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C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus

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Virologica Sinica 2024年第2期39卷 277-289页

作者： Lei Yu xinjin liu Xiaoqin Wei Junrui Ren Xueyun Wang Shuwen Wu Ke Lan State Key Laboratory of Virology Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan430072China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan430072China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan430072China

Influenza A virus(IAV)binds sialic acid receptors on the cell surface to enter the host cells,which is the key step in initiating infection,transmission and *** the factors that contribute to the highly efficient entry of IAV into human cells will help elucidate the mechanism of viral entry and pathogenicity,and provide new targets for *** the present study,we reported a novel membrane protein,C1QTNF5,which binds to the hemagglutinin protein of IAV and promotes IAV infection in vitro and in *** found that the HA1 region of IAV hemagglutinin is critical for the interaction with C1QTNF5 protein,and C1QTNF5 interacts with hemagglutinin mainly through its N-terminus(1–103 aa).In addition,we further demonstrated that overexpression of C1QTNF5 promotes IAV entry,while blocking the interaction between C1QTNF5 and IAV hemagglutinin greatly inhibits viral ***,C1QTNF5 does not function as a receptor to mediate IAV infection in sialic acid-deficient CHO-Lec2 cells,but promotes IAV to attach to these cells,suggesting that C1QTNF5 is an important attachment factor for *** work reveals C1QTNF5 as a novel IAV attachment factor and provides a new perspective for antiviral strategies.

关键词： C1QTNF5 Influenza A virus Viral entry Hemagglutinin Attachment factor

Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China

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Petroleum Research 2019年第2期4卷 113-124页

作者： Shun Zhang Huimin liu Min Wang xinjin liu Huilai liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei Fang Research Institute of Petroleum Exploration and Development Sinopec Shengli Oilfield CompanyShandongDongying257022China Postdoctor Scientific Research Stations Sinopec Shengli Oilfield CompanyShandongDongying257000China Petroleum Development Center of Shengli Oilfield ShandongDongying257022China Petroleum Development Center of Shengli Oilfield Beijing100007China Chongqing Gas Field of PetroChina Southwest Oil&Gasfield Company Chongqing400021China

The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further *** results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore *** minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is *** the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously.

关键词： Shale oil Pore and fracture Diagenesis Clay mineral transformation Dissolution Recrystallization Hydrocarbon-generation and acid expulsion Paleogene Dongying sag

Stability Analysis and Hadamard Synergic Control for a Class of Dynamical Networks

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Intelligent Control and Automation 2010年第1期1卷 36-47页

作者： xinjin liu Yun Zou 不详

Hadamard synergic control is a new kind of control problem which is achieved via a composite strategy of the state feedback control and the direct regulation of the part of connection coefficients of system state variables. Such a control is actually used very often in the practical areas. In this paper, we discuss Hadamard synergic stabilization problem for a class of dynamical networks. We analyze three cases: 1) Synergic stabilization problem for the general twonodenetwork. 2) Synergic stabilization problem for a special kind of networks. 3) Synergic stabilization problem for special kind of networks with communication timedelays. The mechanism of the synergic action between two control strategies: feedback control and the connection coefficients regulations are presented.

关键词： Hadamard Synergic Control Algebraically Graph Theory Decentralized Feedback Control Connection Coefficient Gain Matrix

ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles

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Virologica Sinica 2021年第6期36卷 1387-1399页

作者： Qiuhan Zhang Siliang Li Ping Lei Zixian Li Feifei Chen Qi Chen Yulu Wang Jiami Gong Qi Tang xinjin liu Ke Lan Shuwen Wu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan430072China Medical Research Institute Wuhan UniversityWuhan430072China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan430072China

Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate(PI4P) on ROs. PI4P then binds and induces conformational changes in the RNA-dependent RNA polymerase(Rd Rp) to modulate Rd Rp activity. Here, we targeted 3D polymerase, the core enzyme of EV71 ROs, and found that the host factor Annexin A2(ANXA2) can interact with 3 D polymerase and promote the replication of EV71. Then, an experiment showed that the annexin domain of ANXA2, which possesses membranebinding capacity, mediates the interaction of ANXA2 with EV71 3 D polymerase. Further research showed that ANXA2 is localized on ROs and interacts with PI4KB. Overexpression of ANXA2 stimulated the formation of PI4P, and the level of PI4P was decreased in ANXA2-knockout cells. Furthermore, ANXA2, PI4KB, and 3D were shown to be localized to the viral RNA replication site, where they form a higher-order protein complex, and the presence of ANXA2 promoted the PI4 KB-3D interaction. Altogether, our data provide new insight into the role of ANXA2 in facilitating formation of the EV71 RNA replication complex.

