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Flt3L、TGF-β1及EGFR与急性髓系白血病患者不良预后的关系

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实用癌症杂志 2024年第1期39卷 74-77页

作者：高磊赵梅魏兴禹河南省周口市中心血站 466000 河南省周口市第二人民医院 466000 河南省周口开元医院 466000

目的探究FMS样酪氨酸激酶3配体(Flt3L)、转化生长因子β1(TGF-β1)及表皮生长因子受体(EGFR)与急性髓系白血病(AML)患者不良预后的关系。方法选取120例首次确诊AML患者作为观察组,募集同期体检的100例健康志愿者为对照组,比较2组的Flt3L... 详细信息

目的探究FMS样酪氨酸激酶3配体(Flt3L)、转化生长因子β1(TGF-β1)及表皮生长因子受体(EGFR)与急性髓系白血病(AML)患者不良预后的关系。方法选取120例首次确诊AML患者作为观察组,募集同期体检的100例健康志愿者为对照组,比较2组的Flt3L、TGF-β1及EGFR水平。观察组患者出院后随访3~12个月,根据预后情况将患者分为良好组(86例)和不良组(34例),比较2组的临床资料,采用COX模型分析上述指标与患者不良预后的关系,采用受试者工作特征(ROC)曲线探究上述指标对AML患者不良预后的预测效能。结果观察组Flt3L、TGF-β1水平低于对照组,EGFR水平高于对照组,差异有统计学意义(P<0.05)。不同预后AML患者的Flt3L、TGF-β1及EGFR水平比较差异有统计学意义(P<0.05);COX模型分析显示Flt3L、TGF-β1及EGFR水平为AML患者预后不良的独立影响因素(P<0.05)。经ROC曲线分析显示,Flt3L、TGF-β1及EGFR水平预测AML患者预后不良的AUC为0.874、0.838、0.858。结论Flt3L、TGF-β1及EGFR与AML患者不良预后相关。

关键词： FMS样酪氨酸激酶3配体转化生长因子β1 表皮生长因子受体急性髓系白血病预后

西北中等职业教育与乡村振兴协调发展:时空特征及其驱动因子

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职业技术教育 2024年第9期45卷 53-61页

作者：郭文强曾鑫雷明尹凤至韦星羽新疆财经大学信息管理学院乌鲁木齐830012 北京大学乡村振兴研究院新疆财经大学

实现中等职业教育与乡村振兴的协调发展是激发乡村内生性力量的关键举措。基于西北地区五省(自治区)2011-2021年的面板数据,构建中等职业教育与乡村振兴综合评价指标体系,综合运用熵值法、综合评价模型、耦合协调模型、趋势分析法以及... 详细信息

实现中等职业教育与乡村振兴的协调发展是激发乡村内生性力量的关键举措。基于西北地区五省(自治区)2011-2021年的面板数据,构建中等职业教育与乡村振兴综合评价指标体系,综合运用熵值法、综合评价模型、耦合协调模型、趋势分析法以及地理探测器,对两系统协调演进关系定量测定。研究结果发现:西北地区中等职业教育与乡村振兴综合发展水平大致呈现递增趋势且具有“西低东高,南高北低”空间布局特征;耦合协调度逐年提升,协调互促作用愈加显著,且受到经济发展水平、对外开放程度等多因子的综合影响。基于此提出促进西北地区中等职业教育与乡村振兴区域间协调发展建议:改革教育模式,实现供需匹配;促进创新氛围,吸引人才回流;充分发挥区位优势,挖掘乡村价值。

关键词：中等职业教育乡村振兴耦合协调度地理探测器西北地区

面向太空垃圾捕获的自生长柔性变刚度机械臂设计与控制策略研究

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中国科学：物理学、力学、天文学 2024年第6期54卷 90-101页

作者：房付熠李汶柏魏星宇王叙宁吴志渊易志然张文明上海交通大学机械与动力工程学院上海200240 同济大学航空航天与力学学院上海200092

随着人类探索宇宙步伐的不断加速,太空轨道垃圾已成为一个重大的安全隐患.现有的刚性机械臂、飞网等捕获方式对不同距离、不同尺寸轨道垃圾的适应性有限,缺少一种能够应对各类轨道垃圾的捕获装置和捕获策略.针对这一问题,本文利用曲壳... 详细信息

随着人类探索宇宙步伐的不断加速,太空轨道垃圾已成为一个重大的安全隐患.现有的刚性机械臂、飞网等捕获方式对不同距离、不同尺寸轨道垃圾的适应性有限,缺少一种能够应对各类轨道垃圾的捕获装置和捕获策略.针对这一问题,本文利用曲壳梁可变刚度的特性,设计了一种新型的空间自生长柔性变刚度机械臂,实现了机械臂工作距离的大范围可调性;在此基础上,本文对这种新型的机械臂进行了动力学分析,提出了针对机械臂臂长分配的等矩原则,并建立了相应的算法;进一步的,本文面向跨尺寸的太空垃圾捕获,分别提出了抓取策略和缠绕策略,并采用取样避障和样条曲线方法,对机械臂进行了轨迹规划;最后,本文对所提出的针对自生长柔性变刚度机械臂的控制方法进行了仿真,验证了其可行性.

