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Coherence phase spectrum analyzer for a randomly fluctuated fractional vortex beam

Photonics Research 2024年第1期12卷 33-39页

作者： ZHUOYI wang xingyuan LU JIANBO GAO XUECHUN ZHAO QIWEN ZHAN YANGJIAN CAI CHENGLIANG ZHAO School of Physical Science and Technology Soochow UniversitySuzhou 215006China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shandong Provincial Engineering and Technical Center of Light Manipulations&Shandong Provincial Key Laboratory of Optics and Photonic Device School of Physics and ElectronicsShandong Normal UniversityJinan 250358China Shandong Joint Research Center of Light Manipulation Science and Photonics Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghai 200241China

Fractional vortex beams exhibit a higher degree of modulation dimensions than conventional vortices,thus inheriting superior anti-turbulent transmission properties through the incorporation of additional coherence modulation.However,aliasing the mixed modes induced by coherence degradation makes the quantitative measurement of the topological charge in fractional vortex beams challenging.In this study,a coherence phase spectrum was introduced,and experimental demonstrations to quantitatively determine the fractional topological charge of partially coherent fractional vortex beams were performed.By leveraging the four-dimensional measurement of a partially coherent light field,the source coherence function was inversely reconstructed,and fractional topological charges were determined with high precision by extracting the phase spectrum of the coherence function.Laguerre–Gaussian,elliptical Gaussian,and plane-wave-fraction vortex beams with various degrees of coherence were used to demonstrate measurement precision.The proposed method is applicable to X-rays and electron vortices.It has potential applications in optical encryption,high-capacity optical communication,and quantum entanglement.

关键词： function fractional vortex

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Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway

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Journal of Traditional Chinese Medicine 2024年第2期44卷 251-259页

作者： CHANG Junli ZHAO Fulai SUN xingyuan MA Xiaoping ZHAO Peng ZHOU Chujie SHI Binhao GU Wenchao wang Yongjun YANG Yanping Spine Disease Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Diagnostic and Interventional Radiology University of TsukubaIbaraki 315-0114Japan

OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-catenin signaling pathway.METHODS:Cell viability,apoptosis and cell cycle distribution were examined using cell counting kit-8 and flow cytometry assays.The morphology of cancer cells was observed with inverted phase contrast microscope.The migration and invasion abilities were examined by xCELLigence real time cell analysis DP system and transwell assays.The expressions of poly(adenosine diphosphate-ribose)polymerase,C-Myc,Cyclin B1,cyclin-dependent kinases 1,N-cadherin,Vimentin,Active-β-catenin,β-catenin,p-glycogen synthase kinase 3β(GSK-3β)and GSK-3βwere determined by Western blotting assay.RESULTS:PPⅠ sensitized TRAIL-induced decrease of viability,migration and invasion,as well as increase of apoptosis and cell cycle arrest of MG-63 and U-2 OS osteosarcoma cells.The synergistic effect of PPⅠwith TRAIL in inhibiting the growth of osteosarcoma cells was at least partially realized through the inactivation of Wnt/β-catenin signaling pathway.CONCLUSION:The combination of PPⅠ and TRAIL is potentially a novel treatment strategy of osteosarcoma.

关键词： osteosarcoma tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway beta-catenin polyphyllinⅠ

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A scheme for realizing nonreciprocal interlayer coupling in bilayer topological systems

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Frontiers of Optoelectronics 2023年第4期16卷 71-80页

作者： Xiaoxiao wang Ruizhe Gu Yandong Li Huixin Qi Xiaoyong Hu Xingyuan Wang Qihuang Gong State Key Laboratory for Mesoscopic Physics and Department of Physics Collaborative Innovation Center of Quantum Matter&Frontiers Science Center for Nano-OptoelectronicsBeijing Academy of Quantum Information SciencesPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Hefei National Laboratory Hefei 230088China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Nonreciprocal interlayer coupling is difcult to practically implement in bilayer non-Hermitian topological photonic systems.In this work,we identify a similarity transformation between the Hamiltonians of systems with nonreciprocal interlayer coupling and on-site gain/loss.The similarity transformation is widely applicable,and we show its application in one-and two-dimensional bilayer topological systems as examples.The bilayer non-Hermitian system with nonreciprocal interlayer coupling,whose topological number can be defned using the gauge-smoothed Wilson loop,is topologically equivalent to the bilayer system with on-site gain/loss.We also show that the topological number of bilayer non-Hermitian C6v-typed domaininduced topological interface states can be defned in the same way as in the case of the bilayer non-Hermitian Su–Schrieffer–Heeger model.Our results show the relations between two microscopic provenances of the non-Hermiticity and provide a universal and convenient scheme for constructing and studying nonreciprocal interlayer coupling in bilayer non-Hermitian topological systems.This scheme is useful for observation of non-Hermitian skin efect in three-dimensional systems.

