检索结果-南通市图书馆

浮环轴向长度对高速轻载涡轮增压器转子系统振动特性影响研究

在线全文

学校读者我要写书评

暂无评论

机械工程学报 2019年第23期55卷 173-181页

作者：宾光富黄源钟新利杨峰湖南科技大学机电工程学院湘潭411201 宁波丰沃涡轮增压系统有限公司宁波315336

浮环轴承内外轴向长度结构参数会影响油膜压力分布与偏心率,产生显著分频振动而引发高速轻载涡轮增压器转子非线性振动故障。基于流体润滑理论和浮环力矩平衡方程,推导了含浮环轴承的涡轮增压器转子系统动力学方程,揭示浮环轴承轴向长... 详细信息

浮环轴承内外轴向长度结构参数会影响油膜压力分布与偏心率,产生显著分频振动而引发高速轻载涡轮增压器转子非线性振动故障。基于流体润滑理论和浮环力矩平衡方程,推导了含浮环轴承的涡轮增压器转子系统动力学方程,揭示浮环轴承轴向长度与转子系统振动响应之间的关系。以某型汽油机用涡轮增压器转子系统为例,分析浮环内、外轴向长度对轴承油膜压力、偏心率等动力特性的影响,构建转子系统动力学有限元模型,通过三维振动瀑布图研究不同浮环轴向长度下转子系统频域瞬态振动响应,结果表明:浮环内轴向长度从2.6增加到4.6 mm,导致浮环转速升高,最大内油膜压力减小,轴颈偏心率降低,分频幅值增加且出现分频的轴颈转速由142 kr/min降至76 kr/min,更易产生明显的非线性涡动现象;浮环外轴向长度从3.6增加到6.15mm,使浮环转速降低,最大外油膜压力变小,浮环偏心率及轴颈相对浮环的偏心率减小,低转速下分频幅值减少且出现分频的轴颈转速由10 kr/min升至22 kr/min,可抑制转子系统过早发生非线性涡动,为浮环轴承结构参数设计与试验提供理论支撑。

关键词：浮环轴向长度涡轮增压器转子动力特性频域瞬态响应分析分频振动

Effects of Injection of Oregano Oil Submicron Emulsion on Lipopolysaccharide-induced Pneumonia in Rats

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2021年第1期12卷 63-67页

作者： Fei HAN Guangqiang MA xinli LIANG Xiao huang Hanlin XU Huaqiang WU Jiangxi University of Traditional Chinese Medicine School of Pharmacy Ministry of EducationNanchang 330004China Jiangxi University of Traditional Chinese Medicine School of Life Sciences Ministry of EducationNanchang 330004China Jiangxi University of Traditional Chinese Medicine Key Laboratory of Modern Preparation of TCM Ministry of EducationNanchang 330004China School of Pharmacy Hubei University of Chinese MedicineWuhan 430065China

[Objectives]To explore the effects of injection of oregano oil submicron emulsion on lipopolysaccharide-induced pneumonia in rats.[Methods]Rats induced by lipopolysaccharide were used as animal models of acute *** experiment was divided into blank group,model group,administration group and positive drug control *** morphology of lung tissue and the changes of cells and inflammatory factors in each group were observed,and the anti-inflammatory effects of injection of oregano oil submicron emulsion.[Results]The injection of oregano oil submicron emulsion can improve the pathological injury of rat lung tissue,inhibit the release of IL-6,IL-10,TNF-αcytokines induced by lipopolysaccharide,and significantly reduce the value of CRP.[Conclusions]Oregano oil submicron emulsion has a certain therapeutic effect on lipopolysaccharide-induced pneumonia in rats,and its mechanism may be related to reducing the release of cytoinflammatory factor IL-6,IL-10,and TNF-αand alleviating the injury to tissues and organs.

关键词： Oregano oil TCM antibiotic Pneumonia Cytokine Action mechanism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

以社团组织为原告的行政公益诉讼的制度进路

浙江大学学报（人文社会科学版） 2016年第1期46卷 159-171页

作者：朱新力黄娟浙江大学光华法学院浙江杭州310008 华东政法大学科学研究院上海201620

在我国,落实以社团组织为原告的行政公益诉讼的现实障碍是契合于本土背景的运作规则缺失。鉴于我国尚不成熟的社团组织体系、注重政治目标的司法文化和执着于结果正义的公民维权传统,在推进以社团组织为原告的行政公益诉讼制度时,应结... 详细信息

