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Amplitude of sensory nerve action potential in early stage diabetic peripheral neuropathy:an analysis of 500 cases

Neural Regeneration Research 2014年第14期9卷 1389-1394页

作者： Yunqian Zhang Jintao Li Tingjuan wang Jianlin wang Department of Neurology the Fourth Affiliated Hospital of Kunming Medical University Neuroscience Institute Kunming Medical University

Early diagnosis of diabetic peripheral neuropathy is important for the successful treatment of diabetes mellitus. In the present study, we recruited 500 diabetic patients from the Fourth Affiliated Hospital of Kunming Medical University in China from June 2008 to September 2013：221 cases showed symptoms of peripheral neuropathy （symptomatic group） and 279 cases had no symptoms of peripheral impairment （asymptomatic group）. One hundred healthy control subjects were also recruited. Nerve conduction studies revealed that distal motor latency was longer, sensory nerve conduction velocity was slower, and sensory nerve action potential and amplitude of compound muscle action potential were significantly lower in the median, ulnar, posterior tibial and common peroneal nerve in the diabetic groups compared with control subjects. Moreover, the alterations were more obvious in patients with symptoms of peripheral neuropathy. Of the 500 diabetic patients, neural conduction abnormalities were detected in 358 cases （71.6%）, among which impairment of the common peroneal nerve was most prominent. Sensory nerve abnormality was more obvious than motor nerve abnormality in the diabetic groups. The amplitude of sensory nerve action potential was the most sensitive measure of peripheral neuropathy. Our results reveal that varying degrees of nerve conduction changes are present in the early, asymptomatic stage of diabetic peripheral neuropathy.

关键词： nerve regeneration peripheral nerve injury diabetic peripheral neuropathy neural con-duction electrophysiology sensory nerve motor nerve early diagnosis neural regeneration

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Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis

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Journal of Traditional Chinese Medicine 2015年第1期35卷 63-68页

作者： Yang Lihua wang Yun wang Xiaohua Liu Yanqing Institution of Traditional Chinese Medicine and Western Medicine Nanjing University of Chinese Medicine Institute of Digestive Endoscopy & Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University

OBJECTIVE：To determine the effects of human umbilical cord mesenchymal stem cell （UCMSC） transplantation, alone or in combination with tanshi- none IIA （Tan ⅡA） on hepatic cirrhosis in rats. METHODS： A rat model of cirrhosis was established. Rats were divided into control, UCMSC, and UCSMC plus Tan IIA groups. Rats in the UCMSC group were injected via the tail vein with 0.2 mL Dil-labeled UCMSC suspension. Intraperitoneal Tan ⅡA injections （20 mg/kg） were started on the day of UCMSC transplantation in the UCMSC plus Tan IIA group, and continued for 7 consecutive days thereafter. Rats were sacrificed 1 day, 3 days, 1 month, and 3 months after transplantation and the numbers of Dil-labeled UCMSCs colonizing the liver were determined. Albumin （ALB） and alanine aminotransferase （ALT） levels were measured in venous blood, and mRNA and protein expression lev- els of human ALB and cytokeratin （CK）-18 in liver tissues were determined by reverse transcrip- tion-polymerase chain reaction and western blotting, ***： Serum ALT levels were significantly lower and serum ALB levels significantly higher in rats in the UCMSC group compared with the control group （P 〈 0.05）. Hepatic CK-18 and ALB mRNA and protein expression levels increased after transplantation, and were significantly higher in the UCMSC plus Tan ⅡA group compared with the UCMSC group （P 〈 0.05）.CONCLUSION： Human UCMSCs transplanted into rats with liver cirrhosis can grow and differentiate into hepatocyte-like cells resulting in improved liver function in vivo. Tan ⅡA further influenced transplantation outcomes.

