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基于“肠-关节”轴探讨电针对类风湿关节炎模型家兔肠道菌群及血清炎症因子的影响

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中国中医药信息杂志 2024年第4期31卷 124-131页

作者：刘翠杜小正井维尧苏成红刘莉梅袁博张星华张枫帆陈平李向军王海东甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 甘肃省中医院甘肃兰州730050

目的观察电针对类风湿关节炎(RA)模型家兔肠道菌群及血清炎性因子的影响,探讨其治疗RA的作用机制。方法采用卵蛋白诱导联合完全弗氏佐剂建立RA家兔模型,将造模成功家兔随机分为模型组、益生菌组和电针组,每组6只,另取6只家兔作为正常组... 详细信息

目的观察电针对类风湿关节炎(RA)模型家兔肠道菌群及血清炎性因子的影响,探讨其治疗RA的作用机制。方法采用卵蛋白诱导联合完全弗氏佐剂建立RA家兔模型,将造模成功家兔随机分为模型组、益生菌组和电针组,每组6只,另取6只家兔作为正常组。电针组电针双侧“足三里”“犊鼻”,30 min/次,益生菌组予益生菌胶囊溶液(14.5 mg/kg)灌胃,均1次/d,连续2周。测量家兔膝关节周径、痛阈,HE染色观察结肠组织和滑膜组织病理形态,16S rDNA测序分析肠道菌群结构变化,ELISA检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6含量。结果与正常组比较,模型组家兔膝关节周径显著增加、痛阈显著降低(P<0.01);结肠黏膜损伤严重,杯状细胞缺失,大量炎性细胞浸润;关节囊滑膜表面粗糙,滑膜细胞增生、增厚,炎性细胞浸润明显;肠道菌群物种数目及均匀度减少,变形菌门、厚壁菌门、拟杆菌门相对丰度减少(P<0.05,P<0.01),脱硫杆菌门相对丰度增加(P<0.01),弯曲杆菌属、劳森氏菌属及假单胞菌属相对丰度增加(P<0.01),赫山单胞菌属、草螺菌属相对丰度降低(P<0.01);血清TNF-α、IL-1β、IL-6含量显著升高(P<0.01)。与模型组比较,益生菌组和电针组家兔膝关节周径显著减小、痛阈显著升高(P<0.01,P<0.05);肠黏膜损伤程度减轻,杯状细胞排列基本整齐,炎性细胞浸润减轻;滑膜细胞增生、增厚减轻,少量炎性细胞浸润;肠道菌群物种数目及均匀度增加,变形菌门、厚壁菌门、拟杆菌门相对丰度增加(P<0.05,P<0.01),脱硫杆菌门相对丰度减少(P<0.01),弯曲杆菌属、劳森氏菌属及假单胞菌属相对丰度减少(P<0.01),赫山单胞菌属、草螺菌属相对丰度增加(P<0.05,P<0.01);血清TNF-α、IL-1β、IL-6含量显著降低(P<0.01)。结论电针可显著改善RA家兔症状,降低关节滑膜炎症反应,其机制可能与调控肠道菌群结构有关。

关键词：类风湿关节炎电针肠-关节轴肠道菌群炎性反应兔

In situ synthesis of biomass-derived Ni/C catalyst by self-reduction for the hydrogenation of levulinic acid to γ-valerolactone

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Journal of Energy Chemistry 2019年第10期28卷 204-214页

作者： Shuqi Fang Zhibing Cui Yuting Zhu Chenguang Wang Jing Bai xinghua zhang Ying Xu Qiying Liu Lungang Chen Qi zhang Longlong Ma School of Chemical Engineering and Energy Zhengzhou UniversityZhengzhou 450001HenanChina Key Laboratory of Renewable Energy Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640GuangdongChina University of Chinese Academy of Science Beijing 100049China

Herein,we reported in situ synthesis of biomass-derived Ni/C catalyst by self-reduction with pomelo *** with the conventional method, which includes carbonization, activation, impregnation and reduction, the entire preparation process was simplified to two steps, which was more straightforward. This synthesis method was green as Ni/C can be prepared without any additional chemical and the self-reduction process was realized in N2, which can avoid using H2 thus averting some problems such as storage, transportation and safety of H2. Meanwhile, the size and dispersion of Ni particles can be controlled by changing carbonization *** synthesis mechanism of Ni/C catalyst with selfreduction was investigated, which was mainly attributed to the carbon and reducing gas produced during the carbonization *** the catalytic performance of GVL synthesis, a high yield (94.5%) can be obtained and it exhibited good stability up to 5 cycles without obvious loss of catalytic activity.

