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Pangolin HKU4-related coronaviruses found in greater bamboo bats from southern China

Virologica Sinica 2023年第6期38卷 868-876页

作者： Min Guo Kai Zhao Xingwen Peng Xiangyang He Jin Deng Bo Wang xinglou yang Libiao Zhang Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou510260China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650023China Department of Biomedical Sciences and Pathobiology Virginia Polytechnic Institute and State UniversityBlacksburgVA24060USA Hubei Jiangxia Lab Wuhan430071China

Coronavirus(CoV)spillover originating from game animals,particularly pangolins,is currently a significant ***,vigilance is urgently needed for coronaviruses carried by bats,which are known as natural reservoirs of many *** this study,we collected 729 anal swabs of 20 different bat species from nine locations in Yunnan and Guangdong provinces,southern China,in 2016 and 2017,and described the molecular characteristics and genetic diversity of alphacoronaviruses(αCoVs)and betacoronaviruses(βCoVs)found in these *** RT-PCR,we identified 58(8.0%)bat CoVs in nine bat species from six ***,using the Illumina platform,we obtained two representative full-length genomes of the bat CoVs,namely TyRo-CoV-162275 and *** analysis showed that TyRo-CoV-162275 shared the highest identity with Malayan pangolin(Manis javanica)HKU4-related coronaviruses(MjHKU4r-CoVs)from Guangxi Province,whereas TyRo-CoV-162269 was closely related to HKU33-CoV discovered in a greater bamboo bat(Tylonycteris robustula)from Guizhou ***,TyRo-CoV-162275 has a putative furin protease cleavage site in its S protein and is likely to utilize human dipeptidyl peptidase-4(hDPP4)as a cell-entry receptor,similar to MERS*** the best of our knowledge,this is the first report of a bat HKU4r-CoV strain containing a furin protease cleavage *** findings expand our understanding of coronavirus geographic and host distributions.

关键词： Coronavirus Pangolin HKU4r-CoV Bat HKU4r-CoV Tylonycteris robustula Spillover risk

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Viral Metagenomics Analysis of Planktonic Viruses in East Lake,Wuhan,China

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Virologica Sinica 2013年第5期28卷 280-290页

作者： Xingyi Ge Yongquan Wu Meiniang Wang Jun Wang Lijun Wu xinglou yang Yuji Zhang Zhengli Shi Center for Emerging Infectious Diseases State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences

East Lake(Lake Donghu),located in Wuhan,China,is a typical city freshwater lake that has been experiencing eutrophic conditions and algal blooming during recent *** and fresh water are considered to contain a large number of ***,little is known about their genetic diversity because of the limited techniques for culturing *** this study,we conducted a viral metagenomic analysis using a high-throughput sequencing technique with samples collected from East Lake in Spring,Summer,Autumn,and *** libraries from four samples each generated 234,669,71,837,12,820,and 34,236 contigs(>90 bp each),*** genetic structure of the viral community revealed a high genetic diversity covering 23 viral families,with the majority of contigs homologous to DNA viruses,including members of Myoviridae,Podoviridae,Siphoviridae,Phycodnaviridae,and Microviridae,which infect bacteria or algae,and members of Circoviridae,which infect invertebrates and *** highest viral genetic diversity occurred in samples collected in August,then December and June,and the least diversity in *** contigs have low-sequence identities with known *** detection targeting the conserved sequences of genes(g20,psbA,psbD,and DNApol)of cyanophages further confirmed that there are novel cyanophages in the East *** viral metagenomic data provide the first preliminary understanding of the virome in one freshwater lake in China and would be helpful for novel virus discovery and the control of algal blooming in the future.

