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Flexible organic-inorganic hybrid bioceramic for bone tissue regeneration

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Journal of Advanced Dielectrics 2020年第4期10卷 31-37页

作者： Jing Chen xingmei zhang Beibei Li Yawei Yang The Key Laboratory for Surface Engineering and Remanufacturing in Shaanxi Province School of Chemical Engineering Xi’an University Xi’an 710065P.R.China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education International Center for Dielectric Research Shaanxi Engineering Research Center of Advanced Energy Materials and Devices School of Electronic Science and Engineering Xi’an Jiaotong University Xi’an 710049P.R.China

Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability,bioactivity and *** this study,novel flexible poly(butylene succinate)/polydimethysiloxane-modified bioactive glass/nano-hydroxyapatite(PBSu/PDMS-BG/nHA)hybrid bioceramic with various nHA concentration on the in vitro bone-like hydroxyapatite(HA)formation,biomineralization activity and osteoblast cell biocompatibility were *** rapid precipitation of HA on the hybrid bioceramic surfaces was found after being immersed in simulated body fluid(SBF)for seven *** show that the amount of HA deposition increased with the increase of nHA *** optimized PBSu/PDMS-BG/nHA hybrid bioceramic exhibited good flexibility,high biomineralization activity and good osteoblast cell biocompatibility.

关键词： Sol-gel process nano-hydroxyapatite hybrid bioceramic biomineralization activity cell biocompatibility

Electroextraction of neodymium from LiCl-KCl melt using binary liquid Ga-Al cathode

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Journal of Rare Earths 2023年第8期41卷 1250-1257,I0005页

作者： Li Ding Xuepeng Wang Yongde Yan Valeri Smolenski Wenda Xu Alena Novoselova Yun Xue Fuqiu Ma xingmei zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Yantai Research Institute of Harbin Engineering University Yantai 264006China Institute of High-Temperature Electrochemistry UB RAS Ekaterinburg 620990Russia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityEkaterinburg 620990Russia Yantai Standard Metrology Inspection&Test Center National Steam Flowrate Measurement StationYantai 264000China

The electrochemical behaviour of Nd(Ⅲ)ion was investigated on inert W,active Ga and Ga-AI *** is established that the reduction of Nd(Ⅲ)ion on the inert electrode is a consecutive two-step process while that on the active electrodes is a one-step *** apparent standard potential of the Nd(Ⅲ)/Nd redox couple at different temperatures was determined by open-circuit chronopotentiometry and semi-differential method,and the relationship between temperature and apparent standard potential was further *** thermodynamic properties of Nd in Ga and Ga-Al electrodes such as activity coefficient and activity were evaluated via intermittent coulomb titration and temperature dependence test,and the effect of temperature on activity coefficient was ***,Nd was successfully extracted in form of alloy from molten salt by galvanostatic electrolysis,in which the current efficiency of91.7%for the electroextraction indicates that the binary liquid Ga-Al electrode has favorable performance.

关键词： Rareearths Electroextraction Spent nuclear fuel Pyrochemical processing Lanthanides Binary liquid cathode

Selective Chemosensor of Fe3＋ Based on Fluorescence Quenching by 2,2＇-Bisbenzimidazole Derivative in Aqueous Media

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Chinese Journal of Chemistry 2013年第4期31卷 515-519页

作者： Taibao Wei Jun Liu Hong Yao Qi Lin Yongqiang Xie Bingbing Shi Peng zhang xingmei You Youming zhang Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education of China Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou Gansu 730070 China

2,2＇-Bisbenzimidazole derivative （L） was designed as a fluorescent chemosensor for Fe3＋. This structurally simple chemosensor displays significant fluorescence quenching with increasing concentrations of Fe3＋. L exhib- ited high selectivity and antidisturbance for Fe3＋ among environmentally relevant metal ions in aqueous media. The method of Job＇s plot indicated the formation of 1 ; 2 complex between L and Fe3＋, and the possible binding mode of the system was also proposed. In addition, further study demonstrates the detection limit on fluorescence response of the sensor to Fe3＋ is down to 10-7 mol·L-1 range. The binding mode was investigated by fluorescence spectra, ESI-MS, IR data, ^1H NMR, ^13C NMR and crystal data.

