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Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling

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Journal of Sport and Health Science 2023年第1期12卷 45-51页

作者： Lei Li Jinye Liang Cong zhang Tiemin Liu Chao zhang Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of Biology University of IowaIowa CityIA 52242USA State Key Laboratory of Genetic Engineering Department of Endocrinology and Metabolismand School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China

Melanocortin 4 receptor(MC4R),the most important monogenetic cause of human metabolic disorders,has been of great interest to many researchers in the field of energy homeostasis and public *** MC4R is a vital pharmaceutical target for maintaining controllable appetite and body weight for professional athletes,previous studies have mainly focused on the central,rather than the peripheral,roles of ***,the local expression of MC4R and its behavioral regulation remain *** an attempt to shed light on different directions for future studies of MC4R signaling,we review a series of recent and important studies exploring the peripheral functions of MC4R and the direct physiological interaction between peripheral organs and central MC4R neurons in this article.

关键词： Body weight Energy homeostasis GPCR Melanocortin-4 receptor

Face stability of shield tunnels considering a kinematically admissible velocity field of soil arching

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 505-526页

作者： Wei Li Chengping zhang Dingli zhang Zijian Ye Zhibiao Tan Key Laboratory for Urban Underground Engineering of the Ministry of Education Beijing Jiaotong UniversityBeijing100044China School of Civil Engineering Beijing Jiaotong UniversityBeijing100044China

Existing mechanism of simulating soil movement at tunnel face is generally based on the translational or rotational velocity field,which is,to some extent,different from the real soil movement in the arching *** simulations are carried out first to investigate the characteristics of the velocity distribution at tunnel face and above tunnel *** a new kinematically admissible velocity field is proposed to improve the description of the soil movement according to the results of the numerical *** on the proposed velocity field,an improved failure mechanism is constructed adopting the spatial discretization technique,which takes into account soil arching effect and plastic deformation within soil ***,the critical face pressure and the proposed mechanism are compared with the results of the numerical simulation,existing analytical studies and experimental tests to verify the accuracy and improvement of the presented *** proposed mechanism can serve as an alternative approach for the face stability analysis.

关键词： Tunnel face stability Velocity field Failure pattern Improved failure mechanism Critical face pressure

Real-time optimization power-split strategy for hybrid electric vehicles

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Science China(Technological Sciences) 2016年第5期59卷 814-824页

作者： XIA Chao Ying zhang Cong Institute of Electrical Engineering and Automation Tianjin University

Energy management strategies based on optimal control theory can achieve minimum fuel consumption for hybrid electric vehicles, but the requirement for driving cycles known in prior leads to a real-time problem. A real-time optimization power-split strategy is proposed based on linear quadratic optimal control. The battery state of charge sustainability and fuel economy are ensured by designing a quadratic performance index combined with two rules. The engine power and motor power of this strategy are calculated in real-time based on current system state and command, and not related to future driving conditions. The simulation results in ADVISOR demonstrate that, under the conditions of various driving cycles, road slopes and vehicle parameters, the proposed strategy significantly improves fuel economy, which is very close to that of the optimal control based on Pontryagin's minimum principle, and greatly reduces computation complexity.

关键词： hybrid electric vehicle (HEV) linear quadratic optimal control real-time control energy management strategy

Impacts of Fe2+on 5-aminolevulinic acid(ALA)biosynthesis of Rhodobacter sphaeroides in wastewater treatment by regulating nif gene expression

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Journal of Environmental Sciences 2018年第8期30卷 11-19页

作者： Shuli Liu Zhihong Zheng Jingxi Tie Jia Kang Guangming zhang Jie zhang School of Environmental and Municipal Engineering North China University of Water Resources and Electric PowerZhengzhou 450000China Henan Key Laboratory of Water Environment Simulation and Treatment Zhengzhou 450046China Henan Engineering Research Center of Water Pollution and Soil Damage Remediation Zhengzhou 450046China School of Environment and Resource Renmin University of ChinaBeijing 100872China School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090China

