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BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules

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Cancer Biology & Medicine 2019年第1期16卷 131-138页

作者： Ya Wu Ting Xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao xinhua ye Meiping Shen Xiaohong Wu Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Department of Endocrinology Jiangsu Province Official Hospital Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules.

关键词： Papillary thyroid carcinoma fine-needle aspiration cytology(FNAC) BRAFV600E thyroid imaging reporting and data system(TIRADS) Bethesda classification

Application of the back-error propagation artificial neural network(BPANN) on genetic variants in the PPAR-γ and RXR-α gene and risk of metabolic syndrome in a Chinese Han population

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The Journal of Biomedical Research 2014年第2期28卷 114-122页

作者： Xu Zhao Kang Xu Hui Shi Jinluo Cheng Jianhua Ma Yanqin Gao Qian Li xinhua ye Ying Lu Xiaofang Yu Juan Du Wencong Du Qing ye Ling Zhou Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical University Department of Endocrinology the Affiliated Changzhou Second HospitalNanjing Medical University Department of Endocrinology the First Affiliated HospitalNanjing Medical University Department of Endocrinology the Third Affiliated HospitalNanjing Medical University

This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propaga- tion artificial neural network （BPANN）. We established the model based on data gathered from metabolic syndrome patients （n = 1012） and normal controls （n = 1069） by BPANN. Mean impact value （MIV） for each input variable was calculated and the sequence of factors was sorted according to their absolute MIVs. Generalized multifactor dimensionality reduction （GMDR） confirmed a joint effect of PPAR-9＂ and RXR-a based on the results from BPANN. By BPANN analysis, the sequences according to the importance of metabolic syndrome risk fac- tors were in the order of body mass index （BMI）, serum adiponectin, rs4240711, gender, rs4842194, family history of type 2 diabetes, rs2920502, physical activity, alcohol drinking, rs3856806, family history of hypertension, rs1045570, rs6537944, age, rs17817276, family history of hyperlipidemia, smoking, rs1801282 and rs3132291. However, no polymorphism was statistically significant in multiple logistic regression analysis. After controlling for environmental factors, A1, A2, B1 and B2 （rs4240711, rs4842194, rs2920502 and rs3856806） models were the best models （cross-validation consistency 10/10, P = 0.0107） with the GMDR method. In conclusion, the interaction of the PPAR-γ and RXR-α gene could play a role in susceptibility to metabolic syndrome. A more realistic model is obtained by using BPANN to screen out determinants of diseases of multiple etiologies like metabolic syndrome.

关键词： back-error propagation artificial neural network （BPANN） metabolic syndrome peroxisome prolif-erators activated receptor-γ （PPAR） gene retinoid X receptor-α （RXR-α） gene adiponectin

Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk:a case-control study of a Chinese Han population

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The Journal of Biomedical Research 2011年第1期25卷 33-41页

作者： Juan Du Hui Shi Ying Lu Wencong Du Yuanyuan Cao Qian Li Jianhua Ma xinhua ye Jinluo Cheng Xiaofang Yu Yanqin Gao Ling Zhou Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 210029 China Department of Endocrinology the Affiliated Nanjing First Hospital of Nanjing Medical University Nanjing Jiangsu 210006 China Department of Endocrinology the Affiliated Changzhou Second Hospital of Nanjing Medical University Changzhou Jiangsu 213003 China Department of Endocrinology the Affiliated Yizheng Third Hospital of Nanjing Medical University Yizheng Jiangsu 211900 China

Peroxisome proliferator-activated receptor （PPAR-γ）,which is mainly involved in adipocyte differentiation, has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis. We investigated the frequencies of two common tagging polymorphisms of the PPAR-γ gene and two of PPAR-α with minor allele frequency （MAF）≥ 0.05 in the Chinese Han population and analyzed the correlation between the different genotypes and the risk of type 2 diabetes mellitus （T2DM）. TaqMan assay was performed to test the genotypes in T2DM patients （n = 1,105） and normal controls （n = 1,107）. Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs17817276GG, rs3856806CT and rs3856806CT/TT of PPAR-γ were associated with T2DM, P = 0.023,0.037 and 0.018, respectively. Furthermore, the prevalence of haplotype GT in PPAR-γ was less frequent in the case subjects （0.3%） than in the controls （1.9%） [P 0.001,OR（95%CI）=0.13 （0.06-0.31）]. Patients with genotype TT of rs3856806 had a higher serum level of adiponectin than those with the genotype CC and CT （P = 0.031 and 0.038, respectively）. There was no statistically significant difference between patients and controls in genotype distribution of rs6537944 and rs1045570 of the RXR-α gene. The present study suggests that the variant genotypes in the PPAR-γ gene could decrease the risk for the development of T2DM in the Chinese Han population.