关键词： Enterovirus 71(EV71) Annexin A2(ANXA2) 3D polymerase Phosphatidylinositol 4-kinaseⅢ(PI4KB)

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一类系统的关联反馈广义闭环协调控制

江苏大学学报（自然科学版） 2011年第4期32卷 438-442页

作者：刘新金邹云南京理工大学自动化学院江苏南京210094 江南大学纺织服装学院江苏无锡214122

为解决关联反馈广义闭环协调的能稳性问题,提出一种协调控制器的设计方法.给出关联反馈广义闭环协调控制模型的描述.针对系统矩阵A=AO+AU的直接可调部分AU具有特殊形式:所有行(列)元素全为0或者全不为0的协调能稳性问题,通过将其在数学... 详细信息

为解决关联反馈广义闭环协调的能稳性问题,提出一种协调控制器的设计方法.给出关联反馈广义闭环协调控制模型的描述.针对系统矩阵A=AO+AU的直接可调部分AU具有特殊形式:所有行(列)元素全为0或者全不为0的协调能稳性问题,通过将其在数学形式上等价转化为线性时不变系统的能稳(能检测)问题,得到其可解的充要条件,并给出控制器的设计方法.结果表明:AU具该特殊形式的系统关联反馈广义闭环协调控制问题,可转化为相应的线性时不变系统的无约束控制问题;当AU不具该特殊形式,也即存在某行(列)既有零元又有非零元的情形时,该控制问题不能转化为线性时不变系统的无约束控制问题.对于一般情形下系统的关联协调控制问题,解决的关键是普通意义下的Cayley矩阵乘积与Hadamard矩阵乘积之间混合乘积的处理.

关键词：闭环协调控制系统反馈控制能稳性 Hadamard矩阵乘积关联调节

采用ABAQUS的粘胶机织物拉伸力学性能仿真

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纺织学报 2018年第9期39卷 39-43页

作者：刘倩楠刘新金生态纺织教育部重点实验室(江南大学) 江苏无锡214122

为预测织物拉伸性能,采用有限元方法对织物拉伸力学性能进行数值模拟分析。在实测织物几何结构参数的基础上,借助纺织建模软件Texgen建立了织物模型;利用有限元软件ABAQUS模拟织物拉伸环境,设置材料属性、相互作用和边界条件,得到织物... 详细信息

为预测织物拉伸性能,采用有限元方法对织物拉伸力学性能进行数值模拟分析。在实测织物几何结构参数的基础上,借助纺织建模软件Texgen建立了织物模型;利用有限元软件ABAQUS模拟织物拉伸环境,设置材料属性、相互作用和边界条件,得到织物拉伸变形后应力分布云图以及拉伸时应力-应变曲线图等数值模拟结果;最后通过织物拉伸强力测试实验对数值模拟结果进行了验证。结果显示:模拟所得应力-应变曲线和实验所得拉力-伸长曲线上升趋势大致相同;模拟所得最大拉伸应力与实验所得拉伸应力平均误差为3.03%,证明采用ABAQUS有限元软件模拟粘胶织物拉伸力学性能是可行的。

关键词：粘胶平纹织物拉伸力学性能几何模型有限元模拟

基于切断称重法的细纱机牵伸区内纤维变速点分布研究

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纺织学报 2021年第8期42卷 71-75页

作者：郭明华刘新金生态纺织教育部重点实验室(江南大学) 江苏无锡214122

为探究细纱机牵伸区内纤维的变速点分布,以纺制29.2、22.4、18.2 tex棉纱为例,采用CCZ-X三罗拉双区牵伸细纱机进行纺纱实验,采用等长切断称重法对牵伸区内须条的质量分布进行测试,以其质量变化分布表征变速点分布,得到质量变化折线图,... 详细信息

