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Neuroscience Bulletin 2019年第5期35卷 889-900页

作者： Rui Wang xingyun xu Zongbing Hao Shun Zhang Dan Wu Hongyang Sun Chenchen Mu Haigang Ren Guanghui Wang Laboratory of Molecular Neuropathology Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Pharmacology College of Pharmaceutical SciencesSoochow University

GGGGCC repeat expansions in the C9 ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia(c9 ALS/FTD). It has been reported that hexanucleotide repeat expansions in C9 ORF72 produce five dipeptide repeat(DPR) proteins by an unconventional repeat-associated non-ATG(RAN)translation. Within the five DPR proteins, poly-PR and poly-GR that contain arginine are more toxic than the other DPRs(poly-GA, poly-GP, and poly-PA). Here, we demonstrated that poly-PR peptides transferred into cells by endocytosis in a clathrin-dependent manner, leading to endoplasmic reticulum stress and cell death. In SH-SY5 Y cells and primary cortical neurons, poly-PR activated JUN amino-terminal kinase(JNK) and increased the levels of p53 and Bax. The uptake of poly-PR peptides by cells was significantly inhibited by knockdown of clathrin or by chlorpromazine, an inhibitor that blocks clathrin-mediated endocytosis. Inhibition of clathrin-dependent endocytosis by chlorpromazine significantly blocked the transfer of poly-PR peptides into cells, and attenuated poly-PRinduced JNK activation and cell death. Our data revealed that the uptake of poly-PR undergoes clathrin-dependentendocytosis and blockade of this process prevents the toxic effects of synthetic poly-PR peptides.

关键词： Amyotrophic lateral sclerosis C9ORF72 Poly-PR Clathrin ER stress

Facile Surface Engineering of NiCo_(2)O_(4) to Boost Propane Oxidation Activity

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 19-26页

作者： Yang Jialei Wang Fengyi Lei Yang Zhang Mingchao Sun Shiqiang xu Wenfan Ke Jiaxiang Wu Haojie Li xingyun Qi Jian Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao 266071China School of Chemistry and Chemical Engineering Hubei Key Laboratory of Coal Conversion and New Carbon MaterialsWuhan University of Science and TechnologyWuhan 430081China Department of Burn and Plastic Surgery Qingdao Municipal Hospital Affiliated to Rehabilitation UniversityQingdao 266000China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Spinel oxide(NiCo_(2)O_(4))has demonstrated great potential to replace noble metal catalysts for the oxidation reaction of air pollutants.To further boost the oxidation ability of such catalysts,in this study,a facile surface-engineering strategy wherein NiCo_(2)O_(4) was treated with different alkali solvents was developed.The obtained catalyst(NiCo_(2)O_(4)-OH)showed a higher surface alkalinity and more surface defects compared to the pristine spinel oxide,including enhanced structural distortion as well as promoted oxygen vacancies.The propane oxidation ability of NiCo_(2)O_(4)-OH was greatly enhanced,with a propane conversion rate that was approximately 6.4 times higher than that of pristine NiCo_(2)O_(4) at a reaction temperature 193℃.This work sets a valuable paradigm for the surface modulation of spinel oxide via alkali treatment to ensure a high-performance oxidation catalyst.

关键词： NiCo_(2)O_(4) surface defects alkali treatment propane oxidation

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稀释式自体输血对宫颈癌术后血栓形成的影响

实用妇产科杂志 2015年第9期31卷 684-687页

作者：许正芬徐兴云浙江省嘉兴市妇幼保健院浙江嘉兴314000

目的:评价稀释式自体输血对宫颈癌术后血栓形成的影响。方法:因宫颈癌ⅠB1行宫颈癌根治术的患者80例,随机分成观察组、对照组,每组40例。观察组患者术前采用稀释式自体输血,对照组患者按常规手术。分别于入室开放静脉后(T0)、术毕(T1)... 详细信息

