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Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients

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Oncology Research 2023年第4期31卷 605-614页

作者： SHA ZHU NANWEI XU JIAYU LIANG FENGNIAN ZHAO ZILIN WANG YUCHAO NI JINDONG DAI JINGE ZHAO xingming zhang JUNRU CHEN GUANGXI SUN PENGFEI SHEN HAO ZENG Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China

Background:KMT2(lysine methyltransferase)family enzymes are epigenetic regulators that activate gene transcription.KMT2C is mainly involved in enhancer-associated H3K4me1,and is also one of the top mutated genes in cancer(6.6%in pan-cancer).Currently,the clinical significance of KMT2C mutations in prostate cancer is understudied.Methods:We included 221 prostate cancer patients diagnosed between 2014 and 2021 in West China Hospital of Sichuan University with cell-free DNA-based liquid biopsy test results in this study.We investigated the association between KMT2C mutations,other mutations,and pathways.Furthermore,we evaluated the prognostic value of KMT2C mutations,measured by overall survival(OS)and castration resistance-free survival(CRFS).Also,we explored the prognostic value of KMT2C mutations in different patient subgroups.Lastly,we investigated the predictive value of KMT2C mutations in individuals receiving conventional combined anti-androgen blockade(CAB)and abiraterone(ABI)as measured by PSA progression-free survival(PSA-PFS).Results:The KMT2C mutation rate in this cohort is 7.24%(16/221).KMT2C-mutated patients showed worse survival than KMT2C-wild type(WT)patients regarding both CRFS and OS(CRFS:mutated:9.9 vs.WT:22.0 months,p=0.015;OS:mutated:71.9 vs.WT 137.4 months,p=0.012).KMT2C mutations were also an independent risk factor in OS[hazard ratio:3.815(1.461,9.96),p=0.006]in multivariate analyses.Additionally,we explored the association of KMT2C mutations with other genes.This showed that KMT2C mutations were associated with Serine/Threonine-Protein Kinase 11(STK11,p=0.004)and Catenin Beta 1(CTNNB1,p=0.008)mutations.In the CAB treatment,KMT2C-mutated patients had a significantly shorter PSA-PFS compared to KMT2C-WT patients.(PSA-PFS:mutated:9.9 vs.WT:17.6 months,p=0.014).Moreover,KMT2C mutations could effectively predict shorter PSA-PFS in 10 out of 23 subgroups and exhibited a strong trend in the remaining subgroups.Conclusions:KMT2C-mutated patients showed worse survival compared to KMT2C-WT patients i

关键词： KMT2C Epigenetic regulator Liquid biopsy Prostate cancer Survival Biomarker

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Crop Insurance Premium Ratemaking Based on Survey Data:A Case Study from Dingxing County, China

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International Journal of Disaster Risk Science 2015年第3期6卷 207-215页

作者： xingming zhang Weixia Yin Jun Wang Tao Ye Jintao Zhao Jing’ai Wang State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University School of Geography Beijing Normal University Key Laboratory of Regional Geography Beijing Normal University Academy of Disaster Reduction and Emergency Management Beijing Normal University People’s Insurance Company of China School of Management Langfang Teachers College

Premium ratemaking is an important issue to guarantee insurance balance of payments. Most ratemaking methods require large samples of long-term loss data or farm-level yield data, which are often unavailable in developing countries. This study develops a crop insurance ratemaking method with survey data. The method involves a questionnaire survey on characteristic yield information(average yield, high yield, and low yield) of farming households’ cropland. After compensating for random error, the probability distributions of farm-level yields are simulated with characteristic yields based on the linear additive model. The premium rate is calculated based on Monte Carlo yield simulation results. This method was applied to Dingxing County, North China to arrive at the insurance loss cost ratio and calculate the necessary premium rate. The method proposed in this study could serve as a feasible technique for crop insurance ratemaking inregions that lack sufficient long-term yield data, especially in developing countries with smallholder agriculture.