关键词： Pomelo peel Ni/C Self-reduction Hydrogenation Levulinic acid γ-Valerolactone

“阿尔佤”布朗族、克木人、曼咪人的Heath-Carter法体型研究

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南京师大学报（自然科学版） 2024年第3期47卷 81-86页

作者：肖瑶吕婧祎岩坎翁玉应香宇克莉高新颖姚玥彤程智刘亮高雯芳刘鑫包金萍张兴华天津师范大学生命科学学院天津市动物多样性保护与利用重点实验室天津300387 西双版纳傣族自治州民族博物馆云南景洪666100 景洪市江北街道文化发展服务中心云南景洪666100 天津师范大学体育科学学院天津300387

运用Heath-Carter法对云南省临沧市、西双版纳傣族自治州的“阿尔佤”布朗族、克木人、曼咪人这3个布朗族族群体型特征进行研究.采用随机抽样法测量389例“阿尔佤”布朗族成人(男性183例,女性206例),178例成年克木人(男性67例,女性111例... 详细信息

运用Heath-Carter法对云南省临沧市、西双版纳傣族自治州的“阿尔佤”布朗族、克木人、曼咪人这3个布朗族族群体型特征进行研究.采用随机抽样法测量389例“阿尔佤”布朗族成人(男性183例,女性206例),178例成年克木人(男性67例,女性111例),121例成年曼咪人(男性53例,女性68例)的10项体型指标值,分别计算了3个族群男性和女性的内、中、外因子值.结果显示:“阿尔佤”布朗族(4.1-6.3-1.4)、克木人(4.8-6.3-1.5)、曼咪人(4.0-5.7-1.8)男性均属于偏内胚层的中胚层型,“阿尔佤”布朗族(6.1-5.8-0.9)、克木人(6.4-6.3-0.9)、曼咪人(5.4-5.5-1.2)女性均属于内胚层-中胚层均衡型.3个布朗族族群体型比较中发现,克木人肌肉最发达,脂肪最丰富,曼咪人身材最苗条.与国内12个族群比较发现,这3个布朗族族群与基诺族、羌族、藏族、哈尼族较为接近,这与遗传因素、地理位置、生活方式等相关.

关键词： Heath-Carter法 “阿尔佤”布朗族克木人曼咪人

Observation on Non-conductive Powder Samples by Scanning Electron Microscope

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Observation on Non-conductive Powder Samples by Scanning Ele...

2012 China Functional Materials Technology and Industry Forum

作者： Yuanhui Ma xinghua zhang Xueguang Chen School of Materials Science and Engineering Hebei University of Technology

Different fixation methods have significant influence on observation of samples by scanning electron microscopy when non conductive samples are processed by plasma spudtter coating *** conductive powder samples using different treatments are observed on Philips XL30 scanning electron microscope and Hitachi S-4800 field emission scanning electron *** the small size samples processed by two fixation *** shape were observed more clearly by the ultrasonic dispersion preparation on scanning electron microscope and had less interference of ion sputtering thermal *** effect is not obvious for the large size samples,and the effect of observation for non conducting samples is better on field emission scanning electron microscope at low accelerating voltage.

关键词： scanning electron microscope sample preparation direct dispersion method ultrasonic dispersion method

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生物质转化为高品位烃类燃料研究进展

农业机械学报 2015年第1期46卷 170-179页

作者：张琦马隆龙张兴华中国科学院可再生能源重点实验室广州510640 中国科学院广州能源研究所广州510640

对生物质炼制制备汽柴油与航空煤油等烃类燃料的研究内容与最新成果进行了总结和分析。在生物油改质精制方面,描述了生物油加氢脱氧研究进展,介绍了催化裂化制备烯烃与芳烃产品的基本概念与研究进展。在生物质碳水化合物利用方面,介绍... 详细信息

对生物质炼制制备汽柴油与航空煤油等烃类燃料的研究内容与最新成果进行了总结和分析。在生物油改质精制方面,描述了生物油加氢脱氧研究进展,介绍了催化裂化制备烯烃与芳烃产品的基本概念与研究进展。在生物质碳水化合物利用方面,介绍了生物质纤维素与半纤维素经水解单糖催化转化制备C5/C6烷烃、C8-C15长链烷烃的工艺路线与技术原理,列举了具有代表性的催化剂体系。在木质素利用方面,介绍了木质素催化解聚制备单环酚类化合物及解聚产物加氢脱氧制备烃类燃料的研究进展,同时指出在催化转化过程中需要解决的关键问题。

关键词：生物质纤维素木质素烃类燃料

FLAME ATOMIC ABSORPTION DETERMINATION OF COPPER IN CEREALS FOOD SAMPLES WITH THE PRECONCENTRATION OF POTASSIUM TETRATITANATE WHISKER

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Chinese Journal of Reactive Polymers 2007年第1期16卷 22-30页

作者： XU Wanzhen zhang xinghua YAN Yongsheng LIU Aiqin JING Junjie Department of Chemistry and Chemical Engineering Jiangsu University Zhenjiang 212013 China

