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Evaluating therapeutic outcome in epileptic patients using the changes of interval and duration

Neural Regeneration Research 2007年第11期2卷 655-659页

作者： xinhui cao cong feng Zhumadian Psychiatric Hospital Zhumadian 463000 He＇nan Province China

BACKGROUND： Seizure frequency is in abnormal distribution, and it is not enough to express the trend of concentration using means, and its median loses a lot of information, thus it lacks of a standard for evaluating the therapeutic effects based on seizure frequency. OBJECTIVE： To establish a method for evaluating the therapeutic effects on anti-epileptic drugs using changes of interval and duration of seizure. DESIGN： A prospective cohort study. SETTING： Zhumadian Psychiatric Hospital. PARTICIPANTS： Outpatients and inpatients suffering from epilepsy attending firstly visited Zhumadian Psychiatric Hospital from June 2001 to June 2002 were enrolled. They were diagnosed as epileptic according to the International Classification of Epileptic Seizure by International League Against Epilepsy （1981） based on the clinical history, physical examination, and investigations. The interval time was no more than 6 months. Informed consent was obtained from all the subjects, and the study was approved by the hospital ethical committee. METHODS： ① For the first visit and each follow-up, the following data were recorded, including general demographic information, seizure type, the date and time of ictus, the duration of ictus, and inducement or situation related, according to which the following indexes could be calculated, including seizure styles, interval, duration, cluster frequency and cluster duration. The information from the first review was noted as annals A. The second interview was taken at the end of the evaluating period; the information from the second review was noted as annals B. The third interview was taken within two weeks after the second one; the information from the third review was noted as annals C. The annals B or the annals C were respectively compared with the annals A in the light of the same types or the same styles of the same patient. Summation of the scores of interval change and duration change of the same type or the same style and 5 of

关键词： epilepsy seizure severity scale seizure frequency seizure severity therapeutic effects

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N-doped carbon nanofibers arrays as advanced electrodes for supercapacitors

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Journal of Materials Science & Technology 2020年第20期52卷 144-151页

作者： Guoxiang Pan feng cao Yujian Zhang xinhui Xia Department of Materials Chemistry Huzhou UniversityHuzhou 313000China State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Provinceand Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The advancement of supe rcapacitors largely relies on the innovation of electrode materials with high-rate performance and ultra-long cycling *** this work,unique N-doped nanofibers on carbon cloth(NCNFs/CC) are prepared by an electrodepositio n-annealing method for application in *** as-prepared N-doped nanofibers(N-CNFs) show diameters of 100-150 nm and cross-link with each other fo rming porous conductive *** to enhanced conductivity and reinforced structural stability,the N-CNFs/CC arrays are demonstrated with better electrochemical performance than CNFs/CC counterpart,including higher specific capacitance(195.2 F g^-1 at a current density of 2.5 A g^-1),excellent rate capability(80.5.% capacity retention as the rate increases from 2.5-20 A g^-1) and good cycling stability(99.5.%retention after 10,000 cycles).These reinforced electrochemical properties are attributed to N-doped conductive architecture with faster ion/electron transfer paths and more active *** findings may offe r a new way for construction of advanced high-rate electrodes for energy storage.

关键词： Supercapacitors Carbon fibers Electrode Porous materials Electrodeposition

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Implanting Ni into N-doped puffed carbon: A new advanced electrocatalyst for oxygen evolution reaction

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Chinese Chemical Letters 2020年第9期31卷 2230-2234页

作者： feng cao Guoxiang Pan Yujian Zhang xinhui Xia Department of Materials Chemistry Huzhou UniversityHuzhou 313000China State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang ProvinceDepartment of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Tailored design and synthesis of high-quality electrocatalysts is vital for the advancement of oxygen evolution reaction(OER).Herein,we report a powerful puffing method to fabricate hierarchical porous N-doped carbon with numerous embedded Ni ***,during the puffing and annealing process,rice precursor with N and Ni sources can be in-situ converted into Ni-embedded N-doped porous carbon(N-PC/Ni) *** obtained N-PC/Ni composite possesses a cross-linked porous architecture containing conductive carbon backbone and active Ni nanoparticles electrocatalysts for *** pore formation in N-PC/Ni composite is also proposed because of carbothermic *** N-PC/Ni composite is fully studied as electrocatalysts for *** to increased active surface area,enhanced electronic conductivity and reactivity,the designed N-PC/Ni composite exhibits superior OER performance with a low Tafel slope(~88 mV/dec) and a low overpotential as well as excellent long-term stability in alkaline *** proposed rational design strategy may provide a new way to construct other advanced metal/heteroatom-doped composites for widespread application in electrocatalysis.

