检索结果-南通市图书馆

Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2023年第1期11卷 1-14页

作者： Shiwei Wang Lingling He fan Xiao Meixin Gao Herui Wei Junru Yang Yang Shu Fuyang Zhang Xiaohui Ye Ping Li Xiaohua Hao xingang Zhou Hongshan Wei Department of Gastroenterology Beijing Ditan HospitalCapital Medical UniversityBeijingChina Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Gastroenterology Beijing Huaxin Hospitalthe First Affiliated Hospital of Tsinghua UniversityBeijingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Gastroenterology Peking University Ditan Teaching HospitalBeijingChina

Background and Aims:Collagenβ(1-O)galactosyltransferase 25 domain 1(GLT25D1)is associated with collagen production and glycosylation,and its knockout in mice results in embryonic ***,its role in liver fibrosis remains elusive,particularly in hepatic stellate cells(HSCs),the primary collagen-producing cells associated with liver ***,we aimed to elucidate the role of GLT25D1 in ***:Bile duct ligation(BDL)-induced mouse liver fibrosis models,primary mouse HSCs(mHSCs),and transforming growth factor beta 1(TGF-β1)-stimulated LX-2 human hepatic stellate cells were used in in vivo and in vitro *** LX-2 cell lines with either GLT25D1 overexpression or knockdown were established using lentiviral ***-seq was performed to investigate the genomic ***/MS were used to identify glycosylation *** electronic microscopy(SEM)and second-harmonic generation/two-photon excited fluorescence(SHG/TPEF)were used to image collagen fibril ***:GLT25D1 expression was upregulated in nonparenchymal cells in human cirrhotic liver ***,its knockdown attenuated collagen deposition in BDL-induced mouse liver fibrosis and inhibited mHSC ***25D1 was overexpressed in activated versus quiescence LX-2 cells and regulated in vitro LX-2 cell activation,including proliferation,contraction,and ***25D1 also significantly increased liver fibrogenic gene and protein ***25D1 upregulation promoted HSC activation and enhanced collagen expression through the TGF-β1/SMAD signaling *** spectrometry showed that GLT25D1 regulated the glycosylation of collagen in HSCs,affecting the diameter of collagen ***:Collectively,the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability.

关键词： Collagen Glycosylation Hepatic stellate cells Liver fibrosis TGF-β1

Study on System of Faults in the Gulf of Mexico and Adjacent Region based on Gravity Data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2021年第1期95卷 305-318页

作者： MA Jie WANG Wanyin DU Xiangdong LUO xingang CAI Wenjie YANG Min WANG Dingding Institute of Gravity and Magnetic Technology School of Geological Engineering and GeomaticsKey Laboratory of Western China's Mineral Resources and Geological EngineeringMinistry of EducationChang'an UniversityXi'an 710054China CNOOC Research Institute Co. Ltd.Beijing 100028China Department of Earth Sciences Memorial University of NewfoundlandSt.John'sNL A1B3X5Canada

In the Gulf of Mexico and adjacent landmasses,faults are very complex,and their distribution is closely related to plate tectonics,ocean-land boundary,and former *** plane position of the faults can be identified by the maximum characteristic of the vertical derivative of the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)of the Bouguer gravity *** apparent depth of the faults is inverted by the Bouguer gravity anomaly curvature *** on tectonic evolutionary processes and the plane distribution and apparent depth characteristics of the faults,a complete fault system for the Gulf of Mexico and adjacent areas has been established,including 102 *** apparent depths of 33 first-class faults are 16-20 km and for 69 second-class faults are 12-16 *** F_(1-2)and F_(1-3)subduction fault zones are two caused by the subduction of the Cocos Plate into the old Yucatan and Chorti landmasses;F_(1-11)and F_(1-12)fault zones extend westward to the coast of Guatemala and do not extend into the continent;F_(1-17)and F_(1-20)faults,which control the boundary of the oceanic crust,do not extend southward into the *** fault system,which radiates in a"fan-shaped"structure as a whole,unfolds to the *** of different nature and sizes are distributed in the Cocos Plate subduction zone,Continental,Gulf of Mexico,Yucatan old landmass and Caribbean Plate in NW,NNW,NS,NE and NEE *** the Gulf of Mexico region,the fault system is a comprehensive reflection of former tectonic movements,such as plate movement,drift of old landmasses and expansion of oceanic *** first-class faults control the plate and ocean-continental *** second-class faults are subordinate to the first-class faults or related to the distribution of different sedimentary layers.

