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Zircon U-Pb Ages and Hf Isotopes of Neoproterozoic Meta-Igneous Rocks in the Liansandao Area,Northern Sulu Orogen,Eastern China,and the Tectonic Implications

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Journal of Earth Science 2019年第6期30卷 1230-1242页

作者： Zhaojun Song Huimin Liu Fanxue Meng xingyu Yuan Qiao feng Dingwu Zhou Juan Ramon Vidal Romani Hongbo Yan Shandong Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdao 266590China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China Instituto Universitario de Geologia(Universidad de A Coruna) Campus Universitario de Elvina15071 CorunaSpain

The Sulu Orogen preserves the Neoproterozoic tectonic-magmatic events,corresponding to the breaking up of the Rodinia *** ages and petrogenesis of meta-igneous rocks in the Liansandao area in the northern Sulu Orogen are not *** study reports zircon U-Pb ages and Hf isotopes of these rocks from the Liansandao *** meta-igneous rock samples give similar weighted mean 206 Pb/238 U ages of 744±11,767±12,and 762±15 Ma,respectively,indicating the Neoproterozoic crystallization *** rocks formed coevally with the Wulian and Yangkou intrusions that located along the Yantai-Qingdao-Wulian fault *** Neoproterozoic ages indicate that the meta-igneous rocks from the Liansandao area have affinity to the Yangtze *** three samples haveεHf(t)values of-7.2–-10.5,-6.0–-17.5,and-6.8–-12.0,*** negativeεHf(t)values indicate a primarily crustal ***,the widely variousεHf(t)values that are higher than the continental crust,suggesting magma mixing between mantle-derived materials and the continental crust or source *** with the Hf model ages and geochemical characteristics,the monzodiorite(sample LSD-2)is most likely to be mantle-derived magma then interacted with ancient continental crust,and the granitic protolith(samples LSD-1 and LSD-3)in the Liansandao area might derive from the re-melting of a Paleoproterozoic continental crust at^750 Ma,resulting from the upwelling and underplating of mantle-derived magma formed in an extensional setting due to the break-up of the Rodinia supercontinent.

关键词： Neoproterozoic zircon U-Pb age zircon Lu-Hf isotope Sulu Orogen

Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

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Nano Research 2021年第12期14卷 4577-4583页

作者： Bingbing Bai Chaoyu Gu Xiaohui Lu xingyu Ge Junling Yang Chenfei Wang Yongchun Gu Aidong Deng Yuehua Guo Xingmei feng Zhifeng Gu Department of Stomatology Affiliated Hospital of Nantong UniversityNantong226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong226001China Department of Rheumatology Affiliated Hospital of Nantong UniversityNantong226001China Department of Stomatology Suzhou Ninth People’s HospitalSuzhou215200China

Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery system based on polydopamine (PDA) functionalized mesoporous silica nanoparticles was developed for delivering minocycline hydrochloride (MH) to treat periodontitis. The outer PDA layer and the inner MH of the nanoparticles acted as ROS scavengers and anti-inflammatory agents, respectively. Under the synergistic action of PDA and MH, macrophages were polarized from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. The in vitro experiments provided convincing evidence that PDA could scavenge ROS effectively, and the expression of pro-inflammatory cytokines was attenuated and the secretion of anti-inflammatory cytokines was enhanced through M1 to M2 polarization of macrophages with the cooperation of MH. In addition, the results obtained from the periodontitis rat models demonstrated that the synergetic effect of PDA and MH prevented alveolar bone loss without causing any adverse effect. Taken together, the results from the present investigation provide a new strategy to remodel the inflammatory microenvironment by inducing the polarization of macrophages from M1 toward M2 state for the treatment of periodontitis.

关键词： periodontitis drug delivery reactive oxygen species macrophage polarization inflammatory microenvironment

不同腹腔镜手术治疗胃底贲门部胃肠间质瘤疗效的多中心研究

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中华消化外科杂志 2023年第4期22卷 519-525页

作者：张维富冯兴宇张鹏熊文俊叶再生陈韬邱海波杨悦生王伟陈路川余江王俊江吴德庆周志伟陶凯雄李勇广东医科大学第一临床医学院湛江524023 南方医科大学附属广东省人民医院(广东省医学科学院)胃肠外科普通外科广州510080 华中科技大学同济医学院附属协和医院胃肠外科武汉430022 广东省中医院广州中医药大学第二附属医院胃肠外科广州510120 福建省肿瘤医院福建医科大学附属肿瘤医院胃肠肿瘤外科福州350014 南方医科大学附属南方医院普通外科广州510515 中山大学肿瘤防治中心胃外科华南肿瘤学国家重点实验室肿瘤医学协同创新中心广州510060 汕头大学医学院汕头515041

