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Plant Diversity 2024年第3期46卷 372-385页

作者： Shanni Cao Xue Zhao Zhuojin Li Ranran Yu Yuqi Li xinkai zhou Wenhao Yan Dijun Chen Chao He State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific *** we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis *** atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological *** integration spans a broad spectrum of tissues,including both below-and above-ground *** a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell *** systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene *** together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.

关键词： Arabidopsis Single cell transcriptome Gene regulatory network Data integration Plant cell atlas

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国内外肿瘤儿童营养研究热点的可视化分析

中国临床研究 2024年第1期37卷 94-99页

作者：张月影方继红周新凯皖南医学院护理学院安徽芜湖241000 安徽省儿童医院护理部安徽合肥230000

目的分析国内外“肿瘤儿童营养”相关文献资料,梳理出该领域研究现状、热点及前沿,为开展相关研究提供参考。方法检索Web of Science和中国知网(CNKI)自建库以来肿瘤儿童营养相关文献,应用CiteSpace 6.1.R6软件对国家、机构、关键词... 详细信息

目的分析国内外“肿瘤儿童营养”相关文献资料,梳理出该领域研究现状、热点及前沿,为开展相关研究提供参考。方法检索Web of Science和中国知网(CNKI)自建库以来肿瘤儿童营养相关文献,应用CiteSpace 6.1.R6软件对国家、机构、关键词等节点进行可视化分析。结果共纳入中文文献53篇、英文文献204篇,发文量均呈波动上升趋势;发文量最多且中心性最强的为美国,中国未见排名;国内发文机构主要以大学附属医疗机构为主,首都医科大学附属北京儿童医院最多,国外的发文机构主要是大学和医疗机构,麦克马斯特大学和圣裘德儿童研究医院发文最多;国内研究主要方向为营养状况、营养不良,热点人群是恶性肿瘤、血液肿瘤患儿;国外研究方向主要为营养状况、营养不良和人体成分分析,热点人群是接受化疗或急性淋巴细胞性白血病的患儿。结论通过CiteSpace软件直观展现国内外儿童肿瘤营养研究的相关热点,目前国外相关研究与国内相比较为成熟,可为我国研究者提供参考。

关键词：儿童肿瘤营养状况 CiteSpace软件可视化分析科学知识图谱

A spawning particle filter for defocused moving target detection in GNSS-based passive radar

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Journal of Systems Engineering and Electronics 2023年第5期34卷 1085-1100页

作者： ZENG Hongcheng DENG Jiadong WANG Pengbo zhou xinkai YANG Wei CHEN Jie School of Electronic and Information Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space TechnologyXi’an 710000China

Global Navigation Satellite System(GNSS)-based passive radar(GBPR)has been widely used in remote sensing ***,for moving target detection(MTD),the quadratic phase error(QPE)introduced by the non-cooperative target motion is usually difficult to be compensated,as the low power level of the GBPR echo signal renders the estimation of the Doppler rate less ***,the moving target in GBPR image is usually defocused,which aggravates the difficulty of target detection even *** this paper,a spawning particle filter(SPF)is proposed for defocused ***,the measurement model and the likelihood ratio function(LRF)of the defocused point-like target image are ***,a spawning particle set is generated for subsequent target detection,with reference to traditional particles in particle filter(PF)as their *** that,based on the PF estimator,the SPF algorithm and its sequential Monte Carlo(SMC)implementation are proposed with a novel amplitude estimation method to decrease the target state ***,the effectiveness of the proposed SPF is demonstrated by numerical simulations and pre-liminary experimental results,showing that the target range and Doppler can be estimated accurately.

关键词： Global Navigation Satellite System(GNSS)-based passive radar(GBPR) defocused target moving target detec-tion(MTD) likelihood ratio function(LRF) spawning particle fil-ter(SPF)

Systematic annotation of conservation states provides insights into regulatory regions in rice

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Journal of Genetics and Genomics 2022年第12期49卷 1127-1137页

作者： xinkai zhou Tao Zhu Wen Fang Ranran Yu Zhaohui He Dijun Chen State Key Laboratory of Pharmaceutical Biotechnology Schoolof Life SciencesNanjing UniversityNanjingJiangsu 210023China

Plant genomes contain a large fraction of noncoding *** discovery and annotation of conserved noncoding sequences(CNSs)in plants is an ongoing *** we report the application of comparative genomics to systematically identify CNSs in 50 well-annotated Gramineae genomes using rice(Oryza sativa)as the *** conduct multiple-way whole-genome alignments to the rice *** rice genome is annotated as 20 conservation states(CSs)at single-nucleotide resolution using a multivariate hidden Markov model(Cons HMM)based on the multiple-genome *** states show distinct enrichments for various genomic features,and the conservation scores of CSs are highly correlated with the level of associated chromatin *** find that at least 33.5%of the rice genome is highly under selection,with more than 70%of the sequence lying outside of coding regions.A catalog of 855,366 regulatory CNSs is generated,and they significantly overlapped with putative active regulatory elements such as promoters,enhancers,and transcription factor binding ***,our study provides a resource for elucidating functional noncoding regions of the rice genome and an evolutionary aspect of regulatory sequences in higher plants.

