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Modeling the Prediction on the Efficacy of a Homologous Third Dose of CoronaVac Against SARS-CoV-2 Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 — China, 2020–2021

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China CDC weekly 2023年第5期5卷 103-107,I0006页

作者： Xinhua Chen Xufang Bai Xinghui chen Nan Zheng Juan Yang Juanjuan Zhang Hongjie Yu School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai MunicipalityChina Shanghai Huashen Institute of Microbes and Infections Shanghai MunicipalityChina Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai MunicipalityChina

Summary What is already known about this topic?Previous studies have reported vaccine efficacy or effectiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariants for several vaccine platforms.However,there are currently few data on estimates of inactivated platform coronavirus disease 2019(COVID-19)vaccines,especially against the globally dominant subvariant—Omicron BA.5.

关键词： vaccine acute respiratory

Irreversible Electroporation Ablation for Atrial Fibrillation: Status and Challenges

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Cardiology Discovery 2022年第1期2卷 41-50页

作者： Fei Xie Yonggang chen Xinhua Chen Zhihong Zhao Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province HangzhouZhejiang 310003China The First Affiliated Hospital of Zhejiang University School of Medicine HangzhouZhejiang 310003China Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital Shanghai 201318China

Pulsed electric field(PEF)is a novel energy source by which high-voltage electric pulses are used to create irreversible electroporation.PEF is non-thermal and highly tissue-dependent in which specific targeting of the atrial myocardium is achieved and sparing of adjacent tissues is feasible,theoretically increasing the safety of the procedure,which could potentially break the trade-off between effective lesions and collateral damage and substantially improve risk-benefit ratios in atrial fibrillation(AF)ablation.Although recently published trials have shown a clear effect of AF ablation,large-scale clinical trials are lacking.Current clinical evidence has demonstrated significant efficacy in achieving durable pulmonary vein isolation without ablation-related adverse events.However,their putative benefits regarding efficacy,efficiency,and safety remain to be proven in randomized controlled trials.

关键词： Atrial fibrillation Irreversible electroporation Ablation

Implications of clinical research on adjuvant chemotherapy for gastric cancer: Where to go next?

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Chinese Journal of Cancer Research 2019年第6期31卷 892-900页

作者： Xinhua Chen Hao Liu Guoxin Li Jiang Yu Department of General Surgery Nanfang Hospital Southern Medical University

Postoperative adjuvant chemotherapy(ACT)confers superior gastric cancer(GC)survival in the Eastern cohort.However,is the current standard of ACT already excessive,or is it still necessary to increase its intensity for specific subgroups?Tailored ACT strategies for GC depend on gradual exploration by clinical trials in selected patients.Thus,understanding the implications of previous and current research can help us respond wisely and design effective,rational trials,save medical resources and make better decisions in clinical practice.After reviewing and analyzing studies on ACT for GC patients undergoing curative resection,we found that research strategies for conducting"addition""ACT for specific stages of the disease have achieved great progress in making ACT more tailored and personalized in consideration of pathology stages.Furthermore,trials indicate that"addition"ACT strategies for GC patient subgroups based on histological characteristics might be helpful to move toward a more specific tailored and personalized management approach.Designing ACT research focused on different node statuses should also be conducted according to the biological specificity of lymph node(LN)metastasis.Therefore,future trials designed to determine tailored treatment based on histological and biological characteristics for specific subgroups are urgently needed and conducted as the theme of the 2019 American Society of Clinical Oncology(ASCO):Caring for Every Patient,Learning from Every Patient.

关键词： Gastric cancer(GC) adjuvant chemotherapy(ACT) clinical trial tailored

A multi-purpose prototype test system for mechanical behavior of tunnel supporting structure: Development and application

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第2期15卷 467-476页

作者： Hongbin chen xinhua You Dajun Yuan Yang Ping China State Construction Engineering Corporation Ltd. Beijing100029China Tunnel and Underground Engineering Research Center of Ministry of Education Beijing Jiaotong UniversityBeijing100044China

A multi-purpose prototype test system is developed to study the mechanical behavior of tunnel sup-porting structure,including a modular counterforce device,a powerful loading equipment,an advanced intelligent management system and an efficient noncontact deformation measurement system.The functions of the prototype test system are adjustable size and shape of the modular counterforce structure,sufficient load reserve and accurate loading,multi-connection linkage intelligent management,and high-precision and continuously positioned noncontact deformation measurement.The modular counterforce structure is currently the largest in the world,with an outer diameter of 20.5 m,an inner diameter of 16.5 m and a height of 6 m.The case application proves that the prototype test system can reproduce the mechanical behavior of the tunnel lining during load-bearing,deformation and failure processes in detail.

关键词： Prototype test system Tunnel supporting structure Tunnel fire Lining Mechanical behavior

Line spectrum detection algorithm based on the phase feature of target radiated noise

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Journal of Systems Engineering and Electronics 2016年第1期27卷 72-80页

作者： Enming Zheng Huabing Yu Xinhua Chen Changyu Sun Institute of Acoustics Chinese Academy of Science

In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line spectrum and background noise,a weighted line spectrum detection algorithm based on the phase variance is proposed in frequency domain.After phase difference alignment,the phase variance of line spectrum and the phase of background noise,respectively,are small and big in frequency domain,this method utilizes the weighted statistical algorithm to cumulate the frequency spectrum based on the phase variance,which can restrain the background noise disturbance,and enhance the signal to noise ratio（SNR）.The theory analysis and experimental results both verify that the proposed method can well enhance the energy of line spectrum,restrain the energy of background noise,and have better detection performance under lower SNR.

关键词： information processing underwater target detection line spectrum detection phase variance.

