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Probing mechanical principles of cell-nanoparticles interaction

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Probing mechanical principles of cell-nanoparticles interact...

The Mechanics of Target Drug Delivery

第五届全国固体力学青年学者研讨会

作者： xinghua shi LNM Institute of MechanicsChinese Academy of Sciences

Nanoparticles(NP) such as carbon nanotubes,nanowires,nanofibers,quantum dots and graphene have potential applications for next generation microchips,composites,barrier coatings, biosensors,and drug *** the way cells interact with NP is important for assessing the hazards of NP to human health,for creating safer biomedical diagnostics and therapies,and for regulating occupational and enviromental *** this talk,I will discuss some recent studies on the mechanics of cell-NP interactions,including the mechanics of cellular uptake of NP by receptor-mediated endocytosis and coarse-grained molecular dynamics simulations of complete lipid bilayer segments interacting with *** discussions will be organized around the following questions:Why and how does cellular uptake of NP depend on the particle size,shape,aspect ratio and elasticity? In particular,I will discuss the effect of elastic stiffness on cell-particle interactions and how cylindrical one-dimensional(*** nanotubes) and two-dimensional(***) nanomaterials enter cells.

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医用生物力学 2019年第A1期34卷 184-184页

作者： xinghua shi National Center for Nanoscience and Technology

The rapid development of nanotechnology enables the successful application of target drug delivery,which provides new hope for the clinical examination and *** the whole process of drug delivery,we foundcouple of mechanics problems existed,including the transportation of nanocarriers,the molecular level target and the cellular uptake of *** recent years,we focused on the investigation of diffusion of drug delivery systems in mucus of gastrointestinal(GI)tract and tumor *** studied the stiffness effect and geometric effect of nanoparticles in cell internalization,and found that the shape,stiffness and adhesion of nanoparticle-based drug carriers affect their transportation in biological *** revealed the internal mechanism with a theoretical model for the diffusion of nanoparticles in an adhesive/nonadhesive polymer *** findings shed new light on the design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.

关键词： Mechanics Target Drug Delivery Target

Mechanics of rolling of nanoribbon on tube and sphere

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Mechanics of rolling of nanoribbon on tube and sphere

Effect of defects on the electronic structure of a PbI2/MoS2 van der Waals heterostructure: A first-principles study

中国力学大会——2013

作者： shi xinghua Yin Qifang State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

The configuration of graphene nano-ribbon(GNR) assembly on carbon nanotube(CNT) and sphere is studied through theoretical modeling and molecular *** GNR can spontaneously wind onto the CNT due to van der Waals(vdW) interaction and form two basic configurations:Helix and scroll. The final configuration arises from the competition among three energy terms:The bending energy of the GNR,the vdW interaction between GNR and CNT,the vdW between the GNR

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Science China(Physics,Mechanics & Astronomy) 2020年第3期63卷 64-69页

作者： Wen He HuaWei Li HuiQiong Zhou HongKang Zhao Hui Wang xinghua shi School of Physics Beijing Institute of TechnologyBeijing 100081China Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory for Nanosystem and Hierarchy FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

PbI2/MoS2,as a typical van der Waals(vdW)heterostructure,has attracted intensive attention owing to its remarkable electronic and optoelectronic *** this work,the effect of defects on the electronic structures of a PbI2/MoS2 heterointerface has been systematically *** manner in which the defects modulate the band structure of PbI2/MoS2,including the band gap,band edge,band alignment,and defect energy-level density within the band gap is discussed *** is shown that sulfur defects tune the band gaps,iodine defects shift the positions of the band edge and Fermi level,and lead defects realize the conversions between the straddling-gap band alignment and valence-band-aligned gap,thus enhancing the light-absorption ability of the material.