关键词： structural geology tectonism gravity anomaly fault distribution and apparent depth Gulf of Mexico region

Surgical treatment of congenital basilar invagination with different pathological characteristics: Report of 139 cases

在线全文

学校读者我要写书评

暂无评论

Translational Neuroscience and Clinics 2017年第4期3卷 204-212页

作者： Yinqian Wang Tao fan xingang Zhao Cong Liang Qifei Ga Haijun Zhao Department of Neurosurgery Sanbo Brain HospitalCapital Medical University

Objective: To describe the different pathological characteristics of congenital basilar invaginations and discuss the surgical treatment of such cases. Methods: A total of 139 patients diagnosed with basilar invaginations underwent surgical treatment from 2008 to 2015. Based on Atul Goel's classification and simultaneous consideration of atlantoaxial dislocation or syringomyelia,the cases were subdivided into four groups. Individualized posterior surgical decompression and/or atlantoaxial reset procedures were performed to correct atlantoaxial dislocation,decompress the brain stem,or resolve syringomyelia. The indications and critical points of each procedure were documented. Results: All 139 patients were surgically treated; 27 patients(19.4%) had underwent at least one decompression surgery previously. On an average,there was gratifying clinical improvement based on the Japanese Orthopaedic Association score *** patient exhibited severe post-operative infection,and the fusion instrument was removed. One patient experienced fracture of internal fixation. Two patients exhibited persistent respiratory symptoms at early stages after the surgery. Four patients felt worse at the latest follow-up. There was no surgical mortality. The poor outcome/morbidity in this series was 5.8%(8/139). Conclusion: The different pathological image characteristics of congenital basilar invaginations based on the presence or absence of syringomyelia and/or atlantoaxial dislocation,reflected the pathological features of complicated basilar invaginations more accurately. Based on these features,different posterior decompression and/or reset procedures,combined with occipitocervical fusion and C1-2 fusion,could be tailored to different patients. These individualized surgeries could reduce surgical complications,decrease morbidity and mortality,and further promote positive outcomes.

关键词： basilar invagination syringomyelia atlantoaxial dislocation chiari malformation surgical treatment

在线全文

学校读者我要写书评

暂无评论

机器人辅助腹腔镜治疗膀胱阴道瘘专家共识

微创泌尿外科杂志 2024年第2期13卷 100-103页

作者：傅斌张大宏薛蔚王坤杰李兵吴大鹏韩邦旻黄海罗光恒崔心刚范阳陈路遥南昌大学第一附属医院泌尿外科南昌330006 浙江省人民医院泌尿外科杭州310014 上海交通大学医学院附属仁济医院泌尿外科上海200120 四川大学华西医院泌尿外科成都610041 武汉大学中南医院泌尿外科武汉430071 西安交通大学第一附属医院泌尿外科西安710061 上海交通大学医学院附属第一人民医院泌尿外科上海200080 中山大学孙逸仙纪念医院泌尿外科广州510235 贵州省人民医院泌尿外科贵阳550002 上海交通大学医学院附属新华医院泌尿外科上海200092 中国人民解放军总医院第三医学中心泌尿外科北京100039

膀胱阴道瘘是指膀胱与阴道之间的异常通道,多为医源性造成,手术修补是主要治疗方式。随着机器人手术技术的普及,机器人辅助腹腔镜手术治疗膀胱阴道瘘在临床上的应用越来越广泛,为更好地规范及推广该项技术,特邀请国内泌尿外科领域专家,... 详细信息

膀胱阴道瘘是指膀胱与阴道之间的异常通道,多为医源性造成,手术修补是主要治疗方式。随着机器人手术技术的普及,机器人辅助腹腔镜手术治疗膀胱阴道瘘在临床上的应用越来越广泛,为更好地规范及推广该项技术,特邀请国内泌尿外科领域专家,聚焦术前评估、手术步骤与要点及术后随访,形成了本专家共识。

