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Enhanced stability of Fe-modified CuO-ZnO-ZrO_(2)-Al_(2)O_(3)/HZSM-5 bifunctional catalysts for dimethyl ether synthesis from CO_(2)hydrogenation

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Chinese Journal of Chemical Engineering 2021年第10期34卷 106-113页

作者： Xiao Fan Shoujie Ren Baitang Jin Shiguang Li Miao Yu xinhua liang Department of Chemical and Biochemical Engineering Missouri University of Science and TechnologyRollaMO 65409United States Gas Technology Institute 1700 South Mount Prospect RoadDes PlainesIL 60018United States Department of Chemical and Biological Engineering Rensselaer Polytechnic InstituteTroyNY 12180United States

A series of iron(Fe)modified CuO-ZnO-ZrO_(2)-Al_(2)O_(3)(CZZA)catalysts,with various Fe loadings,were prepared using a co-precipitation method.A bifunctional catalyst,consisting of Fe-modified CZZA and HZSM-5,was studied for dimethyl ether(DME)synthesis via CO_(2)*** effects of Fe loading,reaction temperature,reaction pressure,space velocity,and concentrations of precursor for the synthesis of the Fe-modified CZZA catalyst on the catalytic activity of DME synthesis were ***-term stability tests showed that Fe modification of the CZZA catalyst improved the catalyst stability for DME synthesis via CO_(2)*** activity loss,in terms of DME yield,was significantly reduced from 4.2%to 1.4%in a 100 h run of reaction,when the Fe loading amount was 0.5(molar ratio of Fe to Cu).An analysis of hydrogen temperature programmed reduction revealed that the introduction of Fe improved the reducibility of the catalysts,due to assisted adsorption of H2 on iron *** good stability of Femodified CZZA catalysts in the DME formation was most likely attributed to oxygen spillover that was introduced by the addition of iron *** could have inhibited the oxidation of the Cu surface and enhanced the thermal stability of copper during long-term reactions.

关键词： CO_(2)hydrogenation Cu-ZnO based catalyst Iron(Fe) Dimethyl ether(DME) Stability

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The neuronal basis of how sexual experience modulates male aggression

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National Science Review 2014年第4期1卷 473-474页

作者： xinhua liang Yi Rao Chuan Zhou School of Life Sciences Peking University

Aggression is vital for animal survival and evolution,but excessive aggression should be suppressed for the sake of individual energy expenditure and social *** level is inluenced by environment,social experience and internal *** melanogaster provides an ideal genetic system to understand the molecular and neuronal basis of diferent aspects of ***

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Effects of mixing methods of bifunctional catalysts on catalyst stability of DME synthesis via CO_(2)hydrogenation

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Carbon Resources Conversion 2019年第1期2卷 85-94页

作者： Shoujie Ren Shiguang Li Naomi Klinghoffer Miao Yu xinhua liang Department of Chemical and Biochemical Engineering Missouri University of Science and TechnologyRollaMO 65409United States Gas Technology Institute 1700 South Mount Prospect RoadDes PlainesIL 60018United States Department of Chemical and Biological Engineering Rensselaer Polytechnic InstituteTroyNY 12180United States

The effects of three different mixing methods of CuO/ZnO/Al_(2)O_(3)(CZA)and HZSM-5 bifunctional catalyst on the stability for dimethyl ether(DME)synthesis from carbon dioxide(CO_(2))hydrogenation were *** the bifunctional catalyst was prepared by method A(mixing powder without pelletization),there was no significant change in DME production and catalyst stability when the HZSM-5 loading was varied between 0.1 g and 0.5 g with a fixed CZA loading of 0.5 g,.When the bifunctional catalysts were prepared by method B(pressed into pellets of CZA and pellets of HZSM-5 and then mixed)and method C(mixed CZA and HZSM-5 powders,then pressed into pellets),the mixing methods did not initially impact CO_(2)conversion and had a minor effect on DME ***,long-term tests(100 h)indicated that the mixing method had a significant influence on the catalyst *** B showed the best stability and the extent of catalyst deactivation followed the sequence of method B

关键词： Dimethyl ether(DME) CO_(2)hydrogenation Bifunctional catalyst Mixing method

Pd-modified CuO-ZnO-Al_(2)O_(3)catalysts via mixed-phases-containing precursor for methanol synthesis from CO_(2)hydrogenation under mild conditions

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Carbon Resources Conversion 2024年第1期7卷 10-20页

作者： Xiao Fan Kaiying Wang Xiaoqing He Shiguang Li Miao Yu xinhua liang Linda and Bipin Doshi Department of Chemical and Biochemical Engineering Missouri University of Science and TechnologyRollaMO 65409United States Department of Energy Environmental and Chemical EngineeringWashington University in St.LouisSt.LouisMO 63130United States Electron Microscopy Core Facility University of MissouriColumbiaMO 65211United States Department of Mechanical and Aerospace Engineering University of MissouriColumbiaMO 65211United States Gas Technology Institute 1700 South Mount Prospect RoadDes PlainesIL 60018United States Department of Chemical and Biological Engineering University at BuffaloBuffaloNY 14260United States

