检索结果-南通市图书馆

Never Lost Keys:A Novel Key Generation Scheme Based on Motor Imagery EEG in End-Edge-Cloud System

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2022年第7期19卷 172-184页

作者： Yichuan Wang Dan Wu Xiaoxue liu xinhong Hei School of computer science and Engineering Xi’an University of TechnologyXi’an 710048China Shaanxi Key Laboratory for Network Computing and Security Technology Xi’an 710048China

Biometric key is generated from the user’s unique biometric features,and can effectively solve the security problems in cryptography.However,the current prevailing biometric key generation techniques such as fingerprint recognition and facial recognition are poor in randomness and can be forged easily.According to the characteristics of Electroencephalographic(EEG)signals such as the randomness,nonlinear and non-stationary etc.,it can significantly avoid these flaws.This paper proposes a novel method to generate keys based on EEG signals with end-edgecloud collaboration computing.Using sensors to measure motor imagery EEG data,the key is generated via pre-processing,feature extraction and classification.Experiments show the total time consumption of the key generation process is about 2.45s.Our scheme is practical and feasible,which provides a research route to generate biometric keys using EEG data.

关键词： EEG biometric key generation end-edgecloud system information security

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第9期11卷 2685-2693页

作者： Jinqin Chen Xinhong Liu Shuo Yu Jia liu Rongfang Chen Yunxiao Zhang Ling Jiang Qiuyun Dai Beijing Institute of Biotechnology Beijing 100071China Key Laboratory of Magnetic Resonance in Biological System State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China College of Life Science Hunan Normal UniversityChangsha 410081China University of Chinese Academy of Sciences Beijing 100049China

ω-Conotoxins inhibit N-type voltage-gated calcium(Ca_(v)2.2)channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index.Here,we synthesized and characterized a novelω-conotoxin,Bu8 from Conus bullatus,which consists of 25 amino acid residues and three disulfide bridges.Bu8 selectively and potently inhibits depolarization-activated Ba^(2+ )currents mediated by rat Ca_(v)2.2 expressed in HEK293 T cells(IC_(50)=89 nmol/L).Bu8 is two-fold more potent thanω-conotoxin MVIIA,aω-conotoxin currently used for the treatment of severe chronic pain.It also displays potent analgesic activity in animal pain models of hot plate and acetic acid writhing but has fewer side effects on mouse motor function and lower toxicity in goldfish.Its lower side effects may be attributed to its faster binding rate and higher recovery ratios.The NMR structure demonstrates that Bu8 contains a small irregular tripleβ-strand.The structure-activity relationships of Bu8 Ala mutants and Bu8/MVIIA hybrid mutants demonstrate that the binding mode of Ca_(v)2.2 with the amino acid residues in loop 1 and loop 2 of Bu8 is different from that of MVIIA.This study characterizes a novel,more potentω-conotoxin and provides new insights for designing Ca_(v)2.2 antagonists.

关键词： N-type calcium ion channel ω-conotoxin Bu8 Analgesic activity Structure-activity relationship

In-plane grain boundary induced defect state in hierarchical NiCo-LDH and effect on battery-type charge storage

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第4期16卷 4908-4916页

作者： Jinjin Ban Xiaohan Wen Honghong Lei Guoqin Cao Xinhong Liu Chunyao Niu Guosheng Shao Junhua Hu School of Materials Science and Engineering Industrial Technology Research Institute of Resource and Materials of Henan ProvinceZhengzhou UniversityZhengzhou 450001China State Center for International Cooperation on Designer Low-carbon&Environmental Materials(CDLCEM) Zhengzhou University100 Kexue AvenueZhengzhou 450001China Henan Provincial Key Laboratory for Metal Fuel Battery Foguang Power Generation Equipment Co.Ltd50 Holly StreetZhengzhou 450000China International Laboratory for Quantum Functional Materials of Henan School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China

Domain boundaries are regarded as the effective active sites for electrochemical energy storage materials due to defects enrichment therein.However,layered double hydroxides(LDHs)tend to grow into single crystalline nano sheets due to their unique two-dimentional(2D)lattice structure.Previously,much efforts were made on the designing hierarchical structure to provide more exposed electroactive sites as well as accelerate the mass transfer.Herein,we demonstrate a strategy to introduce low angle grain boundary(LAGB)in the flakes of Ni/Co layered double hydroxides(NiCo-LDHs).These defect-rich nano flakes were self-assembled into hydrangea-like spheres that further constructed hollow cage structure.Both the formation of hierarchical structure and grain boundaries are interpreted with the synergistic effect of Ni2+/Co2+ratio in an“etching-growth”process.The domain boundary defect also results in the preferential formation of oxygen vacancy(Vo).Additionally,density functional theory(DFT)calculation reveals that Co substitution is a critical factor for the formation of adjacent lattice defects,which contributes to the formation of domains boundary.The fabricated battery-type Faradaic NiCo-LDH-2 electrode material exhibits significantly enhanced specific capacitance of 899 C·g^(−1)at a current density of 1 A·g^(−1).NiCo-LDH-2//AC asymmetric capacitor shows a maximum energy density of 101.1 Wh·kg^(−1)at the power density of 1.5 kW·kg^(−1).

