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Novel strategies for the treatment of osteoarthritis based on biomaterials and critical molecular signaling

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Journal of Materials Science & Technology 2023年第18期149卷 42-55页

作者： xingyun huang Zhiyong Wang Huaiyu Wang Di Chen Liping Tong Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Osteoarthritis(OA)is a degenerative disease involving entire *** is often initiated from the low-grade inflammation in synovial tissue and then affects articular cartilage and subchondral *** risk factors,such as aging,mechanical overloading,trauma,overuse,*** involved in OA *** approaches have been utilized to repair cartilage *** them,biomaterials-based mes-enchymal stromal cell(MSCs)therapy is considered as the most promising *** burgeoning material science and manufacturing technologies,such as 3D printing,allow us to mimic native articu-lar cartilage and regulate the artificial cartilage development,regeneration and functional *** this review article,we will summarize the recent progress of biomaterials combined with MSCs or chon-drocytes in repairing cartilage damage induced by *** typical natural and synthetic biomaterials,such as collagen,alginate,hyaluronic acid and poly(ethylene glycol),polylactide acid,polyurethane,*** cartilage repairing will be ***,critical signaling pathways associated with the pro-gression of OA,as well as the targeted pharmacologic,genetic therapies and tissue engineering scaffolds for OA and cartilage repairing are *** will also provide our prospects for future directions in this active research area.

关键词： Osteoarthritis Cartilage Repairing Biomaterials 3D printing Signaling pathways

开孔剂对慢回弹聚氨酯泡沫开孔性的影响及检测方法对比研究

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聚氨酯工业 2024年第1期39卷 42-44页

作者：黄幸运严定尧赵宝成孙国藩江苏巴德聚氨酯股份有限公司江苏淮安223112

将开孔剂KY1216、BDM-5、1900H以不同用量应用于慢回弹聚氨酯泡沫配方中,采用传统吐泡法(TBM)、透气仪法(BM)、塌泡落差法(BCDM)对不同试样的开孔效果进行检测。结果表明,采用BCDM检测泡沫开孔性能时数据直观、判断准确、方便快捷,成本... 详细信息

将开孔剂KY1216、BDM-5、1900H以不同用量应用于慢回弹聚氨酯泡沫配方中,采用传统吐泡法(TBM)、透气仪法(BM)、塌泡落差法(BCDM)对不同试样的开孔效果进行检测。结果表明,采用BCDM检测泡沫开孔性能时数据直观、判断准确、方便快捷,成本低,提高了开孔剂的检测效率,值得作为慢回弹开孔剂的高效检测方法推广和应用。

关键词：慢回弹聚氨酯泡沫开孔剂开孔性能检测塌泡落差法

Current understanding of osteoarthritis pathogenesis and relevant new approaches

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Bone Research 2022年第4期10卷 627-643页

作者： Liping Tong Huan Yu xingyun huang Jie Shen Guozhi Xiao Lin Chen Huaiyu Wang Lianping Xing Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518005China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Orthopedic Surgery School of MedicineWashington University in St.LouisSt.LouisMO 63110USA School of Medicine Southern University of Science and TechnologyShenzhen 518055China Department of Wound Repair and Rehabilitation State Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China Research Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Pathology and Laboratory of Medicine Center for Musculoskeletal ResearchUniversity of Rochester Medical CenterRochesterNY 14642USA

Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the *** molecular mechanisms of OA are currently *** is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA *** better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA *** this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated *** then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage ***,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating ***,our review highlights new directions on the role of the synovial lymphatic system in *** improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.

关键词： pathogenesis swelling concerning

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互花米草有利于我国海岸带蓝碳功能提升

Science Bulletin 2024年第12期69卷 1991-2000页

作者：张靖凡毛德华刘纪化陈雅萍 Matthew Kirwan Christian Sanders 周金戈卢哲覃国铭黄幸运李慧焉恒琦焦念志苏纪兰王法明 Guangdong Key Laboratory of Applied Botany Xiaoliang Research Station of Tropical Coastal Ecosystemsthe CAS Engineering Laboratory for Ecological Restoration of Island and Coastal EcosystemsSouth China Botanical GardenChinese Academy of SciencesGuangzhou 510650China University of Chinese Academy of Sciences Beijing 100049China South China National Botanical Garden Chinese Academy of SciencesGuangzhou 510650China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Marine Research Institute Shandong UniversityQingdao 266237China School of Ecology Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Virginia Institute of Marine Science Gloucester PointVA 23062USA National Marine Science Centre School of EnvironmentScience and EngineeringSouthern Cross UniversityCoffs HarbourNSW 2450Australia Guangdong Eco-engineering Polytechnic Guangzhou 510520China Carbon Neutral Innovation Research Center and Fujian Key Laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361005China Second Institute of Oceanography State Oceanic AdministrationHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China School of Ecology and Environment Hainan UniversityHaikou 570228China