A series of palladium-modified(Pd-modified)CuO-ZnO-Al_(2)O_(3)(CZA)catalysts with various Pd loadings(0.3 wt%to 2.4 wt%)were prepared using the wetness impregnation method,on two CZA supports with different structures that are CZA-aged precursor composed of a mixture of zincian-malachite and hydrotalcite-like phases(CZA-zH),and CuO-ZnO-Al_(2)O_(3)metal oxide nanoparticles(CZA-MO).Enhancement on catalytic activity can be observed on both Pd-modified CZA catalysts in a temperature range of 180-240℃for methanol synthesis via CO_(2)***/CZA-zH catalysts exhibited a more efficient and stable production of methanol at a relatively low reaction temperature of 180℃for 100 hrs of *** improvement of activity is mainly ascribed to a higher surface area and abundant oxygen-containing functional groups(e.g.,-OH)of CZA-zH support,which is beneficial for better adsorption and distribution of Pd *** temperature programmed reduction and X-ray photoelectron spectroscopy results demonstrated a better interaction between Pd and Cu on Pd/CZA-zH catalysts via enhanced reducibility of CuO,and peak shift of Cu to a lower binding *** difference in the efficient utilization of hydrogen spillover effect of Pd promoter over two CZA supports resulted in the different performances for methanol synthesis under mild reaction co℃nditions.

关键词： CO_(2)hydrogenation Low-temperature methanol synthesis Pd-modification CuO-ZnO-Al_(2)O_(3) Hydrogen spillover

Suppression of cell pyroptosis by omeprazole through PDE4-mediated autophagy in gastric epithelial cells

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BIOCELL 2023年第12期47卷 2709-2719页

作者： LIPING YE HUIYAN SUN xinhua liang WENXU PAN LI XIANG WENJUN DU LANLAN GENG WANFU XU SITANG GONG Department of Pediatrics The First School of Clinical Medicine of Jinan UniversityThe First Affiliated HospitalJinan UniversityGuangzhouChina Department of Gastroenterology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina Department of Gastroenterology Guangdong Provincial Clinical Research Center for Child HealthGuangzhou Medical UniversityGuangzhouChina Department of Nephrology Zhuhai Maternal and Child Health HospitalZhuhaiChina

Helicobacter pylori is a risk factor for the development of peptic ulcers with autophagy *** was widely known as the first-line regimen for ***-associated ***:The objective of this work was to assess the role of omeprazole on cell pyroptosis and ***:The clinical samples were *** polymerase chain reaction,western blotting,enzyme linked immunosorbent assay,and immunofluorescence(IF)analysis were conducted to reveal the mechanism of omeprazole on cell pyroptosis and ***:The results revealed that omeprazole could decrease cell pyroptosis,which was attributed to the downregulation of cleaved caspase-1 expression,resulting in the inhibition of gasdermin E and interleukin-18/1βmaturation and secretion as well as the resolution of ***,omeprazole treatment led to drastic downregulation of mammalian target of rapamycin(mTOR)activity was observed in BGC823 cells,leading to enhanced autophagy characterized by increased LC3II expression,which further reduced cell *** omeprazole-mediated phenomenon was enhanced after phosphodiesterase-4(PDE4)inhibitor dipyridamole(DIP)*** addition,activation of mTOR by MHY1485 could rescue the suppression of cell pyroptosis induced by *** importantly,IF analysis suggested that phosphorylation of mTOR and PDE4 activity and caspase-1 were enhanced in ***-infected gastric ***:These findings indicate that omeprazole suppresses cell pyroptosis through PDE4-mediated autophagy in gastric epithelial cells,and DIP enhanced the omeprazole-mediated inhibition of cell pyroptosis,implying that DIP is an alternative combined therapy strategy in improving the treatment of patients with *** infection.

