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Wearable patches for transdermal drug delivery

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药学学报:英文版 2023年第6期13卷 2298-2309页

作者： Jiahui He yuyue Zhang xinge yu Chenjie Xu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong 999077China

Transdermal drug delivery systems(TDDs) avoid gastrointestinal degradation and hepatic first-pass metabolism, providing good drug bioavailability and patient compliance. One emerging type of TDDs is the wearable patch worn on the skin surface to deliver medication through the skin. They can generally be grouped into passive and active types, depending on the properties of materials,design principles and integrated devices. This review describes the latest advancement in the development of wearable patches, focusing on the integration of stimulus-responsive materials and electronics.This development is deemed to provide a dosage, temporal, and spatial control of therapeutics delivery.

关键词： Wearable patch Transdermal delivery Microneedles Drug delivery Biomaterials

Origami-inspired folding assembly of dielectric elastomers for programmable soft robots

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Microsystems & Nanoengineering 2022年第2期8卷 73-83页

作者： Yanhua Sun Dengfeng Li Mengge Wu Yale Yang Jingyou Su Tszhung Wong Kangming Xu Ying Li Lu Li xinge yu Junsheng yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054People's Republic of China Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqing 402160People's Republic of China Department of Biomedical Engineering City University of Hong KongHong Kong SAR 999077People's Republic of China

Origami has become an optimal methodological choice for creating complex three-dimensional(3D)structures and soft robots.The simple and low-cost origami-inspired folding assembly provides a new method for developing 3D soft robots,which is ideal for future intelligent robotic systems.Here,we present a series of materials,structural designs,and fabrication methods for developing independent,electrically controlled origami 3D soft robots for walking and soft manipulators.The 3D soft robots are based on soft actuators,which are multilayer structures with a dielectric elastomer(DE)film as the deformation layer and a laser-cut PET film as the supporting flexible frame.The triangular and rectangular design of the soft actuators allows them to be easily assembled into crawling soft robots and pyramidal-and square-shaped 3D structures.The crawling robot exhibits very stable crawling behaviors and can carry loads while walking.Inspired by origami folding,the pyramidal and square-shaped 3D soft robots exhibit programmable out-of-plane deformations and easy switching between two-dimensional(2D)and 3D structures.The electrically controllable origami deformation allows the 3D soft robots to be used as soft manipulators for grasping and precisely locking 3D objects.This work proves that origami-inspired fold-based assembly of DE actuators is a good reference for the development of soft actuators and future intelligent multifunctional soft robots.

关键词： robot folding dielectric

Micro/nano biomedical devices for point-of-care diagnosis of infectious respiratory diseases

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Medicine in Novel Technology and Devices 2022年第2期14卷 1-14页

作者： Yang Wang Huiren Xu Zaizai Dong Zhiying Wang Zhugen Yang xinge yu Lingqian Chang Key Laboratory for Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Biomedical Information and Engineering Hainan Medical UniversityHaikou471100China School of Water Energy and EnvironmentCranfield UniversityCranfieldMK430ALUnited Kingdom Department of Biomedical Engineering City University of Hong KongHong KongChina

Corona Virus Disease 2019(COVID-19)has developed into a global pandemic in the last two years,causing significant impacts on our daily life in many countries.Rapid and accurate detection of COVID-19 is of great importance to both treatments and pandemic management.Till now,a variety of point-of-care testing(POCT)approaches devices,including nucleic acid-based test and immunological detection,have been developed and some of them has been rapidly ruled out for clinical diagnosis of COVID-19 due to the requirement of mass testing.In this review,we provide a summary and commentary on the methods and biomedical devices innovated or renovated for the quick and early diagnosis of COVID-19.In particular,some of micro and nano devices with miniaturized structures,showing outstanding analytical performances such as ultra-sensitivity,rapidness,accuracy and low cost,are discussed in this paper.We also provide our insights on the further implementation of biomedical devices using advanced micro and nano technologies to meet the demand of point-of-care diagnosis and home testing to facilitate pandemic management.In general,our paper provides a comprehensive overview of the latest advances on the POCT device for diagnosis of COVID-19,which may provide insightful knowledge for researcher to further develop novel diagnostic technologies for rapid and on-site detection of pathogens including SARS-CoV-2.