目的:评价稀释式自体输血对宫颈癌术后血栓形成的影响。方法:因宫颈癌ⅠB1行宫颈癌根治术的患者80例,随机分成观察组、对照组,每组40例。观察组患者术前采用稀释式自体输血,对照组患者按常规手术。分别于入室开放静脉后(T0)、术毕(T1)、术后24小时(T2)抽取两组肘静脉血样,检测血红蛋白(Hb)、血细胞比容(HCT)、凝血功能指标及血液流变学变化指标。用彩色多普勒超声于术前1天及术后7天探测两组患者双下肢深静脉通畅情况。结果:与T0比较,T1及T2时观察组患者Hb和HCT明显降低,与对照组同一时点比较差异有统计学意义(P<0.05)。与T0比较,T1及T2时观察组全血黏度高切变率、全血黏度低切变率、血浆黏度及红细胞聚集指数降低,红细胞变形指数升高;对照组T1及T2时血浆黏度降低且T2时D-二聚体升高(P<0.05)。与对照组比较,观察组T1及T2时全血黏度高切变率、全血黏度低切变率及红细胞聚集指数降低,红细胞变形指数升高,T2时观察组D-二聚体降低(P<0.05)。术后7天时,彩色多普勒超声下,对照组DVT发生率12.5%,观察组无DVT发生。观察组DVT发生率低于对照组(P<0.05)。结论:稀释式自体输血能改善手术患者血液流变学状态,降低发生深静脉血栓形成的危险。

关键词：稀释式自体输血宫颈癌广泛全子宫切除术静脉血栓形成

左炔诺孕酮宫内释放系统对雌激素受体、孕激素受体及胰岛素样生长因子-1的影响

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中华医学杂志 2014年第35期94卷 2763-2765页

作者：吴晓杰刘霞金小英徐兴云浙江省嘉兴市妇幼保健院 314051

目的研究左炔诺孕酮宫内释放系统对子宫内膜息肉局部及周围内膜组织雌激素受体（ER）、孕激素受体（PR）、胰岛素样生长因子（IGF）的影响.方法选取2010至2011年在浙江省嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者,共250例.... 详细信息

目的研究左炔诺孕酮宫内释放系统对子宫内膜息肉局部及周围内膜组织雌激素受体（ER）、孕激素受体（PR）、胰岛素样生长因子（IGF）的影响.方法选取2010至2011年在浙江省嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者,共250例.随机分组为研究组（106例）和对照组（125例）.研究组术后子宫内即时放置左炔诺孕酮宫内释放系统,而对照组不予放置.分别对术中内膜组织及术后6个月子宫内膜活体组织检查,通过免疫组化方法对ER、PR、IGF-1的表达情况进行对比,且追踪随访2年,了解患者子宫内膜息肉复发情况.结果所有患者均手术成功,研究组内膜组织对比发现ER、PR、IGF-1表达术后明显低于术中,差异有统计学意义.对照组术中及术后内膜组织对比ER、PR、IGF-1的表达变化差异无统计学意义.随访2年,对照组101例中11例子宫内膜息肉复发,复发率为10.89％,研究组106例无一例复发,差异有统计学意义（P＜0.01）.结论左炔诺孕酮宫内释放系统对子宫内膜的ER、PR、IGF-1表达存在抑制作用,可能是其抑制子宫内膜息肉复发及形成的主要机制.

关键词：子宫内膜息肉左炔诺孕酮宫内系统胰岛素样生长因子雌激素受体孕激素受体

面向高速PAM4有线收发机的自适应和低复杂度最大似然序列检测器

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计算机辅助设计与图形学学报 2024年第3期36卷 452-463页

作者：许超龙赖明澈吕方旭王强齐星云罗章李世杰张庚国防科技大学计算机学院长沙410000

高速串行收发机是中央处理器、网卡和交换机等高性能芯片的关键部件.判决反馈均衡器(decision feedback equalization,DFE)是高速串行收发机的主要判决电路.针对传统DFE在高码间干扰(intersymbol interference,ISI)信道下的高误码率制... 详细信息

高速串行收发机是中央处理器、网卡和交换机等高性能芯片的关键部件.判决反馈均衡器(decision feedback equalization,DFE)是高速串行收发机的主要判决电路.针对传统DFE在高码间干扰(intersymbol interference,ISI)信道下的高误码率制约串行收发机速率提升的问题,提出一种面向4电平调制(4 pulse amplitude modulation,PAM4)串行收发机的自适应、低复杂度的减状态序列检测器(adaptive reduced-state sequence detector,ARSSD).ARSSD基于最大似然序列检测结构降低检测误码率;结合Viterbi算法和分区算法降低运算复杂度;采用基于迫零算法的ISI参数获取方式实现检测器参数的自适应更新.所提结构最终完成了行为仿真、电路设计以及系统验证.基于模拟前端芯片和现场可编程门阵列电路的实验结果表明,与传统DFE相比,当12~64 Gbps PAM4信号经过−8~−18 dB@16 GHz衰减信道时,32×4路并行ARSSD检测误码率降低2个数量级,与行为仿真结果一致.