关键词：太空垃圾机械臂设计控制策略仿真验证

Experimental crushing behavior and energy absorption of angular gradient honeycomb structures under quasi-static and dynamic compression

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Defence Technology（防务技术） 2024年第6期36卷 47-63页

作者： Jiachen Li Yuchen wei Hao Wu xingyu Shen Mengqi Yuan State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Institute of Occupational Health China Academy of Safety Science and TechnologyBeijing 100012China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

The high variability of shock in terrorist attacks poses a threat to people's lives and properties,necessitating the development of more effective protective *** study focuses on the angle gradient and proposes four different configurations of concave hexagonal honeycomb *** structures'macroscopic deformation behavior,stress-strain relationship,and energy dissipation characteristics are evaluated through quasi-static compression and Hopkinson pressure bar impact *** study reveals that,under varying strain rates,the structures deform starting from the weak layer and exhibit significant interlayer ***,interlayer shear slip becomes more pronounced with increasing strain *** terms of quasi-static compression,symmetric gradient structures demonstrate superior energy absorption,particularly the symmetric negative gradient structure(SNG-SMS)with a specific energy absorption of 13.77 J/cm~*** dynamic impact,unidirectional gradient structures exhibit exceptional energy absorption,particularly the unidirectional positive gradient honeycomb structure(UPG-SML)with outstanding mechanical *** angle gradient design plays a crucial role in determining the structure's stability and deformation mode during *** interlayer separations result in a more pronounced negative Poisson's ratio effect and enhance the structure's energy absorption *** findings provide a foundation for the rational design and selection of seismic protection structures in different strain rate impact environments.

关键词： Negative Poisson's ratio Gradient honeycomb structure Quasi-static compression Dynamic impact Titanium alloy

Attractive egg color?Red eggs facilitate egg acceptance in a cavity-nesting host

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Current Zoology 2024年第1期70卷 112-114页

作者： Jianping Liu xingyu Wang wei Liang College of Biological Sciences and Engineering North Minzu UniversityYinchuan 750021China Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China

Hosts evolve defensive strategies to minimize the reproductive costs of brood parasitism,in turn,the hosts'defense promote the optimization of cuckoo parasitism strategies(Soler 2017).Recognizing foreign eggs and selectively removing them from the nest can minimize the fitness costs associated with rearing parasitic fledglings(Soler 2017).Since Rothstein(1971)first experimented with the addition of a model egg to a host nest in the early incubation period to study host egg recognition,the use of model eggs has become one of the most important methods for testing the egg recognition abilities of hosts(Hauber et al.2019).Some studies have looked at various egg colors and their effect on host egg rejection and found differential responses to egg colors(for more details,see Supplementary Materials),highlighting that more work needs to examine the effect of model egg color on host egg rejection behavior.

关键词： coevolution egg recognition egg mimcry model egg Parus monticolus

Thin paints for durable and scalable radiative cooling

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Journal of Energy Chemistry 2024年第3期90卷 176-182,I0006页

作者： Shanquan Liu Fei Zhang xingyu Chen Hongjie Yan wei Chen Meijie Chen School of Energy Science and Engineering Central South UniversityChangsha 410083HunanChina School of Intelligent Manufacturing Ecosystem Xi'an Jiaotong-Liverpool UniversitySuzhou 215400JiangsuChina

Passive daytime radiative cooling(PDRC) is environment-friendly without energy input by enhancing the coating's solar reflectance(R_(solar)) and thermal emittance(ε_(LWIR)) in the atmosphere's long-wave infrared transmission ***,high R_(solar) is usually achieved by increasing the coating's thickness,which not only increases materials' cost but also impairs heat ***,the desired high R_(solar) is vulnerable to dust pollution in the *** this work,a thin paint was designed by mixing hBN plates,PFOTS,and IPA. R_(solar)=0.963 and ε_(LWIR)=0.927 was achieved at a thickness of 150 μm due to the high backscattering ability of scatters.A high through-plane thermal conductivity(~1.82 W m^(-1) K^(-1)) also can be *** addition,the porous structure coupled with the binder PFOTS resulted in a contact angle of 154°,demonstrating excellent durability under dust *** experiments showed that the thin paint can obtain a 2.3℃ lower temperature for sub-ambient cooling than the reference PDRC coating in the ***,the above-ambient heat dissipation performance can be enhanced by spraying the thin paint on a 3D heat sink,which was 15.7℃ lower than the reference 1D structure,demonstrating excellent performance for durable and scalable PDRC applications.

