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Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu Lian Zhou xinhao Xiang yi Qin Ke Zhang Pengfei He ying Dai Wenxin Niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

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The expressions of Bcl-2 and Bax in gastric carcinoma and precancerous lesions

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The Chinese-German Journal of Clinical Oncology 2008年第1期7卷 14-16页

作者： xinhao yi Qisong Wu Huahui Li Jianmin Wu Department of Laboratory Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Laboratory Medicine Central Hospital of Shengli Oil-Field Dongying 257034 China Department of Laboratory Medicine Qingdao Municipal Hospital Qingdao 266011 China

Objective: To study the expressions of Bcl-2 and Bax proteins and explore the relationships between them and apoptosis in gastric carcinoma and precancerous lesions. Methods: TUNEL method was used to detect apoptosis and im- munohistochemical staining method was used to detect the expressions of Bcl-2 and Bax proteins in 70 cases of chronic gastritis, 49 cases of intestinal metaplasia, 64 cases of dysplasia and 81 cases of gastric carcinoma. Results: The positive incidences of Bcl-2 and Bax were the highest in severe dysplasia. In intestinal metaplasia and dysplasia, positive incidences of Bcl-2 and Bax were higher than those in chronic gastritis and gastric carcinoma. During the process of evolvement from chronic gastritis to intestinal metaplasia then to dysplasia, apoptosis indexes gradually rise up to mid-high dysplasia, which reached the highest point, then it began to fall down, when it reached the lowest point in gastric carcinoma. There were nega- tive correlations between the expressions of Bcl-2, Bax proteins and apoptosis. Conclusion: The expression of Bcl-2 may be an early behavior in the gastric carcinogenesis. Bax had antagonistic effect to Bcl-2. Detections of Bcl-2 and Bax may be beneficial to the early diagnosis of gastric tumor and precancerous lesions.

关键词： Bcl-2 Bax 胃癌病变过程

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Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response

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Cellular & Molecular Immunology 2017年第8期14卷 693-701页

作者： Hongfang Ding Hui Zhang Huifang Ding Dong Li xinhao yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju Department of Pediatrics Shengli Oil field Central Hospital31 Jinan RoadDongyingShandongChina Department of Neurology Qingdao Municipal Hospitalthe Affiliated Hospital of Medical College of Qingdao University1 Jiaozhou RoadQingdaoShandongChina Department of Pediatrics Qilu HospitalShandong University107 West Wenhua RoadJinanShandongChina

Hypoxic-ischemic brain damage(HIBD)is a common cause of infant *** purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD ***-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control ***-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast *** TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot *** tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other *** expression levels of pro-inflammatory cytokines were substantially upregulated after HI *** with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD ***,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression.

关键词： cytokine hypoxia-ischemia mesenchymal stem cell neonatal rat regulatory T cell

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One-step reduction-encapsulated synthesis of Ag@polydopamine multicore-shell nanosystem for enhanced photoacoustic imaging and photothermal-chemodynamic cancer therapy

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Nano Research 2022年第9期15卷 8291-8303页

作者： Xiao-Rui Li Baoli yin Lei Gao xinhao Li Hongwen Huang Guosheng Song yi-Ge Zhou Institute of Chemical Biology and Nanomedicine State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Materials Science and Engineering Hunan UniversityChangsha 410082China

Though imaging-guided multimodal therapy has been demonstrated as an effective strategy to improve cancer diagnosis and therapy,challenge remains as to simplify the sophisticated synthesis procedure for the corresponding ***,an insitu one-step reduction-encapsulated method has been reported,for the first time,to synthesize multicore-shell polydopaminecoated Ag nanoparticles(AgNPs@PDA)as a cancer theranostic agent,integrating amplified photoacoustic imaging,enhanced photothermal therapy,and photothermal promoted dual tumor microenvironment-coactivated chemodynamic *** photoacoustic signal and the photothermal conversion efficiency of AgNPs@PDA nanosystem present a 6.6-and 4.2-fold enhancement compared to those of M-AgNPs-PDA(simply mixing PDA and AgNPs)derived from the increased interface heat transfer coefficient and the stronger near-infrared ***,AgNPs@PDA coactivated by dual tumor microenvironment(TME)enables controllable long-term release of hydroxyl radicals(·OH)and toxic Ag+,which can be further promoted by near-infrared light ***,the high efficiency of AgNPs@PDA nanosystem with prominent photoacoustic imaging-guided synergistic photothermal-chemodynamic cancer treatment is also found in in vitro and in vivo *** a special mention,the formation mechanism of the one-step synthesized multicore-shell nanomaterials is systematically *** work provides a much simplified one-step synthesis method for the construction of a versatile nanoplatform for cancer theranostics with high efficacy.

