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非侵入性神经调控治疗双相障碍的临床研究进展

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中华精神科杂志 2024年第4期57卷 239-244页

作者：赵徐东周和统王敏敏章晓梅祖鑫宋宝华靳西龙沈鑫华钱敏才胡少华湖州市第三人民医院湖州师范学院附属医院湖州313000 浙江大学医学院附属第一医院精神科杭州310003 浙江大学生物医学工程与仪器科学学院杭州310000

双相障碍是一种高复发、高致残、高自杀的慢性精神障碍,安全、有效、起效快的非侵入性神经调控治疗技术已成为双相障碍治疗的研究热点。本文对目前该领域主要技术的较新临床研究进展进行了总结回顾,并对非侵入性神经调控技术未来前景进... 详细信息

双相障碍是一种高复发、高致残、高自杀的慢性精神障碍,安全、有效、起效快的非侵入性神经调控治疗技术已成为双相障碍治疗的研究热点。本文对目前该领域主要技术的较新临床研究进展进行了总结回顾,并对非侵入性神经调控技术未来前景进行了展望。

关键词：双相情感障碍非侵入性神经调控

Construction of an alternative NADPH regeneration pathway improves ethanol production in Saccharomyces cerevisiae with xylose metabolic pathway

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Synthetic and Systems Biotechnology 2024年第2期9卷 269-276页

作者： Yali Qiu Wei Liu Meiling Wu Haodong Bao xinhua Sun Qin Dou Hongying Jia Weifeng Liu Yu shen State Key Laboratory of Microbial Technology Institute of Microbial TechnologyShandong UniversityQingdao266237China Advanced Medical Research Institute Shandong UniversityJinan250012China

Full conversion of glucose and xylose from lignocellulosic hydrolysates is required for obtaining a high ethanol ***,glucose and xylose share flux in the pentose phosphate pathway(PPP)and glycolysis pathway(EMP),with glucose having a competitive advantage in the shared metabolic *** this work,we knocked down ZWF1 to preclude glucose from entering the *** reduced the[NADPH]level and disturbed growth on both glucose or xylose,confirming that the oxidative PPP,which begins with Zwf1p and ultimately leads to CO_(2) production,is the primary source of NADPH in both glucose and *** glucose depletion,gluconeogenesis is necessary to generate glucose-6-phosphate,the substrate of *** re-established the NADPH regeneration pathway by replacing the endogenous NAD^(+)-dependent glyceraldehyde-3-phosphate dehydrogenase(GAPDH)gene TDH3 with heterogenous NADP^(+)-GAPDH genes GDH,gapB,and *** the resulting strains,the strain BZP1(zwf1Δ,tdh3::GDP1)exhibited a similar xylose consumption rate before glucose depletion,but a 1.6-fold increased xylose consumption rate following glucose depletion compared to the original strain BSGX001,and the ethanol yield for total consumed sugars of BZP1 was 13.5%higher than *** suggested that using the EMP instead of PPP to generate NADPH reduces the wasteful metabolic cycle and excess CO_(2)^(++) release from oxidative ***,we used a copper-repressing promoter to modulate the expression of ZWF1 and optimize the timing of turning off the ZWF1,therefore,to determine the competitive equilibrium between glucose-xylose *** strategy allowed fast growth in the early stage of fermentation and low waste in the following stages of fermentation.

关键词： Saccharomyces cerevisiae Xylose Ethanol NADPH Glyceraldehyde-3-phosphate dehydrogenase

IgG Fc receptors play a role in the pathogenesis of neuropathic and inflammatory pain

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IgG Fc receptors play a role in the pathogenesis of neuropat...

中国解剖学会2015年年会

作者： Liu Fan Jiang Haowu shen xinhua Ma Chao Institute of Basic Medical Sciences Neuroscience CenterChinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Department of Anatomy Histology and Embryology

＜正＞Chronic pain may accompany immune-related disorders with elevated level of antigen-specific immunoglobulin（Ig）G of immune complex（IC）in the serum and the affected *** studies revealed the functional receptor for IgG,Fc-gamma-receptors（FcγR）are expressed in nociceptive DRG neurons,and may play a role in the development of chronic ***

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Association analysis of catechol-O-methyltransferase(COMT) rs4680polymorphisms and generalized anxiety disorder in Chinese Han population

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Association analysis of catechol-O-methyltransferase(COMT) r...