为探究细纱机牵伸区内纤维的变速点分布,以纺制29.2、22.4、18.2 tex棉纱为例,采用CCZ-X三罗拉双区牵伸细纱机进行纺纱实验,采用等长切断称重法对牵伸区内须条的质量分布进行测试,以其质量变化分布表征变速点分布,得到质量变化折线图,对比分析纤维在牵伸区内变速集中的位置,从而探究牵伸区内纤维变速规律。结果表明:等长切断称重法可得到牵伸区内纤维变速点分布的位置;在此次牵伸区内纤维变速点分布实验中,须条中的纤维在距前罗拉钳口线20 mm处变速相对集中,且在一定范围内随着前区牵伸倍数的增大,纤维变速点的位置变得不稳定、分散,且远离前罗拉前钳口。

关键词：牵伸区变速点分布等长切断称重法质量分布细纱机纱线质量

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生物基锦纶56赛络菲尔纱的开发与性能

现代纺织技术 2022年第6期30卷 95-101,149页

作者：卓辉刘新金江南大学生态纺织教育部重点实验室江苏无锡214122

以精梳棉与生物基锦纶56(N56)混纺粗纱作为外包纤维原料,N56长丝作为芯丝,在加装全聚纺装置的QFA1528环锭纺细纱机上纺制粗纱与长丝间距、捻度不同的9种18 tex70/30JC/N56/N56长丝(5 tex)赛络菲尔纱,其中外包粗纱混纺比为70∶30。探讨... 详细信息

以精梳棉与生物基锦纶56(N56)混纺粗纱作为外包纤维原料,N56长丝作为芯丝,在加装全聚纺装置的QFA1528环锭纺细纱机上纺制粗纱与长丝间距、捻度不同的9种18 tex70/30JC/N56/N56长丝(5 tex)赛络菲尔纱,其中外包粗纱混纺比为70∶30。探讨当改变粗纱与长丝间距和细纱机捻度时,9种赛络菲尔纱的断裂强力、断裂强度、初始模量以及条干CV和毛羽H值变化。结果表明:当粗纱与长丝间距为8 mm、细纱机设定捻度为120.34捻/10 cm时,所纺纱线的强力、强度、条干和毛羽最优。

关键词：生物基锦纶56 绿色再生赛络菲尔纺全聚纺

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UHMWPE复合纱的纺制及性能测试

丝绸 2021年第4期58卷 24-28页

作者：张洁刘新金江南大学生态纺织教育部重点实验室江苏无锡214122

UHMWPE纤维具有较高的比强度和比模量,但纤维吸湿性差。文章以黏胶短纤维为外包纤维,UHMWPE短纤纱(14.75 tex)及长丝(16.67 tex)为芯丝分别纺制34 tex包芯纱。以黏胶短纤维为中间纤维,UHMWPE短纤纱(14.75 tex)及长丝(16.67 tex)为包缠... 详细信息

UHMWPE纤维具有较高的比强度和比模量,但纤维吸湿性差。文章以黏胶短纤维为外包纤维,UHMWPE短纤纱(14.75 tex)及长丝(16.67 tex)为芯丝分别纺制34 tex包芯纱。以黏胶短纤维为中间纤维,UHMWPE短纤纱(14.75 tex)及长丝(16.67 tex)为包缠纤维分别纺制34 tex赛络菲尔纱。通过改变UHMWPE短纤纱或长丝与须条的间距优化赛络菲尔纱的性能,并对成纱性能进行测试和对比分析。结果表明:相同线密度纱线,以UHMWPE长丝为芯丝或包缠纤维所纺的包芯纱和赛络菲尔纱除断裂伸长率外,在强度、条干及毛羽方面均优于以UHMWPE短纤纱为芯丝或包缠纤维所纺的包芯纱和赛络菲尔纱。在纺制赛络菲尔纱时,UHMWPE短纤纱与须条的间距以8 mm为较优,UHMWPE长丝与须条的间距以6 mm为较优。

关键词：超高分子量聚乙烯复合纱包芯纱赛络菲尔纱纱线强度纱线条干