This study aimed to increase bacterial growth and 5-aminolevulinic acid（ALA） biosynthesis of Rhodobacter sphaeroides in wastewater treatment through adding ferrous ion（ Fe2＋）. Results demonstrated that Fe2＋ effectively enhanced the biomass production and ALA yield of R. sphaeroides. Moreover, the optimal Fe2＋ dosage was found to be 400 μmol/L, which was associated with the highest biomass of 4015.3 mg/L and maximum ALA yield of 15.9 mg/g-dry cell weight（mg/g-DCW）. Mechanism analysis revealed that Fe2＋ vastly improved Adenosine Triphosphate（ATP） production by up-regulating the nif gene expression, and increasing ATP enhanced the biomass and ALA yield by supplying energy for bacterial growth and ALA biosynthesis, respectively. Correlation analysis showed that the ALA and ATP yields had positive relation with nifA and nifU gene expression. In addition, the nifA and nifU gene expression displayed high consistency of co-transcription at the optimal Fe2＋ dosage.

关键词： Ferrous ion 5-Aminolevulinic acid Rhodobacter sphaeroides ATP production nif genes Up-regulation

Effect of feeding parameters on ingot segregation and shrinkage pore in vacuum arc remelting

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Journal of Iron and Steel Research International 2023年第6期30卷 1268-1278页

作者： Dong-bin Jiang Fu-zhong Yang Jian zhang Yang Zhou Li-feng zhang School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Chengdu Advanced Metal Materials Industrial Technology Institute Chengdu 610303SichuanChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The feeding parameters in the final stage of vacuum arc remelting process obviously affect the solute segregation and shrinkage pore *** with the electromagnetic field,fluid flow,and solute transport,a numerical model was built to investigate the effect of feeding parameters on the ingot solidification *** Nb segregation and shrinkage pore depth in the solidified ingot were *** results show that the liquid moves along the solidification front and the vertex flow is formed in the liquid pool,which promotes solute *** the solidified ingot,the Nb segregation in the lower part is negative,while that in the upper part is *** the differential electrode applied,the positive segregation is slightly reduced but the segregation distribution remains *** the feeding current decreases,the positive segregation zone moves toward the ingot top surface,due to the final solidification position moving *** the feeding time extended,the positive segregation moves to the top surface and the shrinkage pore depth is *** the feeding time is set at 12 min,the shrinkage pore depth can be reduced to 21 mm.

关键词： Vacuum arc remelting Feeding parameter Macrosegregation Shrinkage pore Solidification

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

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Neural Regeneration Research 2024年第9期19卷 2041-2049页

作者： Zhihua Wang Wu Zhou Zhixiong zhang Lulu zhang Meihua Li Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Postdoctoral Innovation Practice Base The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Nephrology Nanchang People’s Hospital Affiliated to Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury *** oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox *** is a classic drug used to treat type 2 diabetes that can inhibit *** studies have shown that,when used to treat cardiovascular and digestive system diseases,metformin can also upregulate heme oxygenase-1 ***,we hypothesized that heme oxygenase-1 plays a significant role in mediating the beneficial effects of metformin on neuronal ferroptosis after spinal cord *** test this,we first performed a bioinformatics analysis based on the GEO database and found that heme oxygenase-1 was upregulated in the lesion of rats with spinal cord ***,we confirmed this finding in a rat model of T9 spinal cord compression injury that exhibited spinal cord nerve cell *** intraperitoneal injection of metformin for 14 days was found to both upregulate heme oxygenase-1 expression and reduce neuronal ferroptosis in rats with spinal cord ***,we used a lentivirus vector to knock down heme oxygenase-1 expression in the spinal cord,and found that this significantly reduced the effect of metformin on ferroptosis after spinal cord *** together,these findings suggest that metformin inhibits neuronal ferroptosis after spinal cord injury,and that this effect is partially dependent on upregulation of heme oxygenase-1.

关键词： acyl-CoA synthetase long-chain family member 4 ferroptosis glutathione peroxidase 4 heme oxygenase-1 inflammation iron lipid peroxidation metformin neuroprotection spinal cord injury

Improved Variable Forgetting Factor Proportionate RLS Algorithm with Sparse Penalty and Fast Implementation Using DCD Iterations

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China Communications 2024年第10期21卷 16-27页

作者： Han Zhen zhang Fengrui zhang Yu Han Yanfeng Jiang Peng GNSS Research Center Wuhan UniversityWuhan 430072China School of Information Science and Technology Shijiazhuang Tiedao UniversityShijiazhuang 050043China

The proportionate recursive least squares(PRLS)algorithm has shown faster convergence and better performance than both proportionate updating(PU)mechanism based least mean squares(LMS)algorithms and RLS algorithms with a sparse regularization *** this paper,we propose a variable forgetting factor(VFF)PRLS algorithm with a sparse penalty,e.g.,l_(1)-norm,for sparse *** reduce the computation complexity of the proposed algorithm,a fast implementation method based on dichotomous coordinate descent(DCD)algorithm is also *** results indicate superior performance of the proposed algorithm.

