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以新质生产力促进西藏低空经济高质量发展的策略研究

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西藏发展论坛 2024年第3期 57-61页

作者：肖星月谢春生孙惠君黄保全杨洋西藏自治区发展和改革委员会航空事业发展处中国民航大学空中交通管理学院首都机场集团有限公司大兴机场中土集团福州勘察设计研究院有限公司建筑所中国土木工程集团有限公司

新质生产力是创新起主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。本文从新质生产力核心内涵及其对高质量发展的现实意义为出发点,结合低空经济作为新兴产业所呈现... 详细信息

新质生产力是创新起主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。本文从新质生产力核心内涵及其对高质量发展的现实意义为出发点,结合低空经济作为新兴产业所呈现的典型特征,分析新质生产力与低空经济之间的关系和内在联系。立足西藏自治区低空经济发展的实际情况,客观评价低空产业发展现状,深入剖析存在的难点问题,灵活运用新质生产力的方法论,从强化科技创新、促进产业融合、加强要素供给等方面,提出针对西藏的低空经济高高原发展策略,推动实现低空产业的高质量发展。

关键词：新质生产力西藏自治区低空经济高高原发展策略

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四甲基二丙烯三胺的制备及其应用研究进展

化学世界 2024年第2期65卷 76-82页

作者：孙逸帆姚羽佳肖兴玥张媛媛黄旭娟闫鑫焱蔡照胜盐城工学院化学化工学院江苏盐城224051

四甲基二丙烯三胺(TMBPA)为一种具有仲胺和叔胺结构的线性多胺,在精细化学品的制备中有广泛的应用。介绍了TMBPA的典型制备方法及其在聚氨酯和环氧树脂材料、表面活性剂、基因转染材料、气体吸附与分离材料等领域的应用,分析了制备TMBP... 详细信息

四甲基二丙烯三胺(TMBPA)为一种具有仲胺和叔胺结构的线性多胺,在精细化学品的制备中有广泛的应用。介绍了TMBPA的典型制备方法及其在聚氨酯和环氧树脂材料、表面活性剂、基因转染材料、气体吸附与分离材料等领域的应用,分析了制备TMBPA的重点研究方向。

关键词：四甲基二丙烯三胺制备应用开发精细化学品

Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila

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Neuroscience Bulletin 2020年第10期36卷 1147-1157页

作者： Ting Zhang Daxiao Cheng Cunjin Wu xingyue Wang Qiang Ke Huifang Lou Liya Zhu xiao-Dong Wang Shumin Duan Yi-Jun Liu Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of MedicineHangzhou 310058China Department of Diagnostics Hangzhou Normal University Medical SchoolHangzhou 311121China Department of Laboratory Medicine Hangzhou Normal University Affiliated HospitalHangzhou 310015China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Mental Health Center Zhejiang University School of MedicineHangzhou 310058China

The main lysosomal protease cathepsin D(cathD)is essential for maintaining tissue homeostasis via its degradative function,and its loss leads to ceroid accumulation in the mammalian nervous system,which results in progressive *** evidence implies non-proteolytic roles of cathD in regulating various biological processes such as apoptosis,cell proliferation,and *** these lines,we here showed that cathD is required for modulating dendritic architecture in the nervous system independent of its traditional degradative *** cathD depletion,class I and class III arborization(da)neurons in Drosophila larvae exhibited aberrant dendritic morphology,including overbranching,aberrant turning,and elongation *** of wild-type cathD or its proteolyticallyinactive mutant dramatically abolished these morphological ***,cathD knockdown also led to dendritic defects in the adult mushroom bodies,suggesting that cathD-mediated processes are required in both the peripheral and central nervous *** together,our results demonstrate a critical role of cathD in shaping dendritic architecture independent of its proteolytic function.