关键词： Omeprazole Autophagy Dipyridamole mTOR Cell pyroptosis

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3086-3109页

作者： Yihang Hao Haofan Wang Xianggen Liu Wenrui Gai Shilong Hu Wencheng Liu Zhuang Miao Yu Gan Xianghua Yu Rongjia Shi Yongzhen Tan Ting Kang Ao Hai Yi Zhao Yihang Fu Yaling Tang Ling Ye Jin Liu xinhua liang Bowen Ke State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China College of Computer Science Sichuan UniversityChengdu 610065China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineNational-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic *** primary challenge is to integrate diverse pharmacophores within a single-molecule *** address this,we introduced DeepSA,a novel edit-based generative framework that utilizes deep simulated annealing for the modification of articaine,a wellknown local *** integrates deep neural networks into metaheuristics,effectively constraining molecular space during compound *** framework employs a sophisticated objective function that accounts for scaffold preservation,anti-inflammatory properties,and covalent *** a sequence of local editing to navigate the molecular space,DeepSA successfully identified AT-17,a derivative exhibiting potent analgesic properties and significant anti-inflammatory activity in various animal *** insights into AT-17 revealed its dual mode of action:selective inhibition of NaV1.7 and 1.8 channels,contributing to its prolonged local anesthetic effects,and suppression of inflammatory mediators via modulation of the NLRP3 inflammasome *** findings not only highlight the efficacy of AT-17 as a multifunctional drug candidate but also highlight the potential of DeepSA in facilitating AI-enhanced drug discovery,particularly within stringent chemical constraints.

关键词： Multifunctional drugs Deep simulated annealing Molecule generation Articaine derivatives AI-enhanced drug discovery

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网壳筒体-混凝土芯筒结构的设计方法研究

钢结构(中英文) 2008年第1期 77-78页

作者： Jinghai Gong and xinhua liang

网壳筒体-混凝土芯筒是一种新的结构体系,混凝土芯筒在中心,网壳筒体在外面。混凝土芯筒的剪切刚度大,外部网壳筒体抗倾覆能力也很大,这种组合能减少地震造成的结构损坏,显著提高结构的抗震能力。介绍了构建这种结构的基本设计程序,特... 详细信息

网壳筒体-混凝土芯筒是一种新的结构体系,混凝土芯筒在中心,网壳筒体在外面。混凝土芯筒的剪切刚度大,外部网壳筒体抗倾覆能力也很大,这种组合能减少地震造成的结构损坏,显著提高结构的抗震能力。介绍了构建这种结构的基本设计程序,特别指出了设计的关键问题。进行了综合的结构分析,全面评估了新结构形式的性能。提出了评估这种结构的新的实用方法,采用等价杆系模型近似地模拟钢筋混凝土剪力墙和板,通过调整弹性模量和材料的密度,使其与现有的结构具有相近的整体刚度和质量。最后,通过工程验证了相关的设计方法,证明对于高层建筑设计这是一个合适的方法。

关键词：网壳筒体-混凝土芯筒高层建筑等价杆系模型侧向抗力传递路径

低速冲击作用下碳纤维复合材料铺层板的损伤分析

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复合材料学报 2006年第2期23卷 150-157页

作者：张彦朱平来新民梁新华上海交通大学机械与动力工程学院车身制造技术中心上海200030

建立了一个有效计算模型,以分析碳纤维复合材料层合板在低速冲击作用下的层内和层间失效行为。针对铺层板的层内损伤,在基于应变描述的Hashin失效准则的基础上,建立了单层板的逐渐累积损伤分析模型;针对铺层板的脱层损伤,建立了各向同... 详细信息

建立了一个有效计算模型,以分析碳纤维复合材料层合板在低速冲击作用下的层内和层间失效行为。针对铺层板的层内损伤,在基于应变描述的Hashin失效准则的基础上,建立了单层板的逐渐累积损伤分析模型;针对铺层板的脱层损伤,建立了各向同性脱层损伤模型,通过结合传统的应力失效准则和断裂力学中的能量释放率准则定义了界面损伤演化规律,并在潜在产生脱层的区域模拟为粘结接触,并将脱层损伤模型作为界面的接触行为。该计算模型通过商用有限元软件ABAQUS/Explicit的用户子程序实现。使用该计算模型对碳纤维增强环氧树脂复合材料层合板在横向低速冲击作用下的损伤和变形行为进行预测分析。数值仿真的结果与试验结果进行了比较,取得了满意的结果,验证了该模型的正确性。

关键词：层合板逐渐累积损伤模型脱层损伤模型低速冲击

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两级量测更新的粒子滤波检测前跟踪算法

传感技术学报 2015年第1期28卷 115-120页

作者：陈延军梁新华潘泉梁彦西安石油大学光电油气测井与检测教育部重点实验室西安710065 西北工业大学自动化学院控制与信息研究所西安710072

针对低信噪比下弱目标的检测与跟踪问题,提出了一种基于两级量测更新的粒子滤波器检测前跟踪算法。算法在粒子滤波状态更新之后,在其状态估计附近,引入卡尔曼滤波框架,进行第2级的量测更新,提高了粒子携带信息的利用程度。仿真结果表明... 详细信息

针对低信噪比下弱目标的检测与跟踪问题,提出了一种基于两级量测更新的粒子滤波器检测前跟踪算法。算法在粒子滤波状态更新之后,在其状态估计附近,引入卡尔曼滤波框架,进行第2级的量测更新,提高了粒子携带信息的利用程度。仿真结果表明,新算法获得了更好的检测和跟踪性能。

关键词：弱小目标检测前跟踪粒子滤波两级量测更新

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