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Decade Milestone Advancement of Defect-Engineered g-C_(3)N_(4) for Solar Catalytic Applications

Nano-Micro Letters 2024年第4期16卷 153-218页

作者： Shaoqi Hou Xiaochun Gao Xingyue Lv Yilin Zhao Xitao Yin Ying Liu Juan Fang xingxing Yu Xiaoguang Ma Tianyi Ma Dawei su School of Mathematical and Physical Sciences Faculty of ScienceUniversity of Technology Sydney(UTS)SydneyNSW 2007Australia Laboratory of Plasma and Energy Conversion School of Physics and Optoelectronic EngineeringLudong University186 Middle Hongqi RoadYantai 264025People’s Republic of China School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Department of Chemistry The University of Tokyo7‑3‑1 HogoBunkyoTokyoJapan School of Science STEM CollegeRMIT UniversityMelbourneVIC 3000Australia

Over the past decade, graphitic carbon nitride(g-C_(3)N_(4)) has emerged as a universal photocatalyst toward various sustainable carbo-neutral technologies. Despite solar applications discrepancy, g-C_(3)N_(4) is still confronted with a general fatal issue of insufficient supply of thermodynamically active photocarriers due to its inferior solar harvesting ability and sluggish charge transfer dynamics. Fortunately, this could be significantly alleviated by the “all-in-one” defect engineering strategy, which enables a simultaneous amelioration of both textural uniqueness and intrinsic electronic band structures. To this end, we have summarized an unprecedently comprehensive discussion on defect controls including the vacancy/non-metallic dopant creation with optimized electronic band structure and electronic density, metallic doping with ultraactive coordinated environment(M–N_(x), M–C_(2)N_(2), M–O bonding), functional group grafting with optimized band structure, and promoted crystallinity with extended conjugation π system with weakened interlayered van der Waals interaction. Among them, the defect states induced by various defect types such as N vacancy, P/S/halogen dopants, and cyano group in boosting solar harvesting and accelerating photocarrier transfer have also been emphasized. More importantly, the shallow defect traps identified by femtosecond transient absorption spectra(fs-TAS) have also been highlighted. It is believed that this review would pave the way for future readers with a unique insight into a more precise defective g-C_(3)N_(4) “customization”, motivating more profound thinking and flourishing research outputs on g-C_(3)N_(4)-based photocatalysis.

关键词： Defect engineering g-C_(3)N_(4) Electronic band structures Photocarrier transfer kinetics Defect states

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Enones from aldehydes and alkenes by carbene-catalyzed dehydrogenative couplings

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Chinese Chemical Letters 2024年第9期35卷 150-154页

作者： Kun Tang Fen su Shijie Pan Fengfei Lu Zhongfu Luo Fengrui Che xingxing Wu Yonggui Robin Chi National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China School of chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore

Enones are widely explored in synthetic chemistry as fundamental building blocks for a wide range of reactions and exhibit intriguing biological activities that are pivotal for drug *** development of synthetic strategies for highly efficient preparation of enones thereby receives intense attention,in particular through the transition metal-catalyzed coupling ***,we describe a carbene-catalyzed cross dehydrogenative coupling(CDC)reaction that enables effective assembly of simple aldehydes and alkenes to afford a diverse set of enone ***,the in situ generated aryl radical is pivotal to“activate”the alkene by forming an allyl radical through intermolecular hydrogen atom transfer(HAT)pathway and thus forging the carbon-carbon bond formation with aldehyde as the acyl ***,our method represents the first example on the enone synthesis through coupling of“non-functionalized”aldehydes and alkenes as coupling partners,and offers a distinct organocatalytic pathway to the transition metal-catalyzed coupling transformations.

关键词： Enones Cross dehydrogenative coupling N-Heterocyclic carbene Aryl radical Hydrogen atom transfer

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong Rao Rui su Chenyan Wu xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

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Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis

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Cellular & Molecular Immunology 2023年第4期20卷 423-426页

作者： Qiao Liu Ling Ran Zhengliang Yue xingxing su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu Jianfang Tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang Shanghai Public Health Clinical Center Fudan UniversityShanghaiChina Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqingChina Institute of Immunology Third Military Medical UniversityChongqingChina Stomatological Hospital of Chongqing Medical University ChongqingChina Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhouChina College of Veterinary Medicine Qingdao Agricultural UniversityShandongChina Institute of Immunological Innovation and Translation Chongqing Medical UniversityChongqingChina.8 These authors

The functional exhaustion of CD8^(+)T cells represents a fundamental hallmark of chronic viral infection and cancer and,in both scenarios,is driven by prolonged exposure to persistent cognate antigens in the context of an immunoinhibitory *** CD8^(+)T cells upregulate the expression of a wide diversity of coinhibitory immunoreceptors(also referred to as immune checkpoint receptors),such as PD-1,Tim-3,LAG-3,and ***,exhausted CD8^(+)T cells lose their potential to differentiate into functional memory cells and are characterized by hierarchical loss of effector function,leading to compromised tumor control and viral eradication[1,2].