关键词： Oxygen evolution reaction Electrocatalysis Porous carbon Metal-carbon composites N doping

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Synthesis of NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids for fluorescence imaging in the second biological window

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Journal of Rare Earths 2018年第2期36卷 113-118页

作者： Dongpeng Yang cong cao Wei feng Chunhui Huang Fuyou Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences & Collaborative Innovation Center of Chemistry for Energy Materials Fudan University

Nd doped nanoparticles is commonly used as bioimaging agents but presents poor stability. Here, a polymer coating is applied to NaYF4：Nd nanoparticles using a versatile step-by-step coating strategy. The as-synthesized NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids show good stability in various polar solvent and are very stable in water at least for 6 months. These NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids can exhibit strong down converting photoluminescence when excited by 808 nm lasers. Moreover, these NaYF_4：Nd@NaLuF_4@SiO_2@PS colloids accumulate in liver of mice when used as bio-imaging agents. which exhibit strong fluorescence luminescence in NIR Ⅱ window.

关键词： Neodymium Polystyrene Stability Bioimaging Rare earths

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Liquid-source plasma technology for construction of dual bromine-fluorine-enriched interphases on lithium metal anodes with enhanced performance

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Journal of Materials Science & Technology 2024年第10期177卷 68-78页

作者： Ping Liu Zhong Qiu feng cao Yongqi Zhang Xinping He Shenghui Shen Xinqi Liang Minghua Chen Chen Wang Wangjun Wan Yang Xia xinhui Xia Wenkui Zhang Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313002China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China School of Materials Science&Engineering Zhejiang UniversityHangzhou 310027China Department of Engineering Technology Huzhou CollegeHuzhou 313000China Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611371China School of Materials Science&Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbin 150080China Zhejiang Academy of Science and Technology for Inspection&Quarantine Zhejiang Hangzhou 311215China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

The electrochemical performance of Li metal anode is closely bound up with the interphase between Li and lithium-loaded skeleton as well as solid electrolyte interphase(SEI)on Li ***,for the first time,we propose a novel liquid-source CHBr_(2)F plasma technology to simultaneously construct dual bromine-fluorine-enriched interphases:NiBr_(2)-NiF_(2) interphase on sponge Ni(SN)skeleton and LiBr-LiF-enriched SEI on Li anode,*** on density functional theory(DFT)calculations and COMSOL multiphysics simulation results,SN skeleton with NiBr_(2)-NiF_(2)interphase can effectively decrease the local current density with good *** the LiBr-LiF-enriched SEI on Li surface can function to block electron tunneling and hinder side electrochemical reduction of electrolyte components,thus suppressing the growth of dendrite and facilitating the homogeneous transportation of lithium ***,the Li/SN electrodes with modified interphases show remarkable stability with a low overpotential of 22.6 mV over 1800 h at 1 mA cm^(-2)/1 mAh cm^(-2)and an exceptional average Coulombic efficiency of 99.6%.When coupled with LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cathode,the full cells deliver improved cycling stability with a capacity retention of 79.5%even after 350 cycles at 0.5 *** study provides a facile and new plasma method for the construction of advanced Li anodes for energy storage.