在我国,落实以社团组织为原告的行政公益诉讼的现实障碍是契合于本土背景的运作规则缺失。鉴于我国尚不成熟的社团组织体系、注重政治目标的司法文化和执着于结果正义的公民维权传统,在推进以社团组织为原告的行政公益诉讼制度时,应结合制度本身的特质做出以下安排:(1)先在单行立法中明确相应领域的社团组织享有提起行政公益诉讼的原告资格,而后基于经验的累积制定统一性规定;(2)明确作为原告的社团组织仅具有履行请求权和停止侵害请求权,据此实现对公益的维护;(3)明确上述行政公益诉讼程序与我国代表人诉讼、共同诉讼或诉讼调解机制的衔接规则,在行政公益诉讼程序所搭建的沟通与协商平台上,解决牵涉其中的受害群体的损害赔偿问题。

关键词：行政公益诉讼社团组织原告资格诉讼请求权协商平台

Effect of Pelleted Total Mixed Ration on Production Performance and Serum Biochemical Index of Growing Hainan Black Goats

在线全文

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2019年第1期11卷 19-22,31页

作者： Liu Quanwei Wang Feng Wei Limin huang Lili Sun Ruiping Xing Manping Zheng xinli Institute of Animal Science and Veterinary Medicine Hainan Academy of Agricultural Sciences Haikou 571100 China Hainan Key Lab of Tropical Animal Reproduction Breeding and Epidemic Disease Research Haikou 571100 China

[Objective] The paper was to investigate effects of pelleted total mixed ration on production performance and serum biochemical index of growing Hainan black goats.[Method] Twenty-four growing Hainan black goats with the same genetic backgrounds and similar initial weight of(10.05±0.049) kg were randomly assigned into two treatments, and supplied with Juncao + concentrate(control group), pelleted total mixed ration(experimental group), respectively. The trial lasted 50 d.[Result] The final weight, daily gain and feed intake of experimental group were significantly higher than those of control group(P<0.05), but the feed/gain ratio of experimental group was markedly lower than that of control group(P<0.05). Compared with the control group, the gross profit of experimental group significantly increased( P <0.05).[Conclusion] Pelleted total mixed ration led to better production performance of growing Hainan black goat.

关键词： Growing Hainan black goat Pelleted total mixed ration Production performance Serum biochemical parameters

Effect of Pelleted Total Mixed Ration of Different Particle Sizes on Production Performance and Serum Biochemical Index of Fattening Hainan Black Goats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2019年第1期11卷 23-27页

作者： Liu Quanwei Wei Limin Wang Feng Tan Shuyi Sun Ruiping huang Lili Zheng xinli Institute of Animal Science and Veterinary Medicine Hainan Academy of Agricultural Sciences Haikou 571100 China Hainan Key Lab of Tropical Animal Reproduction Breeding and Epidemic Disease Research Haikou 571100 China

[Objective] The paper to investigate the effects of pelleted total mixed ration of different particle size on production performance and serum biochemical index of fattening Hainan black goats.[Method] Thirty-six fattening Hainan black goats with the same genetic backgrounds and similar initial weight of(19.02±0.22) kg were randomly divided into three treatments. Goats were fed with Juncao+concentrate(control group), pel-leted total mixed ration I(particle size 6 mm, experimental group I) and II(particle size 5 mm, experimental group II), respectively. The trial lasted 45 d.[Result](1) The final weight and daily gain of experimental group II were significantly higher than those of control group( P0.05).[Conclusion] The pelleted total mixed ration with the particle size of 5 mm obtained better fattening ef-fect, and obviously improved the serum total protein level.

关键词： Fattening Hainan black goat Pelleted total mixed ration Particle size Production performance Serum biochemical parameters

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第4期8卷 1874-1888页

作者： Penglei Wang Xuechao Jia Bingbing Lu Han huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu Department of Pathophysiology Basic Medicine Research CenterSchool of Basic Medical SciencesAMSZhengzhou University450000 ZhengzhouChina China-US(Henan)Hormel Cancer Institute 450000 ZhengzhouChina The Department of Pathology Affiliated Cancer Hospital of Zhengzhou University450000 ZhengzhouChina The Department of Dermatology Xiangya HospitalCentral South University410078 ChangshaChina The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention 450000 ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou University450000 ZhengzhouChina Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhouChina

Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic *** of the paradoxical activation induced by a single use of BRAF or MEK inhibitors,dual-target RAF and MEK treatment is thought to be a promising *** this work,we evaluated erianin is a novel inhibitor of CRAF and MEK1/2 kinases,thus suppressing constitutive activation of the MAPK signaling pathway induced by BRAF V600E or RAS *** enzyme profiling,surface plasmon resonance(SPR),isothermal titration calorimetry(ITC),cellular thermal shift assay,computational docking,and molecular dynamics simulations were utilized to screen and identify erianin binding to CRAF and MEK1/*** assay,luminescent ADP detection assay,and enzyme kinetics assay were investigated to identify the efficiency of erianin in CRAF and MEK1/2 kinase ***,erianin suppressed BRAF V600E or RAS mutant melanoma and colorectal cancer cell by inhibiting MEK1/2 and CRAF but not BRAF kinase ***,erianin attenuated melanoma and colorectal cancer in ***,we provide a promising leading compound for BRAF V600E or RAS mutant melanoma and colorectal cancer through dual targeting of CRAF and MEK1/2.