关键词： 4电平调制串化器/解串器最大似然序列检测 Viterbi算法迫零算法现场可编程门阵列

A hint from phosphine complex: The π back-bonding in cobalt-phosphorene composite enables enhanced electrocatalytic performance

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Progress in Natural Science:Materials International 2023年第1期33卷 100-107页

作者： xingyun Li Liangping Xiao Hao Wang Jingting Song Qingchi xu Meidan Ye Jun xu Shenzhen Research Institute of Xiamen University Department of Physics Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials Xiamen University Jiujiang Research Institute of Xiamen University Department of Chemistry National University of Singapore

Regulating the electronic structure of the metal electrocatalyst is fundamental for its performance optimizing. The electronic states of the active metal centers are highly dependent on their coordination environment, especially when bonding is formed. The π back-bonding can induce great electron density redistribution around metals, yet it is barely applied in electrocatalyst design. Herein we electrodeposited metallic cobalt on black phosphorus(BP)nanosheets, forming BP-Co with a unique π back-bonding on the interfaces. The BP-Co exhibited high electrocatalytic activity and stability for hydrogen evolution reaction in alkaline electrolyte. The electrochemical and spectroscopic characterizations demonstrated that the BP acted as σ donor and π acceptor to coordinate with electron-rich metallic Co, similar to the phosphine complex. The directional σ bond strengthen the relationship between BP and Co, while the non-directional π bond accelerated the in-plane electron transfer. The π back donation also decreased the oxophilicity of Co to make BP-Co resist the poison from oxygen species. This study can intrigue new thinking prospective for the electrocatalyst design.

关键词： Black phosphorus Pi back-bonding Electrocatalyst Electrodeposition Electronic structure

Amorphous alloys for electrocatalysis:The significant role of the amorphous alloy structure

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Nano Research 2023年第4期16卷 4277-4288页

作者： xingyun Li Weizheng Cai Dong-Sheng Li Jun xu Huabing Tao Bin Liu School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore 637459Singapore Department of Biomaterials College of MaterialsXiamen UniversityXiamen 361005China Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials College of Materials and Chemical EngineeringChina Three Gorges UniversityYichang 443002China Fujian Provincial Key Laboratory for Soft Functional Materials Department of PhysicsResearch Institute for Biomimetics and Soft MatterXiamen UniversityXiamen 361005China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Division of Chemical and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang LinkSingapore 637371Singapore

Amorphous alloys,also known as metallic glasses,are solid metallic materials having long-range disordered atomic structures.Compared to crystalline alloys,amorphous alloys not only have metallic characters,but also possess several distinct properties associated to the amorphous structure,such as isotropy,composition flexibility,unsaturated surface,etc.As a result,amorphous alloys offer a class of highly promising materials for catalyzing electrochemical reactions.In this minireview,the preparation,characterization and electrocatalytic performances of a variety of metallic amorphous alloy materials are summarized.The influences of the amorphous alloy structure on different electrochemical reactions are discussed.Finally,a summary on the advantages and challenges of amorphous alloys in electrocatalysis is provided,along with some perspectives about the future research directions.

