检索结果-南通市图书馆

Naringenin as a natural immunomodulator against T-cell-mediated autoimmune diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Naringenin as a natural immunomodulator against T-cell-media...

Naringenin modifies the development of lineage-specific effector CD4+ T cells

中国营养学会第十五届全国营养科学大会

作者： Zejin Liu xinli niu Junpeng Wang Henan University

Naringenin is the aglycone of naringin with anti-inflammatory, antioxidant, anti-tumor, anti-atherosclerotic, and antibacterial activities. Current research supports naringenin as a new generation of immune modulators, which is of great significance for preventing and treating T cell-mediated autoimmune diseases. This study aimed to detect the possible effects and molecular mechanisms of naringenin against T cell-mediated autoimmune diseases, including multiple sclerosis(MS), inflammatory bowel disease(IBD), and rheumatoid arthritis(RA), by network pharmacology. Methods Firstly, the target of naringenin was predicted by the Traditional Chinese Medicine Systems Pharmacology(TCMSP), Swiss Target Prediction, the Comparative Toxicogenomics Database(TCD), and the diseases target were studied by GeneGards and DisgeNet database. Then obtain target gene information in UniProt database, submit to String, DAVID database for PPI, GO, and KEGG analysis. The network was visualized by Cytoscape 3.72 software. Finally, the ligands of the core targets were determined from the PDB database, and the molecular docking with naringenin was performed using PyMol and AutoDock software. Results Dietary naringenin ameliorates EAE clinical symptoms via inhibiting T cell proliferation and T cell differentiation, and reducing the CNS cell infiltration by blocking chemokine-mediated migration of DCs and pathogenic T cells into the CNS. The predition of DAVID enrichment analysis, PPI protein networkinteraction analysis, and molecular docking found that a total of sixteen common genes were observed,among which the core gene was PTGS2, ESR1, CAT, CASP3, MAPK1, AKT1, and thepossible molecular mechanism is related to the signaling pathways of HIF-1, estrogen, TNF, and NF-kB. Conclusion This study provided a new strategy and possible molecular mechanism for naringenin in treating T cell-mediated autoimmune diseases through network pharmacological studies. The study results clarified the pharmacological activity of naringenin and provided theoretic

关键词： Naringenin T cells T cell-mediated autoimmune diseases Network pharmacology Inflammation Migration

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Naringenin modifies the development of lineage-specific effe...

Effect of Naringenin on Experimental Autoimmune Encephalomyelitis in Mice

第十三届全国免疫学学术大会

作者： Junpeng Wang xinli niu Chunfang Wu Henan University

Disrupted balance in the lineages of CD4 T cell subsets, including pro-inflammatory T helper(Th) cells and anti-inflammatory regulatory T cells(Treg), is a primary pathogenic factor for developing autoimmunity. We have found that this immunomodulatory effects of naringenin on effector T cells and T-cell mediated experimental autoimmune encephalomyelitis. We therefore explored the effects of naringenin on the development of different effector CD4 T cells. Na?ve CD4 T cells were differentiated under respective Th1, Th2, Th17, and Treg polarizing conditions with naringenin. Percent populations of each differentiated CD4 T cell subsets were determined and the corresponding regulating pathways were investigated as underlying mechanisms. Naringenin mainly inhibited CD4 T cell proliferation and differentiation to Th1 and Th17, but did not affect Th2 cells. Impeded Th1 polarization was associated with inhibition of its specific regulator proteins T-bet, p-STAT1 and p-STAT4 by naringenin. Likewise, Th17 regulator proteins RORγt, p-STAT3 and Ac-STAT3 were also inhibited by naringenin. In addition, naringenin15 promoted Treg polarization and also prevented IL-6-induced suppression of Treg development via down-regulation of p-Smad2/3 as well as inhibition of IL-6 signaling, and the latter was further supported by the in vivo results showing lower soluble IL-6 R but higher soluble gp130 levels in plasma of naringenin-fed compared to the control EAE mice. Naringenin impacts CD4 T cell differentiation in a manner that would explain its beneficial effect in preventing/mitigating T cell-mediated autoimmunity.

关键词： Naringenin CD4+ T cells T cell subsets cell differentiation autoimmune diseases

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effect of Naringenin on Experimental Autoimmune Encephalomye...