关键词： one-step synthesis multicore-shell nanosystem photoacoustic imaging enhanced photothermal therapy dual tumor microenvironment-coactivated chemodynamic therapy

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血清葡萄糖-6-磷酸异构酶与自身免疫性疾病相关性研究

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检验医学 2007年第2期22卷 182-184页

作者：伊心浩朱新兴张旗刘东杨琴胜利石油管理局中心医院山东东营257034

目的探讨血清葡萄糖-6-磷酸异构酶(GPI)水平与各种自身免疫性疾病(AID)的关系。方法比较正常对照和各种AID确诊病例的血清GPI浓度,分析GPI在各种AID中的检测价值。结果类风湿性关节炎(RA)组的GPI浓度和阳性率都显著高于其他AID组和正常... 详细信息

目的探讨血清葡萄糖-6-磷酸异构酶(GPI)水平与各种自身免疫性疾病(AID)的关系。方法比较正常对照和各种AID确诊病例的血清GPI浓度,分析GPI在各种AID中的检测价值。结果类风湿性关节炎(RA)组的GPI浓度和阳性率都显著高于其他AID组和正常对照组(P<0.001),系统性红斑狼疮(SLE)组、干燥综合征(SS)组、多发性肌炎(PM)组、进行性系统性硬皮病(SSC)组和强直性脊柱炎(AS)组GPI的阳性率均在25%以下,显著低于RA组的阳性率(71.0%)。结论在各种AID中,RA组血清中GPI升高最明显。血清GPI检测可作为RA的诊断指标。如果GPI和类风湿因子(RF)联合检测,将对RA的诊断具有较高价值。

关键词：葡萄糖-6-磷酸异构酶自身免疫性疾病类风湿性关节炎

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Metasurface for oscillatory spin splitting along the optical path

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Photonics Research 2022年第9期10卷 I0031-I0037页

作者： YU LI xinhao FAN XUYUE GUO yi ZHANG SHENG LIU BINGYAN WEI DANDAN WEN PENG LI JIANLIN ZHAO MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China Xi’an Ming De Institute of Technology Xi’an 710124China Department of Electronics and Nanoengineering Aalto UniversityEspoo 02150Finland

Spin splitting of light originates from the interplay between the polarization and spatial degrees of freedom as a fundamental constituent of the emerging spin photonics,providing a prominent pathway for manipulating photon spin and developing exceptional photonic ***,previously relevant devices were mainly designed for routing monotonous spin splitting of ***,we realize an oscillatory spin splitting of light via metasurface with two channel Pancharatnam–Berry *** the incidence of a linearly polarized light,the concomitant phases arising from opposite spin states transition within pathways of the metasurface induce lateral spin splitting of light with alternately changed transport direction during beam *** demonstrate the invariance of this phenomenon with an analogous gauge *** work provides a new insight on steering the photon spin and is expected to explore a novel guiding mechanism of relativistic spinning particles,as well as applications of optical trapping and chirality sorting.

关键词： splitting oscillatory analogous

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东营地区HPV感染与宫颈癌的调查与分析

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医学检验与临床 2010年第1期21卷 38-40页

作者：杨长春伊心浩郑妮东营市胜利油田中心医院山东东营257034

目的检测东营地区人乳头状瘤病毒HPV各型在宫颈癌和各级宫颈上皮内瘤变中的表达情况,分析两者之间表达的关系,探讨其作为宫颈癌前病变的特异性标志物的可能性.方法（1）选择经病理确诊的19例宫颈癌、55例CIN（包括CIN Ⅰ级20例、CIN ... 详细信息

目的检测东营地区人乳头状瘤病毒HPV各型在宫颈癌和各级宫颈上皮内瘤变中的表达情况,分析两者之间表达的关系,探讨其作为宫颈癌前病变的特异性标志物的可能性.方法（1）选择经病理确诊的19例宫颈癌、55例CIN（包括CIN Ⅰ级20例、CIN Ⅱ级16例和CIN Ⅲ级19例）和30例宫颈炎患者的宫颈脱落细胞,采用基因芯片技术对PCR扩增产物进行HPV检测,观察不同病情宫颈组织中HPV的感染情况及型别分布状况.结果（1）HPV在宫颈炎、CIN Ⅰ级、CIN Ⅱ级、CIN Ⅲ级和宫颈癌患者组织中的检出率分别为43.3%、50%、68.8%、84.2%和94.7%.CIN Ⅱ/Ⅲ级及宫颈癌组患者HPV检出率明显高于宫颈炎组和CIN Ⅰ组.检出型别主要是HPV16型,在宫颈炎症组、CIN Ⅰ级、CIN Ⅱ级、CIN Ⅲ级和宫颈癌组宫颈刷脱细胞中HPV16型检出的阳性率分别为6.67%、15%、31.3%、42.1%和68.42%.同时随着病情的加重,其阳性率也逐渐升高,其中在宫颈癌组中最高,与宫颈炎症组、CIN Ⅰ组及CIN Ⅱ组比较,差异有显著性（P〈0.05）,与CIN Ⅲ组比较,差别无显著性（P〉0.05）.结论（1）HPV感染是宫颈癌前病变的主要致病因素,其中HPV 16型感染与其密切相关,随着病变程度的加重.HPV 16检出率升高,提示HPV 16为宫颈癌的高危因素.