关键词： Agricultural risk Characteristic agricultural yield Crop insurance North China Premium ratemaking

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广西国有雅长林场桉树与油茶混交造林及病虫害防治技术

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南方农业 2024年第2期18卷 215-217页

作者：张兴明广西壮族自治区国有雅长林场广西百色533000

油茶、桉树是我国广西常见的经济树种,如果采用混交造林技术,不仅能提升林农的经济收益,还能促进当地林业发展。但就目前而言,我国部分地区对桉树与油茶混交造林技术与病虫害防治措施认识不足,导致油茶产量、品质均无法满足市场需求。... 详细信息

油茶、桉树是我国广西常见的经济树种,如果采用混交造林技术,不仅能提升林农的经济收益,还能促进当地林业发展。但就目前而言,我国部分地区对桉树与油茶混交造林技术与病虫害防治措施认识不足,导致油茶产量、品质均无法满足市场需求。为推动油茶产业发展,以广西国有雅长林场为例,分析良种选择、间伐改造、整地、移栽定植、补植、追肥及除草等造林技术,探索桉苗灰霉病、桉树紫斑病、油茶软腐病、广西灰象、大造桥虫等病虫害防治措施。

关键词：桉树油茶混交造林广西国有雅长林场

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Numerical and Experimental Study on Stiffened Composite Panel Repaired by Bolted Joints under Compressive Load

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Journal of Applied Mathematics and Physics 2018年第8期6卷 1763-1771页

作者： Jifeng Xu Yuanpei Lan xingming zhang Kui Du Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aeronautical Science & Technology Research Institute Beijng China

Numerical and experimental study was conducted to investigate the failure mode and strength performance of stiffened composite panel repaired by bolted joints under compressive load, and the results were then compared with those from virgin stiffened composite panel without any damage. A finite element analysis model was established for repaired and virgin stiffened composite panels under compressive load, the 3D Hashin criteria was applied to identify the composite structure failure, and the secondary stress criteria was adopted to identify the adhesive failure between the base laminate and the stiffener. The failure modes of repaired stiffened composite panels were stiffened composite panels breaking off along the bolt joints. The experimental results were consistent with the finite element analysis results, indicating the reliability of the finite element analysis model.

关键词： Stiffened Composite Panel Bolted Joints Repair Compression Performance 3D Finite Element Model

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立式水轮发电机主轴轴线动态研究分析

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大电机技术 2024年第2期 36-41页

作者：张兴明马云华燕翔杨康文强冯爱军华能澜沧江水电股份有限公司昆明650000

水轮发电机轴线分析对水电厂水轮发电机组运行具有重要意义,本文分析了机组日常检修轴线测量存在的弊端以及机组运行过程中轴线监测的重要性,提出一种基于各摆度波形动态研究机组轴线的方法。根据机组实际运行动态,360°采集各方位的摆... 详细信息

水轮发电机轴线分析对水电厂水轮发电机组运行具有重要意义,本文分析了机组日常检修轴线测量存在的弊端以及机组运行过程中轴线监测的重要性,提出一种基于各摆度波形动态研究机组轴线的方法。根据机组实际运行动态,360°采集各方位的摆度值及其相位,采用数学向量合成分析的方法,借助计算机实时计算分析,进行机组轴线动态监测并判断其是否存在曲折以及曲折的方位,从而指导机组检修时的轴线调整。通过对机组实际摆度的采集数据进行举例计算分析,验证了本文所提方法的有效性,对水轮发电机组运行监测以及状态分析具有良好的指导意义。

关键词：水轮发电机主轴机组轴线摆度波形状态监测

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A muon high-resolution pseudorange measurement method: Application to muon navigation in confined spaces

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Chinese Journal of Aeronautics 2024年第4期37卷 391-404页

作者： Haoyang LI Chunxi zhang xingming FAN Longjie TIAN Tianqi LI Yang PANG Yanqiang YANG Institute of Optics and Electronics School of Instrumentation Science and Optoelectronics EngineeringBeihang UniversityBeijing 100191China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Confined spaces such as polar regions, deep earth and deep ocean are crucial navigation scenarios where traditional navigation techniques have difficulty in obtaining external signals for positioning. The cosmic ray muons, which carry the spatial and energetic information, are easy to penetrate these confined spaces. Therefore, the unique muon characteristic provides a new perspective to estimate detector position, which can be considered using in confined spaces navigation.In this paper, a well-developed theory of muon navigation is established by combining a muon pseudorange measurement method. Moreover, an Equivalent Velocity Calculation Model(EVCM)and a Muon Sequence Matching Technology(MSMT) are proposed. The first model corrects flight pseudorange error caused by the relativistic energy loss and the second technology compensates the random error in pseudorange measurement. Further, a series of simulations are performed to analyze the muon events number which can be received by detector in different scenarios with the variations of zenith angle, detector area, varied detector plates gap, and muon flight distance.Meanwhile, the simulation results demonstrate that the muon navigation update rate every 10 minutes can reach 5.989 in confined spaces at 100 m, and further pseudorange error analysis indicates that the meter-level positioning accuracy can be acquired. Finally, we construct a muon coincidence measurement scheme and verify that the laws of the muon positioning system for high-energy muons are consistent with the simulation results.