关键词： COVID-19 Point-of-care testing Micro/nano devices

Recent advances in microsystem approaches for mechanical characterization of soft biological tissues

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Microsystems & Nanoengineering 2022年第4期8卷 1-16页

作者： Enming Song Ya Huang Ningge Huang Yongfeng Mei xinge yu John A.Rogers Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan UniversityShanghai 200433China International Institute of Intelligent Nanorobots and Nanosystems Fudan UniversityShanghai 200433China Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science Fudan UniversityShanghai 200433China Querrey Simpson Institute for Bioelectronics Department of Materials Science and EngineeringDepartments of Biomedical EngineeringNeurological SurgeryChemistryMechanical EngineeringElectrical Engineering and Computer ScienceNorthwestern UniversityEvanstonIL 60208USA

Microsystem technologies for evaluating the mechanical properties of soft biological tissues offer various capabilities relevant to medical research and clinical diagnosis of pathophysiologic conditions.Recent progress includes(1)the development of tissue-compliant designs that provide minimally invasive interfaces to soft,dynamic biological surfaces and(2)improvements in options for assessments of elastic moduli at spatial scales from cellular resolution to macroscopic areas and across depths from superficial levels to deep geometries.This review summarizes a collection of these technologies,with an emphasis on operational principles,fabrication methods,device designs,integration schemes,and measurement features.The core content begins with a discussion of platforms ranging from penetrating filamentary probes and shape-conformal sheets to stretchable arrays of ultrasonic transducers.Subsequent sections examine different techniques based on planar microelectromechanical system(MEMS)approaches for biocompatible interfaces to targets that span scales from individual cells to organs.One highlighted example includes miniature electromechanical devices that allow depth profiling of soft tissue biomechanics across a wide range of thicknesses.The clinical utility of these technologies is in monitoring changes in tissue properties and in targeting/identifying diseased tissues with distinct variations in modulus.The results suggest future opportunities in engineered systems for biomechanical sensing,spanning a broad scope of applications with relevance to many aspects of health care and biology research.

关键词： advances identifying utility

Stretchable,skin-conformable neuromorphic system for tactile sensory recognizing and encoding

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InfoMat 2023年第12期5卷 87-99页

作者： Mengge Wu Qiuna Zhuang Kuanming Yao Jian Li Guangyao Zhao Jingkun Zhou Dengfeng Li Rui Shi Guoqiang Xu Yingchun Li Zijian Zheng Zhihui Yang Junsheng yu xinge yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengduthe People's Republic of China Department of Biomedical Engineering City University of Hong KongHong Kongthe People's Republic of China Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kongthe People's Republic of China Hong Kong Center for Cerebra-Cardiovascular Health Engineering Hong Kong Science ParkHong Kongthe People's Republic of China College of Science Harbin Institute of TechnologyShenzhenthe People's Republic of China Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhouthe People's Republic of China

Expanding wearable technologies to artificial tactile perception will be of significance for intelligent human-machine interface,as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating properties.Skin-compatible and conformable features are required for the purpose of realizing wearable artificial tactile perception.Here,we report an intrinsically stretchable,skin-integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information processing.The integrated system provides desired sensing,synaptic,and mechanical characteristics,such as sensitive response(~0.04 kPa^(-1))to low-pressure,short-and long-term synaptic plasticity,great switching endurance(>10000 pulses),symmetric weight update,together with high stretchability of 100%strain.With neural encoding,demonstrations are capable of recognizing,extracting,and encoding features of tactile information.This work provides a feasible approach to wearable,skin-conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics.

关键词： neural encoding neuromorphic sensing system organic electrochemical transistors tactile sensation triboelectric nanogenerators

Muscle-inspired soft robots based on bilateral dielectric elastomer actuators

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Microsystems & Nanoengineering 2023年第5期9卷 245-254页

作者： Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li xinge yu Lu Li Junsheng yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)ChengduPR China Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqingPR China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering(COCHE) Hong KongSARChina Department of Biomedical Engineering City University of Hong KongHong KongSARChina

Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot design.Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots.Here,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots.To construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator frame.By end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation combinations.Lying on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was realized.Moreover,the directional steering was instantaneous and efficient.With two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°slope.Finally,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated.The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots.

关键词： robot artificial dielectric

Epidermal self-powered sweat sensors for glucose and lactate monitoring

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Bio-Design and Manufacturing 2022年第1期5卷 201-209页

作者： Xingcan Huang Jiyu Li Yiming Liu Tszhung Wong Jingyou Su Kuanming Yao Jingkun Zhou Ya Huang Hu Li Dengfeng Li Mengge Wu Enming Song Shijiao Han xinge yu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

Sweat could be a carrier of informative biomarkers for health status identification;therefore,wearable sweat sensors have attracted significant attention for research.An external power source is an important component of wearable sensors,however,the current power supplies,i.e.,batteries,limit further shrinking down the size of these devices and thus limit their application areas and scenarios.Herein,we report a stretchable self-powered biosensor with epidermal electronic format that enables the in situ detec-tion of lactate and glucose concentration in sweat.Enzymatic biofuel cells serve as self-powered sensing modules allowing the sweat sensor to exhibit a determination coefficient(R2)of 0.98 with a sensitivity of 2.48 mV/mM for lactate detection,and R2 of 0.96 with a sensitivity of 0.11 mV/μM for glucose detection.The microfluidic channels developed in an ultra-thin soft flexible polydimethylsiloxane layer not only enable the effective collection of sweat,but also provide excellent mechanical properties with stable performance output even under 30%stretching.The presented soft sweat sensors can be integrated at nearly any location of the body for the continuous monitoring of lactate and glucose changes during normal daily activities such as exercise.Our results provide a promising approach to develop next-generation sweat sensors for real-time and in situ sweat analysis.