关键词： Rice Comparative genomics Conserved noncoding sequences(CNSs) Conservation states(CSs)

Fault Estimation for a Class of Markov Jump Piecewise-Affine Systems: Current Feedback Based Iterative Learning Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 418-429页

作者： Yanzheng Zhu Nuo Xu Fen Wu xinkai Chen Donghua zhou IEEE College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27695 USA Department of Electronic and Information Systems Shibaura Institute of TechnologySaitama 337-8570Japan

In this paper, the issues of stochastic stability analysis and fault estimation are investigated for a class of continuoustime Markov jump piecewise-affine(PWA) systems against actuator and sensor faults. Firstly, a novel mode-dependent PWA iterative learning observer with current feedback is designed to estimate the system states and faults, simultaneously, which contains both the previous iteration information and the current feedback mechanism. The auxiliary feedback channel optimizes the response speed of the observer, therefore the estimation error would converge to zero rapidly. Then, sufficient conditions for stochastic stability with guaranteed performance are demonstrated for the estimation error system, and the equivalence relations between the system information and the estimated information can be established via iterative accumulating ***, two illustrative examples containing a class of tunnel diode circuit systems are presented to fully demonstrate the effectiveness and superiority of the proposed iterative learning observer with current feedback.

关键词： Current feedback fault estimation iterative learning observer Markov jump piecewise-affine system

基于系统交互模型的二元应对方案对口腔癌患者术后生存质量干预的应用研究

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沈阳医学院学报 2024年第1期26卷 37-42页

作者：滕晓菊马红梅李迎霞周新凯吴瑞芳皖南医学院弋矶山医院护理部安徽芜湖241001 皖南医学院弋矶山医院创伤骨科皖南医学院护理学院皖南医学院口腔颌面外科

目的:探索基于系统交互模型的二元应对方案对口腔癌患者术后生存质量的干预效果。方法:选择某三甲医院口腔颌面外科2021年6月至2022年6月收治的99例口腔癌患者,使用随机数字表法分为对照组50例和观察组49例。对照组给予口腔癌常规护理,... 详细信息

目的:探索基于系统交互模型的二元应对方案对口腔癌患者术后生存质量的干预效果。方法:选择某三甲医院口腔颌面外科2021年6月至2022年6月收治的99例口腔癌患者,使用随机数字表法分为对照组50例和观察组49例。对照组给予口腔癌常规护理,观察组在常规护理基础上实施基于系统交互模型的二元应对方案。比较分析2组口腔癌患者术前、术后第3周和术后第9周的UW-QOL生存质量量表、二元应对量表的得分。结果:2组患者术后第3周、第9周UW-QOL得分均低于入院时,且对照组UW-QOL得分低于观察组(P<0.05);在术后第3周,观察组患者与伴侣共同应对维度的得分优于对照组(P<0.05);在术后第9周,观察组在二元应对总分、消极应对、压力沟通、共同应对、支持应对维度优于对照组(P<0.05)。重复测量方差分析结果显示时间和组别对二元应对量表总分存在交互作用(P<0.05),时间和组别对二元应对量表总分主效应显著(P<0.05)。结论:口腔癌患者生存质量状况欠佳,基于系统交互模型的二元应对方案可提高患者的生存质量,提高患者与伴侣的亲密关系,有利于口腔癌患者疾病康复。

关键词：系统交互模型二元应对方案口腔癌伴侣生存质量

A chromosome-level genome assembly provides insights into Cornus wilsoniana evolution, oil biosynthesis, and floral bud development

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Horticulture Research 2023年第11期10卷 27-44页

作者： Zhenxiang He Haoyu Chao xinkai zhou Qingyang Ni Yueming Hu Ranran Yu Minghuai Wang Changzhu Li Jingzhen Chen Yunzhu Chen Yong Chen Chunyi Cui Liangbo Zhang Ming Chen Dijun Chen State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China Department of Bioinformatics College of Life SciencesZhejiang UniversityHangzhou 310058China Forest Protection Department Guangdong Academy of ForestryGuangzhou 510520China State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha 410004China Xishan Forest Farm Dazu DistrictChongqing 402360China Longshan Forest Farm Lechang 512221China Hunan Horticultural Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China

Cornus wilsoniana *** a woody oil plant with high oil content and strong hypolipidemic effects,making it a valuable species for medicinal,landscaping,and ecological purposes in *** advance genetic research on this species,we employed PacBio together with Hi-C data to create a draft genome assembly for *** on an 11-chromosome anchored chromosome-level assembly,the estimated genome size was determined to be 843.51 *** N50 contig size and N50 scaffold size were calculated to be 4.49 and 78.00 Mb,***,30474 protein-coding genes were *** genomics analysis revealed that *** diverged from its closest species∼12.46 million years ago(Mya).Furthermore,the divergence between Cornaceae and Nyssaceae occurred>62.22 *** also found evidence of whole-genome duplication events and whole-genome triplicationγ,occurring at∼44.90 and 115.86 *** further inferred the origins of chromosomes,which sheds light on the complex evolutionary history of the karyotype of *** transcriptional and metabolic analysis,we identified two FAD2 homologous genes that may play a crucial role in controlling the oleic to linoleic acid *** further investigated the correlation between metabolites and genes and identified 33 MADS-TF homologous genes that may affect f lower morphology in ***,this study lays the groundwork for future research aimed at identifying the genetic basis of crucial traits in ***.