A simple and reliable method has been developed for separation and preconcentration of trace amounts of copper ions in cereals food for subsequent measurement by flame atomic absorption spectrometry （FAAS）. The Cu^2＋ ions are adsorbed selectively and quantitatively during the passage. The retained copper ions were desorbed from the potassium tetratitanate whisker with 10.0mL of 2mol/L sulphuric acid solutions as eluent and were determined by FAAS. The linear range was 0.05μg/mL-0.20μg/mL in the original solution with a correlation coefficient of 0.9998. The detection limit of the proposed method is 2. lng/mL in the original solution （3σ, n=9）. Determination of copper in standard ions showed that the proposed method has good accuracy （recovery was more than 95%）. The method was successfully applied for recovery and determination of copper in cereals food samples

关键词： Flame atomic absorption spectrometry Copper Cereals food Potassium tetratitanate whisker.

Robust centralized fusion Kalman predictor for networked multisensor systems with packet dropouts and uncertain-variance linearly correlated white noises

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Robust centralized fusion Kalman predictor for networked mul...

电流控制电压源逆变器驱动的感应电机逆解耦控制

第三十九届中国控制会议

作者： Guili Tao xinghua zhang Wenqiang Liu College of Media Engineering Communication University of Zhejiang Computer and Information Engineering College Heilongjiang University of Science and Technology School of Information and Electronic Engineering Zhejiang Gongshang University

In this paper, the robust centralized fusion Kalman filtering problem is studied for a class of networked multisensor systems with packet dropouts, uncertain noise variances and linearly correlated noises. The measurement noises and process noises are linearly correlated. By augmentation of the state and measurement, the original system is converted into a stochastic parameter system with uncertain noise variances. Further, using the fictitious noises approach, the original system is converted into one with constant parameter and uncertain noise variances. According to the minimax robust estimation principle, based on the worst-case centralized fusion system with the conservative upper bounds of the noise variances, the robust centralized fusion time-varying Kalman predictor is presented. By use of the Lyapunov equation approach, and introducing a matrix, the robustness of the proposed fused predictor is proved in the sense that its actual prediction error variance is guaranteed to have the corresponding minimal upper bound for all admissible uncertainties. The accuracy relations among the robust local and fused time-varying Kalman predictors are proved. Simulation results show the effectiveness and correctness of the proposed results.

关键词： centralized fusion robust Kalman predictor packet dropouts uncertain noise variances Lyapunov equation approach

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电力自动化设备 2008年第7期28卷 25-28页

作者：张兴华沈捷南京工业大学自动化学院江苏南京210009

在转子磁链坐标系下,以电流控制电压源逆变器供电驱动电机运行。通过在电流内环采用高增益控制器,感应电机模型中的2个定子电流分量可近似为定子参考电流,从而可忽略定子电流动态特性的影响,将以定子电压为控制量的感应电机四阶模型降... 详细信息

在转子磁链坐标系下,以电流控制电压源逆变器供电驱动电机运行。通过在电流内环采用高增益控制器,感应电机模型中的2个定子电流分量可近似为定子参考电流,从而可忽略定子电流动态特性的影响,将以定子电压为控制量的感应电机四阶模型降阶成以定子电流为控制量的二阶模型。采用状态反馈线性化方法求得感应电机的逆系统,将多变量、非线性、强耦合的感应电机动态解耦成转速与转子磁链2个一阶子系统。在此基础上,设计一种积分比例(IP)控制器对解耦子系统进行闭环控制。电流内环采用滞环比较器,直接获得PWM信号,控制逆变器实现电流跟踪,从而使调速系统具有快速的动态响应性能。仿真结果验证所提控制方案的有效性和优越性。

关键词：感应电机逆系统电流控制电压源逆变器解耦控制

感应电机直接转矩控制系统的转矩脉动极小化方法

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电力自动化设备 2015年第10期35卷 140-144,150页

作者：张兴华石万南京工业大学自动化与电气工程学院江苏南京211816

针对感应电机直接转矩控制系统在稳态运行时转矩脉动大的问题,提出了一种转矩脉动抑制方法。基于离散化的感应电机模型,分析了直接转矩控制系统的转矩脉动机理。以转矩误差均方根极小为目标,将采样周期分为非零电压矢量作用时间段和零... 详细信息

针对感应电机直接转矩控制系统在稳态运行时转矩脉动大的问题,提出了一种转矩脉动抑制方法。基于离散化的感应电机模型,分析了直接转矩控制系统的转矩脉动机理。以转矩误差均方根极小为目标,将采样周期分为非零电压矢量作用时间段和零电压矢量作用时间段,推导了最优电压矢量切换时间的计算公式。仿真和实验结果表明所提方法可有效减小直接转矩控制系统的转矩脉动。

关键词：感应电机直接转矩控制转矩脉动分析转矩脉动抑制