关键词： Sweat sensor Self-powered Epidermal electronics Enzymatic biofuel cells Microfluidics

土壤湿度-地表气温耦合对长江中下游地区2022年8月复合型热浪事件的影响

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地球物理学报 2024年第5期67卷 1709-1720页

作者：崔彩珍余锦华代刊云星娥南京信息工程大学气象灾害教育部重点实验室/气象灾害预报预警与评估协同创新中心南京210044 国家气象中心北京100081

2022年8月长江中下游地区的复合型热浪给社会经济、人类健康、农业生产和自然环境等方面均造成了严重影响.本文利用国家信息中心提供的1979—2022年6—8月逐日最高、最低气温和欧洲中期天气预报中心再分析数据集的土壤湿度等资料,定义... 详细信息

2022年8月长江中下游地区的复合型热浪给社会经济、人类健康、农业生产和自然环境等方面均造成了严重影响.本文利用国家信息中心提供的1979—2022年6—8月逐日最高、最低气温和欧洲中期天气预报中心再分析数据集的土壤湿度等资料,定义了复合型热浪事件强度指数及其相应的土壤湿度-地表气温耦合指数,采用分段线性拟合等方法,探讨此次复合型热浪特征及土壤湿度-地表气温耦合的影响.结果表明:(1)2022年8月长江中下游地区的复合型热浪事件强度为1979年以来最强,伴随最强的土壤湿度-地表气温耦合.空间分布显示,强的热浪发生在四川东部、重庆西部、湖南等地,这些区域的土壤湿度严重偏干,蒸发受限,获得的净辐射主要用于地表向上的感热通量,使土壤湿度-地表气温出现强的正反馈过程,对热浪的维持起重要作用.(2)复合型热浪中土壤湿度-地表气温耦合影响日间和夜间热浪的物理强迫及过程不同:日间,地表净太阳短波向下辐射增强的强迫作用,促使发生强的土壤湿度-地表气温耦合,引起日间热浪.夜间,白天积累在土壤的热量,通过减小大气热量通量辐散,使夜间地表气温下降减慢,形成夜间热浪,这与以往研究单独夜间热浪的过程不同,后者认为夜间热浪主要与大气柱水汽增加引起的大气逆辐射增强有关.

关键词：复合型热浪事件土壤湿度-地表气温耦合长江中下游地区

Thin,soft,3D printing enabled crosstalk minimized triboelectric nanogenerator arrays for tactile sensing

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Fundamental Research 2023年第1期3卷 111-117页

作者： Jian Li Yiming Liu Mengge Wu Kuanming Yao Zhan Gao yuyu Gao Xingcan Huang Tsz Hung Wong Jingkun Zhou Dengfeng Li Hu Li Jiyu Li Ya Huang Rui Shi Junsheng yu xinge yu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Hong Kong Center forCerebra-Cardiovascular Health Engineering Hong Kong Science ParkNew TerritoriesHong KongChina State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054China Shenzhen Research Institute City University of Hong Kong Shenzhen 518057China

With the requirements of self-powering sensors in flexible electronics,wearable triboelectric nanogenerators(TENGs)have attracted great attention due to their advantages of excellent electrical outputs and low-cost processing routes.The crosstalk effect between adjacent sensing units in TENGs significantly limits the pixel density of sensor arrays.Here,we present a skin-integrated,flexible TENG sensor array with 100 sensing units in an overall size of 7.5 cm×7.5 cm that can be processed in a simple,low-cost,and scalable way enabled by 3D printing.All the sensing units show good sensitivity of 0.11 V/kPa with a wide range of pressure detection from 10 to 65 kPa,which allows to accurately distinguish various tactile formats from gentle touching(as low as 2 kPa)to hard pressuring.The 3D printing patterned substrate allows to cast triboelectric layers of polydimethylsiloxane in an independent sensing manner for each unit,which greatly suppresses the cross talk arising from adjacent sensing units,where the maximum crosstalk output is only 10.8%.The excellent uniformity and reproducibility of the sensor array offer precise pressure mapping for complicated pattern loadings,which demonstrates its potential in tactile sensing and human-machine interfaces.

关键词： Tactile sensor Triboelectricnanogenerators Self-powering sensors Crosstalk suppression Human-machine interfaces