关键词： peroxisome proliferators-activated receptor-γ retinoid X receptor-α type 2 diabetes mellitus single nucleotide polymorphism serum adiponectin

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肠道菌群影响认知功能机制的研究进展

分子诊断与治疗杂志 2024年第3期16卷 395-397,402页

作者：阮舒萍张青刘娟叶新华南京医科大学附属常州第二人民医院内分泌科江苏常州213164

随着人们对肠道菌群不断深入的探究,已知肠道菌群与肥胖、糖尿病、焦虑、忧郁、神经退行性疾病等多种疾病相关。其中,研究者们发现肠道菌群可以影响认知功能,“微生物-肠-脑轴”逐渐成为研究热点,肠道菌群与中枢神经系统之间的交流涉及... 详细信息

随着人们对肠道菌群不断深入的探究,已知肠道菌群与肥胖、糖尿病、焦虑、忧郁、神经退行性疾病等多种疾病相关。其中,研究者们发现肠道菌群可以影响认知功能,“微生物-肠-脑轴”逐渐成为研究热点,肠道菌群与中枢神经系统之间的交流涉及免疫、神经、内分泌等复杂机制。本文旨在阐明肠道菌群对认知功能的影响及其机制,为认知功能障碍的治疗提供新思路。

关键词：肠道菌群认知微生物-肠-脑轴

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辉南县国有林区森林火灾隐患源头治理措施

吉林林业科技 2024年第1期53卷 42-45页

作者：石岩章森叶新华张杰张影石磊辉南县林业局吉林通化135100 长春市九台区九郊街道吉林长春130500

本文从明确工作指导思想、目标、方式方法和保障措施几个方面总结了辉南县在开展国有林区森林火灾隐患源头治理工作中采取的措施,将森林火灾隐患源头治理工作作为加强国有林区森林防灭火工作的有效手段,使国有林区森林火灾隐患得到有效... 详细信息

本文从明确工作指导思想、目标、方式方法和保障措施几个方面总结了辉南县在开展国有林区森林火灾隐患源头治理工作中采取的措施,将森林火灾隐患源头治理工作作为加强国有林区森林防灭火工作的有效手段,使国有林区森林火灾隐患得到有效遏制,收到了明显成效。

关键词：辉南县国有林区森林火灾治理措施

经阴道超声造影引导穿刺活检在宫颈癌漏诊患者中的临床特征

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影像科学与光化学 2024年第2期42卷 119-127页

作者：朱成涛刘辉王南张楠王丽杰乔薇叶新华南京医科大学附属宿迁第一人民医院超声医学科江苏宿迁223800 南京医科大学第一附属医院(江苏省人民医院)超声医学科江苏南京210029

目的:探讨经阴道超声造影引导穿刺活检在宫颈癌漏诊患者中的临床特征。方法:选取2019年4月至2022年10月于我院经术后病理确诊的95例宫颈癌患者为研究对象,依据患者穿刺活检与术后病理结果分为符合组(n=75)和不符组(n=20)。比较两组患者... 详细信息

目的:探讨经阴道超声造影引导穿刺活检在宫颈癌漏诊患者中的临床特征。方法:选取2019年4月至2022年10月于我院经术后病理确诊的95例宫颈癌患者为研究对象,依据患者穿刺活检与术后病理结果分为符合组(n=75)和不符组(n=20)。比较两组患者临床资料差异,采用受试者操作特征(ROC)曲线确定诊断效能,Logistic回归法分析漏诊危险因素,R 4.0.6软件构建列线图模型,以Bootstrap自抽样法进行模型验证。结果:95例宫颈癌患者经阴道超声造影引导穿刺活检总符合率为78.95%,一致性检验显示Kappa=0.762,一致性较好。宫颈癌Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期的曲线下面积分别为0.543(95%CI:0.07~1.00)、0.877(95%CI:0.74~1.00)、0.640(95%CI:0.15~1.00)和0.734(95%CI:0.29~1.00)。两组患者的年龄、妊娠次数、既往宫颈治疗史、临床症状表现、病检等级、HPV感染、HPV分型、病变/宫颈面积比差异有统计学意义(P0.05)。决策曲线显示,可选阈概率范围大且净获益高,模型临床实用性强。结论:宫颈癌患者经阴道超声造影引导穿刺活检总符合率为78.95%。漏诊患者具有既往宫颈治疗史、临床症状表现明显、妊娠次数<4次、低级别病变、HPV感染阴性、病变/宫颈面积比<50%的临床特征。基于此构建的列线图模型区分度好、准确性高、临床实用性强。