关键词： MEK1/2 BRAF activation

Extraction Technology and Content Determination of Total Flavonoids from Traditional Chinese Medicine Yipichou

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicinal Plant 2021年第1期12卷 47-50,55页

作者： Qianqian LIU Wen ZHONG Zongxi SUN Xiumei MA xinli LU Yusheng huang Jingrong LU Jiangcun WEI Guangxi International Zhuang Medicine Hospital Nanning 530201China Guangxi University of Chinese Medicine Nanning 530200China Guangxi Jialu Human Resource Consulting Co. Ltd.Nanning 530031China

[Objectives]The research aimed to optimize extraction technology of total flavonoids from traditional Chinese medicine Yipichou,and establish methods of extraction and content determination of its medicinal materials.[Methods]Using reflux extraction method,total flavonoids of Yipichou were *** single-factor test,influence of extraction method,extraction solvent concentration,extraction volume and extraction time on content of total flavonoids from Yipichou was *** orthogonal test,extraction conditions were optimized,and optimal extraction technology of total flavonoids from Yipichou was obtained.[Results]The optimal extraction process of total flavonoids from Yipichou was as below:70%of methanol,1∶40 of solid-liquid ratio,and 1.0 h of reflux extraction time.[Conclusions]In the test,total flavonoids were extracted from Yipichou,with better repeatability,and stable and feasible method,which could provide certain scientific basis for studying quality standard of this medicinal material.

关键词： Yipichou Total flavonoids Extraction process Ultraviolet-visible spectrophotometry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

图书情报硕士跨专业现状、困扰与对策研究

大学图书馆学报 2019年第1期37卷 122-128页

作者：尚新丽黄若尧郑州大学信息管理学院郑州450001

基于相关调查数据和第一手资料,阐述了我国图书情报硕士跨专业生源现状,并从图书情报专业的冷门性、入学考试难度较低、专业相关性、学历"镀金"方面对跨专业生源形成原因和跨专业生源给图书情报硕士教育带来的困扰进行了分析,并在此基... 详细信息

基于相关调查数据和第一手资料,阐述了我国图书情报硕士跨专业生源现状,并从图书情报专业的冷门性、入学考试难度较低、专业相关性、学历"镀金"方面对跨专业生源形成原因和跨专业生源给图书情报硕士教育带来的困扰进行了分析,并在此基础之上,提出调整初试科目、延长学制、优化课程设置、因材施教、阅读配置、学科交叉研究、加强人文关怀与心理疏导等相应的解决对策。

关键词：图书情报硕士跨专业生源研究生教育

钾掺杂的锐钛矿TiO_(2)催化丙酸酮基化反应

在线全文

学校读者我要写书评

暂无评论

高校化学工程学报 2024年第3期38卷 459-467页

作者：黄胶王华韩金玉祝新利天津大学化工学院天津300072

酮基化反应是转化生物质衍生羧酸的有效途径之一。为了提高酮基化反应活性和选择性,使用等体积浸渍法制备了不同钾(K)掺杂量的TiO_(2)催化剂,并探究其催化丙酸酮基化反应性能。通过X-射线粉末衍射、透射电子显微镜和X-射线光电子能谱等... 详细信息

酮基化反应是转化生物质衍生羧酸的有效途径之一。为了提高酮基化反应活性和选择性,使用等体积浸渍法制备了不同钾(K)掺杂量的TiO_(2)催化剂,并探究其催化丙酸酮基化反应性能。通过X-射线粉末衍射、透射电子显微镜和X-射线光电子能谱等方法对催化剂的物化性质进行表征。结果表明,TiO_(2)、0.05K(掺杂K的质量分数为5%)催化剂的本征反应速率分别为549.2μmol·g^(-1)·min^(-1)、2 686.2μmol·g^(-1)·min^(-1),K的掺杂显著提高了反应活性,并且在丙酸完全转化时,0.05K催化剂的3-戊酮选择性(99.9%)高于TiO_(2)催化剂(96.2%)。根据X射线光电子能谱的表征,TiO_(2)和钾氧化物之间存在明显的相互作用,促进了表面氧空位的生成从而提高反应活性。

关键词：酮基化 TiO_(2) 钾丙酸 3-戊酮