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Herbal small RNAs in patients with COVID-19 linked to reduced DEG expression

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Science China(Life Sciences) 2023年第8期66卷 1280-1289页

作者： Xiangyu Qiao Fengming Huang Xiaohu Shi xingyu deng Cong Zhang Song Mei Zhiqing Wang Congzhao Zhou Chengyu Jiang Xinghua Tan State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistrySchool of Basic Medicine Peking Union Medical CollegeBeijing100005China Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing100730China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei230027China Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangzhou510440China

In China,more than 80%of patients with coronavirus disease 2019(COVID-19)received traditional Chinese medicine(TCM)as a treatment and their clinical efficacy have been ***,the underlying molecular mechanism remains *** studies have identified herbal small RNAs(s RNAs)as novel functional *** this study,a cohort of 22patients with COVID-19 treated with Toujie Quwen(TQ)granules was *** observed thousands of herbal small RNAs that entered the blood cells of patients after the consumption of TQ *** response to this treatment,the reduced differentially expressed genes(DEGs)were highly correlated with the predicted target genes of the most prevalent herbal s RNAs detected in the ***,the predicted target genes of the top 30 s RNAs from each of the 245 TCMs in the Bencao s RNA Atlas overlapped with 337 upregulated DEGs in patients with mild COVID-19,and 33 TCMs,with more than 50%overlapping genes were identified as effective *** predicted target genes of top 30 s RNAs from Juhong,Gualoupi and Foshou were confirmed *** results not only elucidated a novel molecular mechanism of TCM potential clinical efficacy for COVID-19 patients,but also provided 33 effective COVID-19 TCMs for prescription optimization.

关键词： traditional Chinese medicine Toujie Quwen granules CovID-19 transcriptome

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Delamination Damage Detection in Laminated Composite by LDR-Based Multi-frequency Method

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Transactions of Nanjing University of Aeronautics and Astronautics 2020年第S1期37卷 28-34页

作者： deng xingyu QIU Jinhao JI Hongli ZHANG Chao State Key Laboratory of Mechanics and Control of Mechanical Structure College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

Local defected resonance(LDR)is a recently-developed non-destructive testing method,which identifies damage by detecting the vibrational response of the structural surface under the wideband ultrasonic excitation. The concept of LDR is studied and applied for damage imaging of delamination in composite laminates. Aiming at the problem of poor anti-noise ability and inaccurate damage identification in traditional detection process,an LDR-based multi-frequency method is proposed. Experimental results show that the proposed method can realize the localization and imaging of delamination damage in composite materials.

关键词： carbon fibre reinforced polymer local defect resonance(LDR) multi-frequency non-destructive testing

Experimental and numerical demonstration of hierarchical time-delay reservoir computing based on cascaded VCSELs with feedback and multiple injections

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Science China(Information Sciences) 2024年第2期67卷 279-290页

作者： Xingxing GUO Shuiying XIANG xingyu CAO Biling GU State Key Laboratory of Integrated Service Networks Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology School of MicroelectronicsXidian University

In this paper, we propose and demonstrate experimentally and numerically a hierarchical timedelay optical reservoir computing(RC) system based on cascaded vertical-cavity surface-emitting lasers(VCSELs) with feedback and multiple injections. The prediction performance characteristics of the hierarchical time-delay RC system based on cascaded VCSELs under different reservoir layers are ***, the prediction performance of the hierarchical time-delay RC system is first improved and saturates as the number of reservoir layers increases. Besides, the impacts of key factors on predicting the hierarchical time-delay RC system are also analyzed in detail experimentally and numerically. This proposed hierarchical time-delay RC system based on VCSELs is useful for the further development of RC systems and may be beneficial to improve the ability of RC systems to solve more complex problems.

关键词： vertical-cavity surface-emitting laser reservoir computing neuromorphic photonics time-delay system information processing

Crowdsourcing RTK:a new GNSS positioning framework for building spatial high-resolution atmospheric maps based on massive vehicle GNSS data

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Satellite Navigation 2024年第1期5卷 91-108页

作者： Hongjin Xu xingyu Chen Jikun Ou Yunbin Yuan State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and Technology(APM)Chinese Academy of Sciences(CAS)Wuhan430071China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