关键词： Viral metagenomics East Lake Solexa high-throughput sequencing High-throughput sequencing (HTS) Cyanophage

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Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis

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Virologica Sinica 2023年第6期38卷 971-974页

作者： Weijie Wang Jinxuan yang Pinfang Kang Jinsong Bai Xiaoli Feng Liuqi Huang Yiming Zhang Yuechun Wu Bi Tang Hongju Wang JianJie Jiang Minghua Li Bing Zhao xinglou yang Department of Cardiovascular Disease The First Affiliated Hospital of Bengbu Medical CollegeBengbu233004China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai200438China Kunming Third People's Hospital Kunming650041China Kunming National High-level Biosafety Research Center for Non-human Primates Kunming Institute of ZoologyChinese Academic of SciencesKunming650107China Institute of Organoid Technology Kunming Medical UniversityKunming650500China

Dear editor,The pandemic of coronavirus disease-19(COVID-19)has lasted for more than three years,causing lots of extra death and posing a serious threat to public *** pandemic swept the last global safety island in a matter of months,coinciding with the switch of zero-COVID policy of *** causative agent,SARS-CoV-2,spreads globally and then lurks in the population with sporadic outbreaks in local ***,the sequelae of convalescent COVID-19 patients receded *** pantissue tropism of SARS-CoV-2 results in a wide range of symptoms in patients,including cardiovascular *** complications occur in 20%–44%of hospitalized patients,which is an independent risk factor for COVID-19 mortality(Ma et al.,2022;Patone et al.,2022).Survivors of acute COVID-19 also have a substantial risk of cardiovascular disease burden lasting up to one year(Xie et al.,2022).

关键词： cardiovascular mortality acute

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Study of the Dynamics of Microcystis aeruginosa and its Cyanophage in East Lake using quantitative PCR

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Virologica Sinica 2013年第5期28卷 309-311页

作者： Han Xia Meiniang Wang Xingyi Ge Yongquan Wu xinglou yang Yuji Zhang Tianxian Li Zhengli Shi Virus Resource and Bioinformatics Center State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences Center for Emerging Infectious Diseases State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences

Dear Editor,East Lake,located in the middle and lower reaches of the yangtze River,is a major source of drinking water for local ***,the large increase of population density and the rapid development of industry has r... 详细信息

关键词：铜绿假单胞菌定量PCR 东湖噬藻体蓝藻水华长江中下游铜绿微囊藻人口密度

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Novel hepacivirus in Asian house shrew, China

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Science China(Life Sciences) 2019年第5期62卷 701-704页

作者： Hua Guo Chunlin Cai Bo Wang Fei Zhuo Rendi Jiang Ning Wang Bei Li Wei Zhang Yan Zhu Yi Fan Wushen Chen Weihong Chen xinglou yang Zhengli Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences University of Chinese Academy of Sciences Luohu Center for Disease Control and Prevention Department of Infectious Diseases Robert Koch Institute

Dear Editor,Hepatitis C virus (HCV) is a leading global cause of various liver diseases, including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The genome of HCV is monopartite, single-stranded, positive RNA, about 10 kb in *** is the prototype species of the Hepacivirus genus,which contains 14 species according to the update from the International Committee on Taxonomy of Viruses (Smith et al., 2016).

关键词： RNA In China Novel hepacivirus in Asian house shrew Figure

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儿童泌尿系统感染的抗菌药物的选择与使用策略

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中华儿科杂志 2022年第9期60卷 964-966页

作者：廖毅刘兴楼华中科技大学同济医学院附属同济医院儿科武汉430030

泌尿系统感染(UTI)是儿童期常见的感染性疾病之一,大肠埃希菌是其最常见致病菌。抗菌药物治疗应在留取患儿尿液后尽早开始。治疗UTI的经验性首选药物为二代或三代头孢菌素和阿莫西林克拉维酸。临床上应根据患儿年龄、疾病严重程度以及... 详细信息

泌尿系统感染(UTI)是儿童期常见的感染性疾病之一,大肠埃希菌是其最常见致病菌。抗菌药物治疗应在留取患儿尿液后尽早开始。治疗UTI的经验性首选药物为二代或三代头孢菌素和阿莫西林克拉维酸。临床上应根据患儿年龄、疾病严重程度以及能否耐受口服药物等情况综合考虑,选择口服或静脉治疗。预防用抗菌药物则推荐首选呋喃妥因和甲氧苄啶-磺胺甲噁唑。

关键词：疾病严重程度常见致病菌静脉治疗三代头孢菌素感染性疾病泌尿系统感染磺胺甲噁唑口服药物

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A great pediatrician and scholar devoting his whole life to pediatric infectious and digestive diseases—In memoriam of Professor Yongsui Dong

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Pediatric Investigation 2023年第2期7卷 150-152页

作者： xinglou Liu Sainan Shu Sitang Gong Xiaoping Luo Feng Fang Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gastroenterology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina

Professor Yongsui Dong(April 1932–January 2023)was a chief physician and doctoral supervisor of the Department of Pediatrics,Tongji Hospital,Tongji Medical College of Huazhong University of Science and Technology,and a pioneer,medical educator,and clinical scientist in the field of pediatric infectious and digestive diseases in *** Dong graduated from the Medical College of Fudan University(formerly Shanghai First Medical College)with excellent grades in 1956.

