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基于网络药理学探讨蒙药森登-9汤治疗布鲁氏菌病的作用机制

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包头医学院学报 2024年第5期40卷 72-78,85页

作者：范子旭李星男靳敏王占黎高志祥包头医学院公共卫生学院内蒙古包头014040 内蒙古疾病相关生物标志物重点实验室包头医学院第二附属医院内蒙古医科大学公共卫生学院

目的:运用网络药理学的方法,探讨蒙药森登-9汤(布病Ⅱ号)治疗布鲁氏菌病的作用机制。方法:运用BATMAN-TCM数据库分析蒙药森登-9汤的活性成分及潜在靶点;通过Genecards、OMIM、DisGeNET数据库筛选布鲁氏菌病相关靶点;构建韦恩图,得到疾... 详细信息

目的:运用网络药理学的方法,探讨蒙药森登-9汤(布病Ⅱ号)治疗布鲁氏菌病的作用机制。方法:运用BATMAN-TCM数据库分析蒙药森登-9汤的活性成分及潜在靶点;通过Genecards、OMIM、DisGeNET数据库筛选布鲁氏菌病相关靶点;构建韦恩图,得到疾病交集靶点与蒙药森登-9汤治疗布鲁氏菌病的交集靶点;用Cytoscape软件绘制“药物-成分-疾病-靶点”关系网络图;通过STRING数据库构建“活性成分-疾病”共同靶点的蛋白互作(PPI)网络;使用David数据库对关键靶标进行基因本体功能(GO)及京都基因和基因组百科全书(KEGG)通路富集分析。结果:蒙药森登-9汤活性成分有182个,作用于1306个靶点;布鲁氏菌病靶点620个,药物与疾病交集靶点152个。蒙药森登-9汤治疗布鲁氏菌病的主要活性成分有月桂酸、肉豆蔻酸、亚油酸、茉莉酮、羽扇烯酮、香叶基丙酮、氧化槐果碱、3-壬烯-2-酮等;治疗布鲁氏菌病的核心靶点有IL-6、IL-1β、INS、TNF、PTGS2、JUN、TP53、IGF1、CCL2、HIF1A。富集得到GO条目1064个,其中BP条目834个,CC条目107个,MF条目123个。KEGG信号通路共162条,主要集中在HIF-1信号通路、TNF信号通路、MAPK信号通路、FoxO信号通路、IL-17信号通路等。结论:本研究通过网络药理学的方法初步探讨了蒙药森登-9汤有效成分抗炎、抗病原微生物等作用机制,为布鲁氏菌病的治疗,及进一步研究该方作用机理、临床应用提供了理论依据。

关键词：网络药理学蒙药森登-9汤布鲁氏菌病信号通路作用机制

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

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Journal of Molecular Cell Biology 2020年第8期12卷 630-643页

作者： Yuhong Du xingnan li Qiankun Niu Xiulei Mo Min Qui Tingxuan Ma Calvin J.Kuo Haian Fu Department of Pharmacology and Chemical Biology and Emory Chemical Biology Discovery Center Emory University School of MedicineAtlantaGAUSA Department of Medicine Division of HematologyStanford University School of MedicineStanfordCAUSA

The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug ***,organoid culturing with extracellular matrix to support 3D architecture has been challenging for high-throughput screening(HTS)-based drug discovery due to technical *** genetically engineered human colon organoids as a model system,here we report our effort to miniaturize such 3D organoid culture with extracellular matrix support in high-density plates to enable *** first established organoid culturing in a 384-well plate format and validated its application in a cell viability HTS assay by screening a 2036-compound *** further miniaturized the 3D organoid culturing in a 1536-well ultra-HTS format and demonstrated its robust performance for large-scale primary compound *** miniaturized organoid culturing method may be adapted to other types of *** leveraging the power of 3D organoid culture in a high-density plate format,we provide a physiologically relevant screening platform to model tumors to accelerate organoid-based research and drug discovery.

关键词： human colon organoids KRAS^G12D 3D culture 384-well plate high-throughput screening(HTS) 1536-well plate ultra-HTS(uHTS)

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WES溢流坝水面线的简化计算

应用力学学报 2020年第3期37卷 1321-1329,I0029页

作者：张志昌郝铭李星南西安理工大学水利水电学院西安710048

WES溢流坝是水利工程中最常用的坝面形式之一,研究坝面水面线的简化计算对于工程设计具有重要意义。根据前人对WES溢流坝水面线的试验研究成果,通过计算机作图、利用能量方程和动量方程,研究了溢流坝曲线段、陡坡段和反弧段水面线的简... 详细信息

WES溢流坝是水利工程中最常用的坝面形式之一,研究坝面水面线的简化计算对于工程设计具有重要意义。根据前人对WES溢流坝水面线的试验研究成果,通过计算机作图、利用能量方程和动量方程,研究了溢流坝曲线段、陡坡段和反弧段水面线的简化计算方法和WES曲线弧长的计算方法。提出了坝面曲线段和反弧段水面线的计算公式、溢流陡坡面水面线的显式计算公式、WES溢流坝曲线段曲线长度的计算公式。通过模型试验和前人实测资料对所提出的公式进行验证,结果表明,本文所提公式计算简单,WES曲线段最大误差为7.3191%、陡坡段最大误差为2.8363%、反弧段最大误差为3.6974%。