关键词： Muon navigation Cosmic ray muons Muon detection technology Muon transmission technology Pseudorange measurement

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新年献词

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项目管理技术 2024年第1期22卷 1-1页

作者：张星明《项目管理技术》

光阴荏苒,日月如梭,转眼间新的一年来临了。过去的一年里,《项目管理技术》杂志在项目管理界各位专家读者和新一届编委的关心和支持下,编辑团队焚膏继晷、敬恭桑梓,刊物在内容建设、新媒体拓展和资源积累等方面取得了新的进步,得到了社... 详细信息

光阴荏苒,日月如梭,转眼间新的一年来临了。过去的一年里,《项目管理技术》杂志在项目管理界各位专家读者和新一届编委的关心和支持下,编辑团队焚膏继晷、敬恭桑梓,刊物在内容建设、新媒体拓展和资源积累等方面取得了新的进步,得到了社会的广泛关注和好评。在过去的一年中,《项目管理技术》杂志以传播项目管理理念,引领项目管理发展应用为指引,坚持以内容为王、质量为本,充分发挥新一届编委专家的作用,在探索应用型学术期刊的道路上迈出了新的步伐,取得了新的成绩。

关键词：内容为王新年献词项目管理编辑团队学术期刊资源积累新一届编委质量为本

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Unveiling protein corona composition:predicting with resampling embedding and machine learning

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Regenerative Biomaterials 2024年第1期3卷 27-33页

作者： Rong Liao Yan Zhuang Xiangfeng Li Ke Chen xingming Wang Cong Feng Guangfu Yin Xiangdong Zhu Jiangli Lin Xingdong zhang College of Biomedical Engineering National Engineering Research Centre for BiomaterialsSichuan UniversityChengdu610065China

Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration.When nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of NPs.However,achieving accurate predictions remains a significant challenge.Although several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data distribution.In this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC data.Various ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were obtained.Our ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random Oversampling.Additionally,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification.

关键词： nanoparticles protein corona machine learming resampling technique feature analysis

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An FPGA Implementation of Multi-Class Support Vector Machine Classifier Based on Posterior Probability

An FPGA Implementation of Multi-Class Support Vector Machine...

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2010 3rd International Conference on Computer and Electrical Engineering(ICCEE 2010)

作者： Zhiliang Nie xingming zhang Zhenxi Yang National Digital Switch System Engineering & Technological R & D Center

Aim at the issue that the results of analyzing a classify algorithm of multi-class support vector machines which is based on posterior probability have been found its computation complexity is large, this paper present a simplified algorithm which is suitable for FPGA implementation. The analysis results indicate that this simplified algorithm’s computation complexity is decline. The experimental results in language recognition system show that the mean absolute error between the fixed-point output of the FPGA- based simplified algorithm and the floating point output of the original algorithm which is based on C language is 10-4 order of magnitude, which hardly affect this system’s performance and meet its real-time requirements.

关键词： posterior probability multi-class support vector machine FPGA

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Web-based visualization of spatial objects in 3DGIS

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Science in China(Series F) 2009年第9期52卷 1588-1597页

作者： zhang LiQiang GUO ZhiFeng KANG ZhiZhong zhang LiXin zhang xingming YANG Ling State Key Laboratory of Remote Sensing Science Beijing Normal University Beijing 100875 China Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 China Department of Geodesy and Geomatics School of Land Science and Technology China University of Geosciences Beijing 100083 China

Adaptive rendering large and complex spatial data has become an important research issue in a 3DGIS application. In order to transmit the data to the client efficiently, this paper proposes a node-layer data model to manage the 3D scene. Because the large spatial data and limited network bandwidth are the main bottlenecks of web-based 3DGIS, a client/server architecture including progressive transmission methods and multiresolution representations, together with the spatial index, are developed to improve the performance. All this makes the application quite scalable. Experimental results reveal that the application works appropriately.

关键词： data model progressive transmission spatial index adaptive visualization

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