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Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam xinjie meng Zheng Peng Man Lung Yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta

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Effect of Partial Replacement of Fly Ash by Decoration Waste Powder on the Fresh and Mechanical Properties of Geopolymer Masonry Mortar

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 698-704页

作者：刘惠 ZHANG Ruidong 朱平华 WANG xinjie CHEN Chunhong School of Urban Construction Changzhou UniversityChangzhou 213164China

This study aims to investigate the feasibility of using decoration waste powder(DWP)as a partial replacement for fly ash(FA)in the preparation of geopolymer masonry mortar,and to examine the effect of different DWP replacement rates(0%-40%)on the fresh and mechanical properties of the *** results showed that each group of geopolymer masonry mortar exhibited excellent water retention performance,with a water retention rate of 100%,which was due to the unique geopolymer mortar system and high viscosity of the alkaline activator *** to the control group,the flowability of the mortar containing lower contents of DWP(10%and 20%)was ***,as the DWP replacement rate further increased,the flowability gradually *** DWP could absorb the free water in the reaction system of geopolymer mortar,thereby limiting the occurrence of geopolymerization *** incorporation of DWP in the mortar resulted in a decrease in compressive strength compared to the mortar without ***,even at a replacement rate of 40%,the compressive strength of the mortar still exceeded 15 MPa,which met the requirements of the masonry *** was feasible to use DWP in the geopolymer masonry *** the addition of DWP caused some performance loss,it did not affect its usability.

关键词： fly ash-based geopolymer decoration waste powder masonry mortar workability compressive strength

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The advantages of multi-level omics research on stem cell-based therapies for ischemic stroke

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Neural Regeneration Research 2024年第9期19卷 1998-2003页

作者： Yiqing Wang Chuheng Chang Renzhi Wang Xiaoguang Li xinjie Bao 4+4 Doctor Medical Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Neurosurgery Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina

Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However, despite many years of preclinical research, the application of stem cells is still limited to the clinical trial stage. Although stem cell therapy can be highly beneficial in promoting functional recovery, the precise mechanisms of action that are responsible for this effect have yet to be fully elucidated. Omics analysis provides us with a new perspective to investigate the physiological mechanisms and multiple functions of stem cells in ischemic stroke. Transcriptomic, proteomic, and metabolomic analyses have become important tools for discovering biomarkers and analyzing molecular changes under pathological conditions. Omics analysis could help us to identify new pathways mediated by stem cells for the treatment of ischemic stroke via stem cell therapy, thereby facilitating the translation of stem cell therapies into clinical use. In this review, we summarize the pathophysiology of ischemic stroke and discuss recent progress in the development of stem cell therapies for the treatment of ischemic stroke by applying multi-level omics. We also discuss changes in RNAs, proteins, and metabolites in the cerebral tissues and body fluids under stroke conditions and following stem cell treatment, and summarize the regulatory factors that play a key role in stem cell therapy. The exploration of stem cell therapy at the molecular level will facilitate the clinical application of stem cells and provide new treatment possibilities for the complete recovery of neurological function in patients with ischemic stroke.

关键词： ischemic stroke mesenchymal stem cells metabolomics multilevel omics neural stem/progenitor cells neuroinflammation pathophysiology proteomics stem cell therapy transcriptomes

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Shock-induced energy localization and reaction growth considering chemical-inclusions effects for crystalline explosives

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Defence Technology（防务技术） 2024年第3期33卷 278-294页

作者： Ruqin Liu Yanqing Wu xinjie Wang Fenglei Huang Xiaona Huang Yushi Wen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072HubeiChina Institute of Chemical Materials China Academy of Engineering Physics(CAEP)Mianyang621999SichuanChina

Chemical inclusions significantly alter shock responses of crystalline explosives in macroscale gap experiments but their microscale dynamics origin remains *** shock-induced energy localization,overall physical responses,and reactions in a-1,3,5-trinitro-1,3,5-triazinane(a-RDX)crystal entrained various chemical inclusions were investigated by the multi-scale shock technique implemented in the reactive molecular dynamics *** indicated that energy localization and shock reaction were affected by the intrinsic factors within chemical inclusions,i.e.,phase states,chemical compositions,and *** atomic origin of chemical-inclusions effects on energy localization is dependent on the dynamics mechanism of interfacial molecules with free space volume,which includes homogeneous intermolecular compression,interfacial impact and shear,and void collapse and *** introducing various chemical inclusions,the initiation of those dynamics mechanisms triggers diverse decay rates of bulk RDX molecules and hereby impacts on growth speeds of final *** chemical inclusions can reduce the effectiveness of the void during the shock *** the shockwave velocity of 9 km/s,the parent RDX decay rate in RDX entrained amorphous carbon decreases the most and is about one fourth of that in RDX with a vacuum void,and solid HMX and TATB inclusions are more reactive than amorphous carbon but less reactive than dry air or acetone *** lessdense shocking system denotes the greater increases in local temperature and stress,the faster energy liberation,and the earlier final reaction into equilibrium,revealing more pronounced responses to the present intense *** quantitative models associated with the relative system density(RD_(sys))were proposed for indicating energy-localization mechanisms and evaluating initiation safety in the shocked crystalline ***_(sys)is defined by the density ratio of defective RDX to perfec