关键词： sacrificial template grain boundary oxygen vacancy(Vo) hierarchical structure

Applying a new method for direct collection, volume quantification and determination of N_2 emission from water

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第1期27卷 217-224页

作者： Xinhong Liu Yan Gao Honglian Wang Junyao Guo Shaohua Yan Institute of Agricultural Resources and Environment Jiangsu Academy of Agricultural Sciences College of Resources and Environmental Science Nanjing Agricultural University

The emission of N2 is important to remove excess N from lakes, ponds, and wetlands. To investigate the gas emission from water, Gao et al.（2013） developed a new method using a bubble trap device to collect gas samples from waters. However, the determination accuracy of sampling volume and gas component concentration was still debatable. In this study, the method was optimized for in situ sampling, accurate volume measurement and direct injection to a gas chromatograph for the analysis of N2 and other gases. By the optimized new method, the recovery rate for N2 was 100.28% on average; the mean coefficient of determination（R2） was 0.9997; the limit of detection was 0.02%. We further assessed the effects of the new method, bottle full of water, vs. vacuum bag and vacuum vial methods, on variations of N2 concentration as influenced by sample storage times of 1,2, 3, 5, and 7 days at constant temperature of 15°C, using indices of averaged relative peak area（%） in comparison with the averaged relative peak area of each method at 0 day.The indices of the bottle full of water method were the lowest（99.5%–108.5%） compared to the indices of vacuum bag and vacuum vial methods（119%–217%）. Meanwhile, the gas chromatograph determination of other gas components（O2, CH4, and N2O） was also accurate. The new method was an alternative way to investigate N2 released from various kinds of aquatic ecosystems.

关键词： New method N2 Ebullition collection Direct injection Gas chromatograph

Phenotypic variation in Phoebe bournei populations preserved in the primary distribution area

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2018年第1期29卷 35-44页

作者： Yingang Li Xinhong Liu Junwei Ma Xiaomian Zhang Li-an Xu The Key Laboratory of Forest Genetics and Biotechnology of Ministry of Education Nanjing Forestry UniversityNanjing 210037 China Zhejiang Academy of Forestry Hangzhou 310023 China

Phoebe bournei（Hemsl.） Yang is a rare and protected plant in China. This study was conducted to determine the phenotypic variation in this species and to document phenotypic variation within and among populations of P. bournei. Nested analysis of variance, coefficient of variation, multiple comparisons, principal component analysis（PCA） and correlation analysis were used to analyze ten phenotypic traits in ten natural populations of P.bournei from both the northeastern and the primary region of the range of this species. Significant differences among and within populations were observed in leaf and seed phenotypic traits. Variation among populations（34.92%）was greater than that within populations（26.19%）. The mean phenotypic differentiation coefficient was 53.77% among populations, indicating that variation among populations comprised the majority of the phenotypic variation of P. bournei. The coefficient of variance（CV） of ten traits varied from 6.44 to 18.45%, with an average of 12.03%.The CV of leaf traits among populations（15.64%） was higher than that of seed traits（8.60%）, indicating that seed traits were more stable. The results from CV and PCA indicated that leaf area, leaf length and thousand seed weight were the main factors accounting for the observed phenotypic variations. Significant or highly significant correlations were observed among most leaf and/or in seed phenotypic traits, whereas no significant correlations were observed between phenotypic traits and geographic factors.Based on cluster analysis, the ten populations can be divided into three clusters. These clusters were not a result of geographic distances.

关键词： Phenotypic variation Phoebe bournei Population Principal component analysis Protection and utilization

Microstructure and high-temperature properties of Fe-Ti-Cr-Mo-B-C-Y2O3 laser cladding coating

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2020年第6期38卷 683-688页

作者： Min Zhang xinhong Wang Shushuai liu Kaili Qu School of Mechanical Engineering Shandong UniversityJinan 250061China School of Materials Science and Engineering Shandong UniversityJinan 250061China

Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 powders.Micro structure and properties of the coatings were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive spectrometer(EDS),resistance furnace and high-temperature tribometer.The results show that(Ti,Mo)C particles with flower-like and(Ti,Mo)B2 with block-like shapes are in situ formed during laser cladding.Volume faction of multiple ceramic particles increases with the increasing of Y2 O3.The cumulative oxidation mass of the coating with 2 wt% Y2 O3 is decreased by one-third than that of the coating without Y2 O3.The oxidation layer of the coating with Y2 O3 is getting smooth.Meanwhile,high temperature wear volume loss of the coating with 2 wt% Y2 O3 is about 40% that of the coating without Y2 O3.The coating with 2 wt% Y2 O3 shows a smoother wear scar and few flat grooves are observed after high temperature wear test.

