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Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair

Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei Gu Anmao Li Chunyan He Rui Xiao Jiaxin Liao Li Xu Junhao Mu Xiaohui Wang Mingjin Yang jinyue Jiang Yang Bai xingxing jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao jing Lin Yishi Li Shuliang Guo Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(ECM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and ECM ***,the mechanism of how SOX9 regulates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and ECM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regulated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted ECM *** SOX9 inhibited cell proliferation,migration,and ECM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in ECM deposition,as a direct target of SOX9,which promotes ECM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eECM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： Extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis

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电子结肠镜下圈套器冷切除术与氩离子束凝固术治疗无蒂结直肠息肉的效果比较

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中国医学创新 2024年第7期21卷 50-54页

作者：董锦姜中华金星星滕圣智杨红梅盐城市第一人民医院消化内科江苏盐城224000

目的:观察比较无蒂结直肠息肉患者经电子结肠镜下圈套器冷切除术治疗或氩离子束凝固术治疗的临床效果。方法:将2021年8月—2022年8月就诊于盐城市第一人民医院消化内科的150例无蒂结直肠息肉患者用随机数字表法进行对照探讨。对照组(n=... 详细信息

目的:观察比较无蒂结直肠息肉患者经电子结肠镜下圈套器冷切除术治疗或氩离子束凝固术治疗的临床效果。方法:将2021年8月—2022年8月就诊于盐城市第一人民医院消化内科的150例无蒂结直肠息肉患者用随机数字表法进行对照探讨。对照组(n=75)给予电子结肠镜下氩离子束凝固术治疗,试验组(n=75)给予电子结肠镜下圈套器冷切除术治疗。比较两组手术时间、术中息肉切除时间、住院时间、息肉完整切除率、血清学指标[脂多糖(LPS)、C反应蛋白(CRP)、基质金属蛋白酶-2(MMP-2)]、术后并发症。结果:与对照组比较,试验组手术时间、术中息肉切除时间均更长,息肉完整切除率更低,差异均有统计学意义(P0.05)。术后72 h,两组LPS、CRP均升高,但试验组LPS、CRP均低于对照组,差异均有统计学意义(P0.05);试验组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:电子结肠镜下圈套器冷切除术耗时长,但并发症较少,安全性相对更高,而氩离子束凝固术能够完整切除息肉,避免息肉残留。二者各有优势,建议临床根据患者需要选取最佳术式。

关键词：无蒂结直肠息肉电子结肠镜圈套器冷切除术氩离子束凝固术

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Efficient indica and japonica rice identification based on the InDel molecular method:Its implication in rice breeding and evolutionary research

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Progress in Natural Science:Materials International 2009年第10期19卷 1241-1252页

作者： Bao-Rong Lu,xingxing Cai,Xin jin Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering,Institute of Biodiversity Science,Fudan University,Shanghai 200433,China [a]Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science Fudan University Shanghai 200433 China

An efficient molecular method for the accurate and efficient identification of indica and japonica rice was created based on the poly-morphisms of insertion/deletion(InDel) DNA fragments obtained from the basic local alignment search tool(BLAST) to the entire genomic sequences of indica(93-11) and japonica rice(Nipponbare).The 45 InDel loci were validated experimentally by the polymerase chain reaction(PCR) and polyacrylamide gel electrophoresis(PAGE) in 44 typical indica and japonica rice varieties,including 93-11 and Nipponbare.A neutrality test of the data matrix generated from electrophoretic banding patterns of various InDel loci indicated that 34 InDel loci were strongly associated with the differentiation of indica and japonica *** extensive analyses involving cultivated rice varieties from 11 Asian countries,and 12 wild Oryza species with various origins confirmed that indica and japonica characteristics could accurately be determined via calculating the average frequency of indica-or japonica-specific alleles on different InDel loci across the rice *** method was named as the ’’InDel molecular index" that combines molecular and statistical methods in determining the indica and japonica characteristics of rice *** with the traditional methods based essentially on morphology,the InDel molecular index provides a very accurate,rapid,simple,and efficient method for identifying indica and japonica *** addition,the InDel index can be used to determine indica or japonica characteristics of wild Oryza species,which largely extends the utility of this *** InDel molecular index provides a new tool for the effective selection of appropriate indica or japonica rice germplasm in rice *** also offers a novel model for the study of the origin,evolution,and genetic differentiation of indica and japonica rice adapted to various environmental changes.