关键词：膀胱阴道瘘机器人外科手术腹腔镜共识

在线全文

学校读者我要写书评

暂无评论

盾构衬砌数字化设计平台的开发与应用研究

铁道科学与工程学报 2024年第6期21卷 2430-2441页

作者：骆汉宾李霖皓卢方伟魏然龙凡李清鹏华中科技大学土木与水利工程学院湖北武汉430074 华中科技大学人工智能研究院湖北武汉430074 武汉市政工程设计研究院湖北武汉430023 武汉数字建造产业技术研究院湖北武汉430074

为了对盾构隧道结构设计过程进行降本增效,基于SaaS模式和B/S架构开发了一个Web端的盾构衬砌辅助设计平台(TIM-SAP)。TIM-SAP面向盾构衬砌结构设计业务进行功能交互设计和算法开发,基于生成式建模、网格划分、结构计算、渲染后处理等模... 详细信息

为了对盾构隧道结构设计过程进行降本增效,基于SaaS模式和B/S架构开发了一个Web端的盾构衬砌辅助设计平台(TIM-SAP)。TIM-SAP面向盾构衬砌结构设计业务进行功能交互设计和算法开发,基于生成式建模、网格划分、结构计算、渲染后处理等模块设计程序流程、函数及其调用接口。TIM-SAP能提供衬砌建模、衬砌拼装、隧道建模、荷载计算、横向结构计算、纵向结构计算、衬砌配筋和衬砌出图共8个功能,覆盖建模、计算、配筋、出图的相关作业。其功能模块开发主要用到的技术包括面向B-rep的参数化建模、基于KNN的围岩解析、参数化结构计算和基于RF的配筋方案生成。先通过武汉地铁12号线工程算例对TIM-SAP进行计算结果的调试,然后在武汉新港线盾构隧道设计工程进行了项目应用。研究结果表明,现有成熟的土木工程设计功能模块可以被进一步地集成以实现数字化设计平台和系统的开发。基于算例进行功能调试后,TIM-SAP的计算结果能与现有软件保持一定吻合。结合项目应用情况,TIM-SAP能免去复杂的网格处理、收敛优化、检索查表等操作过程,并提供“一键”生成式建模以支持设计文档中的附图和三维表现。经过与现有软件的操作对比,TIM-SAP减少设计人员的8~60 min工作耗时。该研究成果能提升地下工程的数字化、自动化设计水平。

关键词：盾构隧道结构设计数字化设计盾构衬砌 SaaS

持续皮下稀释胰岛素泵入法治疗外源性胰岛素所致的复合型超敏反应一例

在线全文

学校读者我要写书评

暂无评论

中华糖尿病杂志 2020年第8期12卷 641-644页

作者：李新刚平凡黎明中国医学科学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室100730 首都医科大学附属北京地坛医院内分泌科 100015

外源性胰岛素诱发的复合型超敏反应是一种较为罕见的胰岛素治疗相关的不良反应,以皮疹、瘙痒的注射局部反应合并血糖高低波动及局部脂肪萎缩为特征。该疾病的诊治难度较大,尤其在内源性胰岛素缺乏的糖尿病患者,处理往往极为棘手。笔者报... 详细信息

外源性胰岛素诱发的复合型超敏反应是一种较为罕见的胰岛素治疗相关的不良反应,以皮疹、瘙痒的注射局部反应合并血糖高低波动及局部脂肪萎缩为特征。该疾病的诊治难度较大,尤其在内源性胰岛素缺乏的糖尿病患者,处理往往极为棘手。笔者报道1例52岁女性患者,应用胰岛素强化治疗1个月后出现内源胰岛功能的快速下降,同时伴有反复发作性严重低血糖、注射局部瘙痒、皮疹及局部脂肪萎缩,胰岛素自身抗体阳性。经过生理盐水5~10倍稀释后的胰岛素类似物皮下泵入持续1年后,低血糖发作及注射局部反应均得到有效缓解。