关键词： assembly evolution floral

Towards kernelizing the classifier for hyperbolic data

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Frontiers of Computer Science 2024年第1期18卷 17-31页

作者： Meimei YANG Qiao LIU xinkai SUN Na SHI Hui XUE School of Computer Science and Engineering Southeast UniversityNanjing 210096China MOE Key Laboratory of Computer Science and Information Integration(Southeast University) Nanjing 210096China

Data hierarchy,as a hidden property of data structure,exists in a wide range of machine learning applications.A common practice to classify such hierarchical data is first to encode the data in the Euclidean space,and then train a Euclidean ***,such a paradigm leads to a performance drop due to distortion of data embedding in the Euclidean *** relieve this issue,hyperbolic geometry is investigated as an alternative space to encode the hierarchical data for its higher ability to capture the hierarchical *** methods cannot explore the full potential of the hyperbolic geometry,in the sense that such methods define the hyperbolic operations in the tangent plane,causing the distortion of data *** this paper,we develop two novel kernel formulations in the hyperbolic space,with one being positive definite(PD)and another one being indefinite,to solve the classification tasks in hyperbolic *** PD one is defined via mapping the hyperbolic data to the Drury-Arveson(DA)space,which is a special reproducing kernel Hilbert space(RKHS).To further increase the discrimination of the classifier,an indefinite kernel is further defined in the Krein ***,we design a 2-layer nested indefinite kernel which first maps hyperbolic data into the DA spaces,followed by a mapping from the DA spaces to the Krein *** experiments on real-world datasets demonstrate the superiority ofthe proposed kernels.

关键词： data hierarchy hyperbolic cgeometry drury-arveson space krein space

Saddlepoint Approximation Method in Reliability Analysis:A Review

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2329-2359页

作者： Debiao Meng Yipeng Guo Yihe Xu Shiyuan Yang Yongqiang Guo Lidong Pan xinkai Guo School ofMechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu611731China Institute of Electronic and Information Engineering of UESTC in Guangdong Dongguan523808China Glasgow College University of Electronic Science and Technology of ChinaChengdu611731China Beijing Research Institute of Mechanical&Electrical Technology Ltd.Beijing100083China

The escalating need for reliability analysis(RA)and reliability-based design optimization(RBDO)within engineering challenges has prompted the advancement of saddlepoint approximationmethods(SAM)tailored for such *** article offers a detailed overview of the general SAM and summarizes the method characteristics ***,recent enhancements in the SAM theoretical framework are ***,the mean value first-order saddlepoint approximation(MVFOSA)bears resemblance to the conceptual framework of the mean value second-order saddlepoint approximation(MVSOSA);the latter serves as an auxiliary approach to the *** distinction is rooted in the varying expansion orders of the performance function as implemented through the Taylor *** the saddlepoint approximation and third-moment(SATM)and saddlepoint approximation and fourth-moment(SAFM)strategies model the cumulant generating function(CGF)by leveraging the initial random moments of the *** their optimal application domains diverge,each method consistently ensures superior relative precision,enhanced efficiency,and sustained *** method elucidated is exemplified through pertinent RA or RBDO *** juxtaposing them against alternative strategies,the efficacy of these methods becomes *** outcomes proffered are subsequently employed as a foundation for contemplating prospective theoretical and practical research endeavors concerning *** main purpose and value of this article is to review the SAM and reliability-related issues,which can provide some reference and inspiration for future research scholars in this field.

关键词： Reliability analysis reliability-based design optimization saddlepoint approximation

Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes

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Optoelectronics Letters 2024年第6期20卷 339-345页

作者： WU Qiulin FENG xinkai CHEN Jiaying MA Lei CHEN Huaixi LIANG Wanguo Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350108China University of Chinese Academy of Sciences Beijing 100059China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China1

Thin-film lithium niobate electro-optical modulator will become the key device in the future optical communication,which has the advantages of high modulation rate,low half-wave voltage,large bandwidth,and easy integration compared with conventional bulk lithium niobate ***,because the electrode gap of the lithium niobate film modulator is very narrow,when the microwave frequency gets higher,it leads to higher microwave loss,and the electro-optical performance of the modulator will be greatly ***,we propose a thin film lithium niobate electro-optic modulator with a bimetallic layer electrode structure to achieve microwave loss less than 8 dB/cm in the range of 200 GHz,exhibiting a voltage-length product of 1.1 V·cm and a 3 dB electro-optic bandwidth greater than 160 ***-speed data transmission test has been performed,showing good performance.

关键词： Simulation design of thin film lithium niobate electro-optic modulator with bimetallic layer electrodes