关键词： Cultivated rice Wild Oryza InDel Molecular marker indica-japonica identification Neutrality test

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Mining geographic episode association patterns of abnormal events in global earth science data

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Science China(Technological Sciences) 2008年第S1期51卷 155-164页

作者： WU TianShu,SONG GuoJie,MA XiuJun,XIE KunQing,GAO XiaoPing & jin xingxing Key Laboratory of Machine Perception,Ministry of Education,and Department of Machine Intelligence,Peking University,Beijing 100871,China 1. Key Laboratory of Machine Perception Ministry of Education and Department of Machine Intelligence Peking University Beijing 100871 China

Abnormal events in earth science have great influence on both the natural envi-ronment and the human society. Finding association patterns among these events has great significance. Because data in earth science has characteristics of mass,high dimension,spatial autocorrelation and time delay,existing mining technolo-gies cannot be directly used on it. We propose a RSNN (range-based searching nearest neighbors) spatial clustering algorithm to reduce the data size and auto-correlation. Based on the clustered data,we propose a GEAM (geographic episode association pattern mining) algorithm which can deal with events time lags and find interesting patterns with specific constraints,to mine the association patterns. We carried out experiments on global climate datasets and found many interesting association patterns. Some of the patterns are coincident with known knowledge in climate science,which indicates the correctness and feasibilities of our methods,and the others are unknown to us before,which will give new information to this research field.

关键词： abnormal events association patterns high dimensional clustering earth science data

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Acupuncture reduces sedative and anaesthetic consumption and improves pain tolerance in patients undergoing colonoscopy: aMeta-analysis

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Journal of Traditional Chinese Medicine 2024年

作者： WANG Bingyu jin Fangfang GAO Jiawei YANG Liuxin ZHANG Yali YUAN xingxing ZHANG Yang School of Graduate Studies，Heilongjiang University of Chinese Medicine Department of Gastroenterology， Heilongjiang Academy of Traditional Chinese Medicine Department of Zhang Yali Senior Traditional Chinese Medicine Expert Studio， Heilongjiang Academy of Traditional Chinese Medicine Department of Gastroenterology， the First Affiliated Hospital of Heilongjiang University of Chinese Medicine

OBJECTIVE: To evaluate the effects of acupuncture anesthesia on the consumption of sedatives and anesthetics， pain， and time consumption in patients undergoing colonoscopy， thus providing evidence that acupuncture anesthesia should be extended to endoscopists and ***: Four English and four Chinese databases were searched for randomised controlled trials of acupuncture anaesthesia in patients undergoing colonoscopy， published from database inception to 1 March 2023. Outcomes were consumption of sedatives and anaesthetics， pain tolerance， visual analog scale(VAS) score， the meantime consumption of examination， satisfaction， and adverse reactions. RESULTS: Thirty-one randomized controlled trials with a total of 4790 participants were included. Results showed that acupuncture anaesthesia significantly reduced consumption of sedatives and anaesthetics[9 studies， n = 944， standardized mean difference (SMD)= -0.82， 95% CI(-1.31， -0.33)， P = 0.001]， VAS score [9 studies， n = 1790， mean difference (MD)= -1.13， 95% CI(-1.70， -0.57)， P＜0.001]， meantime consumption [21 studies， n= 3799， MD = -2.09， 95% CI(-3.15， -1.03)， P＜0.001]and adverse reactions of colonoscopy [7 studies， n = 738， odds ratio (OR) = 0.17， 95% CI (0.10， 0.28)， P＜0.001]. Acupuncture also significantly improved pain tolerance [14 studies， n= 1661， OR = 7.05， 95% CI(3.79， 13.12)， P＜0.001]， while no beneficial effects were found for satisfaction[7 studies， n = 843， SMD = 0.02， 95% CI(-0.38， 0.43)， P = 0.91]. CONCLUSION: Acupuncture has beneficial effects on patients undergoing colonoscopy， particularly in reducing consumption of sedatives and anaesthetics， alleviating pain， shorteningthe time consumption of examination and preventing adverse events. As an alternative， effective， inexpensive， and accessible approach， acupuncture anaesthesia should be extended to endoscopists and anaesthesiologists.

