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心脏储备功能指标评估慢性心力衰竭严重程度的研究

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重庆医学 2013年第2期42卷 143-145,148页

作者：吴晓军秦俭郭兴明卢德林肖守中肖子夫重庆医科大学附属第一医院心内科重庆400016 重庆大学生物工程学院重庆市医疗电子工程技术研究中心重庆400030 博精医学与信息工程研究所重庆400044

目的探讨心脏储备功能指标对慢性心力衰竭(CHF)的评估价值。方法将136例CHF患者作为心衰组,46例健康者作为对照组。采用彩色多普勒超声心动图检查,计算左心室射血分数(LVEF);进行6min步行试验(6MWT),采用心脏储备无创监测系统检测舒张... 详细信息

目的探讨心脏储备功能指标对慢性心力衰竭(CHF)的评估价值。方法将136例CHF患者作为心衰组,46例健康者作为对照组。采用彩色多普勒超声心动图检查,计算左心室射血分数(LVEF);进行6min步行试验(6MWT),采用心脏储备无创监测系统检测舒张期时限与收缩期时限比值(D/S),评价LVEF、6MWT及D/S值与心功能状态的相关性。结果心衰组患者的6MWD、D/S值、LVEF明显低于对照组(P<0.05);采用双变量Pearson相关系数法分析显示,D/S值、6WMD与纽约心脏协会(NYHA)心功能分级呈显著负相关(r=-0.659,P<0.01;r=-0.561,P<0.01);LVEF与NYHA心功能分级呈正相关(r=0.203,P<0.05)。结论 D/S值能较好反映CHF患者的心功能状态,可作为评估心功能的一个新型有效指标。

关键词：心力衰竭,充血性评价研究舒张期时限与收缩期时限比值左心室射血分数 6 min步行试验

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基于云服务的城市能源管理信息系统设计

软件工程师 2013年第6期 29-31页

作者：李含春段小平郭星明杭州市能源监察中心浙江杭州310007 浙江经济职业技术学院浙江杭州310018

本文从城市能源管理需求出发,结合区县和行业管理的要求,以杭州市为实证案例,采用云计算技术和云服务架构,进行了能源管理信息系统的设计。系统包括企业申报管理、数据采集审核、区县统计分析和宏观能源监察等功能,突出能源利用效率和... 详细信息

本文从城市能源管理需求出发,结合区县和行业管理的要求,以杭州市为实证案例,采用云计算技术和云服务架构,进行了能源管理信息系统的设计。系统包括企业申报管理、数据采集审核、区县统计分析和宏观能源监察等功能,突出能源利用效率和节能效益分析,有效解决了大中城市能源监察与管理问题。

关键词：能源管理信息系统云服务

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基于智能手机的心音监测系统的研究与设计

计算机工程与应用 2014年第13期50卷 37-41页

作者：李传鹏郭兴明张文英何彦青代婉迪重庆大学生物工程学院重庆400044

心音监测对心脏疾病的检测和预防有重要作用,研究并设计基于智能手机的心音监测系统。该系统由心音测量节点、智能手机节点、服务器端组成。测量节点实现心音信号的采集,智能手机节点接收测量节点的心音并将其经GPRS网络传递到服务器端... 详细信息

心音监测对心脏疾病的检测和预防有重要作用,研究并设计基于智能手机的心音监测系统。该系统由心音测量节点、智能手机节点、服务器端组成。测量节点实现心音信号的采集,智能手机节点接收测量节点的心音并将其经GPRS网络传递到服务器端,服务器端对心音进行远程的监测。其中智能手机节点是该系统的枢纽,其主要功能是分析处理心音:对心音进行小波去噪处理,通过LZ复杂度算法获取心音的特征指标,将特征指标用于心功能的分析评价及其异常预警。通过功能性测试表明该系统能稳定运行。

关键词：智能手机心音监测系统

Understanding tissue-specificity with human tissue-specific regulatory networks

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Science China(Information Sciences) 2016年第7期59卷 51-60页

作者： Weili guo Lin ZHU Suping DENG xingming ZHAO Deshuang HUANG College of Electromics and Information Engineering Tongji University

Tissue-specificity is important for the function of human body. However, it is still not clear how the functional diversity of different tissues is achieved. Here we construct gene regulatory networks in 13 human tissues by integrating large-scale transcription factor(TF)-gene regulations with gene and protein expression data. By comparing these regulatory networks, we find many tissue-specific regulations that are important for tissue identity. In particular, the tissue-specific TFs are found to regulate more genes than those expressed in multiple tissues, and the processes regulated by these tissue-specific TFs are closely related to tissue ***, the regulations that are present in certain tissue are found to be enriched in the tissue associated disease genes, and these networks provide the molecular context of disease genes. Therefore, recognizing tissuespecific regulatory networks can help better understand the molecular mechanisms underlying diseases and identify new disease genes.