目的:探讨不同腹腔镜手术治疗胃底贲门部胃肠间质瘤(GIST)的疗效。方法:采用回顾性队列研究方法,收集2007年12月至2021年12月我国广东省人民医院等14家医学中心收治的251例行腹腔镜根治性切除术胃底贲门部GIST患者的临床病理资料;男123... 详细信息

目的:探讨不同腹腔镜手术治疗胃底贲门部胃肠间质瘤(GIST)的疗效。方法:采用回顾性队列研究方法,收集2007年12月至2021年12月我国广东省人民医院等14家医学中心收治的251例行腹腔镜根治性切除术胃底贲门部GIST患者的临床病理资料;男123例,女128例;年龄为58(24,87)岁。观察指标:(1)治疗情况。(2)不同腹腔镜手术患者的临床病理资料情况。(3)特殊腹腔镜技术亚组分析。正态分布的计量资料以x±s表示,组间比较采用t检验或方差分析;偏态分布的计量资料以M(Q1,Q3)表示,组间比较采用Mann-Whitney U检验或Kruskal-Wallis H检验。计数资料以绝对数或百分比表示,等级资料比较采用秩和检验。结果:(1)治疗情况。251例患者中,202例行胃楔形切除术,26例行特殊腹腔镜技术(10例浆膜剥离切除术、16例经胃腔内切除术),23例行胃结构性切除术(6例全胃切除术、17例近端胃部分切除术)。251例患者中,24例出现术后并发症。(2)不同腹腔镜手术患者的临床病理资料情况。行胃楔形切除术患者性别(男、女),年龄,肿瘤最大径,手术时间,术中出血量,切口长度,术后首次进食全流质食物时间,术后首次进食半流质食物时间,术后住院时间,围手术期并发症,核分裂数(≤5/50高倍视野、6~10/50高倍视野、>10/50高倍视野),危险度分级(极低危险度、低危险度、中危险度、高危险度),肿瘤部位(贲门部、胃底部)分别为93、109例,(59±11)岁,3.50(0.40,10.00)cm,88.00(25.00,290.00)min,20.00(25.00,290.00)mL,4.00(2.00,12.00)cm,3.00(1.00,9.00)d,4.00(1.00,16.00)d,5.00(1.00,18.00)d,14例,164、31、7例,47、83、50、22例,30、172例;行特殊腹腔镜技术患者上述指标分别为19、7例,(49±14)岁,2.55(0.20,5.00)cm,101.00(59.00,330.00)min,27.50(2.00,300.00)mL,4.50(0,6.00)cm,2.50(1.00,10.00)d,4.00(1.00,16.00)d,6.00(1.00,18.00)d,3例,20、5、1例,15、5、2、4例,24、2例;行胃结构性切除术患者上述指标分别为11、12例,(52±10)岁,5.00(0.80,10.00)cm,187.00(80.00,325.00)min,50.00(10.00,300.00)mL,6.00(4.00,12.00)cm,4.00(2.00,8.00)d,6.00(3.00,14.00)d,8.00(2.00,18.00)d,7例,11、5、7例,2、6、6、9例,13、10例;3者上述指标比较,差异均有统计学意义(χ^(2)=6.75,F=10.19,H=17.71、37.50、35.54、24.68、16.09、20.20、13.76,χ^(2)=13.32,Z=28.98、32.17,χ^(2)=82.14,P<0.05)。(3)特殊腹腔镜技术亚组分析。10例浆膜剥离切除术患者术后首次进食全流质食物时间,术后首次进食半流质食物时间,肿瘤位置分型(内生型、外生型、壁间型)分别为4.50(1.00,10.00)d,8.00(3.00,12.00)d,0、8、2例;16例经胃腔内切除术患者上述指标分别为2.00(1.00,4.00)d、3.00(1.00,6.00)d,16、0、0例;两者术后首次进食全流质食物时间、术后首次进食半流质食物时间比较,差异均有统计学意义(Z=-2.65,-3.16,P<0.05);两者肿瘤位置分型比较,差异有统计学意义(P<0.05)。结论:胃楔形切除术是治疗胃底贲门部GIST最常用的腹腔镜手术方式。特殊腹腔镜技术主要应用于贲门部GIST患者,手术重点为保留贲门功能。