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肺栓塞致获得性QT间期延长1例

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临床心血管病杂志 2017年第7期33卷 712-714页

作者：金星星宁波市医疗中心李惠利医院心内科浙江宁波315041

肺栓塞是临床中较常见的危重症,然而由于其临床表现不典型,存在误诊率、漏诊率与病死率高等特点。肺栓塞的常见心电图表现有心动过速、右束支传导阻滞、胸前导联T波倒置、SⅠQⅢTⅢ等,而肺栓塞致继发性QT间期延长,目前全世界范围内报道... 详细信息

肺栓塞是临床中较常见的危重症,然而由于其临床表现不典型,存在误诊率、漏诊率与病死率高等特点。肺栓塞的常见心电图表现有心动过速、右束支传导阻滞、胸前导联T波倒置、SⅠQⅢTⅢ等,而肺栓塞致继发性QT间期延长,目前全世界范围内报道不多,临床重视不够,易引起严重后果。Charles等[1]在1993年报道了首例因肺栓塞而致QT间期延长的病例。

关键词：肺栓塞 QT间期延长室性心动过速

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Nitric oxide-releasing polyurethane/S-nitrosated keratin mats for accelerating wound healing

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Regenerative Biomaterials 2022年第1期9卷 294-302页

作者： Jie Dou Rong Yang xingxing jin Pengfei Li Xiao Han Lijuan Wang Bo Chi Jian Shen Jiang Yuan Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio-functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023P.R.China State Key Laboratory of Materials-Oriented Chemical Engineering College of Food Science and Light IndustryNanjing Tech UniversityNanjing 211816P.R.China

Nitric oxide(NO)plays an important role in wound healing,due to its ability to contract wound surfaces,dilate blood vessels,participate in inflammation as well as promote collagen synthesis,angiogenesis and fibroblast ***,keratin was first nitrosated to afford S-nitrosated keratin(KSNO).As a NO donor,KSNO was then co-electrospun with polyurethane(PU).These as-spun PU/KSNO biocomposite mats could release NO sustainably for 72 h,matching the renewal time of the wound ***,these mats exhibited excellent cytocompatibility with good cell adhesion and cell ***,the biocomposite mats exhibited antibacterial properties without inducing severe inflammatory *** wound repair in vivo demonstrated that these mats accelerated wound healing by promoting tissue formation,collagen deposition,cell migration,re-epithelialization and ***,PU/KSNO mats may be promising candidates for wound dressing.

关键词： keratin nitric oxide wound dressing electrospinning biocomposite

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Predicting influenza-like illness trends based on sentinel surveillance data in China from 2011 to 2019:A modelling and comparative study

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Infectious Disease Modelling 2024年第3期9卷 816-827页

作者： xingxing Zhang Liuyang Yang Teng Chen Qing Wang jin Yang Ting Zhang Jiao Yang Hongqing Zhao Shengjie Lai Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100073China State Key Laboratory of Respiratory Health and Multimorbidity China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionChina Department of Management Science and Information System Faculty of Management and EconomicsKunming University of Science and TechnologyKunming650506China Department of Applied Mathematics&Statistics Stony Brook UniversityStony BrookNY11794-3600USA WorldPop School of Geography and Environmental ScienceUniversity of SouthamptonSouthamptonSO171BJUK

Background Influenza is an acute respiratory infectious disease with a significant global disease ***,the coronavirus disease 2019 pandemic and its related non-pharmaceutical interventions(NPIs)have introduced uncertainty to the spread of ***,comparative studies on the performance of innovative models and approaches used for influenza prediction are ***,this study aimed to predict the trend of influenza-like illness(ILI)in settings with diverse climate characteristics in China based on sentinel surveillance data using three approaches and evaluate and compare their predictive *** The generalized additive model(GAM),deep learning hybrid model based on Gate Recurrent Unit(GRU),and autoregressive moving average-generalized autoregressive conditional heteroscedasticity(ARMA—GARCH)model were established to predict the trends of ILI 1-,2-,3-,and 4-week-ahead in Beijing,Tianjin,Shanxi,Hubei,Chongqing,Guangdong,Hainan,and the Hong Kong Special Administrative Region in China,based on sentinel surveillance data from 2011 to *** relevant metrics,namely,Mean Absolute Percentage Error(MAPE),Root Mean Squared Error(RMSE),and R squared,were calculated to evaluate and compare the goodness of fit and robustness of the three *** Considering the MAPE,RMSE,and R squared values,the ARMA—GARCH model performed best,while the GRU-based deep learning hybrid model exhibited moderate performance and GAM made predictions with the least accuracy in the eight settings in ***,the models’predictive performance declined as the weeks ahead ***,blocked cross-validation indicated that all models were robust to changes in data and had low risks of *** Our study suggested that the ARMA—GARCH model exhibited the best accuracy in predicting ILI trends in China compared to the GAM and GRU-based deep learning hybrid ***,in the future,the ARMA—GARCH model may be used

