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Hepatocellular carcinoma mutation landscape and its differences between Asians and Whites

Hepatobiliary Surgery and Nutrition 2022年第5期11卷 724-728页

作者： xingte chen Qiao Ke Lei Wang Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Hepatopancreatobiliary Surgery Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina

Hepatocellular carcinoma(HCC)is one of the most common malignancies around the world and accounts for 85%to 90%of the pathological types of primary liver cancer(1).In total,905,677 patients die from HCC,which was the third leading cause of cancer-related death worldwide in 2020(2).Despite significant advancements achieved in early detection,liver transplantation,surgical technique,and local and systemic treatment,the overall prognosis of HCC remains dismal with a 5-year relative survival rate of 18.4%(3).

关键词： cancer liver prognosis

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Identification of chromatin organization-related genes associated with clinical and prognostic features of hepatocellular carcinoma

Identification of chromatin organization-related genes assoc...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： xingte chen Fujian Medical University Cancer Hospital

Background: Chromatin organization is a well-studied concept, but no studies have comprehensively analyzed the association between chromatin organization-related genes(CORGs) and hepatocellular carcinoma(HCC) ***: Gene candidates were selected from differentially expressed genes and prognostic genes in The Cancer Genome Atlas(TCGA) database. A gene risk score for overall survival prediction was established using the least absolute shrinkage and selection operator(LASSO) regression, Learning Vector Quantization(LVQ)and random forest(RF) analysis, and this was validated using data from the International Cancer Genome Consortium(ICGC) database. Functional analysis was conducted using gene ontology enrichment, Kyoto Encyclopedia of Genes and Genomes analysis, gene set enrichment analysis, and immune microenvironment and copy number variations(CNV) ***: Initially, 121 CORGs from the TCGA database were screened as differentially expressed between normal and tumor tissues and as genes associated with HCC prognosis. Then, four CORGs(BEND3,CENPA, HDAC1, KDM1 A) were identified using the LASSO regression, LVQ and RF analysis. The four CORGs were used to develop a risk score in the training set, and the risk was validated to have a significant prognostic value in the ICGC set(P < 0.05). Patients with high risk scores had lower tumor differentiation, higher stage, and worse prognosis(all P<0.05). Multivariate Cox regression analyses also confirmed that the risk score was an independent prognostic factor for HCC in both the TCGA and ICGC sets(all P<0.05). Further analysis showed that a high risk score was correlated with the tumor immunity and ***: The risk score predicts HCC prognosis and could thus be used as a biomarker not only for predicting HCC prognosis but also for deciding on treatment.

关键词： chromatin organization gene hepatocellular carcinoma tumor immunity copy number variations risk score

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