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Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

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Chinese Chemical Letters 2024年第7期35卷 360-366页

作者： Jingting Wang Yuanyuan Chen Linlin Han Shasha Xia xingyao zhang Peng Xue Yuejun Kang Jian Ming Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China College of Food Science Southwest UniversityChongqing 400715China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangsha 410082China

Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side ***(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory ***,it faces problems such as poor water solubility,photothermal instability,and low ***,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant *** vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of *** work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.

关键词： Oral administration Astaxanthin Nanocarrier Anti-oxidant activity Colon targeting

Review of Pathogen Identification and Diagnosis Technology of Pinewood Nematode Disease

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Chinese Forestry Science and Technology 2007年第1期6卷 69-76页

作者： zhang Kai LIANG Jun zhang xingyao Research Institute of Forest Ecology Environmental and Protection Chinese Academy of Forestry Beijing 100091 P.R. China

This article briefly introduced the disease incidence and disservice situation in China. The disease is regarded as cancer in pines for its higher spread and death speed and the difficulty in prevention. Strict quarantine is the main measure on countrol of the disease, for there are many difficulties in the prevention. The most important part of the disease study is the early diagnosis and detection.

关键词： pinewood nematod diseasee pine wilt disease Bursaphelenchus xylophilus pathogen identification diagnosis

Total dose irradiation and hot-carrier effects of sub-micro NMOSFETs

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Journal of Semiconductors 2012年第1期33卷 64-67页

作者： Cui Jiangwei Xue Yaoguo Yu Xuefeng Ren Diyuan Lu Jian zhang xingyao Xinjiang Technical Institute of Physics&Chemistry Chinese Academy of Sciences Urumqi 830011China Xinjiang Key Laboratory of Electric Information Materials and Devices Urumuqi 830011China Graduate University of the Chinese Academy of Sciences Beijing 100049China Xi'an Microelectronic Technology Institute Xi'an 710055 China

Total dose irradiation and the hot-carrier effects of sub-micro NMOSFETs are studied. The results show that the manifestations of damage caused by these two effects are quite different, though the principles of damage formation are somewhat similar. For the total dose irradiation effect, the most notable damage lies in the great increase of the off-state leakage current. As to the hot-carrier effect, most changes come from the decrease of the output characteristics curves as well as the decrease of trans-conductance. It is considered that the oxide-trapped and interface-trapped charges related to STI increase the current during irradiation, while the negative charges generated in the gate oxide, as well as the interface-trapped charges at the gate interface, cause the degradation of the hot-carrier effect. Different aspects should be considered when the device is generally hardened against these two effects.

关键词： sub-micro total dose irradiation hot-carrier effect

Transcriptomic response of Pinus massoniana to infection stress from the pine wood nematode Bursaphelenchus xylophilus

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Stress Biology 2023年第1期3卷 534-545页

作者： Yibo An Yongxia Li Ling Ma Dongzhen Li Wei zhang Yuqian Feng Zhenkai Liu Xuan Wang Xiaojian Wen xingyao zhang Key Laboratory of Forest Protection of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of Forestryl00091BeijingChina Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037China Chongqing Forestry Investment and Development Co. Ltd.National Forestry and Grassland National Reserve Forest Engineering Technology Research CenterChongqing 401120China Northeast Forestry University College of ForestryHarbin 150040China

The pinewood nematode(PWN)Bursaphelenchus xylophilus is a forestry quarantine pest and causes an extremely dangerous forest disease that is spreading *** to the complex pathogenic factors of pine wood nematode disease,the pathogenesis is still *** ultimately invades a host and causes ***,little is known about the defence-regulating process of host pine after infection by *** at the molecular ***,we wanted to understand how Pinus massoniana regulates its response to invasion by *** were artificially inoculated with *** solution,while those without *** solution were used as *** inoculated with *** solution for 0 h,6 h,24 h,and 120 h was subjected to highthroughput sequencing to obtain transcriptome *** various time points(0 h,6 h,24 h,120 h),gene transcription was measured in *** inoculated with *** different time points,*** gene transcription differed significantly,with a response to early invasion by *** to Gene Ontology(GO)classification and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis,*** response to PWN invasion involves a wide range of genes,including plant hormone signal transformation,flavonoid biosynthesis,amino sugar and nucleoside sugar metabolism,and MAPK signalling *** them,inoculation for 120 hours had the greatest impact on differential ***,weighted gene coexpression network analysis(WGCNA)was used to analyse transcriptional regulation of *** after PWN *** results showed that the core gene module of *** responding to PWN was“MEmagenta”,enriched in oxidative phosphorylation,amino sugar and nucleotide sugar metabolism,and the MAPK signalling *** family transcription factors with the highest number of changes between infected and healthy pine trees accounted for 20.4% of the total differentially expressed tran

关键词： Pinus massoniana Bursaphelenchus xylophilus Transcriptome WGCNA

Detection to Pathogens of Poplar Cankers by Multiplex PCR Technique

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Chinese Forestry Science and Technology 2012年第3期11卷 85-86页

作者： Feng Xiaohui zhang xingyao Yan Donghui Key Laboratory of Forest Protection of State Forestry Administration Research Institute of Forestry EcologyEnvironment and ProtectionChinese Academy of Forestry

Fungal pathogens causing poplar canker diseases are cosmopolitan in species,and have a wide range of *** pathogens have diverse anamorphs and their morphology overlaps with each other;Their teleomorphs are hardly discovered in ***,the identification of these pathogens is usually limited by the geography,host and taxonomic ***,a culture-independent method used to identify determine pathogens is expected to be developed for field *** amplifying,sequencing and analyzing multiplex nucleic acid templates and genetic marked target sequences,a multiplex PCR technique has been established and used to directly detect various environmental *** this study, four pathogen strains and environmental samples were amplified using fungal universal primers ITS1/ ITS4 and EF1-728F/EF1-986R by general PCR and multiplex *** amplicons were sequenced,and then aligned in *** result showed that the multiplex PCR was able to successfully amplify the target gene and identify the pathogens from environmental samples in the condition of an annealing temperature of 55.6℃and primers final concentration of 0.2μmol·L-1.The multiplex PCR could amplify the target at the concentration level of approximately lng of genomic *** method would provide a useful tool for the identification of canker pathogens by the multiplex PCR and the high-throughput DNA microarray detection of environmental samples.