关键词： WES溢流坝水面线 WES曲线弧长简化计算

地下水数值模型结构不确定性对模拟结果的影响分析

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排灌机械工程学报 2021年第2期39卷 179-185页

作者：李兴男金江跃降亚楠西北水利水电建筑勘察设计院陕西杨凌712100 西北农林科技大学水利与建筑工程学院陕西杨凌712100 西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100

以内蒙古鄂托克旗为例,基于GMS中的MODFLOW模块构建了地下水流数值模拟模型,分析了模型结构(含水层厚度、参数分区)与模型参数不确定性因素对模拟结果的影响.研究结果表明:含水层不确定情景(含水层下边界概化为隔水底板平均值870 m)与... 详细信息

以内蒙古鄂托克旗为例,基于GMS中的MODFLOW模块构建了地下水流数值模拟模型,分析了模型结构(含水层厚度、参数分区)与模型参数不确定性因素对模拟结果的影响.研究结果表明:含水层不确定情景(含水层下边界概化为隔水底板平均值870 m)与实际情况水头差值绝对值的累计和最大为701 m,对模拟结果起了主控作用;当含水层下边界概化为910,940 m时,累计和分别增加为1013,1593 m;与仅考虑单个不确定性因素相比,同时考虑模型参数与含水层不确定情景累计和最大为738 m,同时考虑参数分区与含水层不确定情景累计和最大为791 m.因此,在构建地下水流数值模拟模型时,应优先考虑含水层空间结构概化的合理程度,同时考虑多个不确定性因素对模拟结果的综合影响,使地下水数值模拟模型能更精确地反映真实的地下水流状况.

关键词：地下水数值模拟模型不确定性模型结构含水层参数分区

Additives strategies to improving cycling stability of li metal batteries by modifying electrode electrolyte interphases

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Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan li Pengfei Huang Chunyu Cui Xiaoyuan Ma li Chen Zekun li linhai li Yuhong Tian School of Biological and Chemical Engineering Guangxi University of Science and Technology School of College of Chemistry and Chemical Engineering Hunan University Isky Future Energy Institute

li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a liF and li3N-rich solid electrolyte interphase（SEI）.The liF component increases the robustness of SEI and suppresses the formation of li dendrites,while the li3N component facilitates the transportation and reaction kinetics of li *** a result,the li‖li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with liFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： li metal batteries li dendrites Electrolyte additive

法律家长主义视角下我国人体器官移植制度的法理分析与重构

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医学与社会 2022年第4期35卷 134-138,144页

作者：李星楠阚凯刘姝琪张新蔓大连医科大学人文与社会科学学院辽宁大连116044

随着医学进步,人体器官移植已成为解决人体器官障碍问题的有效手段,但人体器官移植领域中供体缺乏、非法交易等乱象频发也揭露了人体器官移植制度亟待完善的现实。为解决这些问题,可从法律家长主义视角出发,对各国人体器官捐献同意模式... 详细信息

随着医学进步,人体器官移植已成为解决人体器官障碍问题的有效手段,但人体器官移植领域中供体缺乏、非法交易等乱象频发也揭露了人体器官移植制度亟待完善的现实。为解决这些问题,可从法律家长主义视角出发,对各国人体器官捐献同意模式及人体器官来源二元立场进行法理分析,探讨将人体器官移植置于法律家长主义的视角下审视的目的及意义,分析我国人体器官移植制度从无到有及逐渐发展的过程中体现出的国家从单纯的医疗秩序管理到人身权保护的根本理念转换,进而总结人体器官移植制度的立法趋势,重构立法内容:建立“柔性推定”式人体器官捐献同意制度,构建政府参与下的有偿捐献制度,动态调整移植人体器官的供给及获取制度等。从而使人体器官移植在合法的范围内能够最大限度地得以实施,尽可能多地挽救患者生命、提高患者生存质量。

关键词：人体器官移植法律家长主义有偿捐献同意模式

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景颇族民间歌谣的社会价值和艺术特色

德宏师范高等专科学校学报 2020年第4期29卷 70-72,81页

作者：李星楠云南民族大学民族文化学院云南昆明650500

景颇族民间歌谣是景颇族民间艺术发展到一定阶段的重要成果,是景颇族劳动人民智慧结晶的体现。景颇族民间歌谣的起源、发展有着悠久的历史,在民众日常生活中有很重要的作用,是景颇族民间口头艺术和非物质文化遗产的重要组成部分。本文... 详细信息

景颇族民间歌谣是景颇族民间艺术发展到一定阶段的重要成果,是景颇族劳动人民智慧结晶的体现。景颇族民间歌谣的起源、发展有着悠久的历史,在民众日常生活中有很重要的作用,是景颇族民间口头艺术和非物质文化遗产的重要组成部分。本文从民间歌谣的道德教化作用、习俗文化、历史和生活面貌等几方面来探讨景颇族民间歌谣的社会价值和艺术特色。

关键词：景颇族民间歌谣社会价值艺术特色

Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

SEI/dead li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu li Hongzhang Zhang Guiming Zhong Xiaofei Yang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical liPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead li