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Journal of Materials Science & Technology 2007年第4期23卷 574-576页

作者： xinhua LI Kai QIU Fei ZHONG Zhijun YIN Changjian ji Yuqi WANG Key Laboratory of Material Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China

The preparation of porous structure on the molecular beam epitaxy （MBE）-grown mixed-polarity GaN epilayers was reported by using the wet chemical etching method. The effect of this porous structure on the residual stress of subsequent-growth GaN epilayers was studied by Raman and photoluminescence （PL） spectrum. Substantial decrease in the biaxial stresse can be achieved by employing the porous buffers in the hydride vapour phase epitaxy （HVPE） epilayer growth.

关键词： GaN Hydride vapour phase epitaxy Porous buffer

Epigenetic Disorder Plays a Fundamental Role in the Etiology of Type 2 Diabetes

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Wuhan University Journal of Natural Sciences 2013年第1期18卷 9-19页

作者： ZHANG Junlong XIAO xinhua ji Linong Department of Biological Sciences/Suzhou Municipal Key Lab for the Metabolic Syndrome New Drug Development Xi'an-Jiaotong Liverpool University

Type 2 diabetes （T2D） is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the phenomenon of the metabolic memory and developmental origins of adult diabetes argues that epigenetic disorder plays critical roles in the development of T2D. Environmental factors can affect epigenetics during early fetal life until adulthood. Altered epigenetics can be maintained during mitosis and meiosis, so that the subsequent response to environ- mental cue in later life has also been altered. Epigenetic aberra- tions affect miRNA expression and functions, and altered miRNA expression can also affect expression of many genes including those relevant to epigenetics. Thus, the development of T2D is an accumulative process that may involve complex interactions be- tween altered transcription factors, miRNA functions, and in- creased epigenetics disorder in response to environmental stimuli during different stages of life.

关键词： diabetes methylation miRNA diet

Microbial community structure and diversity in deep-sea hydrothermal vent sediments along the Eastern Lau Spreading Centre

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Acta Oceanologica Sinica 2013年第2期32卷 42-51页

作者： WEI Manman ZHANG Rubing WANG Yuguang ji Houguo ZHENG jia CHEN xinhua ZHOU Hongbo School of Minerals Processing and Bioengineering Central South University Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Third Institute of Oceanography State Oceanic Administration Key Laboratory of Biometallurgy Ministry of Education

The aim of this study is to investigate microbial structures and diversities in five active hydrothermal fields＇ sediments along the Eastern Lau Spreading Centre （ELSC） in the Lau Basin （southwest Pacific）. Microbial communities were surveyed by denatured gradient gel electrophoresis （DGGE） and clone library analysis of 16S rRNA genes. The differences in microbial community structures among sediment samples from the five deep-sea hydrothermal sites were revealed by DGGE profiles. Cluster analysis of DGGE profiles sepa- rated the five hydrothermal samples into two groups. Four different 16S rRNA gene clone libraries, repre- senting two selected hydrothermal samples （19-4TVG8 and 19-4TVG11）, were constructed. Twenty-three and 32 phylotypes were identified from 166 and 160 bacterial clones respectively, including Proteobacteria, Bacteroidetes, Firmicutes, Nitrospirae and Planctomycetes. The phylum Proteobacteria is dominant in both bacterial libraries with a predominance of Gamma-Proteobacteria. A total of 31 and 25 phylotypes were obtained from 160 and 130 archaeal clones respectively, including Miscellaneous Crenarchaeotic Group, Marine Group Ⅰ and Ⅲ, Marine Benthic Group E, Terrestrial Hot Spring Crenarchaeota and Deep-sea Hy- drothermal Vent Euryarchaeota. These results show a variety of clones related to those involved in sulfur cycling, suggesting that the cycling and utilization of sulfur compounds may extensively occur in the Lau Basin deep-sea hydrothermal ecosystem.

关键词： microbial diversity deep-sea hydrothermal vent DGGE 16S rRNA gene clone libraries

SARS2基因错义突变所致HUPRA综合征的临床特征和遗传学分析并文献复习

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中华心血管病杂志 2024年第2期52卷 172-179页

作者：黄娟李秋雨吉炜郭晓峰胡晓虹福建省儿童医院心内科福州350011 首都医科大学附属北京安贞医院心内科北京市心肺血管病研究所北京100029 上海交通大学医学院附属上海儿童医学中心心内科上海200127 福建省妇幼保健院儿科福州350001 上海交通大学医学院附属新华医院心内科上海200092

目的分析高尿酸血症-肺动脉高压-肾衰竭-碱中毒综合征(HUPRAS)的SARS2致病基因特定位点的致病性。方法选取2022年3月9日就诊于福建省儿童医院的HUPRAS患儿1例,对患儿进行临床和实验室检查,抽取患儿及其父母外周血进行全外显子基因变异检... 详细信息