关键词： Liver cirrhosis Umbilical cord Mesenchymal stem cells Tanshinone Transplantation

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Optimization of Low-Temperature Exhaust Gas Waste Heat Fueled Organic Rankine Cycle

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Journal of Iron and Steel Research International 2012年第6期19卷 30-36页

作者： wang Hui-tao wang Hua ZHANG Zhu-ming Engineering Research Center of Metallurgical Energy Conservation and Emission Reduction Ministry of Education Kunming University of Science and TechnologyKunming 650093YunnanChina Kunming Iron and Steel Company Kunming 650302YunnanChina

Low temperature exhaust gases carrying large amount of waste heat are released by steel-making process and many other industries, Organic Rankine Cycles （ORCs） are proven to be the most promising technology to re- cover the low-temperature waste heat, thereby to get more financial benefits for these industries. The exergy analysis of ORC units driven by low-temperature exhaust gas waste heat and charged with dry and isentropic fluid was per- formed, and an intuitive approach with simple impressions was developed to calculate the performances of the ORC unit. Parameter optimization was conducted with turbine inlet temperature simplified as the variable and exergy effi- ciency or power output as the objective function by means of Penalty Function and Golden Section Searching algo- rithm based on the formulation of the optimization problem. The power generated by the optimized ORC unit can be nearly as twice as that generated by a non-optimized ORC unit. In addition, cycle parametric analysis was performed to examine the effects of thermodynamic parameters on the cycle performances such as thermal efficiency and exergy efficiency. It is proven that performance of ORC unit is mainly affected by the thermodynamic property of working fluid, the waste heat temperature, the pinch point temperature of the evaporator, the specific heat capacity of the heat carrier and the turbine inlet temperature under a given environment temperature.

关键词： waste heat recovery organic Rankine cycles optimization working fluid exergy pinch point

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Insulin-induced severe thyrotoxic periodic paralysis:A case report

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World Journal of Clinical Cases 2025年第7期13卷 46-51页

作者： Yan-Li wang Jian Li Department of Endocrinology and Metabolism Zigong First People's HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's ***,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of *** article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP *** SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening *** medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week *** was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade *** department tests showed hypokalemia of 1.6 mmol/*** paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g *** in the arms and legs *** was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing *** stopped his insulin and he was discharged with a potassium level of 4.0 mmol/*** Insulin is a trigger for TPP and should be avoided in patients with *** recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.

关键词： Thyrotoxic periodic paralysis Potassium metabolism disorders Insulin Triggers of paralysis Case report

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Synergistic control of dual cross-linking strategy toward tailor-made hydrogels

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Science China Chemistry 2020年第12期63卷 1793-1798页

作者： Xueyu Dou Qingchen Cao Feifei Sun Yaqiang wang Hufei wang Hong Shen Fei Yang Xing wang Decheng Wu Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Simple, efficient and accurate controllable systems for materials are becoming more essential, in response to the explosively growing demands in the fields of chemistry and material science. Herein, tailored hydrogels are explored depending on synergistic regulation of p H-responsive chemical networks with an "on/off" function and physical networks with dynamic selfoptimized arrangement. Thiol-disulfide exchange reaction endows hydrogels with controlled architectures while hydrogen bondstrengthened 2-ureido-4[1H]-pyrimidinone(UPy) moieties contributes a significant increase in mechanical strengths. The integration of that dual cross-linking(DC) network ensures the hydrogels with customized structure and enhanced mechanical property. Such controllably strategy is universally applicable and will open a new avenue to flexibly fabricate desired hybrid hydrogels with distinctive features and functions for their potential applications.