关键词：胃肿瘤胃底贲门部胃肠间质瘤外科手术腹腔镜检查

The forced activation of asexual conidiation in Aspergillus niger simplifies bioproduction

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Synthetic and Systems Biotechnology 2024年第2期9卷 277-284页

作者： xingyu Wu Tingting Zhang Ke Zhang Rui Zhang Man Shi Chenlei Gu Tianqiong Shi Ling Lu feng Xue Qing Xu Chi Zhang School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing210023China College of Marine Life Sciences Ocean University of ChinaQingdao266003China College of Life Sciences Nanjing Normal UniversityNanjing210023China

Aspergillus niger is an efficient cell factory for organic acids production,particularly l-malic acid,through genetic ***,the traditional method of collecting *** spores for inoculation is labor-intensive and *** our study,we used the CRISPR-Cas9 system to replace the promoter of brlA,a key gene in Aspergillus conidiation,with a xylose-inducible promoter xylP in l-malic acid-producing *** strain RG0095,generating strain *** induced with xylose in submerged liquid culture,brlAxylP exhibited significant upregulation of conidiation-related *** induction allowed us to easily collect an abundance of brlAxylP spores(>7.1×106/mL)in liquid xylose ***,the submerged conidiation approach preserves the substantial potential of *** as a foundational cellular platform for the biosynthesis of organic acids,including but not limited to l-malic *** summary,our study offers a simplified submerged conidiation strategy to streamline the preparation stage and reduce labor and material costs for industrial organic acid production using Aspergillus species.

关键词： Aspergillus niger L-malic acid Submerged conidiation Simplify procedures Reduce costs

Identification of the BTA8 gene reveals the contribution of natural variation to tiller angle in rice

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Journal of Integrative Agriculture 2024年第8期23卷 2868-2871页

作者： Junrong Liu xingyu Wang Jing Wang Junhua Ye Mengchen Zhang Qun Xu Yaolong Yang Xinghua Wei Baoyan Jia Yue feng State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China College of Agronomy Shenyang Agricultural UniversityShenyang 110866China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China

Plant architecture is a collection of major agronomic traits that determines rice grain production,and it is mainly influenced by tillering,tiller angle,plant height and panicle morphology(Wang and Li 2006).Tiller angle is one of the critical components that determines rice plant architecture,which in turn influences grain yield mainly due to its large impact on plant density(Wang et al.2022).

关键词： angle panicle agronomic

原发性十二指肠间质瘤行根治性手术临床疗效及预后影响因素的多中心回顾性研究

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中华消化外科杂志 2022年第8期21卷 1056-1070页

作者：崔剑知吴欣张鹏杨琳希周烨尹源冯兴宇叶再生周永建寇有为刘合利朱玉萍赵岩李永文邱海波徐皓叶志坚顾国利汪明曹晖上海交通大学医学院附属仁济医院胃肠外科上海200127 中国人民解放军总医院普通外科北京100853 华中科技大学同济医学院附属协和医院胃肠外科武汉430022 复旦大学附属肿瘤医院胃外科上海200032 四川大学华西医院胃肠外科成都610041 广东省人民医院普通外科广州510080 福建省肿瘤医院胃肠外科福州350014 福建医科大学附属协和医院胃外科福州350001 中国医科大学附属盛京医院普通外科沈阳110004 中南大学湘雅医院胃肠外科长沙410008 浙江省肿瘤医院结直肠外科杭州310022 辽宁省肿瘤医院胃外科沈阳110801 厦门大学附属第一医院胃肠肿瘤外科厦门361003 中山大学附属肿瘤医院胃外科广州510060 南京医科大学第一附属医院普通外科南京210029 厦门大学附属中山医院胃肠外科厦门361004 中国人民解放军空军总医院普通外科北京100142

目的探讨原发性十二指肠间质瘤(GIST)行根治性手术的临床疗效及预后影响因素。方法采用回顾性队列研究方法。收集2010年1月至2020年4月我国17家医学中心收治的741例(上海交通大学医学院附属仁济医院121例、中国人民解放军总医院121例、... 详细信息