High-quality spatial atmospheric delay correction information is essential for achieving fast integer ambiguity resolution(AR)in precise ***,traditional real-time precise positioning frameworks(i.e.,NRTK and PPP-RTK)depend on spatial low-resolution atmospheric delay correction through the expensive and sparsely distributed CORS *** results in limited public *** the mass production of autonomous driving vehicles,more cost-effective and widespread data sources can be explored to create spatial high-resolution atmospheric *** this study,we propose a new GNSS positioning framework that relies on dual base stations,massive vehicle GNSS data,and crowdsourced atmospheric delay correction maps(CAM).The map is easily produced and updated by vehicles equipped with GNSS receivers in a crowd-sourced ***,the map consists of between-station single-differenced ionospheric and tropospheric *** introduce the whole framework of CAM initialization for individual vehicles,on-cloud CAM maintenance,and CAM-augmented user-end *** map data are collected and preprocessed in ***,the crowdsourced data are uploaded to a cloud *** massive data from multiple vehicles are merged in the cloud to update the CAM in ***,the CAM will augment the user positioning *** framework forms a beneficial cycle where the CAM’s spatial resolution and the user positioning performance mutually improve each *** validate the performance of the proposed framework in real-world experiments and the applied potency at different spatial *** highlight that this framework is a reliable and practical positioning solution that meets the requirements of ubiquitous high-precision positioning.

关键词： New GNSS positioning framework Spatial high-resolution atmospheric delay correction Crowdsourced atmospheric delay correction maps Crowdsourced ionosphere Crowdsourced troposphere Ubiquitous

Numerical study on the blocking effect of skin on Flash-Ball Impact and damage assessment

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Defence Technology（防务技术） 2024年第3期33卷 532-545页

作者： Dihua Ouyang Chunwei Qin Xiaowen Qin Qiantao Zhang xingyu Liu Xi'an University of Architecture and Technology Xi'an 710055China Analysis and Testing Center Xi'an University of Architecture and TechnologyXi'an 710055China Engineering University of PAP Xi'an 710086China

To explore the response law of non-lethal large-size kinetic energy projectiles to blunt attack on skin tissue,and to evaluate the skin injury characteristics of the attacked personnel and the use safety of kinetic energy *** on the LS-DYNA simulation software,a three-layer skin simulation model and a Flash-Ball rubber bullet model are established,and the force-time and deformation-time biomechanical corridors of the Flash-Ball rubber bullet impacting human skin tissue are *** corridor curve and the energy transfer and diffusion are analyzed and *** safety evaluation of the damage caused by the rubber bullet shooting a human body at different distances is carried out using the empirical formula of the penetration ***,the safe shooting distance is *** results show that the model used in the simulation has a good correlation with the experimental data,its biomechanical corridor characteristics are different from those of conventional vehicle impact and smallsize projectile response *** energy transfer and action time of medium and low-speed impact may cause greater *** fat layer is the largest energy absorption *** minimum safe shooting distance to ensure skin tissue from penetrating damage is 15.8 m,and the limit specific kinetic energy of skin damage is 7.88 J/cm^(2).This study can be extended to the study of biomechanical response law and safety evaluation under the impact of the same type of large kinetic energy projectile,which provides an important theoretical reference for the police to use large kinetic energy projectiles to conduct safe shooting in peacekeeping operations.

关键词： KIPs Blunt strike Biomechanical response Damage analysis

Experimental crushing behavior and energy absorption of angular gradient honeycomb structures under quasi-static and dynamic compression

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Defence Technology（防务技术） 2024年第6期36卷 47-63页

作者： Jiachen Li Yuchen Wei Hao Wu xingyu Shen Mengqi Yuan State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Institute of Occupational Health China Academy of Safety Science and TechnologyBeijing 100012China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

The high variability of shock in terrorist attacks poses a threat to people's lives and properties,necessitating the development of more effective protective *** study focuses on the angle gradient and proposes four different configurations of concave hexagonal honeycomb *** structures'macroscopic deformation behavior,stress-strain relationship,and energy dissipation characteristics are evaluated through quasi-static compression and Hopkinson pressure bar impact *** study reveals that,under varying strain rates,the structures deform starting from the weak layer and exhibit significant interlayer ***,interlayer shear slip becomes more pronounced with increasing strain *** terms of quasi-static compression,symmetric gradient structures demonstrate superior energy absorption,particularly the symmetric negative gradient structure(SNG-SMS)with a specific energy absorption of 13.77 J/cm~*** dynamic impact,unidirectional gradient structures exhibit exceptional energy absorption,particularly the unidirectional positive gradient honeycomb structure(UPG-SML)with outstanding mechanical *** angle gradient design plays a crucial role in determining the structure's stability and deformation mode during *** interlayer separations result in a more pronounced negative Poisson's ratio effect and enhance the structure's energy absorption *** findings provide a foundation for the rational design and selection of seismic protection structures in different strain rate impact environments.