关键词： controlled hydrogels dual cross-linked network thiol-disulfide exchange hydrogen bonding synergistic regulation

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Unraveling structure evolution failure mechanism in MoS_(2)anode for improving lithium storage stability

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Journal of Materials Science & Technology 2022年第33期128卷 245-253页

作者： Guannan Zu Shiyu Xu Changhao wang Hongyi Li Manchen Zhang Xiaoxing Ke Yuxiang Hu Ruzhi wang Jinshu wang Key Laboratory of Advanced Functional Materials of Education Ministry of China Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Microstructure and Properties of Solids Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

2 H phase molybdenum disulfide(2 H-MoS_(2))possesses the two-dimensional layered structure and high theoretical capacity,presenting excellent lithiation-delithiation ***,the violent capacity decay within dozens of cycles still remains a great challenge due to lacking of in-depth failure ***,a novel decay-recovery-decay failure phenomenon upon long-term cycles is reported for the first time,which originates from the slow size change of Mo nanoparticles(NPs).Decay stages are triggered by many irregular-shaped Mo NPs with the increasing size up to~15 nm,leading to prominent pseudocapacitance failure and capacity *** recovery stages are attributed to the pulverization of coarse Mo NPs through surface sulfurization and accompanying *** overcome the instability issue,proper modifiers should be introduced to restrain the spontaneous growth of Mo NPs,such as aluminum oxide(Al_(2)O_(3)).The strong Mo-Al_(2)O_(3)bond gradually"drags"Al_(2)O_(3)fragments into the active material as the cycle continuously proceeds,resulting in the efficient refinement and the reversible conversion between Mo and MoS_(2).Therefore,the enhanced cycling stability and the capacity retention are successfully *** is expected to provide a new insight into the energy storage of transition metal chalcogenide anode materials in rechargeable batteries.

关键词： 2H-MoS_(2) Decay-recovery-decay Mo nanoparticles Al_(2)O_(3) Enhanced cycling stability

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Boosting Li-ion storage kinetics via constructing layered TiO_(2) anode

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Particuology 2024年第10期93卷 22-29页

作者： Jiyue Hou Fei wang Enfeng Zhang Ying wang Peng Dong Yunxiao wang Yiyong Zhang Xue Li Yingjie Zhang National and Local Joint Engineering Research Center of Lithium-ion Batteries and Materials Preparation Technology Faculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming650093China College of Electrical Information Engineering Panzhihua UniversityPanzhihua617000China University Wollongong Australian Inst Innovat MatInst Superconducting&Elect MatInnovat Campus Squires WayWollongongNSW2500Australia

Due to the typical intercalation-deintercalation mechanism,TiO_(2) holds great promise as a sustainable anode for next-generation lithium-ion batteries(LIBs).However,commercial TiO_(2)(C–TiO_(2))is granular and shows slow ionic conductivity,which greatly hinders its development due to sluggish kinetics,leading to low reversible capacity and inferior rate *** this study,a two-dimensional layered TiO_(2)(L-TiO_(2))anode is prepared via a one-step calcination process,which can effectively shorten the lithium ions diffusion path and improve its lithium ions *** elucidated the enhanced electrochemical performance of L-TiO_(2) as an anode in LIBs through pseudocapacitive acceleration of lithium ions intercalation and deintercalation using various characterization techniques,including different scan rate cyclic voltammetry tests,in situ electrochemical impedance spectroscopy,in situ Raman spectroscopy,and in situ X-ray *** comparison to C–TiO_(2) material,L-TiO_(2) material showcases remarkable electrochemical performance,achieving a capacity of 166 mAh/g after 100 cycles at 0.1 ***,the lithium-ion diffusion coefficient calculated for the L-TiO_(2) is two orders of magnitude greater,underscoring its potential as a negative electrode material for LIBs.

关键词： Lithium-ionbatteries Anode MXene Layered TiO_(2)

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城市扩张与耕地保护耦合对陆地生态系统碳储量的影响——以湖北省为例

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生态学报 2019年第2期39卷 672-683页

作者：柯新利唐兰萍华中农业大学公共管理学院武汉430070

城市扩张对生态系统的影响可以分为城市扩张对生态用地的直接挤占以及为补充城市扩张占用的耕地对生态用地二次挤占两个连锁的过程。以往的研究大多只关注城市扩张对生态系统的直接影响,忽略了城市扩张与耕地保护耦合的间接影响。针对... 详细信息