关键词： Nonreciprocal Bilayer Interlayer coupling Topological photonics

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Coupling Co-Ni phosphides for energy-saving alkaline seawater splitting

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Nano Research 2024年第6期17卷 4797-4806页

作者： Weijia Liu Wenxian Liu Tong Hou Junyang Ding Zhigui wang Ruilian Yin xingyuan San Ligang Feng Jun Luo Xijun Liu State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured MaterialsMOE Key Laboratory of New Processing Technology for Nonferrous Metals and MaterialsSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Hebei Key Laboratory of Optic-electronic Information and Materials the College of Physics Science and TechnologyHebei UniversityBaoding 071002China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaShenzhen 518110China

The coupling of energy-saving small molecule conversion reactions and hydrogen evolution reaction(HER)in seawater electrolytes can reduce the energy consumption of seawater electrolysis and mitigate chlorine corrosion issues.However,the fabrication of efficient multifunctional catalysts for this promising technology is of great challenge.Herein,a heterostructured catalyst comprising CoP and Ni_(2)P on nickel foam(CoP/Ni_(2)P@NF)is reported for hydrazine oxidation(HzOR)-assisted alkaline seawater splitting.The coupling of CoP and Ni_(2)P optimizes the electronic structure of the active sites and endows excellent electrocatalytic performance for HzOR and HER.Impressively,the two-electrode HzOR-assisted alkaline seawater splitting(OHzS)cell based on the CoP/Ni_(2)P@NF required only 0.108 V to deliver 100 mA·cm^(−2),much lower than 1.695 V for alkaline seawater electrolysis cells.Moreover,the OHzS cell exhibits satisfactory stability over 48 h at a high current density of 500 mA·cm^(−2).Furthermore,the CoP/Ni_(2)P@NF heterostructured catalyst also efficiently catalyzed glucose oxidation,methanol oxidation,and urea oxidation in alkaline seawater electrolytes.This work paves a path for high-performance heterostructured catalyst preparation for energy-saving seawater electrolysis for H_(2) production.

关键词： seawater splitting heterostructure electrocatalysis hydrazine oxidation reaction hydrogen evolution reaction

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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang Yong Li Songwang Cai xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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Enhanced rate capability and mitigated capacity decay of ultrahigh-nickel cobalt-free LiNi_(0.9)Mn_(0.1)O_(2) cathode at high-voltage by selective tungsten substitution

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Chinese Chemical Letters 2023年第7期34卷 354-359页

作者： Xingyuan Wang Bao Zhang Zhiming Xiao Lei Ming Minghuang Li Lei Cheng Xing Ou Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China

Owing to the further requirement for electric vehicle market, it is appropriate to lower the cost and improve the energy density of lithium-ion batteries by adopting the Co-free and Ni-rich layered cathodes.However, their practical application is severely limited by structural instability and slow kinetics. Herein,ultrahigh-nickel cobalt-free LiNi_(0.9)Mn_(0.1)O_(2) cathode is elaborate designed via in-situ trace substitution of tungsten by a wet co-precipitation method following by high-temperature sintering. It is revealed that the in-situ doping strategy of high valence W^(6+) can effectively improve the structure stability by reducing irreversible phase transition and suppressing the formation of microcracks. Moreover, the transformed fine particles determined by W-doping can facilitate the kinetic characteristics by shortening Li^(+) diffusion paths. As expected, 0.3 mol% W-doped LiNi_(0.9)Mn_(0.1)O_(2) cathode exhibits a high specific capacity of 143.5 mAh/g after 200 cycles at high rate of 5 C in the wide potential range of 2.8-4.5 V, representing a potential next-generation cathode with low-cost, high energy-density and fast-charging capabilities.

关键词： Lithium-ion batteries Ultrahigh-nickel cobalt-free cathode In-situ tungsten doping High cut-off voltage Rapid charge performance

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Clinical characteristics of testicular non-seminomatous germ cell tumor from West China: a 10-year experience

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Chinese Medical Journal 2022年第13期135卷 1631-1633页

作者： Zeyu Chen Xingyuan Wang Dehong Cao Shi Qiu Jin Li Bo Chen Yin Huang Yige Bao Liangren Liu Qiang Wei Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China Center of Biomedical Big Data West China HospitalSichuan UniversityChengduSichuan 610041China.

To the Editor:Testicular tumor represents 1%of male neoplasms and 5%of urogenital tumors.Non-seminomatous germ cell tumor(NSGCT)accounts for nearly 40%of all testicular cancers.The survival of patients with NSGCT has been improved because of advanced multimodal therapies(orchiectomy,and if necessary,subsequent chemotherapy).[1]However,to the best of our knowledge,survival of NSGCT patients has not been studied in a large Chinese cohort yet.Therefore,this study assessed the clinical characteristics,treatments,and outcomes of patients with NSGCT.