关键词： defect engineering electronic structures PbI2/MoS2 van der Waals heterostructure first-principles study

Aqueous-phase formation of N-containing secondary organic compounds affected by the ionic strength

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Journal of Environmental Sciences 2024年第4期138卷 88-101页

作者： Yuqi Gan Xiaohui Lu Shaodong Chen xinghua Jiang Shanye Yang Xiewen Ma Mei Li Fan Yang Yewen shi Xiaofei Wang Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Guangdong Provincial Observation and Research Station for Coastal Atmosphere and Climate of the Great Bay Area Southern University of Science and TechnologyShenzhen 518055China Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air PollutionJinan UniversityGuangzhouChina Environmental Monitoring Station of Pudong New District Shanghai 201200China Shanghai Municipal Center for Disease Control&Prevention Shanghai 200336China

The reaction of carbonyl-to-imine/hemiaminal conversion in the atmospheric aqueous phase is a critical pathway to produce the light-absorbing N-containing secondary organic compounds(SOC).The formation mechanism of these compounds has been wildly investigated in bulk solutions with a low ionic ***,the ionic strength in the aqueous phase of the polluted atmosphere may be *** is still unclear whether and to what extent the inorganic ions can affect the SOC *** we prepared the bulk solution with certain ionic strength,in which glyoxal and ammonium were mixed to mimic the aqueous-phase *** characterization by High-resolution Mass Spectrometry was performed to identify the N-containing products,and the light absorption of the mixtures was measured by ultraviolet-visible ***-nine N-containing compounds were identified and divided into four categories(N-heterocyclic chromophores,high-molecular-weight compounds with N-heterocycle,aliphatic imines/hemiaminals,and the unclassified).It was observed that the longer reaction time and higher ionic strength led to the formation of more N-heterocyclic chromophores and the increasing of the lightabsorbance of the *** added inorganic ions were proposed to make the aqueous phase somewhat viscous so that the molecules were prone to undergo consecutive and intramolecular reactions to form the *** general,this study revealed that the enhanced ionic strength and prolonged reaction time had the promotion effect on the lightabsorbing SOC *** implies that the aldehyde-derived aqueous-phase SOC would contribute more light-absorbing particulate matter in the industrial or populated area where inorganic ions are abundant.

关键词： Ionic strength Carbonyl-to-imine/hemiaminal Heterocyclic Brown carbon Mass spectrometry Aqueous-phase reaction

基于主动电压抬升的光伏全直流汇集与送出系统网侧故障穿越策略

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电机与控制应用 2024年第4期51卷 20-28页

作者：史兴华张雪垠甘纯马已青闻旭东段金沛赵彪国网浙江省电力有限公司电力科学研究院浙江杭州310014 清华四川能源互联网研究院四川成都610213

光伏(PV)全直流汇集与送出系统中,高压直流(HVDC)侧发生短路故障导致功率消纳能力下降,光伏无法及时感知故障而功率不变,导致系统过压停运。为解决此问题,提出了一种基于主动电压抬升的故障穿越策略,当高压直流变压器高压侧子模块电压... 详细信息

光伏(PV)全直流汇集与送出系统中,高压直流(HVDC)侧发生短路故障导致功率消纳能力下降,光伏无法及时感知故障而功率不变,导致系统过压停运。为解决此问题,提出了一种基于主动电压抬升的故障穿越策略,当高压直流变压器高压侧子模块电压上升到某一水平时,增加中压侧投入的子模块总数以提升中压直流电压,配合具有故障态P-V下垂特性的最大功率点跟踪(MPPT)装置,实现子模块未过压情况下最大功率点跟踪进入限功率模式,实现高压直流变压器端口功率平衡,达到降低子模块过压、完成故障穿越的效果。对所提策略下HVDC变压器子模块过压进行了分析,并仿真验证了策略的有效性和必要性。

关键词：光伏全直流汇集与送出高压直流变压器最大功率点跟踪装置过电压 P-V下垂故障穿越

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接枝高分子对纳米-生物界面黏附性能的调控

科学通报 2022年第31期67卷 3633-3641页

作者：李舒嘉施兴华国家纳米科学中心理论室北京100190 中国科学院大学纳米科学与技术学院北京100049

接枝高分子调控纳米-生物界面的黏附行为在生物医学领域具有广泛应用,相关研究也具有重要的理论意义,从而获得了持续的关注.本文对接枝高分子调控纳米-生物界面的黏附行为所涉及的物理化学机制进行了梳理.通过在纳米药物表面接枝聚合物... 详细信息