关键词： chemosensor fluorescence quenching Fe3+ aqueous media

Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5121-5134页

作者： Feng Long Yao Pan Jinheng Li Suinan Sha Xiubo Shi Haoyan Guo Chuanqing Huang Qian Xiao Chao Fan xingmei zhang Jun-Bing Fan Ying Wang Cancer Research Institute Experimental Education/Administration CenterKey Laboratory of Functional Proteomics of Guangdong ProvinceSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Extracellular vesicles(EVs)have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size,biocompatibility,and high ***,we demonstrate orange-derived extracellular vesicles(OEV)nanodrugs(DN@OEV)by modifying cRGD-targeted doxorubicin(DOX)nanoparticles(DN)onto the surface of OEV,enabling significantly enhancing tumor accumulation and penetration,thereby efficiently inhibiting the growth of ovarian *** obtained DN@OEV enabled to inducement of greater transcytosis capability in ovarian cancer cells,which presented the average above 10-fold transcytosis effect compared with individual *** was found that DN@OEV could trigger receptor-mediated endocytosis to promote early endosome/recycling endosomes pathway for exocytosis and simultaneously reduce degradation in the early endosomes-late endosomes-lysosome pathway,thereby inducing the enhanced *** particular,the zombie mouse model bearing orthotopic ovarian cancer further validated DN@OEV presented high accumulation and penetration in tumor tissue by the transcytosis *** study indicated the strategy in enhancing transcytosis has significant implications for improving the therapeutic efficacy of thedrugdelivery system.

关键词： Extracellular vesicles Transcytosis Cancer treatment Drug delivery system Targeted modification Receptor-mediated endocytosis Intracellular trafficking Recycling endosome

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电子诉讼制度建设的观念基础与适用路径

政法论坛 2019年第5期37卷 117-126页

作者：张兴美吉林大学法学院吉林大学行政学院政治学博士后流动站吉林大学司法数据应用研究中心

电子诉讼是以诉讼为本质,运用信息技术,对诉讼法律关系主体之间法律交往方式的线上再造,它与智慧法院或者互联网法院是不同层面的概念。电子诉讼的制度建构应当坚持以当事人为中心的发展理念,强化诚实信用原则约束,功能等值式的进行。... 详细信息

电子诉讼是以诉讼为本质,运用信息技术,对诉讼法律关系主体之间法律交往方式的线上再造,它与智慧法院或者互联网法院是不同层面的概念。电子诉讼的制度建构应当坚持以当事人为中心的发展理念,强化诚实信用原则约束,功能等值式的进行。信息技术的进步性赋予了电子诉讼在诉讼效益、司法公开、接近正义等方面的比较优势。而信息技术的局限性会对私权保障、诉讼仪式性和直接言词原则造成冲击,这构建了电子诉讼适用的限度。电子诉讼的适用应当尊重当事人的程序选择权。程序选择权的运用会受到主体类型或诉讼行为类型的影响。在当事人选择适用的前提下,法院应当在必要限度内,发挥诉讼指挥权,规范引导电子诉讼适用。

关键词：电子诉讼诉讼价值诚实信用程序选择权直接言词

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第三人撤销之诉原告适格问题研究

法学杂志 2016年第6期37卷 133-140页

作者：张兴美吉林大学法学院吉林长春130012

诉讼第三人制度与第三人撤销之诉原告存在对接上的难题,需要进行目的性扩张解释;诉讼第三人标准不一、适用混乱的尴尬状况给第三人撤销之诉制度原告的确定造成了困难。结合"诉的利益"采取逆推逻辑,有助于第三人撤销之诉适格原告的认定... 详细信息

