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Identification and dipeptidyl peptidase Ⅳ(DPP-Ⅳ) inhibitory activity verification of peptides from mouse lymphocytes

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Food Science and Human Wellness 2022年第6期11卷 1515-1526页

作者： Juan Wang Yujia Xie Yuanyuan Luan Tingting Guo Shanshan Xiao xingxing zeng Shaohui Zhang School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Zhejiang Go Peptides Life Science and Healthcare Technology Co. Ltd.Wenzhou 325000China

The objective of this study was to isolate and identify the intracellular bioactive peptides from mouse lymphocytes before and after lipopolysaccharide(LPS)stimulation,to explore novel peptides and to research the bioactive *** spleen lymphocytes were isolated and cultured with LPS stimulation(experimental group)or not(control group)to collect intracellular *** 385 peptides were analyzed by nanoliter liquid phase-Q Exactive quadrupole ultra-high resolution orbitrap mass spectrometer(Nano LC-Q Exactive Plus)and identifi ed by PEAKS X *** compared with peptides reported,131 novel peptides were discovered,which then were predicted bioactivity by Peptide Ranker and 6 peptides with high bioactivity were predicted function by BIOPEP-UMW *** data showed that they may have dipeptidyl peptidase IV(DPP-IV)inhibitory ***,two peptides showed better potent inhibition were verifi ed with competitive and noncompetitive modes.

关键词： Lymphocytes Peptides Lipopolysaccharide Dipeptidyl peptidaseⅣ(DPP-Ⅳ)inhibitory activity

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan zeng xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

珠江三角洲城市群三维生态足迹动态变化及驱动力分析

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环境科学学报 2017年第2期37卷 771-778页

作者：张星星曾辉北京大学深圳研究生院城市规划与设计学院深圳518055

以自然资本利用的存量、流量分类测度的三维生态足迹方法是区域可持续发展能力评估的最新方法论进展.以珠江三角洲城市群9个地市23年的面板数据为数据源,在测度自然资本利用状况时空变化基础上,利用偏最小二乘法进行驱动力分析.研究表... 详细信息

以自然资本利用的存量、流量分类测度的三维生态足迹方法是区域可持续发展能力评估的最新方法论进展.以珠江三角洲城市群9个地市23年的面板数据为数据源,在测度自然资本利用状况时空变化基础上,利用偏最小二乘法进行驱动力分析.研究表明:1珠江三角洲23年间生态足迹呈递增趋势,生态赤字加剧,自身的可持续发展能力较弱;2珠三角自然资本存量占用呈递增趋势;流量资本消耗呈递减趋势,表明过度消耗存量资本换取发展,区域自然资本流动所受的限制较多;3食品消费结构变化、化石能源消费总量增加以及城市扩张带来的土地利用变化,是生态足迹结构变化的主要成因;4人口规模、社会经济差异和政策因素是区域自然资本利用动态变化特征差异的3个主导因素,科技因素和自然环境因素对研究区自然资本利用变化的影响程度不显著.

关键词：三维生态足迹面板数据自然资本利用偏最小二乘分析

Experimental and Numerical Investigation into the Internal Blast in Explosion Chamber

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Experimental and Numerical Investigation into the Internal B...

城市更新视角下纽约历史街区保护更新模式研究--以格林威治村历史街区为例

第四届国际机械工程与力学会议

作者： Fengsheng CHENG Pu SONG Xiaohui GU Gang NIAN xingxing zeng School of Mechanical Engineering NUST

To study the complex pressure flow filed and blast loading on the inner wall after chargesexploded in cylindrical chamber, dynamic test system was used to obtain the overpressure time history of test points. ANSYS/LS-DYNA was also used to simulate the internal explosion, the interior overpressure distribution can be observed at real time and the simulated overpressure time history of test points and selected feature points were gained. Experimental and numerical results had good consistency. Multiple reflection and superposition of shock fronts are salient features of internal explosion. For cylindrical explosion chamber（length-to-diameter ratio=1）, when spherical or cylindrical （L/D≈1）charge exploded at the geometric center, points which undergo maximum peak overpressure are the center of flat heads, and small deviation of charge position can make great impact on the second and subsequent peak overpressure of those two points. Superposition of shock fronts is the reason why overpressure increase significantly.

关键词： Internal explosion Blast wave Overpressure Testing Numerical simulation

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西部人居环境学刊 2024年第2期39卷 91-97页

作者：左力曾星星重庆大学建筑城规学院山地城镇建设与新技术教育部重点实验室

随着我国城市进入城镇化“下半场”,城市发展的范式产生转变,历史街区价值逐渐显现,历史街区的保护与更新成为城市更新进程中的重要类型。本文聚焦纽约历史街区保护更新模式的研究,以纽约格林威治村历史街区为研究案例,探讨了20世纪60... 详细信息