Spartina alterniflora has rapidly and extensively encroached on China's coastline over the past *** the coastal areas invaded by ***,at most 93%are ***,the effect of *** invasion on soil organic carbon(SOC)stocks of coastal mudflats has not been systematically studied on a national ***,we quantified the nationwide changes in SOC stocks in coastal mudflats associated with *** invasion between 1990 and *** found that *** invasion significantly enhanced SOC stocks in coastal ***,the benefit of *** invasion of coastal SOC stock may be weakened by continuing human *** found that *** invading mudflats added 2.3 Tg SOC stocks to China's coastal blue carbon,while 1.78 Tg SOC stocks were lost mainly due to human activities,resulted in a net SOC stock gain of 0.52 Tg *** findings overturned the traditionally thought that *** invasion would reduce ecosystem services by highlighting that the historical invasion of *** has broadly and consistently enhanced blue carbon stock in coastal China.

关键词： Spartina alterniflora invasion Mudflats China coastal wetland Blue carbon sequestration

Influence of Reaction Conditions on Methanol Synthesis and WGS Reaction in the Syngas-to-DME Process

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Journal of Natural Gas Chemistry 2006年第1期15卷 38-44页

作者： Ligang Wang Deren Fang xingyun huang Shigang Zhang Yue Qi Zhongmin Liu Dalian fastitute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Graduate School of Chinese Academy of Sciences Beijing 100039 China Institute of Applied Catalysis Yantai University Yantai 264005 China

A series of CuO-ZnO catalysts （with different Cu/Zn molar ratios） were prepared, and evaluated under the reaction conditions of syngas-to-dimethyl ether （DME） with three sorts of feed gas and different space velocity. The catalysts were characterized by X-ray diffraction （XRD） and temperatureprogrammed reduction （TPR）. The experiment results showed that the reaction conditions of syngas-to- DME process greatly affected the methanol synthesis and WGS reaction. The influence caused by Cu/Zn molar ratio was quite different on the two reactions; increasing of percentage of CO2 in feed gas was unfavorable for catalyst activity, and also inhibited both reactions; enhancement of reaction space velocity heavily influenced the performance of the catalyst, and the benefits were relatively less for methanol synthesis than for the WGS reaction.

关键词： copper zinc Cu/Zn molar ratio methanol dimethyl ether water gas shift reaction syngas dehydration

Clinical outcomes of second-line chemotherapy in patients with advanced pancreatic adenocarcinoma: a real-world study

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Cancer Biology & Medicine 2024年第9期 799-812页

作者： Yuxiao Liu Xiaofan Guo Peijun Xu Yuning Song Jing huang xingyun Chen Wenbo Zhu Jihui Hao Song Gao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer

Objective: Little progress has been made in recent years using first-line chemotherapy, including gemcitabine combined with nabpaclitaxel, FOLFIRINOX, and NALIRIFOX, for advanced pancreatic adenocarcinoma(APC). In addition, the optimal second-line chemotherapy regimen has not been determined. This study aimed to compare the effectiveness of different types of second-line chemotherapy for ***: Patients with APC who received first-line treatment from January 2008 to January 2021 were considered eligible for this retrospective analysis. The primary and secondary endpoints were overall survival(OS) and progression-free survival(PFS), ***: Four hundred and thirty-seven and 617 patients were treated with 5-fluorouracil-and gemcitabine-based chemotherapy as first-line treatment, respectively. Demographic and clinical features, except age and liver metastasis, were comparable between the two groups(P < 0.05). The median OS was 8.8 and 7.8 months in patients who received a 5-fluorouracil-and gemcitabine-based combined regimen for first-line therapy, respectively(HR = 1.244, 95% CI = 1.090±1.419; P < 0.001). The median OS was 5.6 and 1.9 months in patients who received second-line chemotherapy and supportive care, respectively(HR = 0.766, 95% CI = 0.677±0.867; P < 0.001). The median PFS was not significantly differently between gemcitabine or 5-fluorouracil monotherapy and combination ***: A 5-fluorouracil-or gemcitabine-based combined regimen was shown to be as effective as a single 5-fluorouracil or gemcitabine regimen as second-line therapy for patients with APC.

