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Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

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Nano-Micro Letters 2021年第12期13卷 1-13页

作者： Won Young Kim Miae Won Seyoung Koo xingcai zhang Jong Seung Kim Department of Chemistry Korea UniversitySeoul 02841Korea John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory *** current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and ***-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is *** TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory ***,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse *** vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise *** behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.

关键词： Theranostics Anti-inflammation Mitochondria Hydrogen polysulfides

Sorting Gold and Sand(Silica) Using Atomic Force Microscope-Based Dielectrophoresis

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Nano-Micro Letters 2022年第2期14卷 1-11页

作者： Chungman Kim Sunghoon Hong Dongha Shin Sangmin An xingcai zhang Wonho Jhe Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138United States Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212Republic of Korea Department of Physics Institute of Photonics and Information TechnologyJeonbuk National UniversityJeonju 54896Korea School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States

Additive manufacturing-also known as 3D printing-has attracted much attention in recent years as a powerful method for the simple and versatile fabrication of complicated three-dimensional ***,the current technology still exhibits a limitation in realizing the selective deposition and sorting of various materials contained in the same reservoir,which can contribute significantly to additive printing or manufacturing by enabling simultaneous sorting and deposition of different substances through a single ***,we propose a dielectrophoresis(DEP)-based material-selective deposition and sorting technique using a pipette-based quartz tuning fork(QTF)-atomic force microscope(AFM) platform DEPQA and demonstrate multi-material sorting through a single nozzle in ambient *** used Au and silica nanoparticles for sorting and obtained 95% accuracy for spatial separation,which confirmed the surfaceenhanced Raman spectroscopy(SERS).To validate the scheme,we also performed a simulation for the system and found qualitative agreement with the experimental *** method that combines DEP,pipette-based AFM,and SERS may widely expand the unique capabilities of 3D printing and nano-micro patterning for multi-material patterning,materials sorting,and diverse advanced applications.

关键词： Dielectrophoresis-empowered Pipette/AFM platform On-demand materials sorting Additive 3D printing Multimaterial nano-patterning Nanopipette-based atomic force microscope

Lipid nanomaterials-based RNA therapy and cancer treatment

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Acta Pharmaceutica Sinica B 2023年第3期13卷 903-915页

作者： xingcai zhang Luo Hai Yibo Gao Guocan Yu Yingli Sun School of Engineering and Applied Sciences Harvard UniversityCambridge 02138MAUSA Central Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Laboratory of Translational Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China University of Chinese Academy of Sciences Beijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences/China National Center for BioinformationBeijing 100101China

We summarize the most important advances in RNA delivery and *** describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel *** fundamental properties of the key RNA members are *** introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of *** review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology.

关键词： Antisense oligonucleotides siRNA miRNA mRNA Cancer treatment Nanomedicine RNA therapy Lipid nanoparticles

Microsnoop: A generalist tool for microscopy image representation

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The Innovation 2024年第1期5卷 109-117页

作者： Dejin Xun Rui Wang xingcai zhang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Lab of Computer-Aided Design&Computer Graphics Zhejiang UniversityHangzhou 310058China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University Hangzhou 310018China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Accurate profiling of microscopy images from small scale to high throughput is an essential procedure in basic and applied biological ***,we present Microsnoop,a novel deep learning–based representation tool trained on large-scale microscopy images using masked self-supervised *** can process various complex and heterogeneous images,and we classified images into three categories:single-cell,full-field,and batch-experiment *** benchmark study on 10 high-quality evaluation datasets,containing over 2,230,000 images,demonstrated Microsnoop’s robust and state-ofthe-art microscopy image representation ability,surpassing existing generalist and even several custom *** can be integrated with other pipelines to perform tasks such as superresolution histopathology image and multimodal ***,Microsnoop can be adapted to various hardware and can be easily deployed on local or cloud computing *** will regularly retrain and reevaluate the model using communitycontributed data to consistently improve Microsnoop.

关键词： hardware image representation

Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance

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Bioactive Materials 2023年第1期19卷 1-11页

作者： Haibao Peng xingcai zhang Peng Yang Jiaxu Zhao Wei zhang Nianping Feng Wuli Yang Jing Tang Institute for Translational Brain Research Fudan UniversityShanghai200032China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Pharmaceutical Sciences Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Materials Science and Engineering Stanford UniversityStanfordCA94305United States School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States Engineering Research Center of Molecular-and Neuro-imaging of Ministry of Education School of Life Science and TechnologyXidian University710126China

The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of ***,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug ***,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant ***,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant *** and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis *** RBC membrane could camouflage the nanoplatform for longer *** results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer *** work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by *** defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential.