关键词： dichotomous coordinate descent proportionate matrix RLS sparse systems variable forgetting factor

Geochemistry and geochronology of multi-generation garnet:New insights on the genesis and fluid evolution of prograde skarn formation

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Geoscience Frontiers 2023年第1期14卷 360-371页

作者： Gaobin Chu Huayong Chen Shitao zhang Yu zhang Jiamin Cheng CAS Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou 510640China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitor Central South UniversityChangsha 410083China University of Chinese Academy of Sciences Beijing 100049China

Origin of garnet in skarn(magmatic ***)and the prograde skarn fluid evolution are still *** generations of garnet(Grt1,Grt2)were identified at the Tongshankou deposit:Grt1 is anisotropic with oscillatory zoning and resorbed boundary,whilst Grt2 grew around Grt1 and formed oscillatory ***-situ LA-ICP-MS U-Pb dating of Grt1 and Grt2 yielded a lower intercept^(206)Pb/^(238)U age of 142.4±2.8 Ma(n=57;MSWD=1.16)and 142.3±9.6 Ma(n=60;MSWD=1.06),respectively,coeval with the ore formation and ore-related granodiorite *** Eu anomaly,non-CHARAC Y/Ho value and low TiO_(2)content,together with the mineral assemblages indicate that both Grtl and Grt2 have a hydrothermal *** existence of melt and melt-fluid inclusions in Grt1,together with similar LREE-enriched patterns to the granodiorite,further indicate that Grt1 may have formed in the magmatic-hydrothermal *** U contents and LREE-enriched patterns of Grt1 indicate that fluid I is mildly acidic pH and low fO_(2).The inner gray Grt2 rims(Grt2A)is HREE-enriched with low U contents,indicating that fluid II has nearly neutral pH and high fO_(2).The wider Y/Ho range and LREE-enriched patterns of the outer light-gray Grt2 rims(Grt2B)show that the evolved magmatic fluidⅡhad mixed with an external fluid,characterized by being mildly acidic pH and with high fO_(2)·Our results suggest that the prograde skarn-forming fluids can be multistage at Tongshankou,and the mixing of meteoric water may have been prominent in the prograde skarn stage.

关键词： Multi-generation garnet Mineral chemistry LA-ICP-MS U-Pb dating Fluid evolution Prograde skarn

Position-varying surface roughness prediction method considering compensated acceleration in milling of thin-walled workpiece

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Frontiers of Mechanical Engineering 2021年第4期16卷 855-867页

作者： Zequan YAO Chang FAN Zhao zhang Dinghua zhang Ming LUO Key Laboratory of High Performance Manufacturing for Aero Engine(Ministry of Industry and Information Technology) Northwestern Polytechnical UniversityXi'an 710072China Engineering Research Center of Advanced Manufacturing Technology for Aero Engine(Ministry of Education) Northwestern Polytechnical UniversityXi'an 710072China

Machined surface roughness will affect parts?service ***,predicting it in the machining is important to avoid *** roughness will be affected by system position dependent vibration even under constant parameter with certain toolpath processing in the *** at surface roughness prediction in the machining process,this paper proposes a position-varying surface roughness prediction method based on compensated acceleration by using regression *** reduce the stochastic error of measuring the machined surface profile height,the surface area is repeatedly measured three times,and Pauta criterion is adopted to eliminate abnormal *** actual vibration state at any processing position is obtained through the single-point monitoring acceleration compensation *** acceleration features are extracted,and valley,which has the highest/^-square proving the effectiveness of the filtering features,is selected as the input of the prediction model by mutual information ***,by comparing the measured and predicted surface roughness curves,they have the same trends,with the average error of 16.28%and the minimum error of 0.16%.Moreover,the prediction curve matches and agrees well with the actual surface state,which verifies the accuracy and reliability of the model.

关键词： surface roughness prediction compensated acceleration milling thin-walled workpiece