关键词：

体认语言学观照下隐喻映射的“多源性”研究——基于“愁”的概念隐喻分析

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外国语文 2022年第3期38卷 89-97页

作者：黄兴运谢世坚广西师范大学外国语学院广西桂林541004

作为中国本土化语言理论的一种创新,体认语言学是认知语言学的继承和发展,对语言的成因具有较强解释力。基于“愁”的概念隐喻,本文以体认语言学为观照,从体认者的认知主体性、始源域特征投射的选择性和目标域特征的多样性三个维度系统... 详细信息

作为中国本土化语言理论的一种创新,体认语言学是认知语言学的继承和发展,对语言的成因具有较强解释力。基于“愁”的概念隐喻,本文以体认语言学为观照,从体认者的认知主体性、始源域特征投射的选择性和目标域特征的多样性三个维度系统分析了隐喻映射“多源性”的发生理据。研究表明:(1)隐喻是体认者的一种心理映射,反映其对某一特定事物体验认知的心路历程;(2)隐喻映射是体认者在始源域和目标域之间进行特征选择与聚焦的认知加工过程;(3)体认者的认知主体性、始源域特征投射的选择性以及目标域特征的多样性共同促进相应概念隐喻映射“多源性”的产生。

关键词：体认语言学认知主体性隐喻映射多源性

鄱阳湖苔草洲滩湿地土壤胞外酶活性和化学计量比的高程变化特征

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湖泊科学 2022年第3期34卷 894-905页

作者：黄幸运温秀婷张研戎俊聂明郑博福沈瑞昌江西省流域生态演变与生物多样性重点实验室南昌大学生命科学研究院流域生态学研究所南昌大学生命科学学院南昌330031 江西鄱阳湖湿地保护与恢复国家长期科研基地江西鄱阳湖湿地生态系统国家定位观测研究站南昌330031 南昌大学鄱阳湖环境与资源利用教育部重点实验室南昌330031 江西生态文明研究院南昌大学资源环境与化工学院南昌330031 复旦大学生命科学学院生物多样性与生态工程教育部重点实验室上海200438

土壤胞外酶参与土壤的生物化学过程,其活性和化学计量比能够反映土壤微生物的功能动态.然而,目前湿地生态系统中催化不同生物地球化学关键过程的土壤胞外酶的活性和化学计量比随高程的变化特征还不清楚.以鄱阳湖苔草洲滩湿地6个不同高... 详细信息

土壤胞外酶参与土壤的生物化学过程,其活性和化学计量比能够反映土壤微生物的功能动态.然而,目前湿地生态系统中催化不同生物地球化学关键过程的土壤胞外酶的活性和化学计量比随高程的变化特征还不清楚.以鄱阳湖苔草洲滩湿地6个不同高程样带的表层土壤(0~10 cm)为研究对象,通过测定与土壤碳、氮、磷循环相关的7种水解酶的活性,分析了洪泛平原洲滩湿地土壤碳、氮、磷循环相关酶活性和化学计量比随高程的变化特征和调控机制.结果表明:随着高程增加,鄱阳湖苔草洲滩湿地土壤与碳循环相关的α-葡萄糖苷酶(AG)活性逐渐减小,β-葡萄糖苷酶(BG)活性没有显著变化,纤维二糖水解酶(CBH)活性先减小后增加,木聚糖酶(XYL)活性逐渐增加;与氮循环相关的N-乙酰氨基葡萄糖苷酶(NAG)和亮氨酸氨基肽酶(LAP)活性逐渐减小;与磷循环相关的磷酸酶(PHOS)活性没有显著变化.高程增加后,土壤中BG:NAG逐渐增加,BG:PHOS逐渐减小,NAG:PHOS没有显著变化.结构方程模型表明,鄱阳湖洲滩湿地土壤碳、氮、磷循环相关酶活性最大的影响因素分别为高程、植物物种丰富度和土壤总磷.土壤碳氮酶化学计量比主要是受高程的综合影响,而土壤碳磷和氮磷酶化学计量比主要受土壤pH的直接作用.

关键词：洲滩湿地土壤酶化学计量学高程洪泛平原鄱阳湖

Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants

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Journal of Genetics and Genomics 2021年第1期48卷 92-95页

作者： Meng Lian Fangbing Chen xingyun huang Xiaozhu Zhao Shixue Gou Nan Li Qin Jin Hui Shi Yanhui Liang Jingke Xie Weikai Ge Zhenpeng Zhuang Jiaowei Wang Yinghua Ye Yi Yang Kepin Wang Liangxue Lai Han Wu CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China University of Chinese Academy of Sciences Beijing 100049China Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China Key Laboratory for Major Obstetrics Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education InstitutesThe Third Hospital Affiliated of Guangzhou Medical UniversityGuangzhou 510150China

Base editor-mediated C-to-T base conversion obviates the requirements of double-strand breaks,thereby showing promise as a tool for disease modeling and gene therapy(Gaudelli et al.,2017;Rees and Liu 2018).The most actively used base editor comprises a Cas9 nickase(nCas9)with cytidine deaminase and fused uracil DNA glycosylase inhibitor at the carboxy terminus of nCas9 to inhibit uracil N-glycosylase effects(Pearl,2000;Kunz et al.,2009;Rees and Liu 2018).

关键词： base uracil thereby