关键词： poplar canker multiplex PCR pathogen identification environmental sample

Correlation between Chemical Structure and Biological Activity of Host-Selective Plant Pathogen Mycotoxins

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Chinese Forestry Science and Technology 2007年第1期6卷 62-68页

作者： WEI Shuhua LIANG Jun WE Jianren zhang xingyao School of Resources and Environment of Nanjing Forestry University Nanjing 210037 P.R. China Institute of Forest Ecology Environmental and Protection Chinese Academy of Forestry Beijing 100091. P.R. China

Toxin, one of the most important factors of plant fungal disease, has attracted much attention of many academicians who have been studying pathogen mycotoxin in deep research. The paper summarized chemical structures of some host-selective plant pathogen mycotoxins discovered in recent years and the correlation between biological activity and chemical structure of toxin.

关键词： plant pathogen fungi host-selective toxin chemical structure biological activity

The Relationship between Ozone over Standard and Nitrogen Dioxide in Shihezi in Summer

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Meteorological and Environmental Research 2019年第5期10卷 22-24页

作者： Li Jun Li Yingjiao zhang xingyao Li Weijun Shihezi Environmental Monitoring Station Shihezi 832000China Shihezi Center for Diseases Prevention and Control Shihezi 832003China

By analyzing O3 concentration,NOx concentration and intensity of illumination in Shihezi City in summer of 2015-2018,the relationship between O3 concentration and NOx concentration in summer was *** results showed that O3 concentration rise was 14 h later than NO2 concentration rise when O3 concentration exceeded the standard in Shihezi in ***,NO2 concentration had certain effect on O3 formation.

关键词： Nitrogen oxide Summer Shihezi City Ozone

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外担子菌属真菌的研究综述

林业科学 1998年第1期34卷 113-120页

作者：张星耀中国林业科学研究院森林保护研究所

本文对外担子菌属（Ｅｘｏｂａｓｉｄｉｕｍ）真菌的寄主植物及其症状、寄生性及致病机理、形态学、生活史、寄主与病原关系的超显微构造、培养性状、生理学性质及分子生物学，特别是在分类学等方面的研究状况做了综述。外担子菌属的真... 详细信息

本文对外担子菌属（Ｅｘｏｂａｓｉｄｉｕｍ）真菌的寄主植物及其症状、寄生性及致病机理、形态学、生活史、寄主与病原关系的超显微构造、培养性状、生理学性质及分子生物学，特别是在分类学等方面的研究状况做了综述。外担子菌属的真菌在亚洲、北美、欧洲及大洋洲都有分布，世界记载约有５０种，引起５科木本植物的细胞增生性和肥大性病害，其症状类型多，这可能与植物激素含量的变化有关；该菌的生活史还不太清楚；其担孢子和分生孢子萌发后，芽管可以从气孔、伤口侵入或者从表皮直接侵入寄主叶组织，菌丝存在于寄主细胞间隙，产生吸器状构造；本属菌的分类依据因研究者不同而异；近年对本属菌的ＤＮＡ碱基ＧＣ含量以及２８ＳｒＤＮＡＰＣＲＲＦＬＰ的研究结果体现了本属菌的系统分类学的发展趋势。

关键词：外担子菌属真菌分类学

Residual Film Pollution in the Eighth Division of the Xinjiang Production and Construction Corps

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Research and Application of Materials Science 2023年第1期5卷 11-16页

作者： Weijun LI xingyao zhang Nate KA Xianglin YANG Jianjiang LU Xuyun zhang School of Chemistry and Chemical Engineering Shihezi UniversityKey Laboratory of Environmental Monitoring and Pollutant Control of Xinjiang BingtuanShiheziXinjiang Province832000P.R.China Environmental Monitoring Station of Shihezi ShiheziXinjiang Province832000P.R.China The Fouth Environmental Monitoring Station of Xinjiang Construction Crops KekedalaXinjiang Province835000P.R.China

This study investigated the residual film content and distribution at different soil depths in the Eighth Division of the Xinjiang Production and Construction *** spring plowing in 2019,representative fields in four areas(Anjihai,Shihezi suburbs,Mosuowan and Xiayedi)were selected for residual film *** average content of residual film in the Eighth Division was 104 kg/*** residual film content in the four areas decreased in the order Anjihai>Shihezi suburbs>Mosuowan>*** average amount of residual film collected from cotton fields was greater than that from corn *** film content in the cotton field at soil depths of 0~10 and 10~30 cm was higher than that in the corn field,whereas the residual film content at a 30–50 cm soil depth in the corn field was higher than that in the cotton *** results showed that farmers do not consider the long-term benefits,the high cost and short time of recycling,and the easy recycling of surface residual *** shallow that the higher content of residual film,the less water in the soil of *** same time,the results showed that the quantity of residual film in cotton field had greater influence on cotton quality.

关键词： Eighth Division Residual film Pollution Present situation Problems