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Expressions of matrix metalloproteinases and tissue inhibitor of metalloproteinases after bare and magnetic stent implantation in rabbits

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Journal of Geriatric Cardiology 2008年第2期5卷 111-116页

作者： xinhong guo guoliang jia anlin lu xinguo zhao fei li rongqing zhang Institute of Geriatric Cardiology Chinese PLA General HospitalBeijing 100853China Department of CardiologyXijing HospitalXi''an 710033China Department of CardiologyXijing HospitalXi''an 710033China Department of CardiologyXijing HospitalXi''an 710033China Department of CardiologyXijing HospitalXi''an 710033China Department of CardiologyXijing HospitalXi''an 710033China

Objective We aimed to investigate whether magnetic stent has preventive effect on in-stent restenosis by observing expressions of matrix metalloproteinase (MMP)2, MMP9, tissue inhibitor of matrix metalloproteinase (TIMP)1 and TIMP2 after balloon angioplasty, bare and magnetic stent implantation in rabbits. Methods Rabbits underwent balloon angioplasty, bare and magnetic stent implantation in the left iliac arteries. The changes of MMPs and TIMPs were examined at various time points in the injured arteries using the methods of zymography, Western blot analysis, reverse transcription-polymerase chain reaction (RT-PCR) and morphometric analysis. Results Balloon angioplasty group (BA) and magnetic stent group (MS) showed lower intrinsic gelatinolytic activity and higher expression of TIMPs with less intimae hyperplasia;Whereas bare stent (BS) group exhibited higher intrinsic gelatinolytic activity and lower expression of TIMPs with significant intimae hyperplasia. Conclusion Magnetic stent probably has preventive effect on in-stent restenosis by changing intrinsic matrix metalloproteinases activity and expression of TIMPs.

关键词： restenosis magnetic stent matrix metalloproteinase tissue inhibitor of matrix metalloproteinase

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Ultra-microstructural changes in iliac artery after bare and magnetic stent implantation in rabbits

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Journal of Geriatric Cardiology 2008年第3期5卷 182-185页

作者： xinhong guo~1 guoliang jia~2 anlin lu~2 xinguo zhao~2 fei li~2 rongqing zhang~2 1 Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China 2 Department of Cardiology, Xijing Hospital, Xi’an 710033, China Department of Cardiology Xijing Hospital Xi'an 710033 China

Objective To investigate the preventive effect of magnetic stent on coronary restenosis after percutaneous arterial stenting. Methods Twenty rabbits were divided randomly into 2 *** stent (BS group,n=10) or magnetic stent (MS group,n=10) was implanted in the left iliac artery of the rabbits of the 2 groups,*** (25rag,qd) was administered orally to the rabbits of both groups from 3 days before stenting until the rabbits were *** heparin (2500u,qd) was delivered subcuta- neously after stenting for 7 *** rabbits of each group were randomly selected to be executed at 7 or 30 *** changes in the injured arteries were studied by optical microscopey,transmissive electronic microscopey and *** At 7 days,more myofibroblasts were found migrating from adventitia to tunica media and intima in BS group than in MS *** the media and intima,large amount of smooth muscle cells of synthetic type were *** 30 days after stenting,in magnetic group, most uascular smooth muscle cells (SMCs) under the intima had transformed to contractile type and only little extracellular matrix (ECM) was observed around the SMCs;whereas,in BS group,the SMCs remained to be synthetic type and large amount of ECM was observed around the SMCs,which was composed mainly ofproteoglycans and *** Magnetic stent can inhibit proliferation and migration of SMCs and reducing the production of ECM,and therefore,may prevent restenosis after coronary stenting.

关键词： coronary atherosclorosis disease stent restenosis extracellular matrix smooth muscle cell

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