关键词：经阴道超声造影引导穿刺活检宫颈癌漏诊

Review on Anti-Frost Technology Based on Microchannel Heat Exchanger

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 161-178页

作者：叶振鸿王炜李新华陈江平 Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China Shanghai High Eficient Cooling System Research Center Shanghai 200240China

Frosting is an inevitable adverse phenomenon in many fields such as industrial refrigeration,cryo-genics,and heat pump air conditioning,which may influence the efficiency of the equipment and increase the energy consumption of the system.The complicated louvered-fin structure and fuid-channels arrangements of the microchannel heat exchanger(HEX)will affect the heat transfer performance and frosting characteristics.First,this article analyzes different factors such as refrigerant distribution,refrigerant fow pattern,and HEX surface temperature distribution.Further,combined with the features of the microchannel HEX,the existing anti-frosting technologies and various methods of surface treatment for anti-frosting are summarized.The review focuses on the preparation of superhydrophobic surfaces and their superior properties.Furthermore,the internal mechanism is analyzed in conjunction with the relevant research of our group.Superhydrophobic character has excellent anti-frosting performance and heat transfer performance,which is of great significance for improving energy-saving and system performance.Finally,the future development of superhydrophobic surface technology is analyzed and prospected.

关键词： anti-frost technology microchannel heat exchanger(HEX) superhydrophobic surface

Working Fluid Distribution and Charge Regulation Control in Organic Rankine Cycle

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 188-201页

作者：叶振鸿李新华王炜陈江平 Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China Shanghai High Efficient Cooling System Research Center Shanghai 200240China

Charge-based studies,in particular investigations of mass distribution,are still almost absent,although the efficiency of the organic Rankine cycle(ORC)has attracted a great deal of scholarly attention.This paper aims to provide a new perspective on the intrinsic relationship among the mass distribution,phase-zone distribution in the heat exchanger(HEX),charge of working fuid(WF),rotation speed of the pump(RSP),and system performance.A comprehensive ORC simulation model is presented by linking each component's sub-models,including the independent models for HEX,pump,and expander in an object-oriented fashion.The visualization study of mass distribution of the WF in the system is investigated under different working conditions.Furthermore,the volume and mass of the gas phase,two-phase and liquid phase of WF in the HEX and their variation rules are analyzed in-depth.Finally,the strategies of charge reduction considering HEX areas and pipe sizes are investigated.The results show that the model based on the interior-point method provides high levels of accuracy and robustness.The mass ratio of the WF is concentrated in the liquid receiver,especially in the regenerator,which is 32.9%and 21.9%of the total mass,respectively.Furthermore,2.4 kg(6.9%)WF in the system gradually migrates to the high-temperature side as the RSP increases while 6.1 kg(17.4%)WF migrates to the low-temperature side,especially to the condenser,as the charge in the system increases.Output power and efficiency both decrease gradually after the peak due to changes in RSP and charge.Last,reducing heat transfer areas of the condenser and regenerator is the most effective way to reduce WF charge.

关键词： simulation organic Rankine cycle(ORC) working fuid charge mass distribution

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鸢尾素调控葡萄糖稳态的研究进展

南京医科大学学报（自然科学版） 2022年第6期42卷 886-890页

作者：孙晓鑫张青叶新华南京医科大学附属常州第二人民医院内分泌科江苏常州213164

鸢尾素是一种肌细胞因子,具有诱导白色脂肪褐变、改善胰岛素抵抗等生物学作用。近年来,研究发现鸢尾素具有抑制胰岛β细胞凋亡、增加肌肉和脂肪组织葡萄糖摄取、促进肝糖原合成、抑制肝糖异生及脂肪堆积等作用。鸢尾素通过上述作用能有... 详细信息

鸢尾素是一种肌细胞因子,具有诱导白色脂肪褐变、改善胰岛素抵抗等生物学作用。近年来,研究发现鸢尾素具有抑制胰岛β细胞凋亡、增加肌肉和脂肪组织葡萄糖摄取、促进肝糖原合成、抑制肝糖异生及脂肪堆积等作用。鸢尾素通过上述作用能有效维持机体葡萄糖平衡。基于以上理论研究,文章旨在阐述鸢尾素在调节葡萄糖稳态中的作用及其机制。

关键词：鸢尾素糖尿病葡萄糖稳态肌细胞因子