiming to design and prepare non-noble metal electrocatalysts for hydrogen production at high current density(HCD),NiCoP@FeNi LDH hierarchical nanosheets were deposited on nickel foam progressively us-ing a hydrothermal-phosphorization-electrodeposition process.For hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),NiCoP@FeNi LDH/NF requires only 195 and 230 mV overpotentials to reach 1000 mA cm−2,respectively.For overall water splitting,only 1.70 V is required at 1000 mA cm−2.This is the largest value for non-noble metal-based electrocatalysts reported so far at HCD.The hierarchi-cal structure exhibits good electron transport capability and the porous-macroporous structure enhances the gas release rate,resulting in enhanced hydrogen production at HCD.Especially,the synergistic effect of NiCoP and FeNi LDH contributes to the adsorption-desorption equilibrium of intermediate radicals dur-ing the reaction process and ultimately enhances the catalytic activity.This work provides useful direction for industrial-scale hydrogen production applications at HCD.

关键词： High-current-density Overall water splitting Hydrogen evolution reaction Oxygen evolution reaction

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“合同构成”视角下第三人原因违约的理解与突破——以《民法典(合同编)》第593条为中心

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中共南京市委党校学报 2020年第5期 89-98页

作者：杜新梅中南财经政法大学法学院 430073

既有解释路径多通过限制第三人范围及原因的方式,达到合理限制债务人责任范围的目的。能否将思维不限于"第三人",实为必要的解释路径转换方式,第三人原因违约触及的是合同债权拘束力问题,以传统归责原则作为理论分析工具,无法解决《民法... 详细信息

既有解释路径多通过限制第三人范围及原因的方式,达到合理限制债务人责任范围的目的。能否将思维不限于"第三人",实为必要的解释路径转换方式,第三人原因违约触及的是合同债权拘束力问题,以传统归责原则作为理论分析工具,无法解决《民法典(合同编)》第593条根本症结。在履行障碍法上,"合同构成"理论以救济进路代替传统的原因进路,履行请求权不再是先验的存在,而是与损害赔偿请求权一样,成为合同债权的救济手段。《民法典(合同编)》第593条作为总则中关于第三人原因违约的风险分配规范,在一定程度上可弥补现行合同法风险分配规范的缺漏。司法实践中,债务人自身违约与第三人原因违约的复合不容忽视。可预见性规则作为一个多向度的复合构成,将责任限制于正常人可合理预见的风险范围,整体性地来完成责任限制的任务。

关键词：第三人原因违约合同构成风险分配可预见性

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渐进式肌肉放松训练联合健康教育对肺癌化疗患者消极心理状态、遵医行为及护理满意度的影响

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西部中医药 2020年第3期33卷 130-133页

作者：杜心美北京大学肿瘤医院北京100142

目的:探讨渐进式肌肉放松训练联合健康教育对肺癌化疗患者消极心理状态、遵医行为及护理满意度的影响。方法:将肺癌化疗患者129例采用随机数表法分为观察组65例与对照组64例,对照组患者采用常规护理,观察组患者在常规护理基础上采用健... 详细信息

目的:探讨渐进式肌肉放松训练联合健康教育对肺癌化疗患者消极心理状态、遵医行为及护理满意度的影响。方法:将肺癌化疗患者129例采用随机数表法分为观察组65例与对照组64例,对照组患者采用常规护理,观察组患者在常规护理基础上采用健康教育及渐进式肌肉放松训练,对比两组患者消极心理状态、遵医行为的改善情况及护理满意度。结果:观察组患者干预后紧张焦虑、愤怒敌意、疲乏迟钝、抑郁沮丧评分低于对照组,组间比较差异有统计学意义(P0.05);观察组患者遵医行为优良率为96.9%(63/65),高于对照组的82.8%(53/64),差异有统计学意义(P<0.05);观察组患者护理满意度为95.4%(62/65),高于对照组的79.7%(51/64)(P<0.05)。结论:渐进式肌肉放松训练联合健康教育能够有效改善肺癌化疗患者消极心理状态与遵医行为,提高护理满意度。

关键词：肺癌化疗消极心理状态遵医行为健康教育肌肉放松训练

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The Metabolism of Methylene Blue and Its Derivatives in Japanese Eel(Anguilla Japonica)

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Journal of Ocean University of China 2020年第3期19卷 653-658页

作者： WANG Yali HUANG Xuanyun du Bingtan LV xinmei SUN Jing ZHENG Ruizhou HU Kun National Pathogen Collection Center for Aquatic Animals Shanghai 201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Shanghai Engineering Research Center of Aquaculture Shanghai 201306China East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai 200090China

Methylene blue(MB) is commonly used in aquaculture as a fungicide and antidotes. This study was designed to explore the pharmacokinetics of MB in Japanese eel(Anguilla Japonica) immersed in 10 mg L^-1 and 20 mg L^-1 MB for 0.5 h. The concentrations of MB and its derivatives in the blood, liver, kidney, skin and muscle were determined by HPLC after immersion. The results showed that the changes of drug concentrations in Japanese eel were basically the same in different dose groups, showing a general trend of increasing at first and then decreasing, but the peak time was slightly different. The peak concentration of the drug was positively correlated with the dose level. The peak concentrations of MB in MB(20 mg L^-1) group, MB, azure A and azure B in the tissues of Japanese eel were significantly higher than those in MB(10 mg L^-1) group. Moreover, MB, azure A and azure B remained for a long time and could still be detected at 64 days, and azure C was not detected in tissues.