关键词： amorphous alloys electrocatalysis nonperiodic atomic structure isotropy metastability

High-Energy Lithium-Ion Batteries:Recent Progress and a Promising Future in Applications

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Energy & Environmental Materials 2023年第5期6卷 60-85页

作者： Jingjing xu xingyun Cai Songming Cai Yaxin Shao Chao Hu Shirong Lu Shujiang Ding Chongqing School University of Chinese Academy of Sciences(UCAS)Chongqing 400714China Thin-film Solar Center Chongqing Institute of Green and Intelligent TechnologyChinese Academy of Sciences(CAS)Chongqing 400714China Laboratory of Sustainable Energy Materials Chemistry School of ChemistryXi'an Jiaotong UniversityXi'an 710049China

It is of great significance to develop clean and new energy sources with high-efficient energy storage technologies,due to the excessive use of fossil energy that has caused severe environmental damage.There is great interest in exploring advanced rechargeable lithium batteries with desirable energy and power capabilities for applications in portable electronics,smart grids,and electric vehicles.In practice,high-capacity and low-cost electrode materials play an important role in sustaining the progresses in lithium-ion batteries.This review aims at giving an account of recent advances on the emerging high-capacity electrode materials and summarizing key barriers and corresponding strategies for the practical viability of these electrode materials.Effective approaches to enhance energy density of lithium-ion batteries are to increase the capacity of electrode materials and the output operation voltage.On account of major bottlenecks of the power lithium-ion battery,authors come up with the concept of integrated battery systems,which will be a promising future for high-energy lithium-ion batteries to improve energy density and alleviate anxiety of electric vehicles.

关键词： high-capacity electrode materials high-energy lithium-ion batteries high-voltage cathodes integrated battery systems organic cathode materials

A robust Janus bilayer with tailored ionic conductivity and interface stability for stable Li metal anodes

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Journal of Energy Chemistry 2022年第11期31卷 368-375,I0010页

作者： Guodong Zhang Pengwei Li Kai Chen Hongfei Zheng Wei He Liangping Xiao xingyun Li Qingchi xu Jian Weng Jun xu Department of Biomaterials College of MaterialsXiamen UniversityXiamen 361005FujianChina bDepartment of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional MaterialsXiamen UniversityXiamen 361005FujianChina Shenzhen Research Institute of Xiamen University Shenzhen 518057GuangdongChina

The formation and growth of Li-dendrites caused by inhomogeneous Li deposition severely hinder the commercial applications of Li metal batteries due to the consequence of short-circuiting.Herein,we propose a Janus bilayer composed of black phosphorus(BP)and graphene oxide(GO)as an artificial interface with chemical/mechanical stability and well-regulated Li-ion flux distribution for Li metal anode protection.Owing to the synergy between the fast Li-ion transport of BP in the inner layer and the high mechanical and chemical stability of GO in the outer layer,the GO/BP with good electrolyte wettability acts as a Li-ion regulator that can induce homogeneous growth of Li to suppress the Li dendrites growth.Accordingly,long-term stability(500 h at 1 mA cm^(-2))with a low overpotential of 30 mV is achieved in the symmetric cell with GO/BP-Li anode.Furthermore,the Li–S cell with GO/BP-Li exhibits enhanced cycling performance with a high capacity retention rate of 76.2%over 500 cycles at 1 C.

关键词： Graphene oxide(GO) Black phosphorus(BP) Artificial interface Janus bilayer Li metal batteries

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硼替佐米治疗多发性骨髓瘤的临床综合评价

上海医药 2024年第1期45卷 33-38页

作者：伊佳徐德铎侯幸赟王志鹏陶霞海军军医大学附属上海长征医院药剂科上海200003

目的 :综合评价硼替佐米用于多发性骨髓瘤治疗的临床安全性、有效性、经济性、创新性、适宜性和可及性。方法 :通过各级来源证据对指标进行整合分析。结果 :纳入6篇meta分析和5篇药物经济学研究文章,采用硼替佐米方案治疗多发性骨髓瘤... 详细信息

目的 :综合评价硼替佐米用于多发性骨髓瘤治疗的临床安全性、有效性、经济性、创新性、适宜性和可及性。方法 :通过各级来源证据对指标进行整合分析。结果 :纳入6篇meta分析和5篇药物经济学研究文章,采用硼替佐米方案治疗多发性骨髓瘤的总缓解率优于对照组,不良反应发生率为64.06%,血小板减少和外周神经病变发生率较高。硼替佐米存储要求低、产能充足、部分厂家产品居民可负担性较好,但创新数据不足。结论 :硼替佐米安全性、有效性明确,适宜性、可及性较好,部分方案成本效益较好。

关键词：硼替佐米临床综合评价多发性骨髓瘤