关键词： Cathepsin D Dendritic arborization Sensory neuron Mushroom body Actin Drosophila

BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules

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Cancer Biology & Medicine 2019年第1期16卷 131-138页

作者： Ya Wu Ting Xu xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang xiao Li Qing Yao Xinhua Ye Meiping Shen xiaohong Wu Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Department of Endocrinology Jiangsu Province Official Hospital Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V ***: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound ***: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules.

关键词： Papillary thyroid carcinoma fine-needle aspiration cytology(FNAC) BRAFV600E thyroid imaging reporting and data system(TIRADS) Bethesda classification

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du Yuhua Yan Juehua Yu Tailin Zhu Chu-Chung Huang Lingli Zhang xingyue Shan Ren Li Yuan Dai Hui LV xiao-Yong Zhang Jianfeng Feng Wei-Guang Li Qiang Luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

Explosion Event of Cavitation in Intact Xylem Conduit

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Journal of Applied Mathematics and Physics 2023年第10期11卷 2803-2315页

作者： xingyue Li Fanyi Shen Tiqiao xiao Yanling Xue Li Zhang Rongfu Gao Qian Zhang College of Science Beijing Forestry University Beijing China Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai China Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai China College of Biology Beijing Forestry University Beijing China

Cavitation in plant conduits only involves two processes of air bubbles: the gradual expansion and elongation, and the explosion event. An explosion event of cavitation, which can only occur in intact conduit at water tension, trigs acoustic (or ultrasound) emission and induces air to diffuse with high speed, simultaneously. Synchrotron X-ray phase contrast microscopy (XPCM) was used to capture cavitation event in intact conduits of leaves of corn and rice. Cavitation events occur in certain areas of leaves and have a certain time frame. Before XPCM experiment, several preliminary experiments were done as follows: 1) Paraffin sections of leaves of different species were observed to select samples and to determine the occurrence area of cavitation event of leaves. 2) The time frame of cavitation occurrence was determined by ultrasonic emission. 3) The water potentials of leaves were determined, to know the water state of the leaves during cavitation. Locked the area and time frame of cavitation event in the leaves, consecutive XPCM images of cavitation process were more easily acquired. The images show that the phenomenon of gas bubble fully filling conduits for an instant took place in intact conduits of detached leaves of corn and rice more easily. It is that the gas diffusing in a moment was caused by the explosion of the air seeds which had entered in the intact conduits of the leaves. For living plants, it is suggested that the explosion event of cavitation is the most important for embolism formation.

关键词： Synchrotron X-Ray Phase Contrast Microscopy Explosion Event Cavitation Intact Conduit

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基于半监督神经网络的弹性模量分布重建

生物医学工程学杂志 2024年第2期41卷 262-271页

作者：张潇彭博王锐魏星月罗建文西南石油大学计算机与软件学院成都610500 清华大学医学院生物医学工程系北京100084

在超声弹性成像中,准确重建组织弹性模量分布是一项重要挑战。现有的基于深度学习的全监督重建方法在训练中只使用了添加噪声的计算机仿真位移数据,不能完全模拟在体超声数据的复杂性和多样性。因此,本研究在训练中引入对在体超声射频... 详细信息

在超声弹性成像中,准确重建组织弹性模量分布是一项重要挑战。现有的基于深度学习的全监督重建方法在训练中只使用了添加噪声的计算机仿真位移数据,不能完全模拟在体超声数据的复杂性和多样性。因此,本研究在训练中引入对在体超声射频信号追踪得到的位移数据(即真实位移数据),对模型进行半监督训练,旨在提高网络的预测准确度。实验结果显示,在仿体实验中,加入了真实位移数据的半监督模型的平均绝对误差和平均相对误差均在3%左右,而全监督模型的相应数据在5%左右。在处理真实位移数据时,半监督模型预测错误区域明显少于全监督模型。本文研究结果证实了所提方法的有效性和实用性,为在体超声数据在弹性模量分布重建的深度学习方法中的使用提供了新思路。

关键词：半监督反问题深度学习弹性模量分布重建

The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease

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Translational Neurodegeneration 2016年第1期5卷 95-106页