关键词： neoplasms chemotherapy patients

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自由贸易协定与专利出海——基于TRIPS-plus专利规则视角

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国际贸易问题 2024年第3期 139-156页

作者：王星媛韩剑廖陈成南京大学商学院

本文聚焦于自由贸易协定中的TRIPS-plus专利规则,将自由贸易协定中的TRIPS-plus专利规则与专利出海纳入到一个统一的分析框架,深入揭示TRIPS-plus专利规则影响专利出海的内在机理。同时,利用谷歌专利云数据,在测算各国海外专利申请水平... 详细信息

本文聚焦于自由贸易协定中的TRIPS-plus专利规则,将自由贸易协定中的TRIPS-plus专利规则与专利出海纳入到一个统一的分析框架,深入揭示TRIPS-plus专利规则影响专利出海的内在机理。同时,利用谷歌专利云数据,在测算各国海外专利申请水平的基础上,建立高维固定效应面板泊松模型,实证检验TRIPS-plus专利规则对专利出海的影响效应与方向。研究结果表明:TRIPS-plus专利规则能通过降低专利出海壁垒和提高专利国际市场竞争力来推动一国专利出海活动的开展,且其对以美、日、欧为首的发达国家的专利出海的促进效应最强,而发展中国家只有彼此之间存续TRIPS-plus专利规则,TRIPS-plus专利规则才能为发展中国家专利出海提供动力;虽然TRIPS-plus专利规则为专利出海提供了政策激励,但并不意味着TRIPS-plus专利规则深化水平越高越好;TRIPS-plus专利规则对专利出海的影响效应因自由贸易协定的形式和数量而存在异质性。本文不仅系统评估了TRIPS-plus专利规则的技术创新效应,也为广大发展中国家应对TRIPSplus扩张提供了政策方向。

关键词：自由贸易协定 TRIPS-plus 专利规则专利出海

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论发挥地方立法实施性、补充性、探索性功能的路径——以《上海市体育发展条例》为例

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体育科研 2024年第2期45卷 9-13页

作者：王星元上海市人大社会建设委员会上海200003

我国实行统一而分层次的立法体制,地方性法规作为中国特色社会主义法治体系的重要组成部分,要抓住提高立法质量这个关键,充分发挥地方立法实施性、补充性、探索性功能。《上海市体育发展条例》的立法过程,充分体现牢牢坚持科学立法、民... 详细信息

我国实行统一而分层次的立法体制,地方性法规作为中国特色社会主义法治体系的重要组成部分,要抓住提高立法质量这个关键,充分发挥地方立法实施性、补充性、探索性功能。《上海市体育发展条例》的立法过程,充分体现牢牢坚持科学立法、民主立法、依法立法的总原则,立足反映群众意愿、满足实际需要、固化特色经验,推动解决实践中“无法可依”的具体问题,切实提升地方立法实效性,为提升上海体育治理体系和治理能力现代化水平、促进新时代上海体育事业高质量发展、加快推进全球著名体育城市建设提供了坚实的法治保障。旨在以《上海市体育发展条例》的立法过程和重点条款为例,探讨实现地方立法实施性、补充性、探索性的方法和路径,以期为地方立法工作提供有益的参考和借鉴。

关键词：《上海市体育发展条例》实施性补充性探索性闲置空间建设公共体育设施高危险性体育项目预付费经营活动

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关键核心技术攻关驱动因素及实现路径——以集成电路产业为例的组态分析

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科技管理研究 2024年第2期44卷 1-11页

作者：王兴元许智颖王舒扬山东大学管理学院山东济南250100 山东省创新发展研究院山东济南250101

关键核心技术作为国之重器占据重要战略位置,但关键核心技术的关键驱动要素机制与可实现路径尚未明晰。为揭示关键核心技术攻关有效的驱动因素及组态路径模式,在厘清关键核心技术的概念特征基础上,基于技术-组织-环境理论框架,以集成电... 详细信息

关键核心技术作为国之重器占据重要战略位置,但关键核心技术的关键驱动要素机制与可实现路径尚未明晰。为揭示关键核心技术攻关有效的驱动因素及组态路径模式,在厘清关键核心技术的概念特征基础上,基于技术-组织-环境理论框架,以集成电路产业为例,利用定性比较分析与必要条件分析法对我国28个省份的关键核心技术攻关的必要条件及可实现路径展开研究。结果发现:(1)数字化技术、R&D投入强度、市场化环境和政府支持度是决定关键核心技术攻关的关键因素;(2)存在3条关键核心技术攻关的有效路径,分别是高数字技术下市场导向型、高组织集聚下产业导向型和高研发资助下政府导向型,且均以技术层为基础、组织及环境层为支持;(3)产业协同能弥补关键核心技术攻关的创新要素匮乏的不足,同时政府资助的影响力不容忽视。因此,进一步推动集成电路产业关键核心技术攻关,要以丰富新一代信息技术资本存量与增加科技研发资本流量为两大着力点,在积极为关键核心技术攻关提供政府资金支持的同时引导社会资源投入,为关键核心技术打造良好的外部发展环境。

关键词：关键核心技术集成电路产业协同技术攻关政府资助路径识别

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