接枝高分子调控纳米-生物界面的黏附行为在生物医学领域具有广泛应用,相关研究也具有重要的理论意义,从而获得了持续的关注.本文对接枝高分子调控纳米-生物界面的黏附行为所涉及的物理化学机制进行了梳理.通过在纳米药物表面接枝聚合物,可以抑制生物小分子的随机吸附,从而减少蛋白冠厚度,减轻免疫反应,延长药物的体内循环时间.此外,聚合物接枝还能改变药物载体的表面结构性能,从而提高其在生理组织中的输运效率.本文涉及的机理分为两大类:界面物理和界面化学.前者主要关注微观结构和形态,可以通过接枝密度、接枝长度、链拓扑等进行调节.本文着重介绍了与接枝聚合物的高熵特性密切相关的两种物理机制:熵弹空间位阻和链段动力学.后一类机理通过特殊的化学基团实现,特别是官能团的亲疏水性.通过在接枝链上加入适当的化学基团修饰,可以获得更好的稳定性和更强的生物分子吸附抑制.此外,通过化学基团对温度、光照、pH的依赖性,可以对接枝聚合物涂层的生物黏附性能进行动态调节,实现对外部刺激响应智能化.本文有望为该领域未来的基础理论研究和先进材料开发提供参考.

关键词：接枝高分子纳米-生物界面黏附界面化学界面物理

Alteration of the health effects of bioaerosols by chemical modification in the atmosphere:A review

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Fundamental Research 2024年第3期4卷 463-470页

作者： Ailin Li xinghua Qiu Xing Jiang Xiaodi shi Jinming Liu Zhen Cheng Qianqian Chai Tong Zhu State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

Bioaerosols are a subset of important airborne particulates that present a substantial human health hazard due to their allergenicity and *** reactions in atmospheric processes can significantly influence the health hazard presented by bioaerosols;however,few studies have summarized such alterations to bioaerosols and the mechanisms *** this paper,we systematically review the chemical modifications of bioaerosols and the impact on their health effects,mainly focusing on the exacerbation of allergic diseases such as asthma,rhinitis,and ***,nitration,and oligomerization induced by hydroxyl radicals,ozone,and nitrogen dioxide are the major chemical modifications affecting bioaerosols,all of which can aggravate allergenicity mainly through immunoglobulin E *** processes can even interact with climate change including the greenhouse effect,suggesting the importance of bioaerosols in the future implementation of carbon neutralization *** summary,the chemical modification of bioaerosols and the subsequent impact on health hazards indicate that the combined management of both chemical and biological components is required to mitigate the health hazards of particulate air pollution.

关键词： Bioaerosols Allergenicity Chemical modification Airpollution Climate change

考虑连接件刚度影响的多浮体漂浮光伏方阵运动响应分析

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太阳能学报 2023年第8期44卷 301-306页

作者：施兴华孙哲张婧江苏科技大学船舶与海洋工程学院镇江212100

基于多浮体运动响应计算方法,采用OrcaFlex软件,针对光伏电站漂浮方阵模型多浮体连接件刚度与其运动响应进行数值分析研究。首先,通过与有关浮体连接件试验进行对比,验证数值模拟的合理性;然后,开展对漂浮式光伏方阵在不同刚度连接件下... 详细信息

基于多浮体运动响应计算方法,采用OrcaFlex软件,针对光伏电站漂浮方阵模型多浮体连接件刚度与其运动响应进行数值分析研究。首先,通过与有关浮体连接件试验进行对比,验证数值模拟的合理性;然后,开展对漂浮式光伏方阵在不同刚度连接件下多浮体六自由度运动的数值计算,对横纵浮体六自由度运动进行评估;最后,分析浮体间相对运动对连接件载荷之间的影响。研究结果表明:该研究模型随连接件刚度的增加,横向浮体整体运动响应大于纵向浮体,应更关注横向浮体的连接加强问题。连接件刚度较小时,浮体间的运动约束能力较差;刚度较大时,不利于抵抗浮体间的相互冲击,造成不必要的实际工程成本。

关键词：漂浮式光伏电站漂浮方阵多浮体连接件刚度相对运动