关键词： Shock responses Energy localization Crystalline explosives Chemical inclusions Reactive molecular dynamics

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Credit risk prediction for small and medium enterprises utilizing adjacent enterprise data and a relational graph attention network

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Journal of Management Science and Engineering 2024年第2期9卷 177-192页

作者： Jiaxing Wang Guoquan Liu Xiaobo Xu xinjie Xing International Business School Suzhou Xi'an Jiaotong-Liverpool UniversitySuzhou215028China Financial Technology Research Institute Fudan UniversityShanghai200433China Management School University of LiverpoolChatham StreetLiverpoolL697ZHUK

Credit risk prediction for small and medium enterprises(SMEs)has long posed a complex research *** approaches have primarily focused on enterprise-specific variables,but these models often prove inadequate when applied to SMEs with incomplete *** this innovative study,we push the theoretical boundaries by leveraging data from adjacent enterprises to address the issue of data *** strategy involves constructing an intricate network that interconnects enterprises based on shared managerial teams and business *** this network,we propose a novel relational graph attention network(RGAT)algorithm capable of capturing the inherent complexity in its topological *** doing so,our model enhances financial service providers'ability to predict credit risk even in the face of incomplete data from target *** experiments conducted using China's SMEs highlight the predictive proficiency and potential economic benefits of our proposed *** approach offers a comprehensive and nuanced perspective on credit risk while demonstrating the advantages of incorporating network-wide data in credit risk prediction.

关键词： Risk management SMEC redit risk Transactional data Graph neural network

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Biomimetic Lightweight Design of Legged Robot Hydraulic Drive Unit Shell Inspired by Geometric Shape of Fish Bone Rib Structure

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Journal of Bionic Engineering 2024年第3期21卷 1238-1252页

作者： Zhipeng Huang xinjie Li Xikang Guan Xueqing Sun Chenxu Wang Yuepeng Xu Bin Yu Xiangdong Kong School of Mechanical Engineering Yanshan UniversityQinhuangdao066004China School of Arts and Design Yanshan UniversityQinhuangdao066004China Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Qinhuangdao066004China

The lightweight design of hydraulic quadruped robots,especially the lightweight design of the leg joint Hydraulic Drive Unit(HDU),can improve the robot's response speed,motion speed,endurance,and load ***,the lightweight design of HDU is a huge challenge due to the need for structural *** paper is inspired by the geometric shape of fish bones and biomimetic reinforcing ribs on the surface of the HDU shell are designed to increase its strength and reduce its ***,a HDU shell with biomimetic fish bone reinforcing ribs structure is ***,the MATLAB toolbox and ANSYS finite element analysis module are used to optimize the parameters of the biomimetic reinforcing ribs structure and the overall layout of the ***,the HDU shell is manufactured using additive manufacturing technology,and a performance testing platform is built to conduct dynamic and static performance tests on the designed *** experimental results show that the HDU with biomimetic fish bone reinforcing ribs has excellent dynamic performance and better static performance than the prototype model,and the weight of the shell is reduced by 20%compared to the prototype *** work has broad application prospects in the lightweight and high-strength design of closed-pressure vessel components.

关键词： Hydraulic drive unit Lightweight design of shell Biomimetic fish bone structure design Dynamic and static performance testing

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A Differential Privacy Federated Learning Scheme Based on Adaptive Gaussian Noise

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1679-1694页

作者： Sanxiu Jiao Lecai Cai xinjie Wang Kui Cheng Xiang Gao College of Automation and Information Engineering Sichuan University of Science and EngineeringYibin644000China Sanjiang Research Institute of Artificial Intelligence and Robotics Yibin UniversityYibin644000China College of Mechanical Engineering Sichuan University of Science and EngineeringYibin644000China

As a distributed machine learning method,federated learning(FL)has the advantage of naturally protecting data *** keeps data locally and trains local models through local data to protect the privacy of local *** federated learning method effectively solves the problem of artificial Smart data islands and privacy protection ***,existing research shows that attackersmay still steal user information by analyzing the parameters in the federated learning training process and the aggregation parameters on the server *** solve this problem,differential privacy(DP)techniques are widely used for privacy protection in federated ***,adding Gaussian noise perturbations to the data degrades the model learning *** address these issues,this paper proposes a differential privacy federated learning scheme based on adaptive Gaussian noise(DPFL-AGN).To protect the data privacy and security of the federated learning training process,adaptive Gaussian noise is specifically added in the training process to hide the real parameters uploaded by the *** addition,this paper proposes an adaptive noise reduction *** the convergence of the model,the Gaussian noise in the later stage of the federated learning training process is reduced *** paper conducts a series of simulation experiments on realMNIST and CIFAR-10 datasets,and the results show that the DPFL-AGN algorithmperforms better compared to the other algorithms.