目的分析高尿酸血症-肺动脉高压-肾衰竭-碱中毒综合征(HUPRAS)的SARS2致病基因特定位点的致病性。方法选取2022年3月9日就诊于福建省儿童医院的HUPRAS患儿1例,对患儿进行临床和实验室检查,抽取患儿及其父母外周血进行全外显子基因变异检测,并对所筛选的变异进行Sanger测序验证及生物信息学分析。结果患儿男,6个月,其SARS2等位基因分别携带父系遗传的c.1205G>A/***402His变异和母系遗传的c.680G>A/***227Gln变异,其中c.680G>A既往未被报道。这两个变异人群频率极低,致病性软件预测其有害。Arg402和Arg227均进化高度保守,突变导致其编码的丝氨酰tRNA合成酶的氢键结构及疏水性均产生了变化,提示这两个变异能够解释患儿HUPRAS表型。结论SARS2基因的c.1205G>A/***402His和c.680G>A/***227Gln复合杂合变异可能导致HUPRAS。

关键词：线粒体疾病 SARS2基因 HUPRA综合征错义突变

Revealing HOC1 burst from endoplasmic reticulum in cisplatin-treated cells via a ratiometric fluorescent probe

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Chinese Chemical Letters 2021年第5期32卷 1795-1798页

作者： Shan Wang Beitong Zhu Bingya Wang xinhua Cao Lei Zhu ji-Ting Hou Lintao Zeng Institute of Biomedical Materials Industry Technology Hubei Engineering UniversityXiaogan 432000China College of Light Industry and Food Engineering Cuangxi UniversityNanning 530004China Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Trauma and Disaster RescueCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China College of Chemistry and Chemical Engineering Xinyang Normal UniversityXinyang 464000China

The reactive oxygen species(ROS) are tightly associated with endoplasmic reticulum(ER) ***,the deep and visual insight of aberrant ROS fluctuations in the ER can help us better investigate the ER stress-associated *** this work,a fluorescent probe ERC for HOCI detection in the ER based on phenothiazine-derived coumarin platform was *** the presence of HOCI,ERC exhibited an emission change from 609 nm to 503 nm within *** also showed high sensitivity(0.44 μmol/L)and superb ***,ERC displayed low cytotoxicity,good cell membrane permeability,and appreciable ***,the probe was successfully utilized to image exogenous and endogenous HOCl in living cells and reveal the HOCI burst in cisplatin-treated cancer cells.

关键词： Fluorescent probes Ratiometric HOCl Endoplasmic reticulum Cisplatin

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头皮糠疹的病因及治疗方法研究现状

山东化工 2018年第17期47卷 71-73页

作者：刘千汇赵方舒彭佳铭金玥李冰倩纪鑫华毕建云山东中医药大学药学院山东济南250355 山东中医药大学药学院实验中心山东济南250355

头皮糠疹给人们带来了不同程度的困扰,一直是人们研究的热点。本文介绍了头皮糠疹的定义,从中西医角度对其发病机制和治疗方法进行综述,给头皮糠疹的治疗和预防指明了新的思路和方向。

关键词：头皮糠疹病因治疗综述

Carbon black supported ultra-high loading silver nanoparticle catalyst for electro-oxidation and determination of hydrazine

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Science China Chemistry 2013年第7期56卷 911-916页

作者： TAN Chang XU xinhua WANG Feng LI ZhiLin LIU jingJun ji jing State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology

Carbon black supported ultra-high loading silver nanoparticle catalyst (Ag/CB) was prepared by a modified ethylene glycol reduction method, using ethylene glycol as the reducing agent and sodium hydroxide as the pH adjusting agent. The X-ray diffraction, thermogravimetry and scanning electron microscopy characterizations showed that the Ag nanoparticles crystallized with a face-centered cubic structure and were densely stacked on the CB surface without aggregation, despite such a small average size (ca. 10 nm) and an ultra-high loading mass (392 wt.%). The electrochemical evaluation based on cyclic voltammetry, chronoamperometry and polarization tests revealed that the ultra-high loading Ag/CB catalyst possessed a superior electrocatalytic activity for the oxidation of hydrazine, via a diffusion-limited process and a 4-electron transfer pathway. Moreover, the chronoamperometry response on an electrode modified with this ultra-high loading Ag/CB catalyst exhibited a promising application for determination of hydrazine, due to a broad linear calibration ranging from 50 to 800 μM, a high sensitivity of 0.03795 A/ M and a low detection limit of 3.47 μM.