诉讼第三人制度与第三人撤销之诉原告存在对接上的难题,需要进行目的性扩张解释;诉讼第三人标准不一、适用混乱的尴尬状况给第三人撤销之诉制度原告的确定造成了困难。结合"诉的利益"采取逆推逻辑,有助于第三人撤销之诉适格原告的认定。台湾地区对第三人撤销之诉制度的立法和研究均较早,可以提供有益的比照和参考。

关键词：诉讼第三人第三人撤销之诉诉的利益虚假诉讼程序权保障

送达制度的结构性转向从“结果型”走向“过程型”

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中外法学 2022年第5期34卷 1260-1277页

作者：张兴美吉林大学法学院

我国的送达制度是按照结果导向型思维打造的“结果型”送达。“结果型”送达是以受送达人为主体偏向、以实质性送达效果为制度目标和法院全责型的送达结构,这种结构为送达不能、送而不达等送达难现象提供了制度环境。规范的送达制度应... 详细信息

我国的送达制度是按照结果导向型思维打造的“结果型”送达。“结果型”送达是以受送达人为主体偏向、以实质性送达效果为制度目标和法院全责型的送达结构,这种结构为送达不能、送而不达等送达难现象提供了制度环境。规范的送达制度应当是按照过程导向型思维打造的“过程型”送达。“过程型”送达是以受送达人程序利益为保护对象、以过程理性为制度核心、可实现程序自治的送达结构。由“结果型”送达向“过程型”送达转向是解决我国送达制度困境、重构我国送达制度的具体路径。该路径的实现以强化送达过程的理性建设为重点,信息化手段、社会化方法、交互性机制和推定规则可以为我国送达制度结构性转向提供技术保障。

关键词：送达送达难电子送达过程导向结果导向

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庭审记录方式电子化改革的反思与建构

法学杂志 2019年第1期40卷 125-133页

作者：张兴美吉林大学法学院吉林长春130012

目前我国庭审记录方式电子化改革方案是在既有诉讼法律框架下的"谨慎尝试",是对立法与司法实践进行"弥合"的结果,尚未从本质上回应信息技术在庭审记录制度中的应用。改革旨在优化庭审记录方式,而非改变庭审记录的本质。从庭审记录的制... 详细信息

目前我国庭审记录方式电子化改革方案是在既有诉讼法律框架下的"谨慎尝试",是对立法与司法实践进行"弥合"的结果,尚未从本质上回应信息技术在庭审记录制度中的应用。改革旨在优化庭审记录方式,而非改变庭审记录的本质。从庭审记录的制度机理出发,我国庭审记录方式电子化改革应该强调司法权的引领作用,兼顾当事人的知情权、阅览权、使用权等诉讼权利。通过构建庭审同步录音录像与法庭笔录"并行式"范式,最大限度地彰显信息技术的进步价值。在合理确定基本架构和适用范围的基础上,改革应当不断强化保障,从有效性、便捷性、安全性等维度加强协调机制建设,进而促进庭审记录方式电子化改革规范有序进行。

关键词：法庭笔录庭审同步录音录像科技法庭电子诉讼智慧法院

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加强主体功能区建设促进区域协调发展

经济问题探索 2008年第4期 17-21页

作者：张杏梅山西师范大学城市与环境科学学院山西临汾041004

主体功能区建设是促进我国区域协调发展的重要途径。本文认为主体功能区建设是我国区域协调发展战略的创新,在分析行政区经济管理模式下导致的区域发展不协调的基础上,探讨了主体功能区建设的区域协调功能,提出加强主体功能区建设,促进... 详细信息

主体功能区建设是促进我国区域协调发展的重要途径。本文认为主体功能区建设是我国区域协调发展战略的创新,在分析行政区经济管理模式下导致的区域发展不协调的基础上,探讨了主体功能区建设的区域协调功能,提出加强主体功能区建设,促进区域协调发展的基本对策。

关键词：主体功能区行政区经济区域协调