关键词： Differential privacy federated learning deep learning data privacy

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Occurrence and risk assessment of azole fungicides during the urban water cycle:A year-long study along the Yangtze River,China

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Journal of Environmental Sciences 2024年第7期141卷 16-25页

作者： Yangyang Zhang xinjie Gu Xiuwen Li Qiuyun Zhao Xiaodong Hu Rui Huang Jixiong Xu Zilong Yin Qing Zhou Aimin Li Peng Shi State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Jiangsu Province Hydraulic Research Institute Nanjing 210023China

Azole fungicides(AFs)play an important role in the prevention and treatment of fungal diseases in agricultural ***,limited studies are addressing the fate and ecological risk of AFs in the urban water cycle at a large watershed *** address this gap,we investigated the spatiotemporal distribution and ecological risk of twenty AFs in the lower reaches of the Yangtze River across four ***(CBA),tebuconazole(TBA),tricyclazole(TCA),and propiconazole(PPA)were found to be the dominant *** highest concentrations were measured in January(188.3 ng/L),and November(2197.1 ng/L),July(162.0 ng/L),and November(1801.9 ng/L),*** comparison between wastewater treatment plants(WWTPs)effluents and surface water suggested that industrial WWTPs are major sources of AFs in the Yangtze *** particular,TBA and PPA were found to be the most recalcitrant AFs in industrial WWTPs,while difenoconazole(DFA)was found to be the most potent pollutant in municipal WWTPs,with an average removal rate of less than60%.The average risk quotient(RQ)for the entire AFs was 6.45 in the fall,which was higher than in January(0.98),April(0.61),and July(0.40).This indicates that AFs in surface water posed higher environmental risks during the dry ***,the exposure risk of AFs via drinking water for sensitive populations deserves more *** study provides benchmark data on the occurrence of AFs in the lower reaches of the Yangtze River,and offers suggestions for better reduction of AFs.

关键词： Azole fungicides Spatiotemporal distribution Ecological risk Urban water cycle the Yangtze River

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Comparison of life cycle assessment of large-scale biogas projects with different raw materials in China

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 268-279页

作者： Jiazheng Sun Youpei Qu Xiaoyi Lyu xinjie Ding Xinying Miao Mukesh Kumar Awasthi Jingbo Qu School of Energy and Environment City University of Hong KongHong Kong 999077China College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Agricultural Renewable Resources Utilization Technology and Equipment in Cold Areas of Heilongjiang Province Harbin 150030China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100Shaanxi China

The anaerobic digestion(AD)disposal of stover and cattle manure is of great significance to the development of low-carbon economy and green energy in China,but it will also have an impact on the environment,and the degree of influence is different for various raw *** this study,life cycle assessment(LCA)methods were applied to analyze and compare the impact of corn stovers biogas projects(CSBP)and dairy manure biogas projects(DMBP)on the environment during the whole operation *** results of inventory analysis were evaluated by ReCiPe2016 Hierarchy(H)mid-point(problem-oriented)and end-point(destruction-oriented)method,*** results showed that the net energy efficiency of CSBP was higher(763.903 kW·h/FU)and the greenhouse gas(GHG)emission reduction of DMBP was more(5541.418 kg CO_(2)-eq/FU).The anaerobic digestion(AD)units have the greatest environmental impacts,and human carcinogenic toxicity is the largest environmental impact category(1.16-1.43 PE).The key to reducing environmental impact is reducing the input of chemical substances and the waste of electric *** CSBP and DMBP have a favorable impact on ecosystem quality and resources,and CSBP is more beneficial to the environment(-10.297 Pt).Co-digestion is an important measure to reduce the environmental damage from biogas *** research results provide theoretical support for the selection of raw materials for large-scale biogas projects in China,provide technical basis for reducing the impact of actual operation on the environment,and promote the resource utilization of agricultural waste and carbon dioxide emission reduction and sequestration.

关键词： life cycle assessment environmental impact assessment large-scale biogas projects bioenergy carbon dioxide emission reduction

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Dynamics and genetic regulation of macronutrient concentrations during grain development in maize

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Journal of Integrative Agriculture 2024年第3期23卷 781-794页

作者： Pengcheng Li Shuangyi Yin Yunyun Wang Tianze Zhu xinjie Zhu Minggang Ji Wenye Rui Houmiao Wang Chenwu Xu Zefeng Yang Jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of Plant Functional Genomics Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Agricultural CollegeYangzhou UniversityYangzhou 225009China Jiangsu Co-lnnovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009China

Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize.

关键词： maize nutrient concentration unconditional QTL mapping conditional QTL mapping dynamic trait

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