目的探讨原发性十二指肠间质瘤(GIST)行根治性手术的临床疗效及预后影响因素。方法采用回顾性队列研究方法。收集2010年1月至2020年4月我国17家医学中心收治的741例(上海交通大学医学院附属仁济医院121例、中国人民解放军总医院121例、华中科技大学同济医学院附属协和医院116例、复旦大学附属肿瘤医院77例、四川大学华西医院77例、广东省人民医院31例、福建省肿瘤医院24例、福建医科大学附属协和医院22例、中国医科大学附属盛京医院25例、中南大学湘雅医院19例、浙江省肿瘤医院23例、辽宁省肿瘤医院17例、厦门大学附属第一医院17例、中山大学附属肿瘤医院15例、南京医科大学第一附属医院14例、厦门大学附属中山医院14例、中国人民解放军空军总医院8例)原发性十二指肠GIST行根治性手术治疗患者的临床病理资料;男346例,女395例;年龄为55(17~86)岁。观察指标:(1)新辅助治疗情况。(2)手术及术后情况。(3)随访情况。(4)分层分析。采用门诊或电话方式进行随访,患者行新辅助治疗期间每3~6个月随访1次,行根治性手术治疗后每6~12个月随访1次,了解患者肿瘤复发和生存情况。随访时间截至2022年4月。正态分布的计量资料以x±s表示。偏态分布的计量资料以M(范围)表示,组间比较采用Mann-Whitney U检验。计数资料以绝对数或百分比表示,组间比较采用χ^(2)检验或Fisher确切概率法。采用Kaplan-Meier法绘制生存曲线并计算生存率,采用Log-Rank检验进行生存分析。单因素及多因素分析采用COX回归模型。倾向评分匹配按1∶1最近邻匹配法匹配,匹配容差为0.02。结果(1)新辅助治疗情况。741例患者中,34例行新辅助治疗,治疗时间为8(3~44)个月。34例新辅助治疗患者行手术治疗前肿瘤退缩达部分缓解、疾病稳定、疾病进展分别为21、9、4例。34例患者行新辅助治疗前肿瘤长径为8.0(3.0~26.0)cm,行手术治疗前肿瘤长径为5.3(3.0~18.0)cm,肿瘤退缩比例为31.9%(-166.7%~58.3%)。(2)手术及术后情况。741例患者中,34例行新辅助治疗后接受根治性手术治疗,707例直接行根治性手术治疗。741例患者均顺利完成手术,手术方式为开腹手术、腹腔镜手术、内镜手术分别为633、102、6例;633例开腹手术和102例腹腔镜手术患者手术切除范围为胰十二指肠切除(PD)238例,十二指肠局限性切除497例(十二指肠楔形切除226例、远端胃部分切除55例、节段性十二指肠切除204例、十二指肠肿瘤局部切除或节段性十二指肠联合胃大部切除12例)。741例患者中,131例发生术后并发症,其中并发症Clavien-Dindo分级Ⅰ~Ⅱ级113例,≥Ⅲ级18例。741例患者术后住院时间为13(4~120)d。707例直接行根治性手术治疗患者中,术后评估371例改良美国国立卫生研究院(NIH)危险度分级为极低危、低危、中危,336例为高危。205例高危患者接受术后伊马替尼辅助治疗,治疗时间为24(6~110)个月。(3)随访情况。741例患者均获得术后随访,随访时间为58(7~150)个月。随访期间,110例患者发生肿瘤复发转移。741例患者1、3、5年总生存率分别为100.0%、98.6%、94.5%,1、3、5年无病生存率分别为98.4%、90.9%、84.9%。707例直接行根治性手术治疗患者1、3、5年总生存率分别为100.0%、98.5%、94.3%,1、3、5年无病生存率分别为98.4%、91.1%、85.4%。(4)分层分析。①直接行根治性手术治疗患者预后因素分析。单因素分析结果显示:肿瘤原发灶位置、肿瘤长径、核分裂象计数、改良NIH危险度分级、肿瘤基因信息是影响707例直接行根治性手术治疗原发性十二指肠GIST患者总生存的相关因素(风险比=0.43,0.18,0.22,0.06,0.29,95%可信区间为0.20~0.93,0.09~0.35,0.10~0.50,0.03~0.12,0.09~0.95,P5个/50高倍视野、肿瘤基因KIT第9外显子突变是影响剔除342例缺失肿瘤基因信息患者后365例直接行根治性手术治疗原发性十二指肠GIST患者总生存的独立危险因素(风险比=2.85,2.73,3.13,

关键词：肠肿瘤胃肠间质瘤十二指肠外科治疗近期疗效远期预后

BTA2 regulates tiller angle and the shoot gravity response through controlling auxin content and distribution in rice

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Journal of Integrative Plant Biology 2024年第9期66卷 1966-1982页