2019第四届之江精神医学交流会、浙江省医学会精神病学学术大会、浙江省医师协会精神科医师分会第十二届年会

作者： Qianqian He Zhongxia shen Lie Ren Xing wang Mincai Qian Jianying Zhu xinhua shen Psychosomatic Department Huzhou Third Municipal Hospital

Backgrouds:Catechol-O-methyltransferase(COMT) Val158 Met polymorphism have been reported to be implicated in generalized anxiety disorder(GAD) as well as the treatment response to antidepressants in patients with GAD,but the results were *** this study,we explore the association among COMT,GAD and antidepressant response in Chinese Han ***:One hundred and two patients with GAD and 120 healthy controls(HC) were *** patients were treated with escitalopram or venlafaxine for 8 *** Hamilton Rating Scale for Anxiety(HAMA) were used to assess the treatment *** participants were genotyped for the COMT Val158 Met polymorphism with the method of polymerase chain ***:No significant differences of the frequency of COMT rs4680 polymorphism was found between the GAD and HC group,or between patients with different ***,we found no significant correlation between the COMT rs4680 polymorphism,genders and antidepressant treatment outcome for eight weeks in GAD ***:Our observations indicated that COMT rs4680 genotypes might be neither related with GAD and genders in GAD patients,nor did have effects on antidepressants therapeutic response in GAD *** so,our research will be helpful for providing guidance and direction for future research with higher power.

关键词： generalized anxiety disorder catechol-O-methyltransferase allele genotype antidepressant treatment response

Early improvement predicts 8-week treatment outcome in patients with generalized anxiety disorder treated with Escitalopram or Venlafaxine

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Early improvement predicts 8-week treatment outcome in patie...

2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会

作者： Mincai Qian Zhongxia shen Min Lin Tiefeng Guan Jianhong Yang Liang Li xinhua shen Yonggui Yuan Department of Neurosis and Psychosomatic Diseases.Huzhou Third Municipal Hospital Department of Neuropsychiatry Affiliated ZhongDa Hospital Medical School of Southeast University

Objective To investigate whether early improvement can predict 8-week treatment outcome in patients with generalized anxiety disorder(GAD) treated with escitalopram or *** 226 GAD patients were randomly assigned to receive either escitalopram or venlafaxine for 8 *** severity of the disease was evaluated with Hamilton anxiety rating scale(HAMA) and Hamilton depression rating scale(HAMD) at baseline and at the end of the 1st,2ed,4th,and 8th week,*** improvement was defined as a ≧ 20%reduction from baseline in HAMA score at week 1 or 2,remission as the HAMA score of ￡7,response as a≧ 50%reduction from baseline in HAMA score,and nonresponse as a <50%reduction from baseline in HAMA score,*** sensitivity,specificity,positive predictive value,and negative predictive value were *** In escitalopram-treated patients,the positive and negative predictive value of the early improvement at week 1 were 85.19%and 67.53%,and that at week 2 were 53.75%and 79.17%;In venlafaxine-treated patients,the positive and negative predictive value of the early improvement at week 1 were 84.62%and 65.33%,and that at week 2 were 59.21%and 88.00%,*** The early improvement achieved within the first week of escitalopram or venlafaxine treatment can predict a good 8-week treatment outcome in GAD patients.

关键词： Generalized anxiety disorder escitalopram venlafaxine efficacy early improvement

The role of adiponectin in predicting treatment response among the Chinese population with generalized anxiety disorder

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The role of adiponectin in predicting treatment response amo...

2019第四届之江精神医学交流会、浙江省医学会精神病学学术大会、浙江省医师协会精神科医师分会第十二届年会

作者： Wang Feng Ren Lie Wang Xing Zhang Xiaomi shen Zhongxia Hong Xiujuan Cui Lijun Qian Guoying shen xinhua Huzhou University HuzhouZhejiang 313000PR China Department of Neurosis and Psychosomatic Diseases Huzhou 3rd HospitalHuzhouZhejiang 313000PR Chin

Objective:This study aimed to explore the characteristics of adiponectin and its role in predicting the therapeutic effect on the Chinese Han population with generalized anxiety disorder(GAD).Method:A total of 74 GAD patients were collected from the inpatients of the Department of Psychosomatic Disorders who met the inclusion criteria and were given escitalopram or venlafaxine for 8 ***,the normal healthy controls were selected from *** baseline serum adiponectin level was measured by ELISA,and the Hamilton Anxiety Rating Scale(HAMA) scores were also assessed at 0 week,as well as at 1,2,4 and8 weeks after treatment,***:Differences in serum adiponectin level between GAD patients(n=74) and healthy controls(n=72),as well as between remission and non-remission cases,were *** results suggested that,the serum adiponectin level among GAD patients(3.336±1.704 ug/ml) was higher than that in healthy controls(2.954±1.294 ug/ml),and there was no significant difference between these two groups(P>0.05).Meanwhile,no significant difference was detected in the serum adiponectin level between female(3.627 ± 1.954 ug/ml) and male(3.212 ± 1.592) GAD groups(p>0.05).In addition,differences in the baseline adiponectin level and HAMA reduction rate between remission and non-remission groups were not statistically *** contrast,the baseline adiponectin level was found to be significantly correlated with the HAMA reduction rate(r=0.237,P=0.042) among the GAD ***:Findings in this study seem to suggest that,the baseline adiponectin level can predict the improvement in GAD.