关键词：催化剂改性银纳米粒子电催化氧化测定炭黑扫描电子显微镜联氨高载

利尿肾动态显像20分钟残留率对肾盂成形术时机选择的临床预测价值

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上海交通大学学报（医学版） 2024年第7期44卷 899-906页

作者：纪学理苟金玉陈素芸傅宏亮邹仁健王辉上海交通大学医学院附属新华医院核医学科上海200092

目的·探究利尿肾动态显像中20分钟残留率(20-minute residual rate,R_(20))等参数对于先天性单侧肾盂输尿管连接部梗阻(ureteropelvic junction obstruction,UPJO)患儿肾盂成形术手术时机的预测价值。方法·回顾性分析2018年8月到2023... 详细信息

目的·探究利尿肾动态显像中20分钟残留率(20-minute residual rate,R_(20))等参数对于先天性单侧肾盂输尿管连接部梗阻(ureteropelvic junction obstruction,UPJO)患儿肾盂成形术手术时机的预测价值。方法·回顾性分析2018年8月到2023年8月期间在上海交通大学医学院附属新华医院核医学科初次就诊的110例先天性单侧UPJO患儿的临床资料和利尿肾动态显像结果。随访患儿初次行利尿肾动态显像后的影像检查结果和肾积水进展情况。以患儿是否因肾积水进展行肾盂成形术为结局事件,将患儿分为手术组和非手术组。比较2组患儿年龄、性别、肾积水侧别,以及基线利尿肾动态显像参数包括肾血流灌注率(blood perfusion rate,BPR)、分肾功能(differential renal function,DRF)、达峰时间(time to peak,T_(max))、半排时间(time to half,T_(1/2))及R_(20)。采用Logistic回归分析各参数对肾积水进展的影响。采用受试者操作特征(receiver operating characteristic,ROC)曲线分析利尿肾动态显像参数对患儿是否需要手术干预的预测价值。采用Wilcoxon检验比较行2次利尿肾动态显像患儿的检查参数。结果·在随访过程中有60例患儿因肾积水进展行肾盂成形术,50例患儿肾积水未进展。手术组与非手术组患儿基线状态DRF、T_(max)、T_(1/2)和R_(20)的差异均有统计学意义(均P0.05)。结论·R_(20)对于先天性单侧UPJO患儿肾盂成形术的预测具有重要意义。对于R_(20)≥90.08%的患儿,应尽早行肾盂成形术,以防止肾功能进一步恶化。

关键词：利尿肾动态显像肾盂输尿管连接部梗阻先天性肾积水肾盂成形术残留率

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特应性皮炎生物靶向治疗研究发展

中国临床药理学杂志 2024年第5期40卷 768-772页

作者：刘盈姚采君曾晖陈季芳周春广州新华学院药学院广东广州510520 南方医科大学药学院广东广州510515

特应性皮炎(AD)是最常见的慢性炎症性皮肤病,几十年来,AD的治疗仅限于局部皮质类固醇、局部钙调神经磷酸酶抑制剂,对于中重度AD患者,则仅限于光疗和全身免疫抑制剂。随着AD发病机制地深入研究,许多局部和全身靶向治疗药物正在研发中,可... 详细信息

特应性皮炎(AD)是最常见的慢性炎症性皮肤病,几十年来,AD的治疗仅限于局部皮质类固醇、局部钙调神经磷酸酶抑制剂,对于中重度AD患者,则仅限于光疗和全身免疫抑制剂。随着AD发病机制地深入研究,许多局部和全身靶向治疗药物正在研发中,可能会改变AD的治疗选择。本文结合目前最新的临床试验对AD生物靶向治疗的种类、机制、疗效和安全性研究作一综述,为AD个体化治疗提供一定的理论依据。

关键词：特应性皮炎生物制剂靶向治疗临床试验

基于GMS的长春齐家地下水水源地二级保护区划分

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吉林大学学报（地球科学版） 2022年第3期52卷 955-966页

作者：鲍新华于瀚博计量吉林大学新能源与环境学院长春130021 中国电力工程顾问集团东北电力设计院有限公司长春130021

长春市双阳齐家水源地临近油田,原有的水源地一级保护区不足以调和油田开采与水源地水质安全之间日益突出的矛盾.为了保护地下水饮用水水源地不受油田开发活动的影响,为饮用水水源地所在地区的油田开发布局提出规划建议,首先查明研究区... 详细信息

长春市双阳齐家水源地临近油田,原有的水源地一级保护区不足以调和油田开采与水源地水质安全之间日益突出的矛盾.为了保护地下水饮用水水源地不受油田开发活动的影响,为饮用水水源地所在地区的油田开发布局提出规划建议,首先查明研究区内水文地质条件,然后在原有的一级水源地保护区基础上利用数值法软件GMS(groundwater model system)中的MODFLOW和MT3DMS模块对水源地建立地下水流模型和溶质运移模型,并以此对长春市双阳齐家水源地进行二级保护区划分研究,明确油田开发活动对地下水环境和水源地可能产生的污染程度和范围.模拟结果表明,污染物在地下水中运移1000d时距离污染源400~800m,以此为据共划定二级保护区33.5km^(2),并将原规划在划定的二级保护区内和边缘的油井给出取消建设或适当迁建的建议.

关键词：长春齐家水源地地下水流模拟溶质运移模拟保护区划分 GMS