关键词： Radiative cooling Heat dissipation Solar reflectance Thermal emittance Contact angle

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露天煤矿数字化转型建设思路

露天采矿技术 2024年第2期39卷 20-25页

作者：魏星宇董强陈纲褚立庆张秋霞何帅国家电投集团科学技术研究院有限公司北京102200 国家电投集团内蒙古能源有限公司内蒙古呼和浩特010020 中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122

论述了露天煤矿数字化转型面临的问题和机遇;从工艺、角色、功能3个维度挖掘矿山生产全貌,分析露天煤矿企业数字化转型的途径,认识和总结了矿山生产运作分级流程框架和应用功能与数据流框架,对露天煤矿的数字化转型建设思路进行了探讨。

关键词：数字化转型露天煤矿维度分级业务流程途径

顺铂致肝损伤小鼠Notch信号通路差异基因筛选及针灸对其调控的研究

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世界科学技术-中医药现代化 2024年第2期26卷 367-374页

作者：王建明韩乐于冬冬杜雪源晁利芹范世东王文哲张晨魏星宇河南中医药大学针灸推拿学院郑州450046 河南中医药大学第三附属医院郑州450003 河南中医药大学中医学院郑州450046 河南中医药大学医学院郑州450046

目的通过筛选顺铂(Cisplatin,DDP)致肝损伤小鼠肝组织中Notch信号通路显著性差异基因,探讨针灸改善肝损伤的作用机制。方法雄性KM小鼠随机分成空白组、模型组、针刺组、艾灸组、阻断剂针刺组、阻断剂艾灸组,每组10只。空白组以10 mg·kg... 详细信息

目的通过筛选顺铂(Cisplatin,DDP)致肝损伤小鼠肝组织中Notch信号通路显著性差异基因,探讨针灸改善肝损伤的作用机制。方法雄性KM小鼠随机分成空白组、模型组、针刺组、艾灸组、阻断剂针刺组、阻断剂艾灸组,每组10只。空白组以10 mg·kg^(-1)剂量腹腔注射0.9%NaCl溶液,其余各组腹腔注射同等剂量的DDP溶液,24 h后模型成功。针刺组、阻断剂针刺组取“大椎”和双侧“肝俞”“肾俞”“足三里”干预,艾灸组、阻断剂艾灸组取相同腧穴干预,阻断剂组均于治疗前30 min腹腔注射同等剂量的DAPT。连续干预5天,于第6天取肝脏左外侧叶备检DEGseq、免疫组化以及透射电镜。结果DEGseq初步筛选出57个与Notch信号通路相关差异基因,7个热点基因Notch1、Hes1、Adam17、Lfng、Numb、Hdac1、Notch2与肝损伤关系密切。免疫组化法对7个热点基因进一步筛选,与空白组比,模型组中Notch1、Hes1、Adam17、Lfng、Numb、Notch2、Hdac1蛋白含量上调,差异有统计学意义(P0.05)。超微病理示针灸对损伤的肝细胞具有明显的修复作用,且优于阻断剂组。结论针刺和艾灸可能通过良性调节与Notch信号通路显著性相关的差异基因Notch1、Hes1、Adam17、Lfng的表达,抑制Notch信号通路异常激活,并能改善受损的肝细胞微观结构,减轻DDP化疗所致肝损伤,这可能是针灸减轻DDP致肝损伤的机制之一。

关键词：针灸顺铂肝损伤 Notch信号通路

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New advances in fiber-reinforced composite honeycomb materials

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Science China(Technological Sciences) 2020年第8期63卷 1348-1370页

作者： wei xingyu XIONG Jian WANG Jie XU Wu Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150080China Shanghai Aircraft Design and Research Institute Shanghai 201210China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

In sandwich structures,lightweight cellular materials as the core hold the face sheets far away from the neutral axis to maximize the bending performance of the *** materials as a major type of lightweight cellular materials have been widely applied in various fields,including aerospace,vehicle,marine,architecture and mechanical engineering,due to reliable mechanical properties and excellent *** fiber-reinforced composites is an efficient method to develop ultralight honeycomb materials with superior mechanical *** recent years,fiber-reinforced composite honeycomb materials possessing lightweight and excellent mechanical performances have attracted noticeable attention to replacing traditional aluminum honeycombs and Nomex *** to metal,polymer and Nomex paper,fiber-reinforced composites possess various merits,such as high specific stiffness and specific strength,excellent fatigue property,corrosion resistance and high-temperature ***,the applications of fiber-reinforced honeycomb material for sandwich core have unlimited potential in hypersonic vehicles,long-range rockets,cargo vessels and protective *** the fact that attention has been rapidly increasing,there is a lack of comprehensive reviews of new advances in the field of fiber-reinforced composite honeycomb *** this review,new advances reported by different scientists in the field of fiber-reinforced honeycomb materials have been reviewed and analyzed to provide an in-depth overview and knowledge for beginners in the field of ultralightweight and high-performance composite sandwich *** challenges and prospects for the development of fiberreinforced honeycomb materials have also been presented.

关键词： composite honeycomb materials sandwich structures failure mechanism mechanical property