作者： Zhen Li Junhua Ye Qiaoling Yuan Mengchen Zhang xingyu Wang Jing Wang Tianyi Wang Hongge Qian Xinghua Wei Yaolong Yang Lianguang Shang Yue feng China National Center for Rice Improvement State Key Laboratory of Rice Biology and BreedingChina National Rice Research InstituteHangzhou 310006China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China

Tiller angle is a key agricultural trait that establishes plant architecture,which in turn strongly affects grain yield by influencing planting density in *** shoot gravity response plays a crucial role in the regulation of tiller angle in rice,but the underlying molecular mechanism is largely ***,we report the identification of the BIG TILLER ANGLE2(BTA2),which regulates tiller angle by controlling the shoot gravity response in ***-of-function mutation of BTA2 dramatically reduced auxin content and affected auxin distribution in rice shoot base,leading to impaired gravitropism and therefore a big tiller ***2 interacted with AUXIN RESPONSE FACTOR7(ARF7)to modulate rice tiller angle through the gravity signaling *** BTA2 protein was highly conserved during *** variation in the BTA2 promoter of indica cultivars harboring a less expressed BTA2 allele caused lower BTA2 expression in shoot base and thus wide tiller angle during rice *** of BTA2 significantly increased grain yield in the elite rice cultivar Huanghuazhan under appropriate dense planting *** findings thus uncovered the BTA2-ARF7 module that regulates tiller angle by mediating the shoot gravity *** work offers a target for genetic manipulation of plant architecture and valuable information for crop improvement by producing the ideal plant type.

关键词： auxin domestication gravity response rice tiller angle

In situ polymerization of water-induced 1,3-phenylene diisocyanate for enhanced efficiency and stability of inverted perovskite solar cells

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Interdisciplinary Materials 2024年第2期3卷 316-325页

作者： Shiyao Jia Jiabao Yang Tong Wang xingyu Pu Hui Chen Xilai He Guangpeng feng xingyuan Chen Yijun Bai Qi Cao Xuanhua Li State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'anChina

In the realm of photovoltaics,organometallic hybridized perovskite solar cells(PSCs)stand out as promising contenders for achieving high-efficiency photoelectric conversion,owing to their remarkable performance ***,defects within the perovskite layer,especially at the perovskite grain boundaries and surface,have a substantial impact on both the overall photoelectric performance and long-term operational stability of *** mitigate this challenge,we propose a method for water-induced condensation polymerization of small molecules involving the incorporation of 1,3-phenylene diisocyanate(1,3-PDI)into the perovskite film using an antisolvent *** to this step,the introduction of water triggers the polymerization of[P(1,3-PDI)],thereby facilitating the in situ passivation of uncoordinated lead defects inherent in the perovskite *** passivation process demonstrates a notable enhancement in both the efficiency and stability of *** approach has led to the attainment of a noteworthy power conversion efficiency(PCE)of 24.66% in inverted ***,based on the P(1,3-PDI)modification,these devices maintain 90.15% of their initial efficiency after 5000 h of storage under ambient conditions of 25℃ and 50±5% relative ***,even after maximum power point tracking for 1000 h,the PSCs modified with P(1,3-PDI)sustain 82.05% of the initial *** molecules can rationally manipulate water and turn harm into benefit,providing new directions and methods for improving the efficiency and stability of PSCs.

关键词： antisolvent engineering defect passivation inverted perovskite solar cells

Plant genome editing:CRISPR,base editing,prime editing,and beyond

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Grassland Research 2022年第4期1卷 234-243页

作者： Yujie Xie Syed Inzimam Ul Haq xingyu Jiang Dianfeng Zheng Naijie feng Wenying Wang Jin-Sheng He Quan-Sheng Qiu MOE Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhouGansuChina College of Coastal Agricultural Sciences Guangdong Ocean UniversityZhanjiangGuangdongChina Academy of Plateau Science and Sustainability School of Life SciencesQinghai Normal UniversityXiningQinghaiChina Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization in Qinghai Tibet Plateau Qinghai Normal UniversityXiningQinghaiChina State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems Lanzhou UniversityLanzhouGansuChina

The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system is a fast-growing,genome editing technology that has wide applications in identifying gene functions as well as improving agricultural production and crop ***,we summarized recent advances in the development and applications of genome editing technologies in *** briefly described CRISPR/Cas9 technology and examined the base and prime editing techniques that have been developed from CRISPR *** new prime editing-derived techniques were assessed.

关键词： base editing CRISPR/Cas9 plant genome editing prime editing prime editing-derived techniques