关键词： Negative Poisson's ratio Gradient honeycomb structure Quasi-static compression Dynamic impact Titanium alloy

Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

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Communications in Theoretical Physics 2024年第4期76卷 167-175页

作者： xingyu Qi Zilong Guo Shimin Le Hu Chen Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

Force spectrum measurements with constant loading rates are widely used in single-molecule manipulation experiments to study the mechanical stability and force response of ***-dependent transition rates can be obtained from the transition force distribution,but it is limited to the force range with non-zero force *** constant loading rate control can be realized with magnetic tweezers,the loading rate range is limited due to the slow movement of permanent ***-linear exponential and exponential squared force loading functions are more feasible in magnetic tweezers,while there is no theoretical result available for these two kinds of non-linear force loading *** this study,we solved the unfolding process of a protein following Bell's model under nonlinear exponential and exponential squared force loading functions,which offer a broader range of unfolding force distribution compared to the traditional constant loading rate ***,we derived two force loading functions,which can produce uniform unfolding force *** research contributes fundamental equations for the analysis of experimental data obtained through single-molecule manipulation under nonlinear force loading controls,paving the way for the use of nonlinear force control in magnetic tweezer experiments.

关键词： single-molecule manipulation magnetic tweezers force loading transition rates force distribution

Corrosion behaviors and kinetics of nanoscale zero-valent iron in water:A review

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Journal of Environmental Sciences 2024年第1期135卷 391-406页

作者： Chenliu Tang xingyu Wang Yufei Zhang Nuo Liu Xiang Hu Research Group of Water Pollution Control and Water Reclamation College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Shanghai Collaborative Innovation Centre for WEEE Recycling School of Resources and Environmental EngineeringShanghai Polytechnic UniversityShanghai 201209China

Knowledge on corrosion behaviors and kinetics of nanoscale zero-valent iron(nZVI)in aquatic environment is particularly significant for understanding the reactivity,longevity and stability of nZVI,as well as providing theoretical guidance for developing a cost-effective nZVI-based technology and designing large-scale ***,this review gives a holistic overview on the corrosion behaviors and kinetics of nZVI in ***,Eh-pH diagram is introduced to predict the thermodynamics trend of iron *** morphological,structural,and compositional evolution of(modified-)nZVI under different environmental conditions,assisted with microscopic and spectroscopic evidence,is then ***,common analytical methods and characterization technologies are categorized to establish time-resolved corrosion kinetics of nZVI in ***,stable models for calculating the corrosion rate constant of nZVI as well as electrochemical methods for monitoring the redox reaction are discussed,emphasizing their capabilities in studying the dynamic iron corrosion ***,in the future,more efforts are encouraged to study the corrosion behaviors of nZVI in long-term practical application and further build nanoparticles with precisely tailored *** expect that our work can deepen the understanding of the nZVI chemistry in aquatic environment.

关键词： Nanoscale zero-valent iron(nZVI) Corrosion behaviors Corrosion kinetics nZVI evolution

Review on the design of high-strength and hydrogen-embrittlement-resistant steels

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1572-1589页

作者： Zhiyu Du Rongjian Shi xingyu Peng Kewei Gao Xiaolu Pang Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Institute for Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110010China

Given the carbon peak and carbon neutrality era,there is an urgent need to develop high-strength steel with remarkable hydrogen embrittlement *** is crucial in enhancing toughness and ensuring the utilization of hydrogen in emerging iron and steel ***,the pursuit of enhanced metallic materials presents a cross-disciplinary scientific and engineering *** high-strength,toughened steel with both enhanced strength and hydrogen embrittlement(HE)resistance holds significant theoretical and practical *** ensures secure hydrogen utilization and further carbon neutrality objectives within the iron and steel *** on the design principles of high-strength steel HE resistance,this review provides a comprehensive overview of research on designing surface HE resistance and employing nanosized precipitates as intragranular hydrogen *** also proposes feasible recommendations and prospects for designing high-strength steel with enhanced HE resistance.

关键词： hydrogen embrittlement surface design hydrogen traps nanosized precipitates