第十届全国免疫学学术大会

作者： Junpeng Wang xinli niu Simin Meydani Wu Dayong Henan University Tufts University

The common therapies for autoimmune and inflammatory diseases have limited efficacy and often come with serious side effects.Dietary intervention may play a role in developing preventive and therapeutic strategies for autoimmune disorders.Naringenin,a flavonoid found in high content in citrus fruits,particularly grapefruits,has been shown to have anti-inflammatory property.The present study assessed effect of naringenin on T-cell mediated autoimmunity using the experimental autoimmune encephalomyelitis(EAE),a rodent model for human multiple sclerosis.Female C57BL/6 mice were fed naringenin and then immunized with MOG35-55 to induce EAE.Mice fed naringenin had delayed onset and attenuated symptoms of EAE,as well as reduced immune cell infiltration and demyelination in spinal cord compared to mice fed the control diet.In both peripheral lymph nodes and central nervous system,the EAE-evoked upregulation of pro-inflammatory,pathogenic Th1 and Th17 cell populations were reduced by naringenin supplementation while the frequency of antiinflammatory CD4+CD25+Fox P3+regulatory T cells were not affected.Further,we found that decreased Th1 and Th17populations in lymph nodes of naringenin-fed mice were associated with reduced expression of their respective transcription factors,T-bet and RORγt.In addition,pathologic T cell proliferation induced by ex vivo re-stimulation with MOG35-55 was lower in naringenin-fed mice than in the control mice.Together these results suggest that naringenin may have the potential to ameliorate autoimmune disease by favorably modulating autoimmune response.

关键词： Naringenin Th cell subsets Autoimmune disease Inflammation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

2023年全同态加密研究热点回眸

科技导报 2024年第1期42卷 286-295页

作者：范瑞琦陈铭志牛鑫丽董文阔李晓霖刘硕刘静赵明蔡嘉跃闫闱朱树永郑珂威徐鹏郝沁汾孙凝晖中国科学院计算技术研究所北京100086 无锡芯光同态科技有限公司无锡214104 无锡芯光互连技术研究院有限公司无锡214104 华中科技大学网络空间安全学院武汉430074

在大数据和人工智能时代,全同态加密方法被公认为是解决数据安全与隐私泄露问题的理想技术,但目前存在计算效率差、密文膨胀等问题,严重影响了全同态加密技术的应用和推广。从针对全同态加密算法的硬件加速和围绕全同态加密算法的优化2... 详细信息

在大数据和人工智能时代,全同态加密方法被公认为是解决数据安全与隐私泄露问题的理想技术,但目前存在计算效率差、密文膨胀等问题,严重影响了全同态加密技术的应用和推广。从针对全同态加密算法的硬件加速和围绕全同态加密算法的优化2个方面,回顾了2023年计算机体系结构与密码学相关研究进展:以专用集成电路技术路线为代表的硬件加速效果明显;从算法角度进行优化,进展显著。可以预测,未来几年内,同态加密将与人工智能技术相结合,在跨行业、行业总分机构数据协作和利用中发挥更多价值。

关键词：全同态加密数据安全隐私泄露防护计算机体系结构密码学

Vascularization ability of glioma stem cells in different three-dimensional microenvironments

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第1期3卷 34-43页

作者： Xuanzhi Wang Tao Xu Chaoshi niu Department of Neurosurgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230036China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072People's Republic of China Center for Bio-intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen 518057People's Republicof China

Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been observed.Accurately reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant challenge.However,it is crucial to develop new anti-angiogenic therapies for GBM.In this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments.

关键词： 3D bioprinting xenograft tumors GSC-laden hydrogel scaffold glioblastoma angiogenesis

Modeling tuberous sclerosis complex with human induced pluripotent stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第3期20卷 208-218页

作者： Weibo niu Benjamin Siciliano Zhexing Wen Department of Psychiatry and Behavioral Sciences Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA 30322USA The Graduate Program in Molecular and Systems Pharmacology Laney Graduate SchoolEmory UniversityAtlanta.GA 30322.USA Department of Cell Biology Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA30322USA Department of Neurology Emory University School of MedicineWhitehead Research Building 447.615 Michael StreetAtlantaGA 30322USA

Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ systems including the brain,kidneys,lungs,and skin.Importantly,TSCis also associated with signicant neurological manifestations including epilepsy TSC-associated neuropsychiatric disorders,intellectual disabilities,and autism spectrum disorder.Mutations in the TSCI or TSC2 genes are well-established causes of TSC,which lead to TSC1/TSC2 deficiency in organs and hyper-activation of the mammalian target of rapamycin signaling pathway.Animal models have been widely used to study the effect of TSCl/2 genes on the development and function of the brain.Despite considerable progress in understanding the molecular mechanisms underlying TSC in animal models,a human-specific model is urgently needed to investigate the effects of TSCl/2 mutations that are unique to human neurodevelopment.Data sources Literature reviews and research articles were published in PubMed-indexed journals.Results Human-induced pluripotent stem cells(iPSCs),which capture risk alleles that are identical to their donors and have the capacity to differentiate into virtually any cell type in the human body,pave the way for the empirical study of previously inaccessible biological systems such as the developing human brain.Conclusions In this review,we present an overview of the recent progress in modeling TSC with human iPSC models,the existing limitations,and potential directions for future research.