关键词： drain strictly specific

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试论从源头上防治腐败的逻辑进路

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中国行政管理 2010年第2期 63-66页

作者：张增田苏星星中国科学技术大学管理学院中国科学技术大学管理学研究生合肥230026

从源头上预防和治理腐败是中国特色反腐倡廉建设的主要经验之一,推进此项工作的科学化需要构建其逻辑进路。基于对腐败源头和防治关键点的分析,本文初步构建出反腐败治本抓源头工作的逻辑进路:包括分制权力、限定权力、监督权力和公开... 详细信息

从源头上预防和治理腐败是中国特色反腐倡廉建设的主要经验之一,推进此项工作的科学化需要构建其逻辑进路。基于对腐败源头和防治关键点的分析,本文初步构建出反腐败治本抓源头工作的逻辑进路:包括分制权力、限定权力、监督权力和公开权力。相应地,从源头上防治腐败工作可统统归为四个方面的制度建设:权力分解制度建设、权力规范制度建设、权力监督制度建设和政务公开制度建设,使权力的设置更加科学化和规范化,权力的运行更加合法化和透明化。

关键词：反腐倡廉源头防治行政公开

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深化新工科建设践行新时代美育

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艺术科技 2020年第11期33卷 35-39页

作者：苏星星南京邮电大学教务处教务管理科江苏南京210023

为贯彻执行习近平新时代中国特色社会主义思想和党的十九大精神,落实“立德树人”的根本任务,新工科着力打好“提升质量、推进公平、创新人才培养机制”攻坚战,而新时代美育秉持“以美育人、以美化人、以美培元”的精神,共同培养“五育... 详细信息

为贯彻执行习近平新时代中国特色社会主义思想和党的十九大精神,落实“立德树人”的根本任务,新工科着力打好“提升质量、推进公平、创新人才培养机制”攻坚战,而新时代美育秉持“以美育人、以美化人、以美培元”的精神,共同培养“五育并举”的高素质科技人才。新工科建设和新时代美育均是关乎个人、关乎民族、关乎国家的系统工程。

关键词：新工科美育人才创新理念

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Unexpected nucleation mechanism of T1 precipitates by Eshelby inclusion with unstable stacking faults

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Materials Genome Engineering Advances 2024年第2期2卷 134-144页

作者： Shuo Wang Junsheng Wang Chengpeng Xue Xinghai Yang Guangyuan Tian Hui su Yisheng Miao Quan Li xingxing Li School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina

Aluminum-lithium(Al-Li)alloy is one of the most promising lightweight structural materials in the aeronautic and aerospace *** key to achieving their excellent mechanical properties lies in tailoring T1 strengthening precipitates;however,the nucleation of such nanoparticles remains *** atomic resolution HAADF-STEM with first-principles calculations based on the density functional theory(DFT),here,we report a counterintuitive nucleation mechanism of the T1 that evolves from an Eshelby inclusion with unstable stacking *** precursor is accelerated by Ag-Mg clusters to reduce the barrier,forming the structural *** addition,these Ag-Mg clusters trap the free Cu and Li to prepare the chemical compositions for *** findings provide a new perspective on the phase transformations of complex precipitates through solute clusters in terms of geometric structure and chemical bonding functions.

关键词： Al alloy DFT nucleation phase tranformation precipitation

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“1+X”证书制度下深化高职院校“三教”改革研究

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创新创业理论研究与实践 2023年第3期6卷 20-23页

作者：涂倩苏醒醒浙江安防职业技术学院浙江温州325000

在“1+X”证书制度下,高职院校人才培养模式改革成为高职院校发展急需解决的课题,而“三教”(教师、教材、教法)改革是高职教学改革的重点。该研究从“1+X”证书制度对高职院校人才培养的意义出发,分析“1+X”证书制度下高职院校“三教... 详细信息

在“1+X”证书制度下,高职院校人才培养模式改革成为高职院校发展急需解决的课题,而“三教”(教师、教材、教法)改革是高职教学改革的重点。该研究从“1+X”证书制度对高职院校人才培养的意义出发,分析“1+X”证书制度下高职院校“三教”改革的现状,通过提升教师实践教学能力、开发多元化新型教材、贯彻落实“做中学”理念及引企入校共同培育高职人才,深入推动高职院校教师、教材、教法的改革创新,培养德技双修的复合型人才,推动区域经济社会的发展。

关键词：高职教育 “1+X”证书制度 “三教”改革教师教材教法

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乡村振兴视域下温州乡村旅游景点空间结构演化机理研究

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中阿科技论坛（中英文） 2023年第2期 44-48页

作者：涂倩苏醒醒浙江安防职业技术学院浙江温州325000

文章以温州3A级景区村庄为研究对象,选取2017年、2019年、2021年相关数据,分析了温州3A级景区村庄空间分布规律及其影响因素。研究表明:(1)2017—2021年温州3A级景区村庄数量呈逐年增加趋势,但增速变缓,各县(市、区)3A级景区村庄空间分... 详细信息

文章以温州3A级景区村庄为研究对象,选取2017年、2019年、2021年相关数据,分析了温州3A级景区村庄空间分布规律及其影响因素。研究表明:(1)2017—2021年温州3A级景区村庄数量呈逐年增加趋势,但增速变缓,各县(市、区)3A级景区村庄空间分布不均衡。(2)温州3A级景区村庄,由低密度的“面状”向中、高密度的“片状”“团状”演化;“东北多,西南多,中间少”的空间分布初步形成。(3)运用地理联系率分析温州3A级景区村庄空间结构演化的影响因素,总体来看,各因素对3A级景区村庄发展的影响存在波动性,其中,城镇居民人均可支配收入>农村居民人均可支配收入>农林牧渔业总产值>地区生产总值;而政策环境对3A级景区村庄发展的影响有待增强。

关键词：乡村振兴 3A级景区村庄空间结构演化机制温州市

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