关键词：皮下胰岛素输注胰岛素超敏反应胰岛素稀释胰岛素浓度

在线全文

学校读者我要写书评

暂无评论

移动硬盘盒精密热流道注塑模具设计

工程塑料应用 2021年第1期49卷 97-101页

作者：范玉范佳琦高新刚江苏建筑职业技术学院江苏徐州221116 同济大学上海201804 上海阿为特精密机械股份有限公司上海201804

热流道注塑模具在模具行业中的应用越来越广泛,采用热流道系统不仅可以保证塑件质量、提高材料的利用率,还能显著提高塑件的生产效率。通过对移动硬盘塑料件的结构及成型工艺特点进行分析,设计了移动硬盘塑料件热流道注射模具,重点对热... 详细信息

热流道注塑模具在模具行业中的应用越来越广泛,采用热流道系统不仅可以保证塑件质量、提高材料的利用率,还能显著提高塑件的生产效率。通过对移动硬盘塑料件的结构及成型工艺特点进行分析,设计了移动硬盘塑料件热流道注射模具,重点对热流道模具热平衡计算和热流道浇注系统进行了分析计算,模具采用单点热流道、一模两件潜伏式浇口、外滑块抽芯机构及斜推杆抽芯成型倒扣设计。实践证明,该移动硬盘塑料件模具设计结构合理,在提高塑料件成型质量的同时,提高了材料的利用率及生产效率,为同类结构特点的热流道注塑模设计提供了参考。

关键词：塑料盖板热流道浇注系统模具结构

在线全文

学校读者我要写书评

暂无评论

我国实验动物资源建设的问题与展望

中国科学院院刊 2019年第12期34卷 1371-1378页

作者：赵心刚卢凡程苹田勇中国科学院科技促进发展局国家科技基础条件平台中心中国科学院生物物理研究所

实验动物是支撑我国生命科学和医学研究的重要基础支撑条件。实验动物资源建设和实验动物科技创新有力促进了国家生命科学发展和健康中国的建设。在分析国内外实验动物资源建设发展现状的基础上,文章阐述了我国实验动物资源建设中存在... 详细信息

实验动物是支撑我国生命科学和医学研究的重要基础支撑条件。实验动物资源建设和实验动物科技创新有力促进了国家生命科学发展和健康中国的建设。在分析国内外实验动物资源建设发展现状的基础上,文章阐述了我国实验动物资源建设中存在的包括模型资源建设、法制化、伦理、数据资源整合等突出问题,提出了我国至2035年实验动物资源建设的若干目标和具体建议。希望通过进一步加强我国实验动物资源建设,为支撑我国生命科学和医学发展作出应有的贡献。

关键词：实验动物动物模型实验动物资源动物伦理福利

Metastable state of gas hydrate during decomposition: A novel phenomenon

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2020年第4期28卷 949-954页

作者： Ronghui Sun Zhen fan Lei Yang Yuanping Li Xin Lü Yang Miao Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of TechnologyDalian 116023China School of Chemistry University of GlasgowGlasgow G128QQUnited Kingdom 3 Institute of Science and TechnologyShenzhen BranchChina National Offshore Oil CorporationGuangzhou 510420China CNOOC Research Institute Co.Ltd Beijing 100028China xingang Shipbuilding Heavy Industry Co. Ltd.Tianjin 300452China

Natural gas hydrates are solid compounds with cage-like structures formed by gas and *** intriguing phenomenon that gas hydrates can dissociate at a low rate below the ice freezing point has been viewed as the metastability of *** mechanisms of hydrate metastability have been widely studied,and many mechanisms were proposed involving the self-preservation effect,supercooled water-gas-hydrate metastable equilibrium,and supersaturated liquid-gas-hydrate system *** metastable state of hydrate could be of crucial significance in the kinetics of hydrate formation and decomposition,heat and mass transfer during gas production processes,and the application of hydrate-based technique involving desalination,energy storage and transportation,and gas separation and *** researches have systematically considered this phenomenon,and its mechanism remains *** this work,various mechanisms and hypothesis explaining the metastable state of gas hydrates were introduced and *** studies are still required to reveal the intrinsic nature of this metastable state of gas hydrate,and this work could give some implications on the existing theory and current status of relevant efforts.

关键词： Hydrates Dissociation Metastability Self-preservation Supersaturation