关键词： Induced pluripotent stem cells Three-dimensional cultures Tuberous sclerosis complex Two-dimensional cultures

An integrative mathematical model of microwave ion thruster for mHz-frequency thrust noise analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第4期37卷 121-136页

作者： Xiang niu Hui LIU Daren YU Plasma Propulsion Laboratory Harbin Institute of TechnologyHarbin 150001China

Many high-precision space missions need thrusters to produce thrust with low noise to compensate for disturbances and ensure satellite platform stability. Microwave ion thruster is characterized with a wide thrust range and potential for these missions. A cost-effective and accurate mathematical model is crucial for mHz-frequency thrust noise analysis and feedback controller design. The Particle-In-Cell(PIC) and global models are two common simulation tools. The PIC model is characterized with high accuracy but huge computation cost, which is difficult to analyze long-time performance characteristics. Now, the global model is only used for the discharge chamber with low accuracy and cannot reflect ion extraction properties. In this paper, an integrative mathematical model is built for a 1-cm microwave ion thruster and can reflect ion beamlet divergence and impingement on the Accelerator Grid(AG). Simulation results show good agreement with experiments at 0.06 sccm. However, the model demonstrates worse consistency with experiments when the flux increases to 0.1 sccm, which may be because the influence of neutral gas on the Electron Cyclotron Resonance(ECR) is not considered in the model. A long-time(1000 s) simulation is conducted with this model under 35 μN. It takes 3 hrs, and the thrust noise reaches 1 μN/Hz^(0.5) at 1 mHz.

关键词： Electric propulsion Microwave ion thruster Integrative model Sheath property Ion beamlet divergence Thrust noise Plasma

RNA interference in insects:the link between antiviral defense and pest control

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 2-12页

作者： Jinzhi niu Ruoyu Chen Jin-Jun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqingChina

RNA interference(RNAi)is a form of gene silencing triggered by double-stranded RNA(dsRNA)that operates in all eukaryotic cells.RNAi has been widely investigated in insects to determine the underlying molecular mechanism,to investigate its role in systemic antiviral defense,and to develop strategies for pest control.When insect cells are infected by viruses,viral dsRNA signatures trigger a local RNAi response to block viral replication and generate virus-derived DNA that confers systemic immunity.RNAi-based insect pest control involves the application of exogenous dsRNA targeting genes essential for insect development or survival,but the efficacy of this approach has limited potency in many pests through a combination of rapid dsRNA degradation,inefficient dsRNA uptake/processing,and ineffective RNAi machinery.This could be addressed by dsRNA screening and evaluation,focusing on dsRNA design and off-target management,as well as dsRNA production and delivery.This review summarizes recent progress to determine the role of RNAi in antiviral defense and as a pest control strategy in insects,addressing gaps between our fundamental understanding of the RNAi mechanism and the exploitation of RNAi-based pest control strategies.

关键词： RNAi response systemic RNAi insecticidal dsRNA biological control off-targets

Highly Thermoconductive,Strong Graphene‑Based Composite Films by Eliminating Nanosheets Wrinkles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第1期16卷 328-340页

作者： Guang Xiao Hao Li Zhizhou Yu Haoting niu Yagang Yao College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNational Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China Institute of Laser Manufacturing Henan Academy of SciencesZhengzhou 450052People’s Republic of China Center for Quantum Transport and Thermal Energy Science School of Physics and TechnologyNanjing Normal UniversityNanjing 210023People’s Republic of China

Graphene-based thermally conductive composites have been proposed as effective thermal management materials for cooling high-power electronic devices.However,when flexible graphene nanosheets are assembled into macroscopic thermally conductive composites,capillary forces induce shrinkage of graphene nanosheets to form wrinkles during solution-based spontaneous drying,which greatly reduces the thermal conductivity of the composites.Herein,graphene nanosheets/aramid nanofiber(GNS/ANF)composite films with high thermal conductivity were prepared by in-plane stretching of GNS/ANF composite hydrogel networks with hydrogen bonds andπ-πinteractions.The in-plane mechanical stretching eliminates graphene nanosheets wrinkles by suppressing inward shrinkage due to capillary forces during drying and achieves a high in-plane orientation of graphene nanosheets,thereby creating a fast in-plane heat transfer channel.The composite films(GNS/ANF-60 wt%)with eliminated graphene nanosheets wrinkles showed a significant increase in thermal conductivity(146 W m^(−1)K^(−1))and tensile strength(207 MPa).The combination of these excellent properties enables the GNS/ANF composite films to be effectively used for cooling flexible LED chips and smartphones,showing promising applications in the thermal management of high-power electronic devices.

关键词： Graphene Aramid nanofiber Wrinkles elimination In-plane stretching Thermal conductivity