关键词： Plasma Solid electrolyte interphase LiBr LiF Lithium metal anodes

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Cardiovascular and cerebrovascular outcomes in elderly hypertensive patients treated with either ARB or ACEI

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Journal of Geriatric Cardiology 2012年第3期9卷 252-257页

作者： cong Ma Jian cao Xue-Chun Lu Xin-Hong Guo Yan Gao Xian-feng Liu Li Fan The First Department of Geriatric Cardiology South Building Chinese PLA General Hospital 28 Fuxing Road Beij'ing 100853 China Geriatric Department of Hematology South Building Chinese PLA General Hospital 28 Fuxing Road Beij'ing 100853 China The Institute of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beo'ing 100853 China

Background Although angiotensin converting enzyme inhibitors （ACEI） and angiotensin receptor blockers （ARB） are equally important in the treatment of hypertension, there is less evidence whether they have equal cardiovascular and cerebrovascular protective effects, especially in elder hypertensive patients. This study aims to clarify this unresolved issue. Methods This cross-sectional study included clinical data on 933 aged male patients with hypertension who received either an ARB or ACEI for more than two months between January 2007 and May 2011. The primary outcome was the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. The secondary endpoints were unstable angina, new atrial fibrillation, and transient ischemic attack. Results The median follow-up time was 24 months. Age, drug types, cerebral infarction history, renal dysfunction history were the independent predictors of the primary endpoint. The risk of an occurrence of a primary endpoint event was higher in the ARB group than the ACEI group [P = 0.037, hazard ratios （HR）： 2.124, 95% confidence interval （95% CI）： 1.048-4.306]. The Kaplan-Meier method also suggests that the rate of primary endpoint occurrence was higher in the ARB group than the ACEI group （P = 0.04）. In regard to the secondary endpoints, there were no significant differences between the two treatment arms （P = 0.137, HR： 1.454, 95% CI： 0.888-2.380）. Patient age and coronary heart disease history were independent predictors of the secondary endpoint. Conclusion ACEI were more effective than ARB in reducing cardiovascular and cerebrovascular morbidity and mortality in aged patients with hypertension.

关键词： Angiotensin receptor blocker Angiotensin converting enzyme inhibitor Renin-angiotensin-aldosterone system Angiotensintype 2 receptor

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Development and Application of Multi-phase Nitrides Bonded Silicon Carbide Lintel Blocks for Dry Quenching Furnaces

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China's Refractories 2023年第2期32卷 7-11页

作者： cao Huiyan feng Yanbin ZHANG Xinhua HUANG Zhigang LI Jie WANG xinhui WU Jiguang State Key Laboratory of Advanced Refractories Sinosteel Luoyang Institute of Refractories Research Co.Ltd.Luoyang471039China

Multi-phase nitrides bonded silicon carbide lintel blocks were prepared using industrial SiC(SiC≥98 mass%,3-0.5,≤0.5 and≤0.044 mm),Si powder(Si≥98 mass%,≤0.044 mm),and SiO2 micropowder(SiO2≥96 mass%,d50=0.15 pm)as raw materials,and calcium lignosulfonate as the additive,batching,mixing,and molding on a vibration pressure molding machine,drying and then firing at 1420℃for 10 h in high-purity *** apparent porosity,the bulk density,the cold modulus of rupture,the hot modulus of rupture,and the linear expansion coefficient of the samples were *** phase composition and the microstructure of the samples at different nitriding depths(50,100,and 150 mm)were analyzed by XRD and *** field application effects of the blocks were *** results show that:(1)the multi-phase nitrides bonded silicon carbide refractories can dynamically adjust their own phase composition and minimize structural and thermal stresses,improving the service life of key parts of dry quenching furnaces;(2)calcium lignosulfonate can improve the nitriding micro-environment of multi-phase nitrides bonded silicon carbide lintel blocks,successfully increasing the effective nitriding thickness of the blocks to 300 mm;(3)Sinosteel LI RR provides a unique concept in the design of materials and block types as well as the stable and scientific overall structure,promoting the industrialization process of dry quenching furnaces with long service life in China.

关键词： inclined channel area dry quenching furnaces silicon carbide multi-phase nitrides lintel blocks

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Constructing efficient bacterial cell factories to enable one-carbon utilization based on quantitative biology:A review

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Quantitative Biology 2024年第1期12卷 1-14页

作者： Yazhen Song Chenxi feng Difei Zhou Zengxin Ma Lian He cong Zhang Guihong Yu Yan Zhao Song Yang xinhui Xing School of Life Sciences Shandong Province Key Laboratory of Applied Mycologyand Qingdao International Center on Microbes Utilizing BiogasQingdao AgriculturalUniversityQingdaoChina Department of Chemical Engineering University of WashingtonSeattleWashingtonUSA Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjinChina Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijingChina Center for Synthetic and Systems Biology Tsinghua UniversityBeijingChina Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate Schooland Insttute of Biomedical Health Technology and EngineeringShenzhen Bay LaboratoryShenzhenChina

Developing methylotrophic cell factories that can efficiently catalyze organic one-carbon(C1)feedstocks derived from electrocatalytic reduction of carbon dioxide into bio-based chemicals and biofuels is of strategic significance for building a carbon-neutral,sustainable economic and industrial *** the rapid advancement of RNA sequencing technology and mass spectrometer analysis,researchers have used these quantitative microbiology methods extensively,especially isotope-based metabolic flux analysis,to study the metabolic processes initiating from C1 feedstocks in natural C1-utilizing bacteria and synthetic C1 *** paper reviews the use of advanced quantitative analysis in recent years to understand the metabolic network and basic principles in the metabolism of natural C1-utilizing bacteria grown on methane,methanol,or *** acquired knowledge serves as a guide to rewire the central methylotrophic metabolism of natural C1-utilizing bacteria to improve the carbon conversion efficiency,and to engineer non-C1-utilizing bacteria into synthetic strains that can use C1 feedstocks as the sole carbon and energy *** progresses ultimately enhance the design and construction of highly efficient C1-based cell factories to synthesize diverse high value-added *** integration of quantitative biology and synthetic biology will advance the iterative cycle of understand–design–build–testing–learning to enhance C1-based biomanufacturing in the future.

关键词： ^(13)C-metabolic flux analysis methylotrophic cell factories one-carbon feedstock quantitative biology

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Recent progress in Li and Mn rich layered oxide cathodes for Li-ion batteries

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Journal of Energy Chemistry 2021年第10期30卷 368-385,I0011页

作者： Yiwei Li Zhibo Li cong Chen Kai Yang Bo cao Shenyang Xu Ni Yang Wenguang Zhao Haibiao Chen Mingjian Zhang feng Pan School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055GuangdongChina Center for Advanced Radiation Source(ChemMatCARS) the University of ChicagoArgonneIL 60439United States

Li and Mn rich(LMR)layered oxides,written as xLi_(2) MnO_(3)·(1-x)LiMO_(2)(M=Mn,Ni,Co,Fe,etc.),have been widely reported in recent years due to their high capacity and high energy *** stable structure and superior performance of LMR oxides make them one of the most promising candidates for the next-generation cathode ***,the commercialization of these materials is hindered by several drawbacks,such as low initial Coulombic efficiency,the degradation of voltage and capacity during cycling,and poor rate *** review summarizes research progress in solving these concerns of LMR cathodes over the past decade by following three classes of strategies:morphology design,bulk design,and surface *** elaborate on the processing procedures,electrochemical performance,mechanisms,and limitations of each approach,and finally put forward the concerns left and the possible solutions for the commercialization of LMR cathodes.

关键词： Li-ion batteries Li and Mn rich layered oxide cathodes Electrochemical concerns Progress and perspective

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Optimization and Simulation of Inclined Channel Area Lining for CDQ Ovens

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China's Refractories 2022年第2期31卷 24-29页

作者： cao Huiyan feng Yanbin ZHANG Haiyan MA Zhaoyang LI Jie WANG xinhui WU Jiguang YANG Wengang State Key Laboratory of Advanced Refractories Luoyang Institute of Refractories Research Co.Ltd.Luoyang 471039China

The mechanical force borne by the lintel and“brackets”in the inclined channel area of CDQ and the thermal stress generated by the top-down temperature gradient were simulated by ANSYS *** following conclusions are drawn.(1)The mechanical force has very mild effect on the damage of the“brackets”.(2)The temperature gradient caused by the uneven temperature distribution of CDQ oven is the key factor affecting the“bracket”*** different expansion of refractory materials in various parts results in the thermal stress concentration which tears the“brackets”.(3)The structure adjustment of the“brackets”has very little effect on the thermal stress distribution.(4)The multi-phase nitride bonded silicon carbide for CDQ can effectively alleviate the stress concentration at the“brackets”,realizing the long-life and stable operation.

关键词： coke dry quenching oven inclined channel area ANSYS software thermal stress multi-phase nitrides silicon carbide

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