关键词： tissue-specificity gene regulatory network transcription factor tissue-specific regulation disease gene

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心脏储备降低与心肌酶谱关系的动物实验研究

现代医药卫生 2019年第3期35卷 329-331页

作者：孙丰艳郑伊能周本梅郭兴明重庆大学医院检验中心重庆400044 重庆大学生物工程学院重庆400044

目的探究心脏储备与心肌酶谱指标的变化关系。方法选取22只新西兰家兔,随机分为实验组(n=15)和对照组(n=7),使用阿霉素(ADR)制备心脏储备降低的动物模型。实验组家兔经耳缘静脉注射ADR 1mL/kg,对照组家兔注射等量的生理盐水,每周固定时... 详细信息

目的探究心脏储备与心肌酶谱指标的变化关系。方法选取22只新西兰家兔,随机分为实验组(n=15)和对照组(n=7),使用阿霉素(ADR)制备心脏储备降低的动物模型。实验组家兔经耳缘静脉注射ADR 1mL/kg,对照组家兔注射等量的生理盐水,每周固定时间注射2次,连续注射8周。利用心音特征指标,计算心率(HR)、第一心音与第二心音幅值比(S1/S2)、心脏舒张期与收缩期时限比(D/S),无创评估2组家兔心脏储备,并对家兔采血检测心肌酶谱。结果实验组家兔心脏储备指标较对照组降低,心肌酶谱各指标较对照组升高,差异均有统计学意义(P<0.05)。HR与心肌酶谱指标呈较弱的负相关(P<0.05),D/S和S1/S2与心肌酶谱指标呈较弱的负相关(P<0.05)。结论心脏储备降低时,心肌酶谱显著升高。心脏储备指标可用于心功能无创评估。

关键词：心力衰竭心脏储备心肌酶谱医学检验新西兰兔心音描记术

HOXC10 up-regulation promotes gastric cancer cell proliferation and metastasis through MAPK pathway

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Chinese Journal of Cancer Research 2017年第6期29卷 572-580页

作者： Chen guo Jianing Hou Sheng Ao xingming Deng guoqing Lyu Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShertzhen 518036China

Objective： As an important regulator of embryonic morphogenesis, homeodomain-containing gene 10 （HOXC10） has been found to promote progression of human cancers and its expression indicates poor survival outcome. However, very few studies are available on the role of HOXC10 in gastric carcinoma. Therefore, the aim of this study was to determine the role of HOXC10 in gastric cancer and the potential mechanism underlying its function for cancer biology. Methods： A primary gastric cancer mouse model was obtained via intra-gastric wall injection of gastric cancer cells and was used to evaluate the function of HOXC10 during gastric cancer progression in vivo. Immunohistochemistry was performed to visualize and measure HOXC10 protein expression in gastric cancer tissue. Cells were transfected with plasmids to increase the expression of HOXCIO, and siRNA transfection was performed to suppress HOXC10 expression. Reverse transcription polymerase chain reaction （RT-PCR） and western blotting were utilized to measure mRNA and protein expression, respectively. Proliferation, migration, and invasion were investigated using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay, wound healing assay, and matrigel invasion assay in vitro, respectively. Results： HOXC10 expression was significantly increased in gastric cancer tissues compared to matched normal tissues. HOXC10 up-regulation significantly increased tumor volumes in nude mice. Plasmid transfection significantly increased HOXC10 protein and mRNA expressions and effectively promoted cell proliferation. Moreover, HOXC10 up-regulation significantly promoted migration and invasion of gastric cancer cells. Mechanistic investigation showed that HOXC10 up-regulation significantly increased mRNA and protein expression of mitogen-activated protein kinase （MAPK） signaling related genes, including c-myc, c-jun and p53, while also modulating the phosphorylation of c-Jun N-terminal kinase （JNK）, extracellular signal-r

关键词： HOXCIO proliferation metastasis gastric cancer

A Dual Model Watermarking Framework for Copyright Protection in Image Processing Networks

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Computers, Materials & Continua 2023年第4期75卷 831-844页

作者： Yuhang Meng Xianyi Chen xingming Sun Yu Liu guo Wei Engineering Research Center of Digital Forensics Ministry of EducationNanjing University of Information Science and TechnologyNanjing210044China The University of North Carolina Pembroke31321USA