关键词： The role of adiponectin in predicting treatment response among the Chinese population with generalized anxiety disorder adiponectin

Aberrant amplitude low-frequency fluctuation(ALFF) and regional homogeneity(ReHo) in generalized anxiety disorder(GAD) and their roles in predicting treatment remission

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Aberrant amplitude low-frequency fluctuation(ALFF) and regio...

2020年浙江省医学会精神病学学术大会浙江省医师协会精神科医师分会第十三届年会

作者：沈仲夏 Jianying Zhu Lie Ren Mingcai Qian Yongliang Shao Yonggui Yuan xinhua shen 湖州市第三人民医院 Department of Neurosis and Psychosomatic Diseases Huzhou Third Municipal Hospitalthe Affiliated Hospital of Huzhou University School of Medicine Southeast University Department of Psychiatry Affiliated ZhongDa Hospital of Southeast University

Background:Generalized anxiety disorder(GAD) is a common affective disorder characterized by comprehensive anxiety with dysregulation of brain activity which can be reflected by functional magnetic resonance imaging(f-MRI).We aimed to examine abnormal aberrant amplitude low-frequency fluctuation(ALFF) and regional homogeneity(ReHo) in GAD and evaluate their ability to predict treatment ***:Using resting-state fMRI(Rs-fMRI),we examined ALFF and ReHo in 30 GAD patients and 30 healthy control(HC) *** on DEPASF4.3 Advanced Edition,voxel-based two-sample t-test analysis was performed on the ALFF and ReHo maps to compare GAD to HC groups,and to compare remitters(n=9) and nonremitters(n=21).Pearson’s correlation analysis was used to explore the relationship between baseline Hamilton Anxiety Rating Scale(HAM-A) scores/illness duration and mean ALFF/ReHo *** severity of GAD symptoms was rated with *** was defined as HAM-A≤7 by week ***:Compared to the HC group,GAD patients showed lower ALFF in the right postcentral and right precentral gyrus;lower ReHo in the right precentral,right postcentral,and left precentral gyrus;and higher ReHo in the left posterior cingulate *** values for left postcentral gyrus was negatively correlated with baseline HAM-A,while that of the middle frontal gyrus was positively correlated with baseline HAM-A *** value of the left postcentral gyrus was negatively correlated with baseline HAM-A,while that of the right middle frontal gyrus was positively correlated with baseline HAM-A *** of the right frontaluperiorrbital and right frontalmedial-orbital cortex was positively correlated with illness *** of the left supplementary motor area cortex was negatively correlated with illness *** showed higher ALFF in the left hippocampus and higher ReHo value in the right postcentral cortex compared to ***:These results suggest that altered

关键词： Generalized anxiety disorder(GAD) amplitude low-frequency fluctuation(ALFF) regional homogeneity(ReHo) remission

《重复经颅磁刺激技术在精神障碍临床应用中的操作规范》团体标准解读

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中华精神科杂志 2024年第3期57卷 133-137页

作者：李上达胡少华周和统陈京凯董问天王红星王继军谭立文刘忠纯王化宁程宇琪刘志芬王育梅邓伟沈鑫华魏波李达尧利书臧玉峰陆林黄满丽浙江大学医学院附属第一医院精神卫生中心杭州310003 北京大学第六医院北京100191 首都医科大学宣武医院北京100053 上海市精神卫生中心上海200030 中南大学湘雅二医院长沙410012 武汉大学人民医院武汉430060 空军军医大学西京医院西安710032 昆明医科大学第一附属医院昆明650032 山西医科大学第一医院太原030001 河北医科大学第一医院石家庄050030 杭州市第七人民医院杭州310013 湖州市第三人民医院湖州313000 江西省精神病院南昌330029 华东师范大学上海200062 武汉依瑞德医疗设备新技术有限公司武汉430000 杭州师范大学附属医院认知与脑疾病研究中心杭州310015

重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)已成为精神医学领域重要的治疗手段,然而在临床应用中还存在不少问题。本文对中国医药教育协会发布的T/CMEAS 011-2023《重复经颅磁刺激技术在精神障碍临床应用中的... 详细信息

重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)已成为精神医学领域重要的治疗手段,然而在临床应用中还存在不少问题。本文对中国医药教育协会发布的T/CMEAS 011-2023《重复经颅磁刺激技术在精神障碍临床应用中的操作规范》团体标准进行解读,内容包括rTMS的应用范围、规范性引用文件、rTMS相关术语和定义、场地规范、设备规范、rTMS专业技术人员的能力规范、rTMS的操作流程规范、相关不良反应等,为重复经颅磁刺激技术在精神障碍中的规范应用提供参考。

关键词：重复经颅磁刺激精神障碍操作规范

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图书馆教育模式构建

图书馆学刊 2005年第6期27卷 35-38页

作者：谌新华哈尔滨学院图书馆哈尔滨150086

随着数字信息环境的形成,图书馆教育逐渐成为社会所认同的教育形式。阐述了图书馆教育的概念、特点、作用、内容,介绍了图书馆教育模式。

关键词：网络图书馆图书馆教育模式