随着我国城市进入城镇化“下半场”,城市发展的范式产生转变,历史街区价值逐渐显现,历史街区的保护与更新成为城市更新进程中的重要类型。本文聚焦纽约历史街区保护更新模式的研究,以纽约格林威治村历史街区为研究案例,探讨了20世纪60年代纽约市《城市地标保护法》出台后,纽约市应对不同尺度、不同类型历史街区保护更新项目的模式机制。研究以历史街区的保护更新项目为对象,从历史街区遗产价值与更新模式相互关联的维度,梳理历史街区的发展背景和空间演化过程,解析了历史街区的层积性的历史价值、活态化的文化遗产和多样性的美学特征,详细阐释了应对历史文化传承和城市更新发展双重目标导向下,纽约历史街区从建筑单体到街区,不同尺度、不同类型项目的保护更新模式机制。

关键词：城市更新历史街区保护更新格林威治村模式机制

表面钝化型二维ZSM-5分子筛的制备及甲苯与甲醇烷基化性能

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化工进展 2024年第5期43卷 2696-2704页

作者：曾浩桀周媚邹镇远熊峰曾星星刘宝玉广东工业大学轻工化工学院广东广州510006 化学与精细化工广东省实验室揭阳分中心(广东省榕江实验室) 广东揭阳515200

采用二次晶化技术在二维ZSM-5分子筛表面构筑了具有外表面钝化作用的全硅Silicalite-1结构,通过XRD、SEM、TEM、N_(2)吸附-脱附等温线、Py-IR等手段对所制备的催化剂进行表征,采用固定床反应器评价了表面钝化型二维ZSM-5分子筛在甲苯和... 详细信息

采用二次晶化技术在二维ZSM-5分子筛表面构筑了具有外表面钝化作用的全硅Silicalite-1结构,通过XRD、SEM、TEM、N_(2)吸附-脱附等温线、Py-IR等手段对所制备的催化剂进行表征,采用固定床反应器评价了表面钝化型二维ZSM-5分子筛在甲苯和甲醇烷基化反应中的催化性能。表征结果表明:二次晶化技术在保留ZSM-5分子筛内部二维片层结构的同时成功构筑了全硅Silicalite-1钝化表面,Silicalite-1钝化结构不仅能有效屏蔽二维ZSM-5分子筛外表面Brønsted酸位点,抑制二甲苯异构化副反应的发生,而且对PX(对二甲苯)具有择形扩散的性能,极大提高对二甲苯选择性。实验结果显示:表面钝化型二维ZSM-5分子筛在673K、WHSV=10h^(-1)的条件下表现出了较长的寿命,同时在反应40h后依然有较高的活性,且对二甲苯选择性达到了约35%,在甲苯与甲醇烷基化反应中表现出优异的催化性能,有效促进了甲苯与甲苯烷基化高选择性地制备对二甲苯的工业化应用进程。

关键词： ZSM-5 纳米结构对二甲苯分子筛多相反应

关于现阶段国有企业混合所有制改革的几点思考——基于中国联通混改的实践

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上海市经济管理干部学院学报 2020年第5期18卷 29-35页

作者：曾星星中南财经政法大学马克思主义学院湖北武汉430073

经过改革开放40多年来的发展,混合所有制改革已经成为国有企业改革的重要突破口。随着国有企业混合所有制改革不断深化,国有企业在混改中又凸显出一些新的问题。中国联通通过选择恰当的混改路径、引入合适的战略投资者、构建多元均衡的... 详细信息

经过改革开放40多年来的发展,混合所有制改革已经成为国有企业改革的重要突破口。随着国有企业混合所有制改革不断深化,国有企业在混改中又凸显出一些新的问题。中国联通通过选择恰当的混改路径、引入合适的战略投资者、构建多元均衡的股权结构、优化企业法人治理结构、完善市场化激励和约束机制、深化国有资产管理体制改革等几方面提升竞争能力,中国联通混改实践为国有企业混合所有制改革带来新的尝试和突破,也为其他国有企业混合所有制改革提供一定的参考。

关键词：国有企业中国联通混合所有制改革经验启示

乡村振兴战略视域下农村生态文化建设的实践路径——以湖北省保康县格栏坪村为例

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中共乌鲁木齐市委党校学报 2022年第1期 63-68页

作者：曾星星浙江旅游职业学院马克思主义学院浙江杭州311231

党的十九届五中全会提出了全面实施乡村振兴战略并强调生态文明建设的重要性。作为生态文明建设的核心,农村生态文化建设具有重要的价值,是乡村振兴战略的重要一环、助力剂。通过对湖北省保康县格栏坪村进行实地调研,发现乡村振兴战略... 详细信息

党的十九届五中全会提出了全面实施乡村振兴战略并强调生态文明建设的重要性。作为生态文明建设的核心,农村生态文化建设具有重要的价值,是乡村振兴战略的重要一环、助力剂。通过对湖北省保康县格栏坪村进行实地调研,发现乡村振兴战略视域下农村生态文化建设取得了初步成效,同时也存在着农村生态与人文文化的融合度不深、农村生态文化与产业发展的切入面不广、农村生态文化作用发挥的辐散度不够等问题。对此,在乡村振兴视域下,进一步探索农村生态文化建设的实践路径,要从延长生态旅游的产业链、探索生态化的农业发展道路、开展生态文化教育等方面着手,来实现创新发展,以期为我国农村生态文化建设提供一定的借鉴。

关键词：乡村振兴战略农村生态文化建设实践路径