关键词： Laser composite coatings Rare earth oxide High-temperature oxidation resistance High-temperature wear resistance

Spatiotemporal variations and driving factors of habitat quality in the loess hilly area of the Yellow River Basin:A case study of Lanzhou City,China

在线全文

学校读者我要写书评

暂无评论

Journal of Arid Land 2022年第6期14卷 637-652页

作者： DONG Jianhong ZHANG Zhibin liu Benteng ZHANG xinhong ZHANG Wenbin CHEN Long School of Design and Art Lanzhou University of TechnologyLanzhou 730050China School of Geography and Environment Science Northwest Normal UniversityLanzhou 730070China

Rapid industrialization and urbanization have led to the most serious habitat degradation in China,especially in the loess hilly area of the Yellow River Basin,where the ecological environment is relatively fragile.The contradiction between economic development and ecological environment protection has aroused widespread concern.In this study,we used the habitat quality of Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST-HQ)model at different scales to evaluate the dynamic evolution characteristics of habitat quality in Lanzhou City,Gansu Province of China.The spatiotemporal variations of habitat quality were analyzed by spatial autocorrelation.A Geographical Detector(Geodetector)model was used to explore the driving factors that influencing the spatial differentiation of habitat quality,including natural factors,socio-economic factors,and ecological protection factors.The results showed that the habitat quality index of Lanzhou City decreased from 0.4638 to 0.4548 during 2000-2018.The areas with reduced the habitat quality index were mainly located in the Yellow River Basin and Qinwangchuan Basin,where are the main urban areas and the new economic development areas,respectively.The spatial distribution of habitat quality presented a trend of high in the surrounding areas and low in the middle,and showed a significant positive spatial autocorrelation.With the increase of study scale,the spatial distribution of habitat quality changed from concentrated to dispersed.The spatial differentiation of habitat quality in the study area was the result of multiple factors.Among them,topographic relief and slope were the key factors.The synergistic enhancement among these driving factors intensified the spatial differentiation of habitat quality.The findings of this study can provide a scientific basis for land resources utilization and ecosystem restoration in the arid and semi-arid land.

关键词： Habitat quality spatiotemporal variations driving factors InVEST-HQ model Geodetector model Lanzhou City Yellow River Basin

Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2019年第3期10卷 161-177页

作者： Wei Shao Shasha Li Lu Li Kequan Lin Xinhong Liu Haiyan Wang Huili Wang Dong Wang Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversitySichuan 610041China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Metastasis is the leading cause of human cancer deaths.Unfortunately,no approved drugs are available for antimetastatic treatment.In our study,high-throughput sequencing-based high-throughput screening(HTS^2)and a breast cancer lung metastasis(BCLM)-associated gene signature were combined to discover anti-metastatic drugs.After screening of thousands of compounds,we identified Ponatinib as a BCLM inhibitor.Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models.Mechanistically,Ponatinib represses the expression of BCLM-associated genes mainly through the ERK/c-Jun signaling pathway by inhibiting the transcription of JUN and accelerating the degradation of c-Jun protein.Notably,JUN expression levels were positively correlated with BCLM-associated gene expression and lung metastases in breast cancer patients.Collectively,we established a novel approach for the discovery of anti-metastatic drugs,identified Ponatinib as a new drug to inhibit BCLM and revealed c-Jun as a crucial factor and potential drug target for BCLM.Our study may facilitate the therapeutic treatment of BCLM as well as other metastases.

关键词： anti-metastatic drug discovery gene expression signature high-throughput sequencing-based high-throughput screening Ponatinib breast cancer lung metastasis c-Jun

Design optimized intermixed phase by tuning polymer-fullerene intercalation for free charge generation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第7期30卷 1405-1409页

作者： Qiang Zhang Jiangang liu xinhong Yu Yanchun Han State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences. Changchun 130022 China University of the Chinese Academy of Sciences Beijing 100049 China

The inte rmixed phase is important in effective charge separation due to the formation of cascaded energy landscape between intermixed phase and pure phases in polymer/fullerene solar cells.However,the quantitative relationship between the charge separation and the content of intermixed phase has not been investigated clearly so far.Here,we proposed to tune the content of the polymer/PC71BM intermixed phase by cha nging the polymer solution conformatio n.Poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene](PBTTT)and PC71 BM was selected as a model system.The organization of the PBTTT in solution promotes the formation of ordered aggregates as aging time increases,the interdigitation of side-chains restricts the intercalation of PC71 BM.Therefore,the intermixed phase formed by intercalation PC71 BM to PBTTT side chain can be controlled.When the aging time increasing from 0 to 80 min,the extent of inte rcalation gradually from almost complete intercalated phase to almost non-intercalated.As the content of intercalated phase is about 11%,the charge dissociation is most efficie nt and short circuit current(Jsc)increased from 1.60 mA/cm2 to 4.94 mA/cm2,leading to optimized device performance.

关键词： Solution aging Intercalation Intermixed phase Three-phase morphology Polymer solar cell