城市扩张对生态系统的影响可以分为城市扩张对生态用地的直接挤占以及为补充城市扩张占用的耕地对生态用地二次挤占两个连锁的过程。以往的研究大多只关注城市扩张对生态系统的直接影响,忽略了城市扩张与耕地保护耦合的间接影响。针对这一问题,采用GIS空间分析方法和InVEST模型定量评估了2000年至2015年湖北省城市扩张与耕地保护耦合对陆地生态系统碳储量的影响。结果显示:(1)城市扩张与耕地保护耦合导致湖北省陆地生态系统碳储量减少40.90 Tg;(2)由城市扩张与耕地保护耦合导致的陆地生态系统碳储量的减少量中,耕地保护传导作用间接导致的占比31%。结果表明,城市扩张与耕地保护的耦合是导致生态系统碳储量减少的主要原因之一。忽视城市扩张通过耕地保护的传导作用对生态系统碳储量的间接影响,会导致城市扩张对陆地生态系统碳储量的影响被严重低估。

关键词：城市扩张耕地保护生态系统碳储量 InVEST模型

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LEO satellite clock analysis and prediction for positioning applications

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Geo-Spatial Information Science 2022年第1期25卷 14-33页

作者： Kan wang Ahmed El-Mowafy School of Earth and Planetary Sciences Curtin UniversityPerthAustralia

The positioning service aided by low Earth orbit(LEO)mega-constellations has become a hot topic in recent *** achieve precise positioning,accuracy of the LEO clocks is important for single-receiver *** bridge the gap between the applicable time of the clock products and the time of positioning,the precise LEO clocks need to be predicted over a certain period depending on the sampling interval of the clock *** study discusses the prediction errors for periods from 10 s to 1 h for two typical LEO clock types,*** ultra-stable oscillator(USO)and the oven-controlled crystal oscillator(OCXO).The prediction is based on GNSS-determined precise clock estimates,where the clock stability is related to the GNSS estimation errors,the behaviors of the oscillators themselves,the systematic effects related to the environment and the relativistic effects,and the stability of the time *** on real data analysis,LEO clocks of the two different types are simulated under different conditions,and a prediction model considering the systematic effects is *** to a simple polynomial fitting model usually applied,the proposed model can significantly reduce the prediction errors,*** about 40%-70%in simulations and about 5%-30%for real data containing different miss-modeled *** both clock types,short-term prediction of 1 min would result in a root mean square error(RMSE)of a few centimeters when using a very stable time *** RMSE amounts to about 0.1 m,when a typical real-time time reference of the national center for space studies(CNES)real-time clocks was *** long-term prediction of 1 h,the RMSE could range from below 1 m to a few meters for the USOs,depending on the complexity of the miss-modeled *** OCXOs,the 1 h prediction could lead to larger errors with an RMSE of about 10 m.

关键词： LEO clock prediction USO OCXO relativistic effects

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When Electronically Inert Polymers Meet Conjugated Polymers:Emerging Opportunities in Organic Photovoltaics

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Chinese Journal of Polymer Science 2022年第8期40卷 861-869,I0006页

作者： Jing-Jing wang Long Ye School of Materials Science&Engineering Tianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300350China State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun130033China

Insulating polymers(commodity plastics in particular)are a major category of polymeric materials widely used in our daily life,but they exhibit abysmal electrical ***,conjugated polymers are gaining tremendous interest due to their excellent electrical properties and versatile applications in organic *** this perspective,we provide a concise account of the added value in organic solar cells,as brought by the combined use of conjugated and insulating *** challenging tasks and prospective directions are given to the potential benefits of employing insulating polymer additives,which spans from common commodity plastics to high-temperature resistant resins and thermoplastic ***,the inert polymers can improve many important properties such as mechanical and thermal robustness but not sacrifice optoelectronic performance.

关键词： Organic solar cells Insulating polymers Photovoltaic polymers Miscibility Morphology

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