作者： Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen xingyue Hu Anmu Xie Qin xiao Department of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Xuanwu Hospital affiliated to Capital Medical University BeijingChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Beijing Hospital BeijingChina The Second Hospital affiliated to Zhejiang University School of Medicine HangzhouChina The First Hospital affiliated to Dalian Medical University DalianChina The Second Affiliated Hospital of Soochow University SuzhouChina The First Hospital affiliated to Chongqing Medical University ChongqingChina Xiangya Hospital Central South UniversityChangshaChina Guangdong General Hospital GuangzhouChina General Hospital affiliated to Tianjin Medical University TianjinChina Sichuan Rehabilitation Hospital ChengduChina Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine ShanghaiChina Chinese PLA General Hospital BeijingChina Fujian Medical University Union Hospital FuzhouChina The First Hospital affiliated to Hebei Medical University ShijiazhuangChina Peking Union Medical College Hospital BeijingChina West China Hospital affiliated to Sichuan University ChengduChina Qilu Hospital affiliated to Shandong University JinanChina The First Hospital affiliated to Guangzhou Medical University GuangzhouChina Huashan Hospital affiliated to Fudan University ShanghaiChina Tiantan Hospital affiliated to Capital Medical University BeijingChina The First Hospital affiliated to Anhui Medical University HefeiChina Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine HangzhouChina The Affiliated Hospital Qingdao University School of MedicineQingdaoChina

Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in *** is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural *** the disease progresses,additional complications can arise such as non-motor and neurobehavioral *** treatment and surgical intervention for PD have been implemented in *** 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different *** then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,***,the overall level of treatment for PD in China ***:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of ***:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the *** principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor ***,different treatment strategies should be considered at different stages of the ***,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.

关键词： Parkinson’s disease Treatment guideline optimal therapeutic options China

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土默特地区不同苜蓿品种生产性能的比较

西北农林科技大学学报（自然科学版） 2017年第4期45卷 65-70,78页

作者：肖燕子于洁孟凯李星月米福贵内蒙古农业大学草原与资源环境学院内蒙古呼和浩特010019

【目的】筛选适宜内蒙古土默特地区种植的苜蓿品种资源,确定合理的管理模式,为当地建立苜蓿栽培草地提供优良种质。【方法】对国内外12个苜蓿品种进行区域试验,采用随机区组设计,于2012-2014年每年的初花期进行3次刈割,测定草产量及营... 详细信息

【目的】筛选适宜内蒙古土默特地区种植的苜蓿品种资源,确定合理的管理模式,为当地建立苜蓿栽培草地提供优良种质。【方法】对国内外12个苜蓿品种进行区域试验,采用随机区组设计,于2012-2014年每年的初花期进行3次刈割,测定草产量及营养成分(干物质(DM)、粗蛋白质(CP)、酸性洗涤纤维(ADF)、中性洗涤纤维(NDF))含量,计算相对饲用价值(RFV),根据产量和RFV的耦合作用筛选出最优苜蓿品种。【结果】2012年中苜2号的草产量、CP及RFV值均为最高。2013年草产量最高的是惊喜,但与中苜2号、草原3号无显著差异(P>0.05);中苜2号、草原3号和惊喜的CP含量均高于20%;RFV值最高的是中苜2号,显著高于其他品种(P<0.05)。2014年草产量最高的是惊喜,其次是中苜2号;CP含量最高的是中苜2号;RFV值最高的是中苜2号,其次为草原3号和惊喜。12个苜蓿品种的第1茬草产量对总产量的贡献率均最高。根据苜蓿产草量和RFV值的耦合结果,确定中苜2号、惊喜和草原3号属于较佳品种。【结论】中苜2号、草原3号和惊喜3个品种在年产量及营养品质方面表现较好,均更适合在土默特地区种植,且应在第1茬牧草收获期间做好田间管理。

关键词：苜蓿品种试验牧草产量营养价值