关键词： pediatric doctor diseases

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细胞自噬和人类疱疹病毒相互作用的研究进展

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中国细胞生物学学报 2014年第8期36卷 1207-1212页

作者：黄媛刘兴楼方峰华中科技大学同济医学院附属同济医院儿科临床病毒室武汉430030

自噬是普遍存在于真核生物中的自我保护机制之一,在自噬相关蛋白的参与下形成了完整而复杂的吞噬和自身调节机制,使其防御过程有条不紊地进行。除维持细胞内成分更新外,自噬还可选择性识别并清除入侵的病原微生物,如人类疱疹病毒。人类... 详细信息

自噬是普遍存在于真核生物中的自我保护机制之一,在自噬相关蛋白的参与下形成了完整而复杂的吞噬和自身调节机制,使其防御过程有条不紊地进行。除维持细胞内成分更新外,自噬还可选择性识别并清除入侵的病原微生物,如人类疱疹病毒。人类疱疹病毒在全球范围内普遍存在,感染人群广泛。然而,在与宿主长期共存的过程中,人疱疹病毒已经进化出相当强的抗细胞自噬机制来破坏、阻滞宿主的这一清除作用。

关键词：自噬自噬相关蛋白人疱疹病毒免疫清除免疫逃逸

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大蒜新素对巨细胞病毒感染小鼠脾细胞TGF-β1和IL-10的抑制作用

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武汉大学学报（医学版） 2010年第5期31卷 580-583页

作者：周华舒赛男杨助峰刘兴楼朱单丹方峰华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的:研究大蒜新素对巨细胞病毒(CMV)感染鼠的免疫抑制性细胞因子TGF-β1和IL-10的影响,探讨大蒜新素的抗CMV机制。方法:建立非免疫抑制性鼠巨细胞病毒(MCMV)全身播散性感染小鼠模型;双抗体夹心ELISA法检测感染后1,3,7,14,28,45,60,75,9... 详细信息

目的:研究大蒜新素对巨细胞病毒(CMV)感染鼠的免疫抑制性细胞因子TGF-β1和IL-10的影响,探讨大蒜新素的抗CMV机制。方法:建立非免疫抑制性鼠巨细胞病毒(MCMV)全身播散性感染小鼠模型;双抗体夹心ELISA法检测感染后1,3,7,14,28,45,60,75,90,120d正常对照组、病毒感染组和药物治疗组小鼠脾细胞培养上清中TGF-β1和IL-10水平的时序性变化。结果:MCMV感染后,TGF-β1和IL-10分泌均显著升高,并呈现出急慢性期两次高峰的特点。大蒜新素治疗对MCMV感染鼠各时间点TGF-β1水平均有下调作用,且对其急性期分泌高峰的抑制更明显。大蒜新素治疗对IL-10的急性期分泌高峰影响不明显,却显著下调慢性期IL-10的分泌高峰。结论:大蒜新素能显著抑制MCMV感染后TGF-β1和IL-10分泌,进而增强机体细胞免疫功能而有利于机体清除MCMV病毒,这可能是大蒜新素抗CMV的另一作用机制。

关键词：巨细胞病毒大蒜新素 TGF-β1 IL-10

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搞好县级农机监理工作要把握好几个环节

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山东农机 2005年第6期 22-23页

作者：高兴楼山东省莒县农机局 276500

1宣传、学习和应用法律法规多年来的实践经验告诉我们,要想搞好农机监理工作,首先要抓好法律、法规的宣传和应用工作.

关键词：农机监理工作 1994年环节县级监督管理办法山东省实践经验应用工作法规建设机械安全省政府农业

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