关键词：宫颈癌宫颈上皮内瘤变人乳头状瘤病毒东营地区

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The expressions of Bcl-2 and Bax in gastric carcinoma and precancerous lesions

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Oncology and Translational Medicine 2008年第1期7卷 14-16页

作者： xinhao yi1, 2, Qisong Wu2, Huahui Li3, Jianmin Wu1 1 Department of Laboratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2 Department of Laboratory Medicine, Central Hospital of Shengli Oil-Field, Dongying 257034, China 3 Department of Laboratory Medicine, Qingdao Municipal Hospital, Qingdao 266011, China Department of Laboratory Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Laboratory Medicine Central Hospital of Shengli Oil-FieldDongying 257034China Department of Laboratory Medicine Central Hospital of Shengli Oil-FieldDongying 257034China Department of Laboratory Medicine Qingdao Municipal HospitalQingdao 266011China Department of Laboratory Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

关键词： gastric carcinoma precancerous lesions apoptosis

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一种新颖的基于内模电流控制的矢量控制系统

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变频器世界 2007年第4期 49-52页

作者：阳同光黄志武单勇腾刘心昊李艺中南大学信息科学与工程学院

无速度传感器矢量控制系统中存在两个关键性的问题,即速度辨识的稳定性问题和控制器结构问题。本文提出一种新型的基于模型参考自适应的内模电流控制的矢量控制系统。首先,利用MRAS理论,保证了速度辨识的全局稳定性。然后通过内模控制... 详细信息

无速度传感器矢量控制系统中存在两个关键性的问题,即速度辨识的稳定性问题和控制器结构问题。本文提出一种新型的基于模型参考自适应的内模电流控制的矢量控制系统。首先,利用MRAS理论,保证了速度辨识的全局稳定性。然后通过内模控制实现动态解耦,克服了PI控制不能动态解耦和其他解耦方法中对参数敏感的问题。仿真结果表明:系统对参数变化具有较强的鲁棒性,取得较好的解耦效果和系统控制性能。

关键词：全阶自适应观测器内模控制动态解耦

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MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration

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Genes & Diseases 2022年第4期9卷 1038-1048页

作者： YongSheng Zhang yiLong Yao ZiShuai Wang Dan Lu YuanYuan Zhang Adeyinka Abiola Adetula SiYuan Liu Min Zhu YaLan Yang xinhao Fan MuYa Chen yiJie Tang Yun Chen YuWen Liu GuoQiang yi ZhongLin Tang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124PR China Genome Analysis Laboratory of the Ministry of Agriculture Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124PR China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193PR China

The microRNAs (miRNAs) play an important role in regulating myogenesis by targeting mRNA. However, the understanding of miRNAs in skeletal muscle development and diseases is unclear. In this study, we firstly performed the transcriptome profiling in differentiating C2C12 myoblast cells. Totally, we identified 187 miRNAs and 4260 mRNAs significantly differentially expressed that were involved in myoblast differentiation. We carried out validation of microarray data based on 5 mRNAs and 5 miRNAs differentially expressed and got a consistent result. Then we constructed and validated the significantly up- and down-regulated mRNA-miRNA interaction networks. Four interaction pairs (miR-145a-5p-Fscn1, miR-200c-5p-Tmigd1, miR-27a-5p-Sln and miR-743a-5p-Mob1b) with targeted relationships in differentiated myoblast cells were demonstrated. They are all closely related to myoblast development. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated cell cycle signals important for exploring skeletal muscle development and disease. Functionally, we discovered that miR-743a targeting gene Mps One Binder Kinase Activator-Like 1B (Mob1b) gene in differentiated C2C12. The up-regulated miR-743a can promote the differentiation of C2C12 myoblast. While the down-regulated Mob1b plays a negative role in differentiation. In addition, the expression profile of miR-743a and Mob1b are consistent with skeletal muscle recovery after Cardiotoxin (CTX) injury. Our study revealed that miR-743a-5p regulates myoblast differentiation by targeting Mob1b involved in skeletal muscle development and regeneration. Our findings made a further exploration for mechanisms in myogenesis and might provide potential possible miRNA-based target therapies for skeletal muscle regeneration and disease in the near future.

关键词： Differentiation miR 743a-5p Mob 1b Myoblast Skeletal muscle .Transcriptome

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