关键词： Influenza-like illness Influenza Sentinel surveillance China Predicting Modeling

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中国城市体系网络化研究

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地理学报 2019年第4期74卷 681-693页

作者：胡国建陈传明金星星王强福建师范大学地理科学学院福州350007 南京师范大学地理科学学院南京210023

当前,学者普遍认同城市体系研究的重心从等级范式向网络范式转向。在大量的文献梳理基础上,阐述20世纪80年代以来中国城市体系研究范式的转向过程,并进一步梳理中国城市网络研究的进展、问题与关注重点。结果表明:2010年之后,网络成为... 详细信息

当前,学者普遍认同城市体系研究的重心从等级范式向网络范式转向。在大量的文献梳理基础上,阐述20世纪80年代以来中国城市体系研究范式的转向过程,并进一步梳理中国城市网络研究的进展、问题与关注重点。结果表明:2010年之后,网络成为中国城市体系研究的主流范式,等级体系文献数量呈波动递减趋势,全国和长三角成为热点关注区域;属性数据一定程度上弥补了早期城市网络研究中数据匮乏的状况,关系数据应成为未来研究的侧重点;不同研究视角及其所应用的数据存在着一定的局限性,多元视角的综合研究成为趋势。在此基础上,提出城市网络研究未来可能的突破点,包括:调整国家城市网络的研究框架、超越交通数据直接考察城市间的实体联系、测度企业外部的横向联系、有向加权网络分析和可视化、增加研究中的地理"意味"等。

关键词：城市体系城市网络研究范式研究进展中国

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镀锡AgCuZnSn钎料熔化特性的热力学分析

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稀有金属材料与工程 2017年第9期46卷 2583-2588页

作者：王星星彭进崔大田杜全斌龙伟民华北水利水电大学河南郑州450045 郑州机械研究所新型钎焊材料与技术国家重点实验室河南郑州450001

以BAg50CuZn钎料为基材,采用电镀热扩散组合工艺制备了镀锡AgCuZnSn钎料。为了揭示镀锡银钎料的热力学特性,借助差示扫描量热仪(DSC)测定了镀锡银钎料的熔化温度,运用热分析动力学中的非等温微分法和积分法分析了镀锡银钎料的相变热力... 详细信息

以BAg50CuZn钎料为基材,采用电镀热扩散组合工艺制备了镀锡AgCuZnSn钎料。为了揭示镀锡银钎料的热力学特性,借助差示扫描量热仪(DSC)测定了镀锡银钎料的熔化温度,运用热分析动力学中的非等温微分法和积分法分析了镀锡银钎料的相变热力学特性,并利用金相显微镜和X射线衍射仪(XRD)对钎料熔化后润湿界面的显微组织和物相进行了分析。研究表明,随着Sn含量升高,在吸热峰镀锡银钎料由固态向液态转变的温度区间变窄,非等温微分法和积分法得到的钎料相变活化能均逐渐增大。在Sn含量为7.2%时,镀锡银钎料的相变活化能和指前因子最大,分别为555.56kJ/mol、1.41×10^(32),此时镀锡银钎料相变速率方程的表达式为:k=1.41×10^(32)exp(-5.56×10~5/RT)。7.2%Sn含量的镀锡银钎料在304不锈钢表面熔化后,润湿界面组织主要由Ag相、Cu相、CuZn相、Cu_5Zn_8相、Cu_(41)Sn_(11)相、Ag_3Sn相组成。

关键词：镀锡银钎料熔化特性活化能相变速率差示扫描量热

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