Robust high-resolution beam-forming based on high order cross sensor processing method

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Journal of Systems Engineering and Electronics 2015年第5期26卷 932-940页

作者： Enming Zheng Xinhua Chen Huabing Yu Changyu Sun Institute of Acoustics Chinese Academy of Science

In order to obtain the robust high-resolution beamforming, a high order cross sensor processing(CSP) approach is developed. According to the relation ship between the target bearing and the phase difference of each element receiving signal, this method exploits the property that the same diagonal of covariance matrix with the same phase difference and obtains(2M-1)(N-1)virtual elements(N is the original array number) by executing M order CSP. The extended virtual elements can effectively increase the physical aperture of linear array, reduce the main lobe width of beam-forming, and improve the bearing resolution. The CSP method accumulates the data on the same sub-diagonal of the covariance matrix, which can decrease the impact of background noise on beam-forming. The theoretical analysis and experimental results both show that this method has high resolution in bearing estimation, compared with the MUSIC method, which has better robustness under the lower signal-to-noise ratio(SNR).

关键词： cross sensor processing(CSP) beam-forming virtual element robustness high-resolution

Diagnosis and treatment of icteric hepatitis caused by erythropoietic protoporphyria:A case report

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Liver Research 2022年第2期6卷 116-120页

作者： Hanqing Huang Leiqin Cai xinhua Li Shuru chen Department of Infectious Diseases and Key Laboratory of Liver Disease of Guangdong Province The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology People's Hospital of Longhua District of ShenzhenShenzhenGuangdongChina Guang Dong Clinical Research Center for Metabolic Diseases Department of EndocrinologySun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongChina

Erythropoietic protoporphyria(EPP)is a rare inherited disease caused by partial deficiency activity of the enzyme ferrochelatase(FECH),resulting in excessive accumulation of protoporphyrin IX in erythrocyte and tissues.Here,we report a patient with photosensitive dermatitis and acute icteric hepatitis caused by EPP,whose clinical and biochemical results successfully improved following 2-month treatment with glucose load,ursodeoxycholic acid capsules,and cholestyramine powder.This case provides a reference for a combination therapy strategy for patients with liver and skin injury caused by EPP.

关键词： Erythropoietic protoporphyria(EPP) Inherited disease Photosensitive dermatitis Jaundice Ferrochelatase(FECH) Liver injury Icteric hepatitis

An Enhanced Axial-flux Magnetic-geared Machine with Dual-winding Design for Electric Vehicle Applications

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中国电工技术学会电机与系统学报(英文) 2023年第3期7卷 239-247页

作者： Weinong Fu Qinying Wu Shuangxia Niu Yuanxi chen xinhua Guo Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055China college of information science and engineering Huaqiao UniversityFujian361021China IEEE The Hong Kong Polytechnic University Hong Kong999077China

Axial-flux magnetic-geared machine(MGM) is a promising solution for electric vehicle applications for combining the virtues of both axial-flux electric machine and magnetic gear. However, generalized MGMs are limited by the torque density issue, accordingly inapplicable to industrial applications. To solve the abovementioned issue, an improved axial-flux magnetic-geared machine with a dual-winding design is proposed. The key merit of the proposed design is to achieve enhanced torque performance and space utilization with the proposed design, which installs a set of auxiliary winding between modulation rings. With the proposed design, overload protection capability, and fault-tolerant capability can be also achieved, for the proposed machine can work with either the excitation of armature windings or auxiliary windings. The pole-pair, slot combination, and parametric design is studied and optimized by the 3d finite-element method and designed C++ optimization software. Electromagnetic analysis and performance comparison indicate that the proposed machine can achieve a torque enhancement of 68.6% compared to the comparison machine.

关键词： Axial-flux Dual-winding Magnetic-geared machine Torque enhancement

Concurrent improvements of corrosion resistance and coercivity in Nd-Ce-Fe-B sintered magnets through engineering the intergranular phase

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Journal of Materials Science & Technology 2022年第15期110卷 239-245页

作者： Jiaying Jin Yongming Tao xinhua Wang Zeyu Qian Wang chen chen Wu Mi Yan School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsKey Laboratory of Novel Materials for Information Technology of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China

Usually the improved coercivity of rare earth(RE)based 2:14:1-type permanent magnets via RE-rich intergranular additives is achieved at the cost of more corrosion channels and deteriorated corrosion resistance,which remains a challenging hurdle in the RE-Fe-B community.Distinctly,here we report the concurrent improvements of corrosion resistance and coercivity in 40 wt.%Ce-substituted Nd-Ce-Fe-B sintered magnets through engineering the intergranular phase using simple(Nd,Pr)H_(x)additive.The dehydrogenated Nd/Pr changes the RE concentration gradients between 2:14:1 matrix and intergranular phases during sintering and enlarges the fraction of corrosion-resistant REFe_(2) phase,rather than the conventionally assumed Nd/Pr-rich intergranular phase with high chemical vulnerability.The spontaneous formation of REFe_(2) intergranular phase after(Nd,Pr)H_(x) addition generates the uniquely enhanced corrosion resistance against the hot/humid and acidic environments,and counts as one peculiar feature of Nd-Ce-Fe-B magnets at high Ce substitution level,being distinct from previously reported Ce-free/lean RE-Fe-B.Simultaneously,the formation of continuous grain boundaries enhances the coercivity from 8.7to 12.5 k Oe with trace addition of(Nd,Pr)H_(x).Above findings may spur progress towards developing a high-performance Nd-Ce-Fe-B permanent magnet.

关键词： Abundant rare earth Ce Corrosion resistance REFe_(2) Coercivity Microstructure