关键词： Metal-organic framework Defect nanostructures Ferroptosis Membrane-camouflaged Multi-drug-delivery

Tea-derived carbon materials as anode for high-performance sodium ion batteries

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Chinese Chemical Letters 2023年第4期34卷 519-525页

作者： Huayan Wang Huixin Chen Chi Chen Miao Li Yiming Xie xingcai zhang Xianwen Wu Qiaobao zhang Canzhong Lu Engineering Research Center of Environment-Friendly Function Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021China CAS key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138United States School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States Xiamen Key Laboratory of Rare Ear School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China

Sodium-ion batteries(SIB) have attracted widespread attention in large-scale energy storage fields owing to the abundant reserve in the earth and similar properties of sodium to lithium. Biomass-based carbon materials with low-cost, controllable structure, simple processing technology, and environmental friendliness tick almost all the right boxes as one of the promising anode materials for SIB. Herein, we present a simple novel strategy involving tea tomenta biomass-derived carbon anode with enhanced interlayer carbon distance(0.44 nm) and high performance, which is constructed by N,P co-doped hard carbon(Tea-1100-NP) derived from tea tomenta. The prepared Tea-1100-NP composite could deliver a high reversible capacity(326.1 m Ah/g at 28 m A/g), high initial coulombic efficiency(ICE = 90% at 28 m A/g),stable cycle life(262.4 m Ah/g at 280 m A/g for 100 cycles), and superior rate performance(224.5 m Ah/g at 1400 m A/g). Experimental results show that the excellent electrochemical performance of Tea-1100-NP due to the high number of active N,P-containing groups, and disordered amorphous structures provide ample active sites and increase the conductivity, meanwhile, large amounts of microporous shorten the Na+diffusion distance as well as quicken ion transport. This work provides a new type of N,P co-doped high-performance tomenta-derived carbon, which may also greatly promote the commercial application of SIB.

关键词： Tea tomenta Co-doped Hard carbon Initial coulombic efficiency Sodium-ion batteries

Split-Ring Structured All-Inorganic Perovskite Photodetector Arrays for Masterly Internet of Things

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Nano-Micro Letters 2023年第1期15卷 25-42页

作者： Bori Shi Pingyang Wang Jingyun Feng Chang Xue Gaojie Yang Qingwei Liao Mengying zhang xingcai zhang Weijia Wen Jinbo Wu Materials Genome Institute Shanghai UniversityShanghai 200444People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhenPeople’s Republic of China School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Physics Shanghai UniversityShanghai 200444People’s Republic of China The Advanced Material Thrust The Hong Kong University of Science and Technology(Guangzhou)GuangzhouPeople’s Republic of China

Photodetectors with long detection distances and fast response are important media in constructing a non-contact human-machine interface for the Masterly Internet of Things(MIT).All-inorganic perovskites have excellent optoelectronic performance with high moisture and oxygen resistance,making them one of the promising candidates for high-performance photodetectors,but a simple,low-cost and reliable fabrication technology is urgently ***,a dual-function laser etching method is developed to complete both the lyophilic split-ring structure and electrode *** novel split-ring structure can capture the perovskite precursor droplet efficiently and achieve the uniform and compact deposition of CsPbBr3 ***,our devices based on laterally conducting split-ring structured photodetectors possess outstanding performance,including the maximum responsivity of 1.44×105 mA W^(−1),a response time of 150μs in 1.5 kHz and one-unit area<4×10-2 *** on these split-ring photodetector arrays,we realized three-dimensional gesture detection with up to 100 mm distance detection and up to 600 mm s^(−1) speed detection,for low-cost,integrative,and non-contact human-machine ***,we applied this MIT to wearable and flexible digital gesture recognition watch panel,safe and comfortable central controller integrated on the car screen,and remote control of the robot,demonstrating the broad potential applications.

关键词： Split-ring Dewetting Perovskite photodetector array Human-machine interface Gesture recognition

Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei zhang Xingchen Geng Zhanrong Li xingcai zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

Scalable fabrication and active site identification of MOF shell-derived nitrogen-doped carbon hollow frameworks for oxygen reduction

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Journal of Materials Science & Technology 2021年第7期66卷 186-192页

作者： Jiashen Meng Ziang Liu Xiong Liu Wei Yang Lianzhou Wang Yan Li Yuan-Cheng Cao xingcai zhang Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandSt LuciaQLD4072Australia Shenzhen Power Supply Col.Ltd. Shenzhen CityChina State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan430074China John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States

Nitrogen-doped carbon materials as promising oxygen reduction reaction(ORR) electrocatalysts attract great interest in fuel cells and metal-air batteries because of their relatively high activity, high surface area, high conductivity and low cost. To maximize their catalytic efficiency, rational design of efficient electrocatalysts with rich exposed active sites is highly desired. Besides, due to the complexity of nitrogen species, the identification of active nitrogen sites for ORR remains challenging. Herein, we develop a facile and scalable template method to construct high-concentration nitrogen-doped carbon hollow frameworks(NC), and reveal the effect of different nitrogen species on theirORRactivity on basis of experimental analysis and theoretical calculations. The formation mechanism is clearly revealed, including low-pressure vapor superassembly of thin zeolitic imidazolate framework(ZIF-8) shell on ZnO templates,in situ carbonization and template removal. The obtained NC-800 displays better ORR activity compared with other NC-700 and NC-900 samples. Our results indicate that the superior ORR activity of NC-800 is mainly attributed to its content balance of three nitrogen species. The graphitic N and pyrrolic N sites are responsible for lowering the working function, while the pyridinic N and pyrrolic N sites as possible active sites are beneficial for increasing the density of states.

关键词： MOF shell Nitrogen-doped carbon Hollow framework Oxygen reduction Active nitrogen sites