关键词： methylene blue Anguilla japonica thiazine dye aquaculture

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In situ reduced MXene/AuNPs composite toward enhanced charging/discharging and specific capacitance

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Journal of Advanced Ceramics 2021年第5期10卷 1061-1071页

作者： Zixiang ZHENG Wei WU Tao YANG Enhui WANG Zhentao du xinmei HOU Tongxiang LIANG Hailong WANG Beijing Advanced Innovation Center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Technology BeijingBeijing 100083China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China

In this work,gold nanoparticles(AuNPs)decorated Ti_(3)C_(2)T_(x) nanosheets(MXene/AuNPs composite)are fabricated through a self-reduction reaction of Ti_(3)C_(2)T_(x) nanosheets with HAuCl_(4) aqueous solution.The obtained composite is characterized as AuNPs with the diameter of about 23 nm uniformly dispersing on nanosheets without aggregation.The composite(MXene decorated on 4.8 wt% AuNPs)is further employed to construct supercapacitor for the first time with a higher specific capacitance of 278 F·g^(-1) at 5 mV·s^(-1) than that of pure Ti_(3)C_(2)T_(x) and 95% of cyclic stability after 10,000 cycles.Furthermore,MXene/AuNPs composite symmetric supercapacitor with filter paper as separator and H_(2)SO_(4) as electrolyte,is assembled.The supercapacitor exhibits a high volumetric energy density of 8.82 Wh·L^(-1) at a power density of 264.6 W·L^(-1) and ultrafast-charging/discharging performance.It exhibits as a promising candidate applied in integrated and flexible supercapacitors.

关键词： supercapacitors MXene gold nanoparticles(AuNPs) self-reduction composite

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颌骨修复重建的分子调控机制研究进展

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四川大学学报（医学版） 2024年第1期55卷 224-229页

作者：杜信眉谢静邹玲口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓科成都610041

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以... 详细信息

临床上常见因外伤、肿瘤及炎症等导致的颌骨损伤。由于颌骨独特的生物力学特性和生理功能,如何精确有效地修复重建颌骨并恢复其功能和美观是口腔颌面外科领域的一项重要挑战。颌骨损伤后的自然修复过程,包括血肿形成、炎症反应、骨化以及骨重塑等阶段。骨形态发生蛋白(bone morphogenetic proteins,BMPs)、转化生长因子-β(transforming growth factor beta,TGF-β)、血管内皮生长因子(vascular endothelial-derived growth factor,VEGF)等生长因子在促进颌骨骨再生中发挥着重要的作用。细胞因子如白细胞介素和肿瘤坏死因子在调节炎症反应和骨修复中具有双重作用。近年来,分子生物学研究在颌骨修复重建领域中已经取得了显著进展。组织工程技术在颌骨修复中有着重要的应用,包括干细胞疗法、生物活性支架和生长因子递送系统。但这些治疗手段所涉及的复杂的颌骨修复重建分子调控机制尚不清晰,有待进一步研究。未来的研究方向将集中在精确控制这些分子过程,以及开发更高效的组合治疗策略,以促进颌骨的有效和功能性重建。本综述旨在探讨颌骨修复重建的分子调控机制及其治疗策略的最新进展,为颌骨修复重建的机制提供分子层面的理解。

关键词：骨重建骨形态发生蛋白转化生长因子-β 血管内皮生长因子组织工程综述

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基于ResNet-GWO的冷源系统节能优化

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东南大学学报（自然科学版） 2020年第5期50卷 866-874页

作者：杜佳敏李舒宏李新美东南大学能源与环境学院南京210096 南京福加自动化科技有限公司南京210046

针对中央空调冷源系统运行能耗高、设备之间高度耦合机理建模困难、参数众多难以随环境变化动态调节的问题,引入智能化算法进行建模优化.以某经过初步节能改造且冷水主机并联运行的地铁站空调冷源系统实测运行数据为基础,结合冷源系统... 详细信息

针对中央空调冷源系统运行能耗高、设备之间高度耦合机理建模困难、参数众多难以随环境变化动态调节的问题,引入智能化算法进行建模优化.以某经过初步节能改造且冷水主机并联运行的地铁站空调冷源系统实测运行数据为基础,结合冷源系统运行原理建立能耗预测残差神经网络(ResNet)模型.采用灰狼优化算法(GWO)对某典型夏季制冷日运行工况进行寻优计算.仿真结果表明,冷源系统ResNet模型在测试集上的平均相对误差、平均绝对误差值分别为1.5485%、2.2394,预测精度高于BP神经网络模型和支持向量回归机模型;优化结果显示,GWO优化后的能耗值相比遗传算法(GA)、粒子群优化(PSO)更低,较实际运行平均节能10.45%,其中冷水主机能耗降低8.14%,而各主机冷冻水供水温度相等时冷机节能率仅为5.37%.因此,基于ResNet-GWO的仿真优化策略可用于实现中央空调冷源系统的高能效运行.

关键词：中央空调冷源系统节能运行残差神经网络灰狼优化

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