Image processing networks have gained great success in many fields,and thus the issue of copyright protection for image processing networks hasbecome a focus of attention. Model watermarking techniques are widely usedin model copyright protection, but there are two challenges: (1) designinguniversal trigger sample watermarking for different network models is stilla challenge;(2) existing methods of copyright protection based on trigger swatermarking are difficult to resist forgery attacks. In this work, we propose adual model watermarking framework for copyright protection in image processingnetworks. The trigger sample watermark is embedded in the trainingprocess of the model, which can effectively verify the model copyright. And wedesign a common method for generating trigger sample watermarks based ongenerative adversarial networks, adaptively generating trigger sample watermarksaccording to different models. The spatial watermark is embedded intothe model output. When an attacker steals model copyright using a forgedtrigger sample watermark, which can be correctly extracted to distinguishbetween the piratical and the protected model. The experiments show that theproposed framework has good performance in different image segmentationnetworks of UNET, UNET++, and FCN (fully convolutional network), andeffectively resists forgery attacks.

关键词： Image processing networks copyright protection model watermark

元宇宙赋能数字经济和推动经济高质量发展的建议以杭州市为例

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智能物联技术 2023年第4期55卷 67-70页

作者：明振东赵磊刘晓燕张菊芳郭星明杭州数字经济联合会浙江杭州310012 中电海康集团有限公司浙江杭州311100 浙江省科技宣传教育中心浙江、杭州310007 浙江省智慧城市促进会浙江杭州310007 浙江经济职业技术学院浙江杭州310018 杭州自动化技术研究院有限公司浙江杭州310012

元宇宙作为数字经济的新兴赛道,是赋能实体经济发展的重要抓手和推动经济高质量发展的重要引擎,全国已有多个省市出台了元宇宙相关的产业支持政策。本文以杭州市为例,分析了杭州市元宇宙产业发展存在的问题,并提出了相应的产业发展建议... 详细信息

元宇宙作为数字经济的新兴赛道,是赋能实体经济发展的重要抓手和推动经济高质量发展的重要引擎,全国已有多个省市出台了元宇宙相关的产业支持政策。本文以杭州市为例,分析了杭州市元宇宙产业发展存在的问题,并提出了相应的产业发展建议。本文认为杭州市元宇宙产业存在整体规划不明确、关键核心技术不强、产业链和产业生态不完善以及产业融合赋能不深的问题。为了实现元宇宙的赋能作用和推动经济高质量发展,具体的建议包括:加快前瞻统筹规划;加强技术攻关,推动产业平台创新;完善产业生态,引导产业健康发展;坚持数实融合,催生一批标杆性应用。

关键词：元宇宙数字经济赋能产业融合

AGO2a but not AGO2b mediates antiviral defense against infection of wild-type cucumber mosaic virus in tomato

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Horticulture Research 2023年第5期10卷 38-48页

作者： Liling Zhao Yingfang Chen xingming Xiao Haiying Gao Jiamin Cao Zhongkai Zhang Zhongxin guo Vector-borne Virus Research Center State Key Laboratory for Ecological Pest Control of Fujian and Taiwan CropsCollege of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002 China 2Key Laboratory of Agricultural Biotechnology of Yunnan Province Biotechnology and Germplasm Resources Research InstituteYunnan Academy of Agricultural SciencesKunming650221 China

Evolutionarily conserved antiviral RNA interference(RNAi)mediates a primary antiviral innate immunity preventing infection of broad-spectrum viruses in ***,the detailed mechanism in plants is still largely unknown,especially in important agricultural crops,including *** of pathogenic viruses evolve to possess viral suppressors of RNA silencing(VSRs)to suppress antiviral RNAi in the *** to the prevalence of VSRs,it is still unknown whether antiviral RNAi truly functions to prevent invasion by natural wild-type viruses in plants and *** this research,for the first time we applied CRISPR-Cas9 to generate ago2a,ago2b,or ago2ab mutants for two differentiated Solanum lycopersicum AGO2s,key effectors in antiviral *** found that AGO2a but not AGO2b was significantly induced to inhibit the propagation of not only VSR-deficient Cucumber mosaic virus(CMV)but also wild-type CMV-Fny in tomato;however,neither AGO2a nor AGO2b regulated disease induction after infection with either *** findings firstly reveal a prominent role of AGO2a in antiviral RNAi innate immunity in tomato and demonstrate that antiviral RNAi evolves to defend against infection of natural wild-type CMV-Fny in ***,AGO2a-mediated antiviral RNAi does not play major roles in promoting tolerance of tomato plants to CMV infection for maintaining health.

关键词： immunity invasion media