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An overview for monitoring and prediction of pathogenic microorganisms in the atmosphere

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Fundamental Research 2024年第3期4卷 430-441页

作者： Jianping Huang Danfeng Wang Yongguan Zhu Zifeng Yang Maosheng Yao Xiaoming Shi Taicheng An Qiang zhang Cunrui Huang xinhui Bi Jiang Li Zifa Wang Yongqin Liu Guibing Zhu Siyu Chen Jian Hang Xinghua Qiu Weiwei Deng Huaiyu Tian Tengfei zhang Tianmu Chen Sijin Liu Xinbo Lian Bin Chen Beidou zhang Yingjie Zhao Rui Wang Han Li Collaborative Innovation Center for Western Ecological Safety College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease(Guangzhou Medical University)Guangzhou 510230China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Vanke School of Public Health Tsinghua UniversityBeijing 100084China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 510640

Corona virus disease 2019(COVID-19)has exerted a profound adverse impact on human health.Studies have demonstrated that aerosol transmission is one of the major transmission routes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Pathogenic microorganisms such as SARS-CoV-2 can survive in the air and cause widespread infection among people.Early monitoring of pathogenic microorganism transmission in the atmosphere and accurate epidemic prediction are the frontier guarantee for preventing large-scale epidemic outbreaks.Monitoring of pathogenic microorganisms in the air,especially in densely populated areas,may raise the possibility to detect viruses before people are widely infected and contain the epidemic at an earlier stage.The multi-scale coupled accurate epidemic prediction system can provide support for governments to analyze the epidemic situation,allocate health resources,and formulate epidemic response policies.This review first elaborates on the effects of the atmospheric environment on pathogenic microorganism transmission,which lays a theoretical foundation for the monitoring and prediction of epidemic development.Secondly,the monitoring technique development and the necessity of monitoring pathogenic microorganisms in the atmosphere are summarized and emphasized.Subsequently,this review introduces the major epidemic prediction methods and highlights the significance to realize a multi-scale coupled epidemic prediction system by strengthening the multidisciplinary cooperation of epidemiology,atmospheric sciences,environmental sciences,sociology,demography,etc.By summarizing the achievements and challenges in monitoring and prediction of pathogenic microorganism transmission in the atmosphere,this review proposes suggestions for epidemic response,namely,the establishment of an integrated monitoring and prediction platform for pathogenic microorganism transmission in the atmosphere.

关键词： Aerosol transmission Epidemic monitoring methods Epidemic prediction modelsEpidemic response Multidisciplinary cooperation

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou xinhui Huang Chunmei zhang Yongjie Ma Jinqiu Hu Xiaoyan Bi Junyu Ma Mengyao Li Dong Lu Liang Hu Jiahua Fan Fuli Ya Department of Nutrition School of Public Health Dali University Department of Laboratory Teaching Center School of Public Health Dali University Department of Health Management Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine School of Integrative Medicine Shanghai University of Traditional Chinese Medicine School of Public Health Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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Resonant enhancement of magnetic damping driven by coherent acoustic phonons in thin Co_(2)FeAl film epitaxied on GaAs

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Journal of Semiconductors 2021年第3期42卷 66-72页

作者： Lin Song Wei Yan Hailong Wang Jianhua Zhao xinhui zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Laser Institute Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266000China

The magnetic dynamics of a thin Co_(2)FeAl film epitaxially grown on GaAs substrate was investigated using the timeresolved magneto-optical Kerr measurement under an out-of-plane external field.The intrinsic magnetic damping constant,which should do not vary with the external magnetic field,exhibits an abnormal huge increase when the precession frequency is tuned to be resonant with that of the coherent longitudinal acoustic phonon in the Co_(2)FeAl/GaAs heterostructure.The experimental finding is suggested to result from the strong coherent energy transfer from spins to acoustic phonons via magnetoelastic effect under a resonant coupling condition,which leads to a huge energy dissipation of spins and a greatly enhanced magnetic damping in Co_(2)FeAl.Our experimental findings provide an experimental evidence of spin pumping-like effect driven by propagating acoustic phonons via magnetoelastic effect,suggesting an alternative approach to the possible long-range spin manipulation via coherent acoustic waves.

关键词： magnetic damping coherent longitudinal acoustic phonons magnetoelastic effect long-range spin manipulation

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoY-2 variants

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Signal Transduction and Targeted Therapy 2022年第3期7卷 780-789页

作者： Xiaojing Chi xinhui zhang Shengnan Pan Yanying Yu Yujin Shi Tianli Lin Huarui Duan Xiuying Liu Wenfang Chen Xuehua Yang Lan Chen Xiaoqian Dong Lili Ren Qiang Ding Jianwei Wang Wei Yang NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical College100176 BeijingChina School of Medicine Tsinghua University100084 BeijingChina

The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid accumulation of mutations,posing significant challenges to the effectiveness of vaccines and therapeutic antibodies.Although several neutralizing antibodies were authorized for emergency clinical use,convalescent patients derived natural antibodies are vulnerable to SARS-CoV-2 Spike mutation.

关键词： neutral antibodies clinical

考虑电力市场化交易的电碳表计量及实现方法研究

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电网技术 2024年第6期48卷 2297-2306页

作者：王春妍卢达李贺龙陈昊张新卉中国电力科学研究院有限公司北京市海淀区100192

电力间接碳排放是电力用户碳排放的主要来源之一,碳排放流是计算电力间接碳排放的重要方法。目前,基于碳排放流的计量理论尚未考虑电力市场化交易的影响,缺乏相应工程应用的实现方法,参与电力市场化交易的用户难以准确获得其用电量所对... 详细信息

电力间接碳排放是电力用户碳排放的主要来源之一,碳排放流是计算电力间接碳排放的重要方法。目前,基于碳排放流的计量理论尚未考虑电力市场化交易的影响,缺乏相应工程应用的实现方法,参与电力市场化交易的用户难以准确获得其用电量所对应的间接碳排放量。为解决这一难题,该文研究碳排放流理论的分布式电能实现方法,考虑电力市场化交易对交易双方及相关用户碳排放因子的影响,提出含电力市场化交易的电力系统源、网、荷全过程电碳排放量计量方法;并研究存在绿电交易、储能等情况下的电碳排放因子特点及计算方法。基于上述理论,研制了电碳表及其相关系统,并利用电碳表系统对某地电网部分实际拓扑进行分析,验证了所提方法的有效性及电碳表的实用性。

关键词：碳计量电碳表电碳排放因子电力市场化交易绿电交易储能

考虑残余应力的钢桥面板-肋双面焊裂纹应力强度因子计算方法

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中南大学学报（自然科学版） 2024年第2期55卷 810-821页

作者：肖新辉陈方怀张海萍刘扬肖康海湖南工业大学土木工程学院湖南株洲412007 长沙理工大学土木工程学院湖南长沙410114

建立焊接分析有限元模型,对顶板-纵肋双面焊构造的焊接过程进行数值模拟,拟合得到顶板焊趾细节沿板厚方向分布的横向残余应力分布经验公式;建立钢桥面板断裂力学数值模型,结合统一的权函数表达式,推导适用于顶板焊趾处裂纹最深点和表面... 详细信息

建立焊接分析有限元模型,对顶板-纵肋双面焊构造的焊接过程进行数值模拟,拟合得到顶板焊趾细节沿板厚方向分布的横向残余应力分布经验公式;建立钢桥面板断裂力学数值模型,结合统一的权函数表达式,推导适用于顶板焊趾处裂纹最深点和表面点应力强度因子的新权函数,并将权函数计算的应力强度因子与有限元计算的应力强度因子进行对比。研究结果表明:顶板-纵肋双面焊顶板焊趾处残余应力沿板厚方向处于拉—压—拉状态,呈正弦函数分布;在二次应力分布下,权函数法与有限元法计算所得顶板焊趾处裂纹最深点应力强度因子最大相对误差为7.4%,表面点应力强度因子最大相对误差为4.1%;在焊接残余应力场下,权函数法与有限元法计算所得顶板焊趾处裂纹最深点应力强度因子最大相对误差为7.6%,表面点应力强度因子最大相对误差为8.6%;权函数法能有效计算钢桥面板-肋双面焊顶板焊趾处疲劳裂纹应力强度因子。

关键词：正交异性钢桥面板权函数法疲劳裂纹应力强度因子焊接残余应力

Nsp2 and GP5-M of Porcine Reproductive and Respiratory Syndrome Virus Contribute to Targets for Neutralizing Antibodies

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Virologica Sinica 2019年第6期34卷 631-640页

作者： Jia Su Lei Zhou Bicheng He xinhui zhang Xinna Ge Jun Han Xin Guo Hanchun Yang Key Laboratory of Animal Epidemiology of the Ministry of Agriculture College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology China Agricultural University

Porcine reproductive and respiratory syndrome virus(PRRSV)is characterized by its genetic variation and limited cross protection among heterologous strains.Even though several viral structural proteins have been regarded as inducers of neutralizing antibodies(NAs)against PRRSV,the mechanism underlying limited cross-neutralization among heterologous strains is still controversial.In the present study,examinations of NA cross reaction between a highly pathogenic PRRSV(HP-PRRSV)strain,JXwn06,and a low pathogenic PRRSV(LP-PRRSV)strain,HB-1/3.9,were conducted with viral neutralization assays in MARC-145 cells.None of the JXwn06-hyperimmuned pigs’sera could neutralize HB-1/3.9 in vitro and vice versa.To address the genetic variation between these two viruses that are associated with limited crossneutralization,chimeric viruses with coding regions swapped between these two strains were constructed.Viral neutralization assays indicated that variations in nonstructural protein 2(nsp2)and structural proteins together contribute to weak cross-neutralization activity between JXwn06 and HB-1/3.9.Furthermore,we substituted the nsp2-,glycoprotein2(GP2)-,GP3-,and GP4-coding regions together,or nsp2-,GP5-,and membrane(M)protein-coding regions simultaneously between these two viruses to construct chimeric viruses to test cross-neutralization reactivity with hyperimmunized sera induced by their parental viruses.The results indicated that the swapped nsp2 and GP5-M viruses increased the neutralization reactivity with the donor strain antisera in MARC-145 cells.Taken together,these results show that variations in nsp2 and GP5-M correlate with the limited neutralization reactivity between the heterologous strains HP-PRRSV JXwn06 and LP-PRRSV HB-1/3.9.

关键词： Porcine reproductive and respiratory syndrome virus(PRRSV) Neutralizing antibody(NA) Non-structural protein 2(nsp2) Structural proteins(SPs)

A genome-wide association study on growth traits in orangespotted grouper(Epinephelus coioides) with RAD-seq genotyping

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Science China(Life Sciences) 2018年第8期61卷 934-946页

作者： Hui Yu Xinxin You Jia Li xinhui zhang Shuai zhang Shoujia Jiang Xueqiang Lin Hao-Ran Lin Zining Meng Qiong Shi BGI Education Center University of Chinese Academy of Sciences Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals BGI Academy of Marine SciencesBGI Marine BGI State Key Laboratory of Biocontrol Institute of Aquatic Economic Animals and the Guangdong Province Key Laboratory for Aquatic Economic Animals Sun Yat-Sen University Laboratory of Aquatic Genomics College of Life Sciences and Oceanography Shenzhen University

The orange-spotted grouper, Epinephelus coioides, is one of the most popular fish in China and Southeast Asian countries because of its important economic value. However, molecular mechanism underlying the growth of orange-spotted grouper has never been fully understood. Herein, we performed a genome-wide association study(GWAS) on a natural population of 198 individuals aiming to screen the whole genome of orange-spotted grouper for identification of growth-related loci by restrictionsite associated DNA sequencing. In this research, 261,366 single nucleotide polymorphisms(SNPs) were developed, in which110 SNPs were identified to be correlated with growth and 20 SNPs were further confirmed to be associated with both body weight and total length. From these identified SNPs, we annotated a total of 34 genes, including adgrb2, csnkza1, cers5, col22 a1,creb5, dnd1, dzank1, dnai1, npy2 r, fat3, lrrk2, lrp5, map3 k9, and so on. Among these candidate genes, npy2 r(neuropeptide Y receptor Y2) was reported to play a critical role in growth of the orange-spotted grouper. In addition, population structure,principal component analysis, kinship matrix and linkage disequilibrium were examined to verify the accuracy and reliability of our GWAS results. Our data will also provide a valuable genetic resource for further marker-assisted selection program to improve growth quality in groupers.

关键词： coioides 生长特点染色体橘子协会基因资源人口结构 SNP

CNES分析框架下的黄河流域高级别文化旅游景区空间分布与影响因素研究

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干旱区资源与环境 2024年第5期38卷 199-208页

作者：王慧娴张鑫慧胡泽鹏杨蓓山西财经大学文化旅游与新闻艺术学院太原030006 山西财经大学山西文化旅游产业技术创新研究院太原030006 华东师范大学城市与区域科学学院上海200241

黄河文化作为中华文明的重要组成部分,其保护、传承及弘扬具有战略意义,文化旅游景区承载着黄河流域特色文化,是增强文化认同和坚定文化自信的物质载体。文中从文化底蕴(C)、自然环境(N)、经济基础(E)、社会条件(S)四个维度构建文化旅... 详细信息

黄河文化作为中华文明的重要组成部分,其保护、传承及弘扬具有战略意义,文化旅游景区承载着黄河流域特色文化,是增强文化认同和坚定文化自信的物质载体。文中从文化底蕴(C)、自然环境(N)、经济基础(E)、社会条件(S)四个维度构建文化旅游景区空间分布影响因素的CNES分析框架,运用GIS空间分析、地理探测器等方法,对黄河流域高级别文化旅游景区的空间分布特征及其影响因素进行探索。研究发现:1)黄河流域高级别文化旅游景区分布不均衡,呈现空间集聚形态。2)影响景区空间分布的单因子影响强度具有差异,交通、GDP、气温为影响黄河流域高级别文化旅游景区空间分布的主导因素,降水、旅游收入、博物馆、人口、河流为重要因素,全国重点文物保护单位、旅游政策为一般因素。3)景区空间分布受多因素共同影响,以双因子增强类型为主。4)分析框架中各维度作用不尽相同,经济维度作用>社会维度作用>自然维度作用>文化维度作用,CNES分析框架在黄河流域得以验